AR226-1307-5 Summary * APFO reproductive effects, 8/23/2002 Created By:Nancy S Selzer on 10/07/2002 at 01:47 PM Document Category: Mammalian Toxicology Testing Sub Category : PFOA Consortium Products Additional Authors: Nancy S Selzer/AE/DuPont Li APFO Reproductive effects summary.d 0 .Edit History: Editor Nancy S Selzer/AE/DuPont Edit Date 10/07/2002 01:48:54 PM *Onlypast five adits are shown 000050 PTDB00OB30 EID613678 DuPont Summary - August 23,2002 Oral (Gavagc) Two-Generation (One Litter Per Generation) Reproduction Study of Ammonium Perfluorooctanoate (APFO) in Rats 3M study conducted at Argus (Argus Study #T-6889.6) The multigeneration reproduction study with APFO has been reviewed and DuPont's position on the study is reported below, in addition to some comments on potential endocrine effects of APFO.

r AR226-1404 Tl CC: POLYMERS OCCUPATIONAL H E A L T H COPY LIST A R A R G - IH-0 / f JUNE II, 1991 TO: POLYMERS OCCUPATIONAL HEALTH SITE CONTACTS FROM: / Ut V)AjMY<1tS.nULB3E*RGAELs - ACCEPTABLE EXPOSURE LIMITS The following changes were made in the AEL list at the June meeting.

* -1 * 0 0 3 -A A E V . 3-77 E.

kZtb-f& l'J PERSONAL AND CONFIDENTIAL CC: J.

Attachment 2 * 77& Analytical Report Air Sampling Fluorochemical Report DuPont Washington Works - Air Sampling Program Round 9 Exygen Research Report No.

SOIL ADSORPTION - REVISED TEST SUBSTANCE____________________________________________ Id en tity: Perfluorooctanesulfonate; m ay also be referred to as P FO S or F C -95. (1 O ctanesulfonic acid, 1,1 ,2 ,2 ,3 ,3 ,4 ,4 ,5,5 ,6 ,6 ,7 ,7 ,8 ,8 ,8 -h e p ta d e c a flu o ro -, potassium salt, C A S # 2 7 9 5 -3 9 -3 ) R em arks: The test substance is a w hite powder.

Pathology and Toxicology RMcar Laboratories, Inc.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (E.G..DAPHNIA) TEST SUBSTANCE Identity: Perfluorooctanoic add; may also be referred to as PFOA, FC26, or FX-1001.

3.M Press Box - 3M Phasing Out Some o f its Specialty Materials http://www. 3m.com/profile/pressbox/fluorochem.html *ff 3M News AR&3.& _ 661/-!

IHTEROFFICE MEMORANDUM DFarte:: Dept : Tel Mo: 23-Apr-1997 02 :12pm DAVID E.

STUDY TITLE Extraction of Potassium Perfluorooctanesulfonate from Red Blood Cells and Serum for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher ANALYTICAL REPORT DATE June 2, 2003 PERFORMING LABORATORY / TESTING FACILITY Exygen Research 3058 Research Drive State College, PA 16801 Phone: 814-272-1039 STUDY SPONSOR 3M Environmental Technology and Safety Services Building 2-3E-09 POBox 33331 St.

D u P o n t-15302 Study Title Ammonium Perfluorooctanoate: Age Effect on the PFOA Plasma Concentration in Post-Weaning Rats Following Oral Gavage Test Guidelines: None applicable AUTHOR: Paul M.

P M226-/93S Proven Results. i \ m Analytical Report itf 3M Company Analysis o f PFOA and PFOS in W ater Samples from O akdale M unicipality E05-0074 m Exygen Report No.

AR226-2207 Debbie J Mulrooney 11/02/2001 09:43 AM To: Robert F Pinchot/DEV/AE/DuPont@DuPont cc: Subject: C8 Particle Density Rob, In addition to the particle size distribution, I need a particle density in order to start doing a sensitivity analysis.

AR226-2295 ^ Paul J Bossert 01/28/2003 05:05 PM To: cc: S u b je c t Gerald L Kennedy/AE/DuPont@ DuPont, Robert W Rickard/AE/DuPont@ DuPont Catherine A Barton/AE/DuPont@ DuPont, David M Rurak/AE/DuPont@ DuPont, John R Bowm an/AE/DuPont@ DuPont, M.