ACUTE TO XIC ITY TO FISH (M UM MICHOG) TEST SUBSTANCE________________________________________________ Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-780. (1Octanesulfonic acid) (CAS # 2795-39-3).

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M n -IW Benchmark Doses for Liver Tumors in Sprague Dawley Rats fed Perfluorooctane Sulfonic Acid Potassium Salt (PFOS) David W.

3M M edical Department Study: T-6295.22 Analytical Report: FACT-TOX-160 LIMS E00-1668 3M Medical Department Study: T-6295.22 Analytical Report: FACT TOX-160 LIMS E00-1668 Study Title 36> Extended Recovery Study Following a 26-W eek Capsule Toxicity Study (FACT-TO X-030) with Perfluorooctane Sulfonate Acid Potassium Salt (PFOS; T-6295.22) in Cynomolgus Monkeys IIO 3 A nalytical Laboratory Report Title Determination of the Presence and Concentration of PFOS in Serum and Liver Samples of Cynomolgus Monkeys Data Requirem ent Not Applicable A u th o r 3M Environmental Laboratory Study Completion Date May 3, 2002 Performing Laboratories Sera and Liver Analyses Sera and Liver Extractions 3M Environmental Laboratory Building 2-3E-09,935 Bush Avenue St.

Northwest Bioanalytical A6_ IAH Study No.

\& 2> March 31, 2003 To: Mary F.

9 ff COLUM BUS.

3M Specialty Materials 3M Center St.

S'A f f O A !

Proven Results

3M Specialty Materials 3M Center St.

AR226-1735 PFOS: A DIETARY LC50 STUDY WITH THE MALLARD WILDLIFE INTERNATIONAL LTD.

Katherine E.

Wildlife International, Ltd. -1 - Project Number 454A -106 PFOS: A 96-HOUR SHELL DEPOSITION TEST W ITH THE EASTERN OYSTER (Crassostrea virginica) ADDENDUM WILDLIFE INTERNATIONAL, LTD.

Group Summary P Generation Group Group 1 Group II Group III Group IV Group V NUMBER OF DAYS OF DATA COLLECTION NUMBER OF DAYS IN ESTRUS % OF DAYS IN ESTRUS 21 g 43% 21 8 41% 21 9 42% 21 8 39% 21 9 42% NUMBER OF DAYS IN % OF DAYS DIESTRUS IN DIESTRUS NUMBER OF % OF DAYS DAYS IN IN PROESTRUS PROESTRUS 9 41% 9 45% 9 45% 10 45% 9 43% 3 16% 3 14% 3 13% 3 15% 3 15% "N" FOR MEAN CYCLE MEAN CYCLE NUMBER OF LENGTH LENGTH CYCLES 30 4.3 4.6 30 4.0 4.6 28 4.1 4.3 30 4.3 4.4 29 4.1 4.6 P Generation nimal I 13801 13802 13803 13804 13805 13806 13807 13808 13809 13810 13811 13812 13813 13814 13815 13816 13817 13818 13819 13820 13821 13822 13823 13824 13825 13826 13827 13828 13829 13830 13831 13832 13833 13834 13835 13836 13837 13838 13839 13840 13841 13842 13843 13844 13845 13846 13847 13848 13849 13850 Group 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 MEAN CYCLE LENGTH 3.75 3.20 3.75 3.67 3.75 5.33 4.00 4.25 4.25 4.25 4.50 9.00 4.00 5.00 5.00 4.33 4.00 4.00 4.00 4.00 4.25 4.00 4.00 3.40 4.67 3.75 4.25 3.75 4.00 4.00 3.67 4.25 4.00 3.75 4.00 4.00 4.00 4.50 3.75 4.33 3.75 4.00 4.25 3.75 4.00 4.00 4.00 4.00 4.00 4.25 NUMBER OF CYCLES 5.00 6.00 5.00 4.00 5.00 3.00 5.00 4.00 5.00 5.00 4.00 2.00 5.00 4.00 4.00 5.00 5.00 5.00 5.00 4.00 5.00 5.00 5.00 6.00 5.00 5.00 5.00 4.00 4.00 5.00 5.00 5.00 5.00 5.00 5.00 2.00 5.00 2.00 5.00 5.00 4.00 4.00 5.00 4.00 4.00 5.00 4.00 5.00 5.00 6.00 13851 13852 13853 13854 13855 13856 13857 13858 13859 13860 13861 13862 13863 13864 13865 13866 13867 13868 13869 13870 13871 13872 13873 13874 13875 13876 13877 13878 13879 13880 13881 13882 13883 13884 13885 13886 13887 13888 13889 13890 13891 13892 13893 13894 13895 13896 13897 13898 13899 13900 13901 13902 CO CO CO P Generation 2 3.25 6.00 2 3.75 5.00 2 4.00 4.00 2 4.00 5.00 2 3.75 5.00 2 3.75 4.00 2 4.50 4.00 2 4.00 5.00 2 3.80 5.00 2 4.25 5.00 3 5.00 3.00 3 3.75 5.00 3 4.00 5.00 3 4.67 4.00 3 4.00 4.00 3 4.67 3.00 3 4.00 5.00 3 3.75 5.00 3 4.00 5.00 3 4.00 4.00 3 3.75 5.00 3 3.75 5.00 3 4.00 5.00 3 5.00 3.00 3 4.00 4.00 3 3.75 4.00 3 4.25 4.00 3 4.25 5.00 3 4.00 6.00 3 4.00 4.00 3 5.00 4.00 3 4.00 5.00 3 3.75 5.00 4.00 5.00 #DIV/0!