Interim Report #2 Epidemiology, 220-3W-05 Medical Department 3M Company St.

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Oct 02 02 03:2Sp Ralph Cooper 919 541-5138 p.2 A ff M $6 _ H8 ft* S*> USE* UNITED STATES ENVIRONMENTAL PROTECTION AGENCY National Health and Environmental Effects Research Laboratory Reproductive Toxicology Division Research Triangle Park, NC 27711 October 2, 2002 OFFICE OF RliSUARCH AND DEVELOPMENT MEMORANDUM SUBJECT: Control v$.

30 June 2003 To: Mary F.

RECiiiVEO O P P NC IC 200*4MAY 12 AH 9= 10 -4&224r mo FINAL REPORT PROTOCOL 418-028 ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 FINAL REPORT DATE: 31 JULY 2003 PROTOCOL 418-028 - ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 TABLE OF CONTENTS SUBJECT 1.

3M Specialty Materials 3M Center St.

/q / Toxicological Summary PFOS Dietary Chronic Pilot Reproductive Study: Northern Bobwhite Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-potassium salt.

AR226-2210 Robert Pinchot 11/05/2001 03:02 PM ________ ____________________ To: Debbie J Mulrooney/AE/DuPont@DuPont, Steven L Grise/AE/DuPont@DuPont, Mary A Kaiser/AE/DuPont@DuPont, Ron J Buchanan/AE/DuPont@DuPont>Roger J Zipfel/AE/DuPont@DuPont cc: Ta-W ei Fu/SE/DuPont@DuPont, Bernard J Reilly/AE/DuPont@DuPont, David M Rurak/AE/DuPont@DuPont, Chris E Shoop/AE/DuPont@DuPont, Robert L Ritchey/CL/DuPont@DuPont, Charles J Zarzecki/AE/DuPont@DuPont, Stephen T Breske/AE/DuPont@DuPont Subject: Mulit Media Consent Order APFO data requirements It looks like we are getting close to agreeing on the requirements for a Consent order between the W V Dept, of Environmental Protection, the W V Department of Health and Human Resources, and DuPont.

AR226-2227 ,/?

AR226-2235 Steven L Grise 12/14/2001 09:50:47 AM To: cc: Subject: Robert F Pinchot/DEV/AE/DuPont@DuPont, Bernard J Reilly/AE/DuPont@DuPont, Debbie J Mulrooney/AE/DuPont@DuPont Steven L Grise/AE/DuPont@DuPont C.O.

AR226-2259 Debbie J Mulrooney ' 02/20/2002 12:47 PM To: Todd M Krieger/AE/DuPont@DuPont cc: Steven H Swearingen/AE/DuPont@DuPont, Robert F Pinohot/DEV/AE/DuPont@DuPont Subject: Re: Environmental Impact Study Q The new stack height is much higher than what we modeled (85 vs. 55 ft) and the new flow rate is also much higher (12,400 scfm vs. 4710 scfm).

Fluoropolymers Monitoring Technical Group September 18,2003 AR226-2339 EXP000593 Agenda Program Overview - EPA Suggested Priority Change Discussion Landfills Soil Sampling Biota Sampling Possible Sources of Exposure EXP000596 APFO M anufacture // Fluoropolymer Summary Processing * Articles of Commerce EXP000597 APFO Manufacture 99% Reduction in emissions as compared to prior manufacture Air dispersion modeling Water monitoring - Prior Manufacturer - New technology baseline Program Plant Design LOI LOI/other LOI Timing In place Complete Ongoing Ongoing >99% Emissions Rduction APFO M anufacture Air Dispersion Modeling Water Monitoring Fluoropolymer Summary Processing Articles of Commerce EXP000598 LOI ECA \c Non-Fluoropolymer Products Program Timing Commitment to not sell APFO outside fluoropolymer industry LOI Ongoing EXP000599 >99% Emissions Reduction APFO M anufacture Air Dispersion Modeling Water Monitoring Fluoropolymer Summary Processing - Fluoropolymer M anufacture * Dry Resin Processing Articles Aqueous R esin Processing * of Commerce EXP000600 LOI ECA Fluoropolymer Manufacture Global Material Balance 50% Emissions Reduction Commitment 2002 Status - 48% reduction from the baseline Monitoring/Modeling Commitments - Air dispersion modeling - Groundwater - Soil - Landfill Program pre-LOI pre-LOI LOI LOI/other Other Other Timing Complete 2006 12/31/03 Ongoing (Today) (Today) >99% E m ission s Reduction APFO M anufacture Air Dispersion M odeling Water Monitoring Fluoropolymer Summary >50% Emissions Reduction Fluoropolym er M anufacture Air Dispersion M odeling Water Sampling/ Monitoring EXP000602 LOI ECA Processing/Articles o f Commerce Program Timing Articles of commerce testing - "New " Articles of Commerce - "Aged" Articles of Commerce Dispersion processors material balance Incineration testing LOI ECA LOI ECA 12/31/03 2004 12/31/03 6/30/04 0CPOOO6Q4 >99% E m ission s Reduction APFO M anufacture AnDispersion M odeling Water Monitoring LOI EGA Fluoropolymer Summary >50% Emissions Reduction Fluoropolym er M anufacture Air Dispersion M odeling Water Sampling/ Monitoring ---------------------------------------------------------------------------- Articles o f Commerce Testing Dispersion Processors Material Balance Aged Articles o f Commerce Testing Incineration Testing EPA Proposal Delay "Articles of Commerce" testing and goal date and accelerate "Air dispersion modeling" at Fluoropolymer manufacturing sites in order to expedite the process to determine if additional monitoring (and ECA) is needed at these facilities.

AR226-3360 > ATMOMSPEHCAEHLRACINCOISHLMOIFSLESOTFCIMnFFEL2SnU+1OACNRHDO2CTDHEE2LGOORHMAEDRATION Valrie Bossoutrot*, Tanya Kelly#, Isabelle Magneron*, Wahid Mellouki*, Howard Sidebottom#, Klaus Wirtz and Georges Le Bras* * LaCbe*onrCtarthooeidmreeiEsdtsertyuCdDoimeopsbaAurtsmmtiboeinnetn,ettUaSlneyisvstedremslietMyseRCdoiatlelcertrgifesn,,eDCou,NbVRliaSnleO(nIcRrliLaa)(nSsP()F) SETAC Prague 18-22 April 2004 Context : Long chain perfluorinated carboxylic acids (PFCAs, CnF2n+1C(0)0H, n = 6-12) oPbFseCrAvesd:innfoisthgaenndermaallmymusaelsd directly in consumer or industrial m- parteesruimalasbly degradation products of precursor chemicals : potentially FTOHs Fluorotelomer alcohols (FTOHs, CnF2n+1CH2CH2OH) : --UPsreosd:uicnttieornm: e5dxi1a0te6skignymra1n(u(82f0a0%c%tupnroeolynomfpdoeirlvyicemraseperpipclricoadtuiocntss)) -- AOtbmseorsvpehdeirnicthsoeuartcmesos:pdheegrread(uaptioton 1o35poplgymnre3r) and non polymeric materials - EthxapteicntceodrtpoorpaatretiFtiToOn Hinsto(?

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