Document zz31780X91D5e8mzXv2pzn1Oa

POnSTOHN ' VINYL CHLORIDE medical survey RESULTS AUGUST 4, 1975 BFG14076 21473001 TABUS 1 OCCUPATIONAL GROUPINGS OF STUDY PARTICIPANTS in parrsrawN health survey Acute Model (Based on Present VC Exposure) A. Current Rubber Workers B. Current Plastics C. Current Chemical Workers High E^5)03^re Medium Exposure 7lj-^ 19 V Low Exposure 3GJ D. Current Salaried Chemical Workers E. Forner Chemical Workers new elsevvtiere in Plant F. Maintenance G. Miscellaneous Total C* - All Current Chemical Plant Employees (Groups C+D+E+F) Nurrber of Individuals Tested Number of Individuals Possible Percer Tested 134 . 80 126 216 105 164 62% 76% 77% 50 71 66 6 533 120 101 131 - 42% 70% 50% - Chronic Model (Based on Total VC Exposure) 1. High Exposure Current Chemical Workers 35 2. Medium Exposure Current Chemical Workers 44 3. Low Dqposure Current Chemical Markers 47 125* tC s o BFG14077 TABLE Z ESTIMATES CF AVERAGE OP VC EXPOSURE (PRE 1974) AM34G CHEMICAL WORKERS High Average Exposure (250 ppm) Service Utility Reactor Operators Relief Operators Strippers Senior Operator "A" Operator 1 ...Coagulator Operator Stabilizer Operator Medium Average Exposure (75 ixsn) Centrifuge Operators Tank Farm Supply Men Pilot Plant low Average Exposure (25 ppn) Dryer Operators Baggers Truckers Janitors BFG14078 21473003  TABUS 3 ** None Average Above Avg. Excessive Pottstown Alcohol Consumption Classification Deer Wine 0 <3 cans/day 0.8 p/day' 4-6 cans/day {2.4-3.6 p) >6 cans/day 0 <1 hottle/wk (2.76 y) 1.1-2 bottles/wk (3.0-5.5 y) >2 bottles/wk Score Overall for an Individual - Mixed Drinks 0 <5 drinks/wk (3.25 y) 6-8 drinks/wk (3.9-5.2 yi/wk. >8 drinks/wk 04* 0 no drinking at all 1 all three categories are average or below :2 above average in any one category 3 excessive in anv one category 21473004 . BFG14079 TABLE 4 DEMOGRAPHIC PARAMETERS OF OCCUPATIONAL GROUPS ACUTE GROUPS A. Current Rubber Workers B. Current Plastics Workers C. Current Chemical Workers low Exposure Medium Exposure High Exposure D. Current Chemical Salaried E. Dormer Chemical i F. Maintenance Mean Alcohol Consumption Score 1.38 ' 1.34 1.34 1.25 1.42 1.37 . 1-14 , 1.41 1.26 Heavy Drinkers Mean Age (Yr.) 11(8%) 6(8%) 11(9%) 1(3%) 3(16%) 7(10%) 1(2%) 12(17%) 5(8%) 40.3 44.4 42.3 . 41.4 45.5 41.3 36.4 ' 42.4 47.1 Females . Non-Wiil 0 2(3%) 0 0 0 0 0 0 0 [ 5(4%) 2(3%) 4(3%) 2(6%) 1(5%) 1(1%) 1(2%) 0 0 CHRONIC GROUPS Low Exposure Medium Exposure High Exposure : -1.34 * 1.30 1.39 6(17%) 2(11%) 3(4%) 30.8 48.0 49.5 0 0 1(3%) .0 0 4(9%) BFG14080 SOOVTZ i; TABLE 5 ' HISTORY OF PREVIOUS LIVER Q OR GALL BLADDER DISEASE ACUTE GROUPS Number of Persons Having a History of: 1, Hepatitis 2. Cirrohsis 3. Gall bladder Disease ABC Current Current Current Rubber Plastics Chemical 3(2%) 0 4(3%) 1(1%) 0 3(4%) 5(4%) 1(1%) 3(2%) D Chemical Salaried E Former Chemical F Maintenance 0 0 1(2%) 4(6%) 0 3(4%) 1(2%) 0 1(2%) C 10(3%) 1(0%) 8(3%) Total Tested 14(3%) 1(0%) 15(3%) BFG14081 1. 5G0T 50 - 59.9 60 - 79.9 i 80 Toted Abnormal Mean 2. > & Total Bilirubin 1.1 - 1.4 1.5 - 1.8 > 1.9 Current Rubber 4(3%) 1(1%) 1(1%) 6(4%) 31.6 6(5%) 2(2%) 0 TABUS 6 SEVERITY OF OBSERVED LIVER FUNCTION ABNORMALITIES ACUTE GROUPS Current Plastics Current Chemical Cliemical Salaried Former Chemical Maint. 2(3%) 5(4%) 1(2%) 2(3%) 4(6%) 0 3(2%) 1(2%) 2(3%) 1(2%) 1(1%) 0 0 1(1%) 0 3(4%) 32.1 8(6%) 32.6 2(4%) 30.7 5(7%) 34.5 5(8%) 32.6 4(5%) 4(5%) 0 4(3%) 4(3%) 0 4 (8%) 1(2%) 1(2%) 3(4%) 1(1%) 0 5(8%) 0 0 0^ r c* Total Tested 12(4%) 18(3%) 7(2%) 8(2%) 1(0%) 3(1%) 20(6%) 29(6%) 16(5%) 2(1%) 1(0%) 26(5%) 5(1%) 1(0%) Total Abnormal Mean 8(74) ,69 5(6%) .63 4(3%) ,64 6(12%) .69 4(6%) .63 5(8%) .63 19(6%) 32(6%) 21473007 BFG14082 i TABLE 6 SEVERITY OF OBSERVED LIVER FUNCTION ABNORMALITIES (continued) ACUTE GROUPS 3. LCH *226 - 250 251 - 275 _ 276 Current Rubber 1(1%) 0 1(1%) Total Abnormal Mean 2(2%) 170.9 Current Plastics 3(4%) 0 0 4(4%) 173.8 Current Chanical 2(2%) 0 0 4(3%) 169.8 Chemical Salaried 1(2%) 0 0 1(2%) 61.3 Former Chemical 5(7%) 2(3%) 1(1%) Maintenance. 2(3%) .0 0 69.3 2(3%) 68.8 4. Alkaline _ Phosphatase y 86 -'115 ~'isu2%) 116 -a145 (3 ( 3%) > 146 0 Total Abnormal Maan 18(15%) 66.6 8(10%) 2( 3%) 0 10(13%) 65.8 15(12%)' 1( 1%) 0 16(13%) 66.1 3(6%) 0 0 3(6%) 61.3 8(11%) 3 ( 4%) 0 11(15%) 69.2 4(6%) 0 1(2%) 5(8%) 68.8 C* 10(3%) - 4(1%) 1(0%) Tbtal Tested 14(3%) 5(1%) 2(0%) 19(6%) 32(6%) 30(10%) 53(10%) 4 ( 1%) 9( 2%) 1( 0%) 1C 0%) 35(11%) 63(12%) 21473008 BFG14083 SGCT 50 - 59 60 - 79 > 80 tABLE 7 SEVERITY OF OBSERVED LIVER FlffXmOtJ ABNORT-RLUTES CHRttllC GROUPS Low Current OTanical Medium -- 0 2(4%) 0 3(7%) 1(2%) 1(0%) 2(6%) 0 0 Total Abnormal Mean Total Bilirubin 1.1 - 1.4 1.5 - 1.8 > 1.9 2(4%) 30.8 1(2%) 0 0 4(9%) 35.0 1(2%) 0 0 2(6%) 32.1 2(6%) 0 0 Total Abnonral Mean UH 226 - 250 251 - 275 > 276 1(2%) .63 1(2%) 1(2%) 0 1(2%) 65 1(2%) 1(2%) 0 2(6%) .65 0 0 0 b ** py Total Afanorral Mean Alkaline Phosphatase 86 -115 116 - 145 > 146 2(4%) 164.8 o 4sv eoA r 7(15%) 0 0 2(5%) 176.6 4(9%) 0 0 0 168.4 4(11%) 1(3%) 0 Total Abnormal Mean 7 (15%) 65.9 4(9%) 63.7 5(14%) 69.0 21473009 BFG14084 TABLE 8 LIVER ABNORMALITIES ACUTE GROUPS Number Tested: la*\< Hepatomegaly by Palpation Hepatomegaly by Percussion Liver Size by Percussion 12 - 13 14 - 15 > 16 Hepatomegaly by Doth Palpation .and Percussion Current Rubber y 9(7%) 4(3%/ 3 0 l' 1(1%). Current Plastics 8(10%) 5C6%) 4 1 0 3( 4%) Current Chemical 17(14%) 7 ( 6%) 4 2 1^. 6( 5%) Chemical Salaried i/ 7(14%) S 2( 4%) Former Chemical 10(14%) 1( 1%) 1 i1 10 0 0 2< 4%) 1{ 1%) Maint. *> . C* / 11(17%) 45(14%) 11(17%) 21 ( 7%) 8 3 0 6(10%) 15(5%) Total Tested 61 (U%) 30( 6%) 19 ( 4%) 21473010 1 i Number Tested: Hepatomegaly by Palpation Hepatomegaly by Percussion Liver Size by Percussion 12 - 13 14 - 15 > 16 Hepatomegaly by Both Palpation and Percussion TABIC 9 LIVER ABIXMMJ3TES ACUTE CHEMICAL GROUPS Low Mediun 4(11%) 2< 6%) 1 0 1 2( 6%) 4(21%) 1( 6%) 0 1 0 1( 5%) Hiqh 9(13%) 4{ 6%) 3 1 0 3( 4%) 21473011 BFG14086 21473012 BFG14087 Nuntoer Tested Hepatanegaly by Palpation Hepatanegaly by Percussion Liver Size by Fercussion 12 - 13 14 - 15 ' 1 16 Hepatanegaly by Both Palpation. * . and Percussion TABLE 10 LIVER ABNORMALITIES CHRONIC GROUPS Current Chemical Workers Lew 47 Medium 44 High 34 S' 2(4%) B (18%) 7(20%) 2(4%) 2(4%) 3(9%) 122 001 100 2(4%) 2(5%) 2(6%) BFG14088 TABLE 11 HEPATOt-EGALY AND TYJO OR MOKE ABNORMAL LIVER FUNCTION TESTS Case Acute Group 1 Maint. 2 Former 3 Chem-H 4 Plastics 5 Plastics 6 Rubber 4 7 Chan-M 8 Oiem-H 9 Chem-M Chronic Group Med. - High High Low Hepat. by paipYes Yes Yes Yes Yes No Yes .1,0 Yes Hepat by Perc. Yes Yes Yes No No Yes Yes Yes Yes SCOT (40) 57 47 46 45 43 50 47 57 63 IDH (225) 246 246 256 177 145 279 201 137 124 Aik. Phos. (85) 83 78 45 91 86 69 88 90 46 Total Bilirubin (1.00) 1.10 .40 1.00 .60 .60 .60 .60 .60 1.40 Age 46 70 55 53 59 48 49 48 64 Table 12 Liver Scans Total number of liver scans performed in study. Normal to all 3 readers: Abnormal to 1 reader only: Abnormal to 2 readers: Abnormal to all 3 readers: 123 94 25 4 0 Reader fil to to Definitely Abnormal 2 - 2 Probably Abnormal 13 16 _2 31 Focal Defect 2 9 2 13 Diffuse Disease 7 13 _Z 20 Other 4 Z 4 VToez.wz BFG14089 TABLE 13 SUtfMy OF LIVER ABtJDRMALnTES Liver Disease a) History of blood transfusion History of hepatitis Presence of hepatitis antigen (by lab) b) History of liver disease in family c) Hepatomegaly by percussion (>11 cm.) Palpable liver edge Splenomegaly Platelet count d) SGOT >40 >50 LDII >226 Alkaline phosphatase >86 _>116 Total bilirubin >1.1 >1.6 GGTP >26 >41 Sorbitol dehydrogenase _>60 >130 Ornithine carbamyltransferase Total protein ^<6 ^>500 Total in study Group A Current Rubber Group C Current Chemical 4 ( 3.0Z) 3 ( 2.22) 5 < 3.72) 11 ( 8.72) 5 ( 4.02) 2 ( 1.62) 5 ( 3.72) 5 ( 4.02) 4 ( 3.02) 9 ( 6.72) 1 ( 0.72) 0{ 0) 7 ( 5.62) 17 (13.52) 0( 0) 0 ( 0) 22 (16.42) 6 ( 4.52) 2 ( 1.52) 18 (13.42) 3 ( 2.22) 6 ( 6.02) 2 ( 1.52) 4 ( 3.02) 1 ( 0.72) 38 (28.42) 12 ( 9.02) 7 ( 5.2%) 1 ( 0,72) 25 (19.8%) 8 ( 6.3%) 4 ( 3.2%) 16 (12.7%) 1 ( 0.8%) 4 ( 3.2%) 0( 0) 4 ( 3.2%) 0 ( 0) 36 (28.6%) 12 ( 9.5%) 9 (7.1%) 2 ( 1.6%) 134 126 21473015 BFG14090 TABIE 14 HYPERTENSION (ACUTE GROUPS) Blood Pressure Rubber Chemical . a) History of blood pressure medication or water pills 10( 7.5%) Told of 1-Lah blood pressure by physician in past ' 25(18.7%) 22(17.5%) 33(26.2%) b) Blood pressure reading: Systolic > 141 33(24.6%) > 151 15(11.2%) /-Diastolic ~ 91 20(14.9%) >101 8(6.0%) 33(26.2%) 15(11.9%) 33(26.2%) 8( 6.3%) c) Fundal arteriolar narrowing Fundal A-V crossing changes Fundal hemorrhages Fundal exudates 16(11.9%) 10( 7.5%) 0( 0 ) __ 0 { 0 ) 19(15.1%) 16(12.7%) 1( 0.1%) __ 3( 2.4%) Total in Study *p < 0.05 134 126 9T0 ZLfrJ?. BFG14091 I TABLE 15 HYPERTENSION (BORDERLINE AND DEFINITE) ACUTE GROUPS Systolic Hypertension (> 140) 141 - 160 161 - 180 181 - 200 >_ 201 A Current Rubber 25(19%) 8( 6%) 0 0 B Current Plastics C Current Chemical 13 (16%) 6 ( 8%) 2( 2%) 1( 1%) 26(21%) 3 ( 2%) 1< 1%) 3( 2%) Chemical Salaried 5(10%) 2( 4%) 0 0 E Former Chemical 14(20%) 7(10%) 2 ( 3%) 0 Haint. * 15(23%) 6( 9%) K 2%) 0 C* 60(19%) 18 ( 6%) 4 ( 1%) 3 ( 1%) Total 33(25%) 22(23%) 33(26%) 7(14%) 23(32%) 22(33%) Diastolic Hypertension <> 90) 1 91 - 110 111 - 130 131 - 150 1 151 15(11%). 3< 2%) 0 0 20(25%) 1( 1%) 0 0 29(23%) 3( 2%) 0 0 5(10%) 0 0 0 12(17%) 0 0 0 16(24%) 2 ( 3%) 0 0 62(20%) 5( 2%) 0 0 Total 18(13%) 21(26%) 32(25%) 5(10%) 12(17%) 16(24%) BFG14092 TABLE 16 CENTRAL NERVOUS SYSTEM SYMPTOMS (ACUTE GROUPS) History of severe, persistent headaches History of losing consciousness or fainting History of 1fsing consciousness or fainting on job Total in study Group A Current Rubber 11 ( 8.2S) 27 (20.lt) _3 ( 2.2%) 134 Group C Current Chemical 18 (14.3%) 32 (25.4%) _ ( 7.1%) 126 21473018 BFG14093