Document zzkygjJ9n9nbVqVqYoz8wD1Q6

1231 Omnksl Abstracts Vet M, 29B7 * ll ctirlty. C. V. Martinyan. BiW. Zh. Armemii lift), method usmg rats that ran be of value in predicting the effects (lOCCXArmrnUn). In previous studies it was ntablnhed that of chronic treatment with psychothcrupevtiCN on tle aeute tosie- the decompn. of proteins is accelerated by potvwini with rhlcrfoprene. This process can be interrupted and the protna cun* ity of other medicinal agents is described. Results obtained by this method showed that nortriptyline, like amitnptylinr. tn* taiaed In cells rapidly restored with hypmuliite soln. by an an- haneed the tuatcuy uf mmt cerebral depressants tn an additive * known merhanitnu Studies made to cluculate the influence of manner. Doth of the antuJcpecssive eimipds. marki-dly fiutenti- chloroprcne and Uypmulfite on cathrpsm ensymes were mcon- ated the toxicity uf phywstumme and to a lesser drgne |nhar. cHtsive, and it is wtented that the most important factor in this pine. Ephrdrine toxicity was sixmliantly attfaeimiznl by modulation is related to the transaminases. Expts. were con* thymolcptic prrtratmviit. Tlic test failed to verify reports that ducted using normal rats (control) and rats poisoned with rliloro* the tncyclic antitlrprew-ives dangcmuaiy potentiate the tosieity prenc (t mg.A. 2 hrs. daily, 2-3 months). The activities of of ale. or monoamine oxidase inliibitors. Results indicated that ghstamic-osalacrtie transaminase and glutamic-pyruvic trans s variety of medicinal agents an be uses! m the aoruiptyline aminase were measured by using the Reitnun and Pnnkd traatid patient without any problem of sigmffrant drug inter- method (CA SI. IMMHA) and are expressed in Yroblcvski units. action. RCYG The activities of the enzymes decreased 10-19% in blood, liver, 1234c Chlorinated aadines and their saaitafytozicologi&al and kidneys and 41-31% m the splwn of poisoned animals. In characteristics. G. D. Rhatnuev. Kktm. Fuktory 1`uriaa. in vitro erpts. the ditmue in enzyme activity in normal tissues Arrdy 1 tkk Ctgim. ZnacktnU, 53., l/#urv 1965. lOri-lOt Russ). srat4.7-8.4% and in poisoned animals 2J-7.1%? in the spleen the decrease was 0.4-0.5%. Hyposulfiic also loners the enzymic ac- however, the combination, hyposulfite-chlotoprenc re stores it to the initial level and in some oscs even a higher level Monochloroanihoe is used in the production of insecticides and dyes. m-Motiochinroaniline (Ijandp-monochloroanilinc *11; dis solve in H*0 (5 g./l.), in which they cause an unpleasant taste and odor. The odor and taste pererption thresholds were 2.0 k reached. Chloroprcne does not affect the activity of pyridoxal phosphate. These results lad to the assumption that the in hibitory action of chloroprcne an be explained by its reaction and 7.2 for I and 1.5 and 3-0 mg./I. for II, resp. In a c^nen. uf 150 mg./l. 2 and II lowered the B.O.D. of water. Threshold conens. art 1.5 mg./S. for I and 0.75 me./I. for XI. The L.D.* with Use protein pan of the enzyme. L. B. Bedighian 1231c Changes is the rsttriAcd fatty adds aad cholesterol in serum and liver of rats after application of orotic aeiJ aad hepato- - -4oxic substances. F. Musit and J. Sucva tSkoda-Werkt-Krank- enhauses, Tlzcn. Czech). Fette Setfen Anttnckm. 55(9). 748-50 ()9GG)(G.). Changes in the serum and hepatic Lvds of choles values (stomach administration) for I and II. resp., were XUH and 401 for white mire, 1104 and 308 for white rats, and 750 and 350 mg./kg. fur guinea pigs. A 3-month sub-acute expt., conducted on white rats with stomach administration of 0.1 L.D.w levels, caused the formation o mcthcmoylubin and re duced the hemoglobin level and the erythrocyte count. From terol and esterided fatty acids following oral administration of Ar/.Z*.. Kktm. 1966 X). Pt. II. Abstr. No. 81414. MVRK CC2* (0.5 ml.As.) fur the tmraperitoncal admit.! *ration uf ethio- 1237y Tosieity of thioacetamido. Z. Hniban. W. Gradman. aine (250 mg.Ac.) to rats were in some casts normalized follow* A. Slesers, and M. Lubran (Imiiv. uf Chicago). Lab. Inveit. 15 mg oral administration of orotic acid <liuwmg./kg.) given (11). 2746-00(190CHEng). ThioacctamkJc (I). fed to rats in a ss cither a preventive or as a therapeutic arent. CMJG diet eontg. 50 mg./kg. body wt./day for 5 days, produced high 1232k Acute (mouse and rat) and short-ten- .rat) tonicity serum lactic dehydrogenase levels and eentrolobular necrosis of studies on dibotyh diethylene glycol bispbth ate). D. E. the liven within 24 hrs.: the enzyme levels decreased and the Hall, Patricia Austin, ar.n F. A. hairweatser :3n:ish Ind. Biol. necrotie areas were resorbed within 3 days of feeding the diet. Res. Assoc., Carshalton, Enel.), Food Cusmct. Toxicol. 4(4), Severe degenerative changes in the kidneys, hematuria, and in 3S3-8(196C)(Eng). Acute and short-term feedinr studies have creased serum urea N and scrum creatinine levels occurred w ithin been arried out on a samoie eontg. S0% dibutyl (rhethyknc gly- 48 hn. of treatment. The lethal effects of the above level of I . col bisphthalatc) (DDGB). The intraperitoneal L.D.m in both were correlated with the renal damage. Excess dietary casein mice and rats was approx. 11-2 f /kg. This di sc when given hydrolysate, methionine, or guanosine reduced the mortality w. orally wa tolerated by both species wjthsut td affect. The and reaai toxicity oi I. although these vompds. did not prevent toxicity by either rouu in mice was enhanced wnen UDGD wns the nuclear and uuciwlar enlargement ut hepatic ceds and or the administered in arachis nil <jt>% vol./vo!.). In 9t>-day study cells of the proximal convoluted tubules of the kidney occurring in rats given dietary level* of 0.U (control), 0.25, 1.0. and 2.5% in trated rats. 67 references. BPJN DDGB, significant growth retardation occurred in both sexes at 12351 Poisoning by grass. C. H. Gallagher, J. H. Koch, aD levels apart from maies on C.25%. This effect was attribut and H. Hoffmann (Univ. Sydney). A'rtr Scientist 31(510), 412- able, at least in part, to reduced ford intake, although this effect 14(19tV>)(Hng). Acute and chronic neuromuscular disorders was less marked in females. There were no hematological occur in sheep feeding on the pasture grass Phalanx tuberosa. .---changes or effects on kidney function. At the 1.0and 2.5% diet This crass contained 0.3% (dry wt.) try;*tamine alkaloids. ary levels, the relative liver and heart wts. in males and the rela Tissues irom sheep undergoing acute poisoning showed nn ht>tol. tive brain wts. in both sexes were sjmifieantly increased. No alterations, wnercas the brain and kidneys uf chronically poisoned _pathoi. changes were found that eouifi be attributed to DDGB. animals showed deposits of green pigment. The pigment was In view of the effect on erowth at the lowest dietary level of noted in the mitochondria cells of the mid-brain, brain stem, and 0J25%, a no-effect level in the diet of rats for 90 days could not spinal cord. It is suggested that these chances are related to the be established for the particular batch of DDGB tested. oxidative deamination oi A'.iV-dimclhyltryptamine ir.d 5-mc- RCTT thoxy-.V.A'-dimethyUryptamme. The protective action oi Co 12J3t Reaction of hydrexocobalamia with thiols. Norman against the ehrnnic form of the disease, reported by others, may Adler, Thomas Medwick, and T. J. Poznanski (Merck Chcm. be related to the prevention of degenerative changes in nerve Div., Merck A* Co., lte.. Rahway, N.J.). J. Am. Cktm. Site. tissue or to the acceleration of alkaloid metabolism. 88(21), 501-20(lt*G6;;ng). Hvdroxocobalamin reacts with W. L- Downs thiol compds., as exemplified by elutathionc, to form relatively 1230p Vinyl chloride; industrial toiieologic aspects. I. weak 1:1 inner coordination complexes. Previously reported in Griroreseu and Gh. T*!>3. lire. C*tm. (Buclmrcst) 17(Sj, 4'H.i- consistencies in the generality of this faction are explained in dOlilbJOXRom). A hypothesis was put forward, claiming that .terms of the simultaneous role of thiul compds. as completing and CHt CHCl (1) cmttd rvaet with H;0 at the level nf the hvpattc reducing agents. KCJC cell, yielding ethylene monurhlorohydrin, which could be o\i- 1234a Kcurotozic effects induced by alleviating agents. dized to ehloral and chloroacvtic acid (II). 11 could Ik elimi 31. C. Donclli, R kmo. and S. Garattim. J. Phaem. Peafmo nated as such in the urine or Ik metabolised further thruugh ami- tel. U(lI). 7U-2(l`s*ihBm:). In dvcrrnsme order of effeetive- nation t eJycnrrd. Ait anal, method w,i* develpcd for detec wes, vt-tvyptnplian mustard,- o-sarc*lysine. glycine mustard, t- tion of XI in urine, a%unimi; that the only other mirec oi U sarcolysine. pt-wrculv-me. and akinini* mustard pastured a could be massive inception of wine yeast or mh.il.tti(in of ir.c'dori*. typical pattern of neurotoxicity when administered mu.tcrrr- ethvlenr. An aliquot (Jtxt ce.) of urine, acidified with brully to fats. The typirat pattern of rur*n\ictty mcludvd a H:SO (2 ec.) extrt. with EtA> (2tX) ce.). shaking vigormdy. latency time of uImhii mi nun.. followed by sicns rvntral ami Milling for 24 ho. The t\t. is Uinil Unhyd. stimulation, io4 **ifioi.ilv mov* limits. .owl sierrotvpe lHh.iv**, rv.ifai. (dryness under redueixl pn*sstirr, ami I Ik ihIu i- *(-- imJ ending with el*auc e*#v*dsnis ami ivj*ntwi tome rxtvn- wilvnl m .'ll' J, uq. ale. j*ln. lit..* cc.). Oin* ilriqi nf the **an sannt. Mamiipd nittstatd. telfamme, rvrlo|4M|ihamtilr,. ami (25 31) 1.) h (dared mi Whatman No. 1 i*aiw*r sirt|s (* ^ chlorutntiut'il were not Hiiimlmic w to-n admtm*trrd in ih*ws of 3 Ctli.), ilfHil, and ehrmtuliaeratduxl Itv .iMetnltiie noth**!, 100 y/rut. lnlfaiwfitw*n*l administration of Na |lniyt*w IlfXI using as rlutuut llie mitt. NUdHI-KtOII 11,0 (1.2H 4) for a mg.Ak ) was inrllretivr tn preventing the iw urotoxic eflivt* in* duced by the alkylating acvntx. where;*- Na phew*4urbit#uic Showed S cU*;ir prnfrctivr effect. Cydnrir :iml lliMirn (1 g./ perad of 0 hrs Tlic strips, dnnl in aif. are ki*|i| 24 hrs. in a coned. Nil* atm., hvatixl l**r 5 mm. at NO*, sprayed with dW ninhyilrin in MeOII, ami drnxl, 11m IX is indicated by rnMnii- kg., intrai-ril.aHallyl were ulvi imflxftivc ni pfrxiutine the vudet s|M*ts. l*or distinct development, tin- sinjo. are spi.n*'! rurolovit* nct-. CMJN fiflaMv with Id*'* Cm NO,), learnimv fed s|is|. The Kt 4* -l 12JSK Effect of chronic ooftnptvlme prrtreatment nn the was (sl.iltlnlHd wdii a s*4n. ! J) .HI ll/ei*., as d.fwi. 1 :** scute totlcii) of various medicinal wgrntx in tats I* It- M%*r-, (unit ,ilw iniurilvn'i I II. .hmI % nnprtie, ,1 ly (ls its, -i t' I). O. k.iuynrt, .mil U. C. Awh *** t *- I ills .v C., <'mtoiield. (NO,),, llw rsln. of II from urine was deiinMistr.iPsI liy ttt 'l- Indiana). J, /*W. .Vi. 55U1), 1317- lN(ltk.nlaig). A mg a min. i4 2-a* Il/ec. iu urnw as alnvi, tutlmg (lie i*mi%* v ^ f 20619001 \ BFG04254 P hf Itt 14--ToiJcoJoor VoL 66, 1967 1249 ipendinr po<t, elwtiit* the fl Sth EtOH. and dctf. colnrimrtrL version process. Eaptl.. acute KH poisoning was produced m \ cally. The extn. ywM ai IVlitninary tmt thovrd rats by adminwterin* L.U.w NHOAc, prrcedid by varyme r" ko II in cliw. healthy |icr>innrl, !iik anion* the <ta(l of !*pr* dmvs of protective amino acids and Jhtir mitt*. Based on fttin| plants of the sampled persons gave a pm. reaction mortality and convulsions, arginine (I) provides tlic mmt effec |e |tie method. Extensive tots *hv*( that mmt ol the put. tive protect mo at as low a dose as 0.5 miUimolc/k*. A mitt. reactions i.ere obtained with staff employed '*$ yean in the (A) of L^rnithinr ami t-aspartic acid at u dmc of 1.0 millimole/ plant*, la theac rates the protcinograms nitdiiMil, the * kg. protects as effectively as 1. A ctivnparvwin of bfc>d NH gtubulin fraction bring hueher and the vclobulin fractiua and urea levels using 1 and A shows 1 to be more effective a pro being tower titan in the pertom with nr*, reactions to the pres- tector than A. In rats lutoaie.ited witha L.D.*of NlUOAcand nee of SI in the urine. It was concluded that the capacity of protected by A. w-mcthylapartic and mtceted intrapertwior.illy the orfafuam to metabolite II decreased after 2 yean. in dose of 3.4 nuinmoiej/ky. produces approx. 54Vr m^wtabty M. Ben Elietcr and 90% convulsions. Vtiiinn* this same procedure but sub IKOf Effect *f bexachlero-p-gyJeoe ingestion on the oxidative stituting I for A, the mortality and convulsions pcrcentiees de phosphorylation of rat liver mitochondria. HMa*Vins Chan* crease. Further, a dote of 0.5 millimole I/kg. produces d and Chcw-To Yuan (SmoSuvict Friendship limp., Pelcin*, mortality and 207e convulsions, while a dote of 1.0 millimole China). Hr Hu* Hsuek Yu 3'Am( II* ll' Lt Hsuek Pa* I/kg. produces 21% mortality and 33% convulsions. 07 refer 4(3), 27)-KlVG6)fCh). Oral administration of hesaehlom>p> ences. Domenic A. Vavata xylene (I, 05 *./kg./day) to rats uncoupled the oxidative phuo- 124Sv Erythrocytic ALA dehydratase sad lead. D. Bonsig- ' phorybtimt of the liver mitochondria, in extent proportional to oore, P, Calttsano, and C. Cartasecna (Umv. Crnna). Pan- the duration of I treatment. The Uccnatc in tbe production of mintm Mtd. (Engl. Ed.) 1(7-8), 282-4{lMC)(En*). Fcrsons ATP with insufficient energy supply of tissue may be the basis havmc Pb poisoning showed an increnscd urinary excretion of of the toxic reactions of I such as generalised weakness, fatme, aminolevulinic acid (ALA) (1). which wras associi. witn a sig doziness, headaehe. BHJJ nificantly decreased activity of 1 dehydratase in the erythrncvtcs. 1241a Adreaaluio-i&activation capacity of the normal and sI The assay of 2 dehydratase may be of sigmncancc in asosing the tha CCL-poisoned Ihrar perfused in vitro. Emma Custmer, L. gravity of Pb poisoning, since ia expti. animals the level of I Vxislcr, and Viorio Cfcivu (Arad. Kep. Sc., Romania, Bu dehydratase was related to the extent of the poisoning. charest). Stmdii CtrttiAti Baioertnal. 17(4), 355-7'lVCGHKom). B. S. S. R. Rao -----Konual rat livers, and livers originating from CCU-tfvatcd rats * 1246c Relations between the porphyrin metabolism and the were perfused with adrenaline in vitro. The latter showed a nicotinic acid metabolism in tatunure poisoning. L. Peeora. tower rate of adrenaline degradation as compared with the former. A. Silvcstroni. and A. Brancaccio (Vmv. Naples). Feumtnma ,,____ btjq Med. (Engl. Ed.) 8(7-3). 2S4-8(19tiG)(*). Poisonmz of rab ** *12421 Pyruvic add coeteat la acute barbi arete poisoning. bits with PbtOAch decreased nicotinic acid (1) by 75kc m the B. F. Munuhov (S. M. Kirov M:i. Med. Acad., Lcnincrad). blood and urine and markedly increased erythrocyte-free proto Ter. Afkk. 38(10), JU3--l(l9G6)(kuss). In deep eoma due to porphyrin (11) U3-247 y rl) and urinary eoproporphyrin (UI) barbiturate intoxication. 1J ms. Ct pyruvie acid (1) was found (14-341 y/'24 hrs.), aminolevulime acid (IVj (U.2-21 mg./l.), in tbe blood. Its omen, decreased wuh recov-y ti. 0.< t mg. %. prn>hobUino*cn (V) (traee-4.6 mg./l.), and xanthurenie acid When the I concn. reached 1 .8-2 mg. lr, compi lation* occurred (VI) (1.0-13.3 m*./24 lira.). I administration either concurrently and the respiration was disturbed. The 1 cn.n. was directly w*ith or 13 days after Pb poisoning increased nicouncmiu and proportional to the severity of intoxieacion, as observed in a total nicotinuha and markedly inhibited (by 5Oe0%) the effects of of 32 poisoned humans. Miloslav Kalab Pb poisoning on II, III. IV. V, ami VT. The cfiects ci Pb poison 1243# Inhibition of biosrnthesis of protein and nucleic acids ing are probably mediated through inhibition of pyridine coen- by phenolic compounds in vivo. C. V. Kukushkina. L. B. Cor- aytse sjmthesi* directly or indirectly through vitamin B inhibi baeheva, and X. M. Emanuel (lust. Chcm r iyt.. Moscow). tion. HFJN Vep*. Afrit. 12(5), >6fir,ifKuaxV \fiev wi*h the 1247k Porphyrias in tetraethyl lead poisoning. M. Crc*>et Ehrlich ascites carcinoma or solid hepatoma XXI! were inuctcd and P. Chtcsura (Univ. Padua, Italy). Med. (nsl. with a mixt. of uniformly "C-labvlcd L-amtno acids il) \W **c./ Ed.) 8(7--3), 2V5-301< jybGdLm;). Tne level* o anun^jcvuiimc mouse), Ka formate-*4C (II) (5 *c.) or adenine-2-wC illl) (IT acid, Pb, and porphyrins were detd. in blood and urine samples *e.). After 30 min., one group was injeeted intrapcmonenlly of persons having Pb poisoning due to inorg. Pb sal;* or Pb with Pr gallate (IV) in 0.9% XaCl and another, with 4-mcthyi- tetraethyl and aUo in expti. animals with expti. Pb poisoning. 2,&4i-frrJ-butylphcnol (V) in 3% aq. Twcen-SO. Controls were Pb poisonine due to Pb tetraethyl caused a significant increase in injected with the resp. solvents. Asestic tluid samples were taken the levels of free protoporphyrin in crytnrocytcs, while Pb poi- __ from mice with Ehrlich tumors at time intervals frum 0 to 130 .soaing due to inorg. Pb salts caused an increased urinary excre min. and the ceils washed with a 5 4.1 mixt. of U.9% NaCl, tion of aminolevulinic acid and coproporphyria. 0.3Jf XaiHPOi, and 0.3.Ur KHil'O*. Mice w ith solid tumors were B. S. S. R. Rao sacrificed after 120 min. and the tumors, liver, kidneys, and 1248t Aflatoiia Bt injury in rat and monkey liver. Donald spleen were removed and homogenized. When 1 was used, the J. Svoboda. Harold Grady, and John Higgmton (Umv. oi Kan cells were treated with eold 5% ChCCOOH and the pptd. pro sas, Med. Center. Kansas City). Amer. J. Pathol. 49(G), 1U23- teins isolated and examd. When II and III were used, 5% Cl#- 51(lSG6)(Eng). Oral administration of pure arlatoxm bi `0.45- CCOOH washings were ettd. with Et^O, the aq. layer evapd., 3.73 mg./kg.) or insrapcritnncal injection of a 0.1C7-me./kg. and the residue (aeid-sol. fraction) examd. for radioactivity. dose into rats produced periportal parenchymal cell nccrusi* and The cid-tnsol. fraction wa* washed with cold 9fifi EtOH and slight bile duct proliferation, together with sepn. of the granular heated for 10 min. at 30* with EtOl 1- Et*(> 12 I) to remove lipids. and fibrillar components of the nucleolus wuth the formation of A sample was examd. fur radioactivity and the rest ettd. with nucleolar caps. The alterations m fine structure were aU*> found 10% NaCl (pH 7.4-7.6) for 30 min. at S*3*. Nucleic acids were in monkeys after oral administration of U.45 mg. punned a da- pptd. by adding 3 volt, of cold VGr,\ EtOH and washed with toxin I*,/kg. or intrapcntoncal injection of a 2.5-mg,/kc^ d>se. ?U% EtOH. In mice with ascites tumors. injection of 75 m*./ The livers of rats rcccmnc an oral U.45*nig./kg. d*>sc 24-72 hrs. kg. of V decreased I incorporation into protein by 30% a* eom- before sacrifice showed decreased levels of KXA and prntem in ""^arcd with the controls; 2UD mc./kg. of V inhibited I incorpora- * both the nucleus and cytrplasm. The RNA-to-DNA ratio in a lion almost completely. Injection id 100 me. of V/k*. de total liver homogenate dccrcuMxf by 40*.r. and tliat in a nuclear creased 111 incorporation into nucleic acids by 20**!; 2UU mg. of fraction by 8%; the protein-ti^-DNA ratio in the total iioinn^e- VA. inhibited 111 tucuriM*ation almost c**mi*lvUly. Injec- natc decreased by 24* i,* P;0 ratios showed decreasing vaiues *TM1hhi of kd mg. oflV/kr. or of I2?fi?rg. of V/kg. after !> min. de with wmeeiig faitctimial damage to fftc hepatic mtivtnnutrta creased 21 ine*rpurutM*i into acil>iMWtl. IratlMi by ik.Vi' j., after adinimstratimi of allaloxin tt*. Utli O coiisunuuioii and into nucleic arid by 54-ril*,. into aewi--4 fraction by .ih-i%* photphorylatnm aiix* tnhilnUii, altliouch the essentially normal and into proteins, by 3t*-44`,. In mtev with 4ul ltetutottiu. in- O etn\uinpiMm 72 hrs. alter administration of tiie toxin may lave jectwm of l.TU mg. of IV/kg. after l.in mm. ilmnwl 1 nicnrfvira- indicated rttmity of respiration without the concomitant rvturu Imi into tumor protein- by 21**. : 2*** m*. of IV A*, decreased t* normal (*lw*s]hirylatvwi levels. The acute hepatic Icnnhis 1 ioCiir|MfatMHi ly Injtcom ol 2i** me.'ka. *f IV ilsm-n by luhl mierr>coiy f Uvi-r frm treatid tmH>kry. re* bad wo effect m pr4iin hwisyntlH-sts in kwlm-y* ami tin* liver of umblul (Ik* elumtes in Irumati Imt during acute viral nciiatitis. normal miev ami in kidneys of tumor-lwanm: imcv which %h*m-vl ArimiiiiotralMNi d pure aiUtoxin U ll ppm. of a syntlu iic dirt wkih* activation of 1 uicortMifatwm in tin liver. ljert*o 4 3W fetl ad libitum to rats for 3-1 weeks) did not*pr*lucv the uucUar. , *. of lV/kg. decrvjsiil 1 uieoC|*irutiwi into spleen proteins of nuckvlar. and eytplasmic alterations found after the acute normal and tumor.bcarmg miev by 3i'i; 13) mc./k*. luil wo administration, although well-differentiated hepjPcvUuUf carci effect mi protein bh**yiilicMs in the spleen. Fi bs llorek nomas apiwunnj in rats 1miw livers otherwise sluiwed little ab- 1244w Esfenmcoul infosicatinn by salts. Pro tection by some ammo unis and their mechanism of actum. F. t'liiniio ami K. Sdvalore <1 mv. \*a|4>i. .Iphf. 13 worouhty. .V r* /<roia*. lll'J V 1246a Distribution and escretien of cycUmate-^C sodium in animals. J#o4*lh.it I*. Miller. L, K. Miehuel Crawlonl. U.dort ti*i, 7*7 KT l*v4iH lt.il I. T in ln In in *'*hiv 4 XH, into C. SoMh fs. and l^t| \'. Cai<ho.ii (Ih pt. of llurnuid., Al-*-**tf ufu ikLilive l* tin po-l* vIvmi .ilI>n*Ul to mill aiwl Niirth CToc.ii:**). /<i<nkw, /liopon. K>i. 25-.J, rlirmiie Nila int\ie.iwm by some e*oi|U. milli llw nw !ff-7( Faktltliiigj. Na cyclamutv-M(' ihstnliutsHi, exert loot. 20619002 BFG04255 % Mil-MNI \* rtrifiMuta fMiMtftMlt, n myclh. lloftwww ksMMffln irr Cmi|iIm r~rn|rnmda 1k;tfrfirrr*'>r(tii with *rorbtc. pMMirmc *f f*mlwM^ciiii * ir* Imi mate IM nVai# nr ltk)4rMUv^Mircl^ Ik^r Hfc^wUffiowyrm tfrrtfiiifrt may be rl in cases vMh iMf Hlrrtt of nrfpKmvrla aallitr, hMWftla to prefersY*a *f# K tambw 2 mam anUiuhrreuiow* arraarilleM fdihydro- aUt^omjifia and IAS), fji'riwicia ami kammeta art aiarf male Vuu trM*mycta MUalf ar Iiaf4rmtrr^aycui amt u.Vir irnratlT--. TWm MUbaiei *hoid fer limited bv ibiimii *lth tmcrtialft fWHifi and streptomycin rralaiawi. Florimycto and kuamcll M Matte and should be weed arty ta euttonary conditions vuh caadad tanlaatlaa of heating.--Asthsra. -- --- f 30951. TAYLOR, T. G,, K. M. L. MORRIS, and JEAN ttftKCXY. (Act. Rea. Crvnc. Rnultry Rea. Cent., Edinburg*. kdw WC.) Effect if dtetarv esreaaea d vllanlai A and D an anme cunMttluents a( too " FSariTcliifaa. "LWT J WTtl VM): 713-Hir IKl.-Croato" af rhKfcj were given diets containing 4 levels af vttamtns A and D( t, 10. 100 and 1000 time* the Rstl level. In all It comMnitlono. with the abject af tmestlratlng a psenlble tnlatmlaia between tbs S vtUailaa. Only diets containing loco times the tonal level (apprug. 1700 limes the dietary requirements) af 1 ar tot* vuamiaa aeprenaad growth end toducei chance* in uie blood. The packed cell tolnmt van substantially reduced from tvkaf are tn vw ciucbe give* the highest -towel af vuamta A. Tbla via probably due la an effect toe viumftb an to* fnpltty af the red eclla and thus an thatr llfe.apa*. Chkbo (tvea the toxic level af vitamin D shoved an increnae In plasma C ad s decrease tn plasma Inorganic R. The highest level af vitamin A dryreward plasma Ca without Influencing pla*ma Inorganic R. increasing amounts af vtuimn A riven u camMnatian vlth the hlghact level af vuamln D caused a procreative increaae in the piasma inorganic R. The highest level af dietary vlumln A significantly Increased Ca activity tn the plasms of 3 lysosomal cnavmaa: acid phosphates*, R^lueufonidaae and arylsulphausc. Excess vitamin D oven la conjunction srtth the tosal level af vitamin A significantly depreaeed the plasma acid phosphatase and the activity of this enzyme Inereaasd wtth Increasing amounts af vitamin A. Excess vita rain 2> had na toDueseo an toe other hydrolases studied. A marked antagonism between the effects af azreosive amounta of the 2 vitamin* aceurrcd ..... only in respect af toctr actions on the plasma levels af Ca. Inorganic R and acid phosphatase, all af vhteh are involved ta hone metabolism. ,, . . SOI52. TUMARIQN, R. X. (N. f. Cimalera Inst. Epidemiol. Micro** Mot. Acad. Med. Set. USSR. Moscow, USSR.) K vnprofiu o mejtaolsia# tefestchvekogo deintviya antioloitomr trtratsthltnovoi grur^ na pscheu'. fMechaalam af the tcx-c vi>ct r( the tctracvcltne croup 01 anUlncttcs on toe liver.I A?*TfcOn>3 13*?): u4T-*52. 136d. iLn^t. aum,~] --ChlorteiracycUna in hirn donee In rata increased hietid.n* deaminase and urekanlnaae activity. OeytetracveUne had a alight effect an ------- "*blstldincdeamtoaar activity and suppressed uronantnase activity. Tetra cycline effect van similar to ihat of oxytetracyeltne. CMorietrucycltea baa a higher toxicity.--Author. 30153. TTVL'MAKKOV, V. N., and B. K. LUGOVSIOX. Saaudistyo oalaaheneniya prl lechenll paikhieheskl bol'nvkh amtnaxiaom. rVaseular cor: plication* tfurtne ammuuie feMorbrnmastnel treatment ___________ ymc^r paiu^ri ~s;i KEtfcgRsrcCTai&HJiT i ^ x gLiaagovA 41(1): lii-liiJ >999. (Enct. aun.J--The main avndromca vara cerebral hemorrhages and ihrambutin taseular alfectiana af vitally Important organa. Ammaaine prutaoiy increases coacuisbtUty. A thorough control flmluding laboraiortal and tents) of old m'tenia and -- patients with hypertensive eiecaae must be made la the process af inlMtlM treatment.--From auth. sum. 30934. WEISS. HARVEY J. (Mi. Sinai Heap.. Raw York, M. Y,, } LOUIS M. ALCDOirr. and *NAl'L KOC1WA. The rffeet af aallevlaten on tor Hemostatic properties nf platelets in man. J LlN ESYtil titiiT Jlbi-21*5: niusTfh A.--infefauon oTlTg of uprU, but not af snoium salicvlate. priutuceda signUIrani prolonga tion af toe bleeding iimr n normal male -uoj-cta when compared 1" %ltb tbe eflertn af a puerbu. Similar dillrreneea tn the t*<i af too S drugs an platelets was -las observed. Aspirin Incest inn resulted I11 Impaired platelet asjricainn ov en*eeti*e usnoe and vs* assoc1st*d with a decreased rrleane uf plate ut AiJN; solium saltcvlats had *0 % offer1 an men* tjfves. In ntro. tnrubxlNm H platelet-rich Plasma vn* tn wfkimum aspirin eonceniraiitm ul 0.945 m* `ml liaiWfrt bnth toe sdhestao af ptaielcis ta eonneetivr unewe and im release af ADR as veil ss the 2ndary wave af platelet ttt,*reeilim ornduerd with ADR ar eptnegnrtne. $ndim aatieylate Had no nflett sn taeae reacUooo, which were also normal >n pattern* wit* van Wtllebrsnd'a disease, tnhlbiiery ffct rrodeed tnr >nce*llng a amcla l.l g dote f ^trtn va* detrcuble for 4-3 dav* st wMn time MUcyUte was to mirr drienable In Ibe bind, w**h iMir*tr* an irreversible effect to the platelet. A#pm* also tnhitoied toe release af ptatele* ATF. hut tad so effect an tor platelet aurfact Ctorre, seatlaWe platrt4 AYR or ADP, or Ibe iMtrvrttm nf ADP to plasma ADPtte, Theaa support to* bypmne*a* that mgestimi nf Mprut. in contrast |vu. M| um to sadism naltcylitt, prolong* Ihr Weeding time to Inhibiting the release M platelet ADP. pernapa rrflecttnc tn* fiodingt m Slur c*8 systems that aspirin alters membrane pcrmrahillif .--AuUwtrs. MSS. ANONYMOUS. The Sidney and oral ealrtum Iherapv. ARM INTERN Mf.D 19(5): 1^*1 -1032. iJIT.'-Hougn r*c671* valushfe as an antacid, severe and penstbty irreveratbis mjurv # tbe kidney stay occur from tts protongrd use ta ennjmictlon vttk a high bib MUM. Evidence *f renal IukIIo* fltirruvr may to above by a visa In scrum creatinine and renal N. During treatmem with CaCOS a pattent's serum Ca level should he watched for early signs of Ca nephropathy wilhla too tat 7 days af treatmacl. INDUSTRIAL TOXICOLOGY (Sat also "Pathology* ander Respiratory System; "Environmental Health - "Occupatttoil Health,' and `Radiation HcaRh* * under RuMtc Health) 30959. CANDEVIA, BRYAN. (Dtv. Tborae. Mad^ Untv. N. S. ydney, N, 9. W^ Aval.) Putfumtarv function in asbestos workers: A three-year follow-up gtudr. AmlR kLV RESKDff 94(31: 4J3. 421. Ulto. 1117. (Span, and Ft. sum.|--Ventilatory upieliy and ucutilatoiy r*opanao 10 a standard atrelit teat were measured m a acnea fit 41 mala worker* in a factory making asbestos products, and was repeated about 3 1/3 yr later. Tw* ive men left the tnomtyy during tot toteribt*. They bad a significantly lover vital capacity after adjustment for age, and a stgstficanth higher ventilatory requirement for exercise than those who remained in toe Industry. Thin pattern af functional abnormality contrasts with that found la subjects admitting to persistent cough and sputum, tn vhsen a significant reduction vas demonstrated to ac*-adju*ted farced capintlory volume at 1 sac. lit a control scries, observed and predicted changes In pulmorary function over the observation period showed reasonable agreement. The asbestos workera showed s greater decrease to forced expiratory volume at 1 sec. than presided, and possibly greater changes in vital capacity and ventilatory require eM for exercise. The trend toward functional abnormality is coslatent with, although not Indicative of, toe development of astostasia. Ecru) pulmonary function tests are likely to be more Informative than aarlAl roentgenograms.--From auth. sum. - 3C5S7. KARRIS. D. KLffWIM. and W. G. F. ADAMS. Aer*>-o*-- oceurrtiH! in men eneayea tn the potymerixMion nf vtoyi EBjTTltD Jr^i47.',~",7T5-7H. 11/us. I*a7^--3W cases ot aeroosteolysis occurring tn men engaged in the polymentatton of vinyl chloride are desertoed. Tn* bones affected were the terminal phalanges of the fingers and in* saeroutae joints, but in 1 case the patella and to the ocher toe pual.ingcs af the feet were involved. The condition was-accompanied by Raynaud's phenomenon and skin lesloss. This condition is probably a self-Uniting disease.--Authors. 309SI. SAMEDOV, X. G. O aespetslftcheskthh proyieleniyskft delatvlys uglevodorodov v malykh conisvntrautyakh. TNonsorctflc manifestations of low concentrations of hrdrocarbont.i AlLiib RCb2H "IT SI-11. U. Prom: Wr IHWlP.TR FARMAKOL X>aOTER SREDSTVA TOK51KOL. t9M. No. 4.54.915. (TransUttm) --Workers wtre letted at a pvtreleum-procesalng plant where too concentration of hydrocarbon vapors did not exceed the maximum allowable (0.03-0.49 mg/1. Rabbits and guinea pigs were treated under various static regimes with the vapors af rusoitoe 0-70 sc 0.05-1.t m\/t 4 be/day. 9 times/week for 4 me. The workera and toe animal* showed a rise tn toe concentration of Mood acefyiebotne and epinephfine-Uk* suostancea. Animals treated constantly and avanly with increasing hydrocarbon concentration* shoved toes# tendencies, but they were less marsed. Cholinesterase aetivitv ta the workers did not differ from that af controls, but H vas redued In treated aatmalc, especially when the treatment wan with fluctaausg cancrntratlonc af hydrocarbons. FaeudachaUneaterase activity sta not change ta either persona ar animals. Dally urinary raeretton sf 1T-ketaateraidi by treated rsbbtis was af a pnasic r ha racier: the alevsicd activity af the atfrenncerticsl function vas soon replaced by reduced activity. Only under toe action of snarpty fluctuating hydrocarbon concentrations was mere a pratanceo rise in l7-*rtm steroid eacrellon. Maatmum depression to the concrmraimn of vitamins C and B) In toe slond, urine, and organs wss anted m animals treated wun steadily and evenly tnerrasing and also eurpiy fluctuating hydrocarbon concentrations. Chances n toe eleetrehrte metatoUtm with loo conrenfTaliens %aa tnsigntlieaM. Tbe priactmJ ehatntes vttb lav hydrocarbon concentrations were In the funettmai condition af the autonomic tid endocrine systems (Chances in toe metabolism of mediating substances and vitamins and in adreno cortical fmvttanl. These Changrs are probably aoupRIfd and d A campraestdey-stopianonal nature. Oner a eertam prriod they may land to paralatont and teen organic changes. 30999. fRAX. tvAR. (Dep. Surg.. UnaUssrenet. Haaaleholm. 9wod4 Ftngur injury caused by pumt spray fur ACTA CXXR ^ 20613003 I BFG04256