5/23/84 PERSONAL U CONFIDENTIAL cc.

^ 4 2 2 - V / 7 6 CANCER PREVALENCE IN SUBJECTS EXPOSED TO PERFLUOROOCTANONIC ACID (PFOA) James Dahlgren MD1, Ayman B Ibrahim M DU' \Raphael Warshaw2, Harpreet Takhar MPH3 1.

Final Report 28-Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats Fraunhofer ITEM - Study No.: 01G 00 0 02 Original ... of 2 Test Facility: Fraunhofer Institute of Toxicology and Experimental Medicine [Fraunhofer ITEM] Nikolai-Fuchs-Str. 1 30625 Hannover Germany Director: Prof.

tW g;en RESEARCH ^P.Prreecciisse Research.

RESEARCH .Precise Research.

< A Z Z '' N 6 HELEN WAY N 7 HELENA RD N *5.- % ^S T* ^ECvIMATiON . t' .*- *.

AJP000903 AR226-2072 C *r T * i * * 34 * C1av '"' ,l -0 '' _X ' .* :i <1 vi" *X* rS--i ty 0 ta-.:: *T< * .r* k- *o *o ** r O * # tri U . kr r4 ^ ' ;5S K fi. 5* O ## SS; FO) < iTM* i LU \[-0.

AR226-2148 SSG EID942803 RJZ027542

AR226-2146 ATMOSPHERIC MODELING STUDIES WASHINGTON WORKS NEAREST LUBECK NEIGHBOR ANNUAL EXPOSURE IS CA. 0.03 UG/M3 (10% CEG) ASSUMING 85% UTILXTY/90% EFFICIENCY OF FINE POWDER DRIER SCRUBBER.

Item 10: Monitoring - Fluoropolymers EPA Data Needs: (Draft 9-21-03) Data Need LOl Commitment MRealenausfeascturing Dwaastateownatreerl,ealasnesdftiollaliera,cwhaatteer, Irwamlffneariaraolnfca,eosmdinatwlrfeuismitwafelilaetaaeocstltrietfeo,uaPrnrc,iFhnoOagntAe to Creolenatisneused monitoring of MSitaensufacturing Concentration of 'PslgbmfauaFrinoraocOfdntiuaalfAunic,itfdleiwlaeiwcnwslaetasuaaattiterecreirw,hnr,,agasttoeeirla,,t wScmouaanrsnfctaueecwfneatacrwtateutarirto,iennlrags,ngsadirtftoeiluslnldewacahtaetre, Limited biota data Modeling ofPFOA in air AnededdistiboenyaolnddatLaOl EPA Proposal to Address Data Needs Manufacturing none McPaodFondOncitAieitonontirrneaadlatiibori,nosstoaoilf, Scocnreceennitnragtiloenvealnmdoenxitteonrting ofPFOA in air to quantify Samqcaurneauetifncaincstgpuerlceinivegesl,fmapcloialnnitititseo,srhinegrboivfoPrFesO,Aaviinanb,iotetrare(esgtr,iafilsshpaencideso)thaetr AR226-2340 EXP000011 - 1- EXP000012 r~~ Item 10: Monitoring - Fluoropolymers EPA Data Needs: (Draft 9-21-03) Data Need MOfafnSuitfeacftruorming CPsgagmfuaFnrororcaadOnfuindaclAbnuiiceetidfenionaiewtntwtcsraaatfaaurttditeiorreooirm,rnw,n,gsnoofil, LOI Commitment Anededdistiboenyaol nddatLaOI PsgmuFraorOfnuauAncfdeacwcwotanuatcrteeiernrnfgtarronsamidttieosns in McPaodFondOncitiAeitnootnirrneaadltaibiori,nosstoaoilf, Limited biota data Modelingofair contamination EPA Proposal to Address Data Needs Monitoring of PFOA in air to quantify concentration and extent ofoffsite contamination AWabtedoadcdriokdtilsiol,teintcooatnleqadgulrtaoomnutdaniefndytuwefPraamFtceOtirunAremintoihgnneisgteiortxoertisuen.nngdGt,wasrnioamdtuenilrledaovwrfeftaleotroetWerf ccaoosnhntitanamgmtiomnnaattiioonn apytoB iJesite...^........

AR226-2414 -9 s u e ^ H pUjQ. 3/13/8?

AR226-2533 FLUOROPOLYMERS 81-4 PAGE 10 3.

RECYCLED \ CO AR226-2621 CWK PROJECT CLF LEACHATE SAMPLING 6/04 CLF LEACHATE SAMPLING 6/04 EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING, EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPUNG EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING EFFLUENT/RIVER SAMPLING SRCNAME THEME DATESMPL SMPLT SAMPLE NUMBER FBLK1 Blank Water 6/3/2004 FB CWK-K-FBLK1 SUMP 1,2,3,5-COMP Other liquid 6/3/2004 FS CWK-Z-SUMP 1,2,3,5-COMP AD3-JUNE10 Surface Water 6/11/2003 DUP CWK-W-AD3-JUNE10-2 AD3-JUNE10 Surface Water 6/11/2003 DUP CWK-W-AD3-JUNE10-2 AD3-JUNE10 Surface Water 6/11/2003 FS CWK-W-AD3-JUNE10 AD3-JUNE10 Surface Water 6/11/2003 FS CWK-W-AD3-J UNE10 AD3-JUNE2-8 Surface Water 6/11/2003 FS CWK-W-AD3-JUNE2-8 AD3-JUNE2-8 Surface Water 6/11/2003 FS CWK-W-AD3-JUNE2-8 AD3-JUNE9 Surface Water 6/10/2003 DUP CWK-W-AD3-JUNE9-2 AD3-JUNE9 Surface Water 6/10/2003 DUP CWK-W-AD3-JUNE9-2 AD3-JUNE9 Surface Water 6/10/2003 FS CWK-W-AD3-JUNE9 AD3-JUNE9 Surface Water 6/10/2003 FS CWK-W-AD3-JUNE9 DRI13 Surface Water 6/9/2003 FS CWK-W-DRH3 DRI13 Surface Water 6/9/2003 FS CWK-W-DRH3 DRI14 Surface Water 6/9/2003 FS CWK-W-DRH4 DRI14 Surface Water 6/9/2003 FS CWK-W-DRH4 DRH 5 Surface Water 6/9/2003 FS CWK-W-DRI15 DRH 5 Surface Water 6/9/2003 FS CWK-W-DRH5 DRH 6 Surface Water 6/9/2003 FS CWK-W-DRH6 DRI16 Surface Water 6/9/2003 FS CWK-W-DRH6 DRH 7 Surface Water 6/9/2003 FS CWK-W-DRH7 DRH 7 Surface Water 6/9/2003 FS CWK-W-DRI17 DRI18 Surface Water 6/9/2003 FS CWK-W-DRH8 DRH 8 Surface Water 6/9/2003 FS CWK-W-DRH8 DRH 9 Surface Water 6/10/2003 FS CWK-W-DRH9 DRI19 Surface Water 6/10/2003 FS CWK-W-DRH9 DR120 Surface Water 6/10/2003 FS CWK-W-DRI20 DRI20 Surface Water 6/10/2003 FS CWK-W-DRI20 DRI21 Surface Water 6/10/2003 FS CWK-W-DRI21 DRI21 Surface Water 6/10/2003 FS CWK-W-DRI21 DRI22 Surface Water 6/10/2003 FS CWK-W-DRI22 DRI22 Surface Water 6/10/2003 FS CWK-W-DRI22 DRI23 Surface Water 6/10/2003 FS CWK-W-DRI23 DRI23 Surface Water 6/10/2003 FS CWK-W-DRI23 DRI24 Surface Water 6/10/2003 FS CWK-W-DRI24 DRI24 Surface Water 6/10/2003 FS CWK-W-DRI24 DRO01 Surface Water 6/9/2003 DUP CWK-W-DRO01 -2 DRO01 Surface Water 6/9/2003 DUP CWK-W-DRO01-2 DRO01 Surface Water 6/9/2003 FS CWK-W-DRO01 DRO01 Surface Water 6/9/2003 FS CWK-W-DRO01 DRO010 Surface Water 6/9/2003 FS CWK-W-DRO010 DRO010 Surface Water 6/9/2003 FS CWK-W-DRO010 DRO011 Surface Water 6/9/2003 FS CWK-W-DRO011 DRO011 Surface Water 6/9/2003 FS CWK-W-DRO011 DRO02 Surface Water 6/9/2003 FS CWK-W-DRO02 C8 results Envista 111104.xls Page 1 TOP BOTTOM FILTERED CASNO ANALYTE RsItPost RsItVal UNITS Hit LAB_ANALYTE QUAL_EPA 0 T 3825261 FC-143 <10 5 NG/L 0 FC-143 0 T 3825261 FC-143 124000 124000 NG/L 1 FC-143 T 3825261 FC-143 81400 81400 NG/L 1 FC-143 T 2795393 PFOS 133 133 NG/L 1 PFOS T 3825261 FC-143 78600 78600 NG/L 1 FC-143 T 2795393 PFOS 161 161 NG/L 1 PFOS T 3825261 FC-143 139000 139000 NG/L 1 FC-143 T 2795393 PFOS 121 121 NG/L 1 PFOS T 3825261 FC-143 97400 97400 NG/L 1 FC-143 T 2795393 PFOS 131 131 NG/L 1 PFOS T 3825261 FC-143 96900 96900 NG/L 1 FC-143 T 2795393 PFOS 147 147 NG/L 1 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 <50 25 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS NQ 0 NG/L 0 PFOS T 3825261 FC-143 154 154 NG/L 1 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 56.7 56.7 NG/L 1 FC-143 T 2795393 PFOS NQ 0 NG/L 0 PFOS T 3825261 FC-143 140 140 NG/L 1 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 233 233 NG/L 1 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ . 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 50.9 50.9 NG/L 1 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 NQ 0 NG/L 0 FC-143 T 2795393 PFOS <50 25 NG/L 0 PFOS T 3825261 FC-143 378 378 NG/L 1 FC-143 QUALJNHOUSE REVIEW METHODNO PREPMTHD PREPREP DRY 01M-008-046 NS NS W 01M-008-046 NS NS W 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01 M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01 M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01 M-008-046 None NS 1 01 M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 1.M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 01M-008-046 None NS 1 C8 results Envista 111104.xls CWK LAB NUMBER RSLTMOD RESULT UNIT MDL PQL L000264-2 < 10 NG/L 10 50 L000264-1 124000 NG/L 10000 50000 L34720-42 81400 NG/L 5000 L34720-42 133 NG/L 50 L34720-45 78600 NG/L 5000 L34720-45 161 NG/L 50 L34720-16 139000 NG/L 10000 L34720-16 121 NG/L 50 L34720-23 97400 NG/L 5000 L34720-23 131 NG/L 50 L34720-26 96900 NG/L 5000 L34720-26 147 NG/L 50 L34720-17.

AR226-2885 E.

PURPOSE: This is a rangefinding study designed to provide an estimate of .