DEPARTMENT OP HEALTH AND HUMAN SERVICES Safety and Health Robert A.

Study Title Soil Adsorption/Desorption Study o f Potassium Perfluorooctanesulfonate (PFOS) Data Requirem ent Based on OECD 106 A u th o r M ark E.

ACUTE TOXICITY TO FISH ARW W TEST SUBSTANCE Identity: Perfluorooctanesulfonyl fluoride; may also be referred to as POSF, or FX-8. (1-Octanesulfonyl fluoride, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, CAS #30735-7).

PiR11-OM30 CO RN ING Hazleton MUTAGENICITY TEST ON T-6564 IN AN IN VIVO MOUSE MICRONUCLEUS ASSAY FINAL REPORT AUTHOR Hemalatha Murli, Ph.D.

Internal Correspondence /tfU U -o M ia To: P .

A r n 6 -o w BIODEGRADATION (ABS/LAS Shake Culture Test) TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, PFO, FC-116, FC-126, FC-169, or FC-143.

A R Z K > - 0 5 l5 MICROBIOS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as P F O A ammonium salt, Ammonium perfluorooctanoate, PFO , FC-116, FC-126, FC-169, FC-143, or as a major component of FX-1003.

3M Environmental Technology and Services PO Box 33331 St.

CAS Number 2991-51-7 3M Company Voluntary Use and Exposure Information Profile Perfluorooctane sulfonamido ethyl acetate 1 I.

3M Specialty Materials June 15, 2000 3M Center St.

yWi<26_ 06uS PFOS Medical Surveillance/Epi - I 00013 Interim Report #1 Epidemiology, 220-3W-05 Medical Department 3M Company St.

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* AR226-2097 Sample Date Range Concentration Range Action Level Industrial Hygiene m1/1 12/31/97 100% ' Sample Dt Sample# Duration Type Employe* Name STO: 07 TECHNICAL LOG: 2S2 BLDG.3 -GENERAL 6/2S/07 6890 390 A Pern Chemical C-8/FC-143 BTO: 08 LOG: 0 TEFLON BLDG. 162ROOF-GENERAL 7/9/97 7137 362 A 7/9/97 7138 362 A 7/21/97 7130 370 A 7/21/97 7219 371 A 7/21/97 7225 368 A 7/22/97 7 1 370 A 7/22/97 7220 374 A 7/22/97 7226 375 A 7/22/97 7232 384 A 7/23/97 7141 396 A 7/23/97 7221 400 A 7/23/97 7227 7123197 7233 374 A 391 A 7/24/97 7142 362 A 7/24/97 7222 7124197 7228 7124/97 7234 361 A 338 A 366 A 7/2397 7223 354 A 7/2397 7229 351 A 7/2397 7235 351 A 7/29/97 7230 376 A 8/397 7224 378 A 8/397 7231 371 A 8/5/97 7236 370 A C-8/FC-143 C-8/FC-143 C-6/FC-143 08/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C45/FC-143 C-8/FC-143 C-8/FC-143 C-8/F-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-B/FC-143 08/FC-143 C-8/FC-143 GSA-0-143 C-8/FC-143 C-8/FC-143 C-B/FC-143 C-8/FC-143 C-8/FC-143 BTO : 08 TEFLON LOC: 048 B-162 OUTSIDE SMOKING AREA - 2ND LEVEL 7/9/97 7143 382 A C-8/FC-143 Tuesday, May23,20001:16:50 PM Cone Unit Percent 0.08 MPB 89% 0.1 MPB 0.13 MPB 0.15 MPB 0.113 MPB 0.26 MPB 0.07 MPB 0.17 MPB 121 MPB 019 MPB 0.11 MPB 0.16 MPB 1.08 MPB 0.51 MPB 0.14 MPB 0.39 MPB 213 MPB 096 MPB 034 MPB 0.69 MPB 2 9 MPB 217 MPB 007 MPB 019 MPB 0.3 MPB 17/9% 23.2% 268% 202% 46.4% 125% 30.4% 2161%" 339% 19.6% 28.6% 192.9%" 91.1% 25/0% 69.6% 380.4% " 171.4% " 60.7% 1232% " 517.9% " 387.5% " 125% 33.9% 53.6% 043 MPB 768% Page 1 of 12 AJPQ00462 E ID 072868 SampleDt Sample# Duration Type Employee Name 7/10197 7144 7/11/97 7145 7/21/97 7146 7/22/97 7147 7/23/97 7148 7/24/97 7149 7/25/97 7150 8/4/97 7151 8/7/97 7152 387 A 370 A 366 A 377 A 390 A 352 A 351 A 354 A 367 A Per Chemical C-6/FC-143 C-8/FC443 ' C-8/FC-143 C-8/FC-143 C-8/PC-143 C-8/FC-143 C-6/FC-143 C-8/FC-143 C-fl/FC-143 BTO : 08 TEFLON PISLOC 100 - MONOMER OPERATOR CONTROL ROOM (08PA/P8/PC) 7/21/97 7207 372 A C-8/FC-143 7/22/97 7208 351 A C-S/FC-143 7/23/97 7209 398 A C-8/FC-143 7/24/97 7210 7/25/97 7211 352 A 355 A C-8/FC-143 C-8/FC-143 7/28/97 7212 3375 A C-8/FC-143 8/4/97 7213 356 A C-8/FC-143 8/5/97 7214 376 A C-8/FC-143 8/7/97 7215 367 A C3/FC-143 8/8/97 7216 307 A C-8/FC-143 8/12/97 7217 458 A C-a/FC-143 8/13/07 7218 335 A C-8/FC-143 BTO: 06 TEFLON LOG: 113 P/S - SHIFT MECHANIC (58MD) 3/13/97 25282 390 P 6/25/97 25793 370 P 10/21/97 26712 360 P 55MD C-8/FC-143 58MD C-8/FC-143 58MD C3/PC-143 BTO: OS TEFLON LQC: 708 P/S - FINE POWDER PACKOUT (08PJ) 6/24/97 25792 360 P 10/6/97 26426 390 P HEADLEY, ANNE MARIE 08PJ C-8/FC-143 08PJ C-8/FC-143 BTO: 06 TEFLON LOG: 710 FP&D AUTOCLAVE CONTROL ROOM 7/9/97 8862 363 A 7/10/97 8863 388 A Tuesday.

AR226-2115 r Test Results Industrial Hygiene Sam ple Date R ange 1/1/88 12/31/88 C oncentration R ange Action Level 100% Sam ple D t S am ple# D uration T ype Em ployee Name BTO: 08 TEFLON LOG: 0 ACIDNEUTPIT-GENERAL 5/4/88 40895 1440 Z Pere Chem ical C one Unit Percent C-8/FC-143 0 .0 3 MPB 5.4% BTO : 08 TEFLON LOC : 109 P /S - DAY POLY/MON ESI WIECH (COMB W/TMO10S) 7/27/88 14397 420 P none C-8/FC-143 0.03 MPB 5.4% BTO: 08 TEFLON LOG: 701 FINE POWDER DRYER-EAST SIDE #2 2/21/88 46265 Oqfvlwg Z 4/16/88 46286 6/14/88 46287 393 Z 450 2 9/5/88 46289 490 Z 9/25/88 46238 390 Z 11/13/38 46290 300 Z C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 BTO: 08 LOC: 702 TEFLON FINE POWDER DRYER CONTROL ROOM (ALSO SEE TTF031 2/10/88 36612 6/24/88 36615 6/25/88 36614 330 Z 420 z 420 z C-8/FC-143 C-8/FC-143 C-8/FC-143 8/20/88 36616 10/14/88 36617 330 z 330 z C-8/FC-143 C-8/FC-143 BTO; 08 TEFLON LOC: 703 FINE POWDER PACKOUT ROOM 1/17/88 34561 450 z 1/18/88 34560 360 z 2/29/88 34563 360 z 4/5/88 40678 420 z 4/26/88 34664 450 z 6/21/68 40903 381 z 6/23/88 40901 420 z 6/24/88 40902 420 z Tuesday, January 16,2001 9:41:56AM C-8/FC-143 C-8/FC-143 C S /F C -1 4 3 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 0.183 MPB <0.005 MPB 0.107 MPB 0.11 MPB 0 5 3 MPB 0.32 MPB 32.7% 0.9% 19.1% 19.6% 94.6% 57.1% 0.072 MPB <0.03 MPB <0.03 MPB 0.04 MPB <0.03 MPB 12.9% 5.4% 5.4% 7.1% 5.4% 0.065 MPB 0.1 MPB 0.068 MPB 0.034 MPB 0.006 MPB <0.03 MPB <0.03 MPB <0.03 MPB 11.6% 17.9% 12.1% 6.1% 1.1% 5.4% 5.4% 5.4% Page 1of 12 AJP003893 EJD113027 Sam ple Dt Sam ple# D uration T ype Em ployee Name 8/23/88 41082 9/5/88 41097 10/1/SB 41108 10(31/88 41124 370 Z 450 z 401 z 339 z BTQ : 08 TEFLON LQC i ' 704 A/S - FINE POWDER 0 8 WEIGH HOOD 1/17/88 34883 <0 z 6/13/88 34988 420 z 9/5/88 34090 4S0 z 9/25/88 34989 390 z BTO: 08 TEFLON LQC: 70S DISPERSION PACK OUT AREA 3/29/86 37381 450 z 8/18/88 37383 360 z BTO: 03 LQC: 706 TEFLON FINE POWDER DRYER #3 3/27/88 34271 360 z 4/25(88 34270 360 z 8/20(38 34273 330 z 8/28/88 34272 450 z 10/25/88 34278 420 z 11/11/88 34274 330 z 11/11/88 34275 330 z BTO: 0B L O t: 70S TEFLON P/S - FINE POWDER PACKOUT (08PJ) 4/14/88 14135 420 p 4/29/88 14147 420 p 6/23/88 14195 420 p 7/7/88 14349 420 p 7/18/88 14403 420 p 7/27/88 14399 420 p 8/1Q/B8 14394 420 p BTO: 08 TEFLON@ LOG: 710 FP8D AUTOCLAVE CONTROL ROOM 2/9/88 46048 ........................ . 330 z -------------- --------------- Tuesday, January 16,2001 9:41:56AM Pere Chemical C-/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 Cone Unit <0.03 MPB <0.03 MPB 0 .0 3 MPB 0 .0 3 MPB Percent 5.4% 5.4% 5.4% 5.4% C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 0.396 MPB 0.07 MPB >1.0 MPB >1,0 MPB 7D.7% 12.5% 178.6%** 178.6%** C-8/FC-143 C-8/FC-143 0.04 MPB 0.3 MPB 7.1% 53.6% C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C -8/F C 4 4 3 08/F C 443 08/FC -143 0.072 MPB 0.144 MPB 0 .0 3 MPB 0.04 MPB 0.16 MPB 0.1 MPB 0.07 MPB 12.9% 25.7% 5.4% 7.1% 28.6% 17.9% 12.5% none C-8/FC-143 none C-8/FC-143 none C-8/FC-143 acme C-8/FC-143 none C-8/FC-143 none C-8/FC-143 none C-8/FC-143 0.178 MPB 0 .0 3 MPB 0 .0 3 MPB 0 .0 3 MPB <0.03 MPB 0 ,0 3 MPB 0 ,0 3 MPB 31.8% 5.4% 5.4% 5.4% 5.4% 5.4% . 5.4% C -8 /F C 4 4 3 ....... . . 0.413 MPB 73.8% Page 2 of 12 AJP003894 EID 113028 Sample Dt Sam ple# Duration Type Employee Name 2/9/8B 46047 6/1/83 46049 6/13/B 46048 6/24/83 46050 8/28/88 46061 10/19/88'40052 10/19/88 46053 330 Z 435 Z 420 Z 420 Z 450 z 480 z 480 z BTO: 08 LOC : 712 TEFLON NORTH END OF DRYER #3 1/18/88 46332 360 z 6/13/88 46333 420 z 8/24/88 46334 375 z 10/25/88 46335 420 z BTO : CB LOC: 715 TEFLON SOUTH END DRYER#2 1/23/88 46008 357 z 6/13/88 46010 420 z 8/24/88 46011 360 z 10/14/88 46347 330 z BTO : 08 LOC: 717 TEFLON ROOF AREA-GENERAL 1/3/88 46083 330 Z " 6/1/88 46084 435 z 8/23/88 46085 360 z 10/31/88 46086 344 z BTO: 08 LOC: 719 TEFLON MOISTURE CHECK 2/3/88 46345 330 z 6/21/88 46346 386 z BTO : 08 LOC : 720 TEFLON INJECTION PUMP AREA 1/3/88 40596 330 z 4/25/88 40677 360 z 10/14/88 41109 330 z Tuesday, January 16,2001 9:41:56 AM Pera Chemical C-8/FC-143 C-8/FC-143 C-8/FC-143 C-S/FC-143 C-8/FC-143 C-S/FC-143 C-8/FC-143 Cone Unit 0.095 MPB 0.177 MPB OOS MPB 0 .0 3 MPB 0.03 MPB 0.06 MPB 0.1 MPB Percent 179% 31.6% 14.3% 5.4% 5.4% 10.7% 17.9% C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 0.155 MPB 0.087 MPB 0.05 MPB 0.1 MPB 27.7% 15.5% 8.9% 17.9% C-8/FC-143 C-S/FC-143 C-8/FC-143 C-S/FC-143 0.252 MPB 0.135 MPB 0 .0 3 MPB 0.35 MPB .0% 24.1% 5.4% 62.5% C-8/FC-143 C-8/FC-143 C-S/FC-143 C-8/FC-143 0 .0 3 MPB 0.196 MPB 0 .0 3 MPB 0.2 MPB 5.4% 35.0% 5.4% 35.7% C-S/FC-143 C-S/FC-143 0.091 MPB 0 .0 3 MPB 16t3% 5.4% C-8/FC-143 C-8/FC-143 C-8/FC-143 0.149 MPB 0.089 MPB 0.08 MPB 26.6% 15.9% 14.3% PageSof 12 AJP003895 EID 113029 Sam ple Dt S am ple# D uration Type Em ployee Name BTO : 08 TEFLON LOC : 726 AISLE IN FRONT OF WAX SEPARATOR 1/23/88 35497 345 Z 4/16/88 35499 369 Z 8/18/88 35504 360 Z BTO : 08 TEFLON LOC 727 FINE POWDER CELL AREA 8/18/08 3S177 360 Z BTO : 08 LOC: 728 TEFLON WAXROOM- B-162-1S T FLOOR 1/3/88 37197 330 Z 4/16/88 40682 329 Z 8/23/88 41083 350 Z 8/31/88 41098 360 Z BTO: 08 LOC : 731 TEFLON A/S - INSIDE F.P.