WARF INSTITUTE, INC.

A fm G - c r a G -s ' Final Report Unscheduled DNA Synthesis in Rat Liver Primary Cell Cultures With PFOS PREPARED FOR: 3M Corporate Toxicology COVANCE STUDY NUMBER: 20784-0-447 THE DEVELOPMENT SERVICES COMPANY FINAL REPORT UNSCHEDULED DNA SYNTHESIS IN RAT LIVER PRIMARY CELL CULTURES WITH PFOS AUTHOR Maria A.

AR <AA6 - 06US~ NOTE TO FILE DATE: September 29, 2000 FROM: Karen Lannon SUBJECT: PFOS Substitutes - Carpet Treatment A meeting was held from 1:00 pm to 2:00 pm on September 15, 2000 to discuss PFOS alternatives for carpet treatment.

gGH& - 0 2 0 0 - $ 1 5 J R zz6 -0 % lys -y Laboratory Report, Analysis of FCs in Samples of Children's Sera, May 21, 1999 The data submitted on perfluorooctanesulfonate contains analytic data when certain general conditions have been met.

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ftp. a & e - t i t # Protein Binding of Perfluorohexane Sulfonate, Perfluorooctane Sulfonate and Perfluorooctanoate to Plasma (Human, R at, and Monkey), and Various Human-Derived Plasma Protein Fractions STUDY ID: 9921.7 Southern Research Institute 2000 Ninth Avenue South P.O.

_ 14fe D u P on t-13309 Perfluorooctanoic Acid: Lactational and Placental Transport Pharmacokinetic Study in Rats Work Request Number 14787 Service Code 1569 Protocol Haskell Animal W elfare Committee Number: <> -1- RECEIVED 0PPTNC1C 2803SEP -* AH 8*1* 5 Perfluorooctanoic Acid: Lactational and Placental Transport Phannacokinetic Study in Rats D u P on t-13309 TABLE OF CONTENTS Page INTRODUCTION...............................................................................................................................3 OBJECTIVE........................................................................................................................................ 3 SPONSOR AND TEST FACILITY............. ....................................................................................3 REGULATORY COMPLIANCE.....................................................................................................3 STUDY DESIGN................................................................................................................................4 A.

^2Z&~ l72(p Determination of Possible Interference of Perfluorooctane Sulfonic Acid Potassium Salt with Rat Cholesterol Date: 8/17/99 Study: 6329 263 Serum Vehicle Blank Blank 0 ug/mL 0 ug/mL 1.08 mg 3.23 mg 6.46 mg /mL_______/mL_____ /mL mg/dL #1 mg/dL #2 mg/dL #3 68 66 66 65 67 66 66 65 65 65 65 65 66 66 65 mean s.d. 66.33333 65.66667 65.66667 65.33333 65.66667 1.527525 0.57735 0.57735 0.57735 1.154701 Method Principle (Trinder reaction) Cholesterol esters present in serum or plasma are hydrolyzed qualitatively in to free cholesterol and fatty acids by microbial cholesterol esterase.

Laboratory R eport-Revision 1 Analytical Report of Data for PFOS Dietary LC50 Study with Mallards (Sera and Liver) Laboratory Report No.

PFOS: A REPRODUCTION STUDY WITH THE MALLARD FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

PERFLUOROOCTANESULFONYL FLUORIDE (POSF; T-7661.4) TOXICITY STUDY BY INHALATION ADMINISTRATION TO CD RATS FOR 13 WEEKS FOLLOWED BY A 4 WEEK RECOVERY PERIOD Volume 2 MIN 313/023622 PERFLUOROOCTANESULFONYL FLUORIDE (POSF; T-7661.4) TOXICITY STUDY BY INHALATION ADMINISTRATION TO CD RATS FOR 13 WEEKS FOLLOWED BY A 4 WEEK RECOVERY PERIOD Volume 2 Sponsor 33BMUSMMtuSNPiAlaCCd5.uieo5nlnr,1gpt3eo23rr2,-a30t2e-22TE0o,-x0i2c,ology, Research Laboratory HWAHCPEENaluuocm2nnGoo8ttbnliiLlnnrb4eAigguHydddNrgSRyooeD,,nnos,.haLdiri,efe, Sciences Ltd., Report issued: 28 September 2005 Page 366 of 740 MIN 313/023622 CONTENTS Page CONTENTS................................................................................................................................... 2 COMPLIANCE WITH GOOD LABORATORY PRACTICE.................................................... 4 QUALITY ASSURANCE STATEMENT................................................................................... 5 CONTRIBUTING SCIENTISTS.................................................................................................. 6 SUMMARY................................................................................................................................... 7 INTRODUCTION......................................................................................................................... 9 EXPERIMENTAL PROCEDURE................................................................................................

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