BACK TO MAIN BIODEGRADATION (Acclimated Activated Sludge and Sediment Cultures) TEST SUBSTANCE______________________________________ Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder.

'wf 3M Specialty Materials FYI-00-001378 3M Center St.

New Datatiff AR.&3.6-062.5 Completion of two generation reproductive studies for perfluorooctane sulfonate and EpetFrfOluSoEro, oacntdancerossusl-ffoonsatetreinstgufdoyllow up to Pharmacokinetics during pregnancy studies Second species (rabbit) teratology study Completion of 180 day repeat dose study in primates with one year recovery 3M Medical Department March 7,2000 I Pending Two-year feeding studies EtFOSE - In-life done 4/2000 Perfluorooctane sulfonate - In-life done 4/2000 6 month and one year recovery after 180 day feeding study in primates ADME study in primates 3M Medical Department March 7,2000 Pending Human sera studies Health claims study Update mortality study Mechanistic and metabolic studies 3M Medical Department March 7,2000 3 ResultsFo- sRteerpirnogdSutcutidoines/Cross- N0.O4 EmLg/fkogr/dreopfrpoedruflcutiovreoeonctdapnoeinstuslfonate is Perinatal mortality is predominantly a pup effect rather than a maternal effect Effect on cholesterol metabolism is hypothesized mechanism - studies planned to test hypothesis 3M Medical Department March 7,2000 ResultsD-oPseriSmtuatdeyRepeat 0.15 mg/kg/d well tolerated for 6 months (apparent NOEL) Cholesterol level decreased at perfluorooctane sulfonate serum concentrations greater than 100 ppm (in the high dose group) 2 deaths in males at 0.75 mg/kg/d that were apparently compound relateyd At the high dose (0.75 mg/kg/d) body weight liver weight and liver morphology were affected 3M Medical Department March 7,2000 r Results - Sera Concentrations Perfluorooctane sulfonate serum concentrations increase linearly with dose in l8o3w-1a0n7dpmpmid) dose groups (16-20 ppm and Perfluorooctane sulfonate serum tchoencheinghtradtoisoengs rfooullpows, ewditahbmipahxaimsicumcurvvaeluiens at 250-300 ppm 3M Medical Department March 7,2000 Background "19O6r8ganic fluorine" reported in human sera in 3M medical surveillance from 1976 to present Aconmalpyosuesndfosrdsopseecaiffitcerflu19o9ro2o-rdgeatneicction limit less than 50 ppb in 1997 Mcoocncuutltepimpaltpeiooanrnaaarlllyyysseiesxrpfaroossamemd)hpfilsientsodr(nipcoeanrfn-ludorooctane sulfonate at less than 50 ppb 3M Medical Department March 7,2000 7 Background Various studies, including medical surveillance, done over the last 25 years In the last two years have used outside experts to identify needs and help define studies Have created Scientific Advisory Panel for additional review 3M Medical Department March 7,2000 2 Review - Data in Health Effects Paper ADME Metabolic precursors to perfluorooctane sulfonate Repeat dose feeding studies - rat and primate Genotoxicity Teratology 3M Medical Department March 7,2000 Review - Data in Health Effects Paper (Continued) Cross-sectional study of exposed employees Mortality study at production plant site Irnepterroidmucdtaivtae fsrtoumdy2-generation Interim data from new repeat dose primate study 3M Medical Department March 7,2000 10 Results The additional data does not suggest a health risk associated with the levels of perfluor loctane sulfonate found in the sera of occupationally or non-occupationally exposed employees, blood bank samples or commercially available serum. 3M Medical Department March 7,2000 //

3.M Press Box - 3M Phasing Out Some o f its Specialty Materials http://www. 3m.com/profile/pressbox/fluorochem.html *ff 3M News AR&3.& _ 661/-!

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A * .z 4 > -t 7 z AIR QUALITY DISPERSION MODELING ANALYSIS OF C8 EMISSIONS DuPont Fayetteville, North Carolina Facility Prepared by: Charles J.

/ < 79 May )<;. 2001 Christine T Whitman EPA Administrator 1101 A O'SEPA Headquarters Ariel R on Building 1200 Pennsylvania Avenue, N W Washington, D.C. 20400 RECEIVED MAY 2 3 2001 CHAIRMAN'S OFFICE Dear Ms Whitman, 1 am writing you this day to inform you o f soma criminal actions of which 1 have derailed liuTwIcri^c.

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NORTHERN KENTUCKY OFFICE SUITE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011-4704 SOS-331-2S3S 513-3S1-2S3S FAX: 513-381-6613 DAYTON, OHIO OFFICE SUITE 900 110 NORTH MAIN STREET DAYTON, OHIO 45402-1786 937-22B-2S3S FAX: 937-228-2616 Robert A, Bilott (513) 357-9638 bilott@taftlaw.com TAFT, STETTINIUS & HOLLISTER LLP 425 WALNUT STREET, SUITE 1800 CINCINNATI, OHIO 45202-3957 513-381 -2838 FAX: 513-381-0205 www. taftlaw. com CLEVELAND, OHIO OFFICE 3500 BP TOWER 200 PUBLIC SQUARE CLEVELAND, OHIO 44114-2302 216-241-2838 FAX: 216-241-3707 COLUMBUS, OHIO OFFICE 21 EAST STATE STREET COLUMBUS, OHIO 43215-4221 614-221-2638 FAX:614-221-2007 /9S May 12,2005 FEDERAL EXPRESS Dr.

* TestRsults ) , i AR226-2132 file:///C|AVINDOWS/TBMP/R]D C-8FC143 9-24-81 thru 7-19-01 6pages.htm 1 o f 12 Test Results Sam ple Data Range Concentration Range Action Level Industrial Hygiene 9/24/81 7/18/01 100% Sam ple Dt Sample # Duration Type Employee Name Pens BTO : 17 RESEARCH LOG : 019 WEIGH AND ADD C-8 TO POLYKETTLE 7/29/83 39740 411 Z 1/13/84 12116 409 P nono 8/17/84 12117 380 P none 4/30/85 12118 360 P none Chemical Cone Unit Percent C-8/FC-143 <0.03 MPB 5.4% C-8/FC-143 0.06 MPB 10.7% C-8/FC-143 0.34 MPB 60.7% C-8/FC-143 0.13 MPB 23.2% BTO: LOC : 17 RESEARCH 057 AROUND FLUOROCARBON EXTRUDERS 11/9/81 49895 2 C-8/FC-143 0.08 MPB 14.3% BTO: 17 RESEARCH LOC : 065 PPD SEMIWORKS 7/29/83 39741 410 Z C-B/FC-143 <0.03 MPB 5.4% AJP006929 BTO : LOC : 17 RESEARCH 066 FLUOROCARBON PANEL BOARD 10/14/83 39883 330 z 1/13/84 12224 414 P 6/21/84 12225 300 p 8/13/85 12362 380 p 8/13/85 12363 360 p norie none none none C-8/FC-143 0.03 MPB 5.4% C-8/FC-143 0.06 MPB 10.7% C-8/FC-143 <0.03 MPB 5.4% C-8/FC-143 0.055 MPB 9.8% C-B/FC-143 0.13 MPB 8/28/2001 5:09 PM EID 140171 TestResults 1/3/86 12370 1/3/86 12371 7/1/86 12383 7/1/86 12384 8/14/86 13212 8/14/86 13213 10/13/86 13279 10/13/86 13280 11/19/86 13348 11/19/86 13349 310 P 315 P 373 P 375 P 360 P 365 P 405 P 404 P 380 P 380 P file:///C|AVINDO'WS/TEMP/RD C-8 FC143 9-24-81 thru 7-19-01 OpagesAlm none none none none none none none none none none 23.2% 08/FC-143 <0.03 MPB 5.4% C-8/FC-143 0.07 MPB 12.5% C-8/FC-143 0.208 MPB 37.1% C-8/F0143 0.139 MPB 24.8% 06/FC-143 0.121 MPB 21.6% C-8/FC-143 0.577 MPB 103.0% 08/FC-143 0.458 MPB 81.8% 08/FC-143 0.09 MPB 16.1% C-8/FC-143 0.026 MPB 4.6% C-8/FC-143 0.204 MPB 36.4% Tuesday, August 28,2001 3:16:19 PM P an el of6 2 of 12 Sample Di Sam ple # Duration Type Employee Name BTO: 17 LOC: 068 RESEARCH SP AREA REFRIGERATION UNIT 1/27/97 25054 380 P Pars Chemical 08PM C-8/FC-143 Cone Unit Percent 0.1 MPB 17.9% .