Document zozLxx26q19zQzwR1Nvv0xx2m

TOXICITY OF PYDRAUL FLUIDS Pydraul F-9 There has been considerable toxicity research on Pydraul P-9. Attached is a discussion and interpretation of the toxicity studies. The results may ho summarized in a briefer fashion as follows: In the case of oral feedings, it was found that the minimum lethal dose for rats was 10.6 to 15,8 grains per kilogram of body weight. In rabbits, the oral MLD was Q.57 to O.85 gramsj in both casoo the undiluted material was introduced Into the animal stomach by means of a rubber tube catheter. Pydraul F-9 was patch tested full strength according to the method of Schwartz and Peck, which is the standard test for In dustrial chemicals. Two hundred and five volunteers were tested and there vms no evidence of primary skin irritation or sensi tization, pydraul 625 The Oral LDkq of 3^3 grama per kilogram when tested with rats, and the Oral Minimum Lethal Dose of 4.25 to 5.00 grams per kilo gram when tested with rabbits Indicate that Pydraul 685 may be olassed as "relatively harmless" to "slightly toxic" from the standpoint of oral ingestion. Potential irritation studies with rabbits show that it is only a mild irritant to skin and eyes. In acute vapor inhalation studies, rats survived a Bix-hour expo sure to atmospheres saturated with vapors of the product. The above figures are lower than those obtained in studies with Pydraul F-9. This comparison is significant since Pydraul F-9 has been used since 1949 with no reports of skin irritation or other toxic effects. Pydraul 150 The toxicity report on Pydraul 150 indicates that it is prac tically Innocuous when fed orally to rats since the animals sur vived single doses of 80.5 grams per kilogram with loss of appetite and severe diarrhea as the only toxic effects. The fluid apparently is not absorbed through the unbroken skin of rabbits since this species survived doses up to 9.9 grams per kilogram of body weight. In rabbit skin and eye irritation studies, Pydraul 150 was no more irritating than a 10^ soap solu tion tested similarly. As indicated with pydraul F-9, however, Pydraul 150 will cause severe pain if there is accidental splashing In the eyes of hvsnans. Rats survived a six-hour exposure to an atmosphere saturated with Pydraul 150 vapors. DSW 009479 STLCOPCB4001202 -2- Pydraul A-gQQ Our Interpretation of the toxicity data obtained on this newer synthetic hydraulic fluid 1b Uliat accidental ingestion la not a particular hazard in view of the high oral lethal dooe (oral LD<)Os 10,1)00 nig/kg). Similarly, single massive akin exposures should not be Immediately hazardous (Skin MLD: 025 to 1,250 mg/kg). The lethal dose following skin penetration Is such, however, that prolonged and repeated skin contact should be avoided, Suoh exposure must also be avoided to prevent skin Irritation, We also feel that vapor Inhalation should be avoided when the fluid is at elevated temperatures. Such exposure again relates to prolonged or repeated exposures rather than massive or acute exposure. In the case of the latter, workmen would probably not voluntarily subject themselves to concentrations that are hazardous for short periods, Pydraul AC In animal toxicity studies with Pydraul AC, the oral lethal dose in rate is approximately 40 grams per kilogram and for rabbits, 3.5 to 4.5 grams per kilogram. The greater sensitivity of rabbits is typical of this type of fluid. This lethal dose Is of ouch an order, however, that the fluid may be considered only "slightly tcocio" to man from the standpoint of occidental Ingestion of single oral doses. The fluid may be absorbed through the unbroken skin of rabbits in dOBes resulting in death, but again the minimum lethal dose is such that accidental massive skin exposures to man do not present a hazard, ttkln and eye irri tation studies with rabbits would classify the fluid as a mild Irritant. Laboratory animals survived six-hour exposures to an atmosphere saturated with the vapors of the fluid. On the basis of this data, it is concluded that Pydraul AC requires no special handling precautions other than avoiding prolonged or repeated akin contact. Accidental splashing in the eyes will result In moderately severe pain and irritation but no permanent damage should result. DSU 009480 STLCOPCB4001203