Document zrbd92pN7VrZBV5XGZwEJmvg
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NOTE TO FILE - AR 226
150 DATE: March 28, 2001
FROM:
Karen Lannon
SUBJECT: 3/26/01 Perfluoroalkanoic acids
/1R 4 orto
AR 226-_ 1005
Rich Purdy, an independent toxicologist, gave the attached presentation to EPA on March 26, 2001. The meeting attendee list is also attached.
3 3m
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Contain NC Loi
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Perfluoro fatty acids
F(CF,),COO
From:
Perfluorooctanoic acid
(PFOA) " ePerfluoro telomer alcohols
F(CF,),CH,CH,OH
o Perfluoro telomer sulfonates
o Perfluoro telomer iodides
Perfluorooctanoic acid
(PFOA)
Not a Problem like PFOS:
Not as bioaccumulative Not as toxic o Not Found in wildlife
tissues or human blood
3
Or is it?
Relative Toxicity
oIn a PFOS rat
reproduction study the
LOEL for the dams was
.
48 ppm liver (0569)
oln a rat PFOA feeding
study the female LOEL
was 0.3 ppm liver (0445)
eWildlife PFOA Levels
O 0.04 ppm in California
sea lion liver (0962)
O 0.18 ppm in albatross
liver (0962)
Detection limits high Little homologue monitoring
y
28 day rat gavage dosing followed by 28 days depuration
(0951)
3mg/kg/day PFOS 30mg/kg/day telomer alcohol
' Depuration phase data
Chemical Day 1 Day 14
PFOS
377 240
Telomer alcohol
PFOA
0.164 0.016
C10
1.7 1.4
C12
0.12 0.08
Day 28 191
0 2.2 0.1
{
Perfluoro fatty acids
look like PFOS:
Electronegative rods with a negative charge at one end
- Are they in the same class?
`
Similarities:
1. Extremely Persistent 2. Surfactants-less than
monolayer. 3. Bioaccumulation . Mechanism:
Enterohepatic recycling
(0008 & 0449) 4. Mechanism of Toxicity
a. Mitochondrial Uncoupling (0167 & 0169)
b. Wasting Syndrome i. PFOS
1. 53 wk feeding (0956)
2. 7 day feeding
(Haughom and Spydevold)
i yp
3. 90 day feeding (0139)
4. Rabbit 13 day gavage (0949)
5. Fish ?
6. Quail 5 day
.
feeding (0953)
7.90 day rhesus (0137)
8. 26 wk Cynomolgus (0957 and 0958)
ii. PFOA
1. 13 wk feeding
study (0449)
2.7 day feeding
(Haughom and Spydevold)
3.50 mg/kg 14
days (Cook et al 1992)
8
4. carcinogenicity
study (0437) c. Upregulate aromatase
d. Lower Cholesterol
e. Not Carcinogenic
i NO CB
9
Other Possible Class Members:
F(CF,), CF,CH,CH,0H
P=1.0 F(CF,), CF,CH,COOH
P=0.3 Alpha dihydro perfluoro fatty acids
F(CF,); CF=CHCOOH + HF 0.95
F(CF,), CF=CHOH + CO, P=1.0
F(CF,), CHF-CHO
P=1.0
F(CF,), CHF-COOH
P=.05 Alpha monohydro perfluoro fatty acids.
F(CF,), CHOH-COOH +HF
P=1.0
F(CF,); CHO-COOH
P=?
F(CF,), COOH
pean NC CB
10
Bago ef.al Anal Biochem. US 336-53 (113)
-
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Example of Incomplete
Metabolism
OR
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Oo
:
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CgF,,S-NH,
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PFOSA
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PFOS
12
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Contain13NC CBI
Propose PFOA same Class as
PFOS
1. Look alike
2. Surfactants
3. Very persistent
4. Biomagnify via
-
enterohepatic recirculation
5. Uncouple mitochondria
6. Cause wasting
7. Up-regulate aromatase
8. Reduce serum
cholesterol
9. Not carcinogens
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(acm) 240-1628
202 260 2369
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Mary beste,
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202-200 - 1%69
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EETD/ICB
202-2o- 1538
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Contain NO CRI
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