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HCCE!V0 18/23 IS: 28 1992 AT 1638582 2 (P8UTC0 PA62 rggh 8Y:UTKSC-H SPH i 10-23-92 . 14*10 T137944B77* iaoncfi4 ;# 2 PSRSOKALi CURRICUt.UK VITAE Thomas D*. Downs Born August 2ft, 2.033 In Xalamaioo# Michigan Married# with four children worn Address! POBox 20106# Houston# TX 77225 Homo Addrossi 5101 Austin Stroot# Houston#. TX 77004 Telephone! 713-702-4421 (offloe)# 713-522-5500 (homo) EDUCATIONI B.8. Western Xiohigan university xalaaasoo# Michigan# i960 (Mathematics) K.FH Tho University of Hiohlgan Ana Arbor, xiohigan# 1002 (Biostatistios) Ph.D. Tho University of Xiohigan Ann Arbor# Xiohigan# loos (Biostatistios) MILITARY SERVICES _ tJnltod Statoa Amy, aotivo sorviao# April 1953-April 1956 Unitod Staton Army# aotivo rosorvo# 1950-1959 Honorably discharged, 1061 ACADEXIC APPOINTMENTSt Vrofossor of Biometry, Tho University of Texas Xoalth soianoa Cantor at Houaton, School of Public Healths 1975-Present Aaaooiata in Toxicology# Tho University of Texas Health soienee Center at Houaton# graduate School of Biomedical Sciencesi 1091-Present Adjunot Professor of statietioa# Rice Universityt 1075Present Xseoeiato Professor of Biometry# The university of Tomas Health science Center at Houston# school of Public HealthI 1070-1975 Adjunot Associate Professor of Kathematioal sciences# Aloe university! 1072-1075 Assistant professor of Biometry# Case western Reserve Univereityi 1065-1070 UCC 074251 -L- tfrra.urn IB/23 IS: 29 1992 AT *1638502 PACE 3 (PRIETED PACE 3) 1 sllft By'uTOCH* SPH 110-21-92 J 14519 5 7137844877-* 4830502 i 3 Tom Down* cv, page i VISITING PROTBSSORSHIPBl The university of Leads# England (six veeks, 1974) Harvard university, Cambridge (six veeks, 1977) HONORS1 1, senior Mathematics Avard, western Michigan Univ., 1990 9. Kappa Kho Sigma Honorary Bolsnoe rraternity, western Michigan univ., i960 - 3. Cum Laude, Western Michigan Univ,, 1990 4. Delta Omega Honorary Public Health Society# univ. of Michigan, 1999 5. u.s. Public Health service Traineeship, Univ. of Michigan, 1990-1994 9. Outstanding Teacher Avard, univ, of Texas School of Public Health, 1903-84 academic year PROFESSZONAL SOCIETIESI 1, American Association Advancement of Selenoe 9. American Chemical Association a. American Statistical Association 4, Biometrics Society 5. society for Epidemiologic Research 9. Society for Risk Analysis (Co-rounder and Past President, Lone Star Chapter) COURSES TAUGHTt l. Medical Statistics, 1995-1973 3, Elementary Blostatistios, 1995-1971, 1981, 1982 a. Theory of statistics, 1998-1949 4, Multivariate Analysis, odd-numbered years 1959-1983, 1984-19S7 5, Linear Models, 1970# 1972, 1974, 1985 5. Directional Statistics, 1975, 1983, 1985 7. Time series Analysis, Even-numbered years 1974-1984 8. Risk Assessment, 1980-1982, 1988-1992 9. intermediate Biometric Methods# 1988, 1989 10. Risk Anelyels, 1989-1992 UCC 074252 SENT BYSUTHSC-H SPH 1 irn`*iu< im> .10-23-82 . H20 71378448T7* 4630502 ;# 4 Ton Downs CV# pegs 3 REPORTSI 1. Downs# T*# 1971a Tori consumer Product Safety Coamission, estimation Equations for the Vises Hospital furvty 2. Downs# T.# 197. Tori Dlaaond Shamrock Cbsnioal Company. Coamunity Risk xnasssaant from Emissions from vinyl chlorids Plants 3. Downs# T. # stallonss# R.# Trankowski# T. and Debarthe# b., 1977* Tori The soolaty of Plastics Industries. X critical review of the literature on vinyl ohloride and birth defects 4* Downs# T# 1972, yon The society of Plasties Industries.. X orltioal review of the proposed HIOSH occupational exposure standards for styrene 5. Downs# T.# Tori pennsoil corporation. Mortality among solvent dewaxing workers 6. Downs# T.f 1979. Tori The American Petroleum institute. Comment# on the proposed SPA water guallty criteria 7. Battigelli# M. # Downs# T.# Lachtman, D.# Kilby# T. and Weir# p,# 1979. Tori The Engine Manufacturers Association. Comments on ths proposed IRLO oriteria for identifying and estimating risk fron carcinogenic substances a. Stallones# R* and Downs# T.# 1979. Tors The xmerioan Industrial Health Council. x critical raview of ''Estimates of the Traction of Cancer in the United states Related to Occupational factors". 9. Downs# T.# 1979. Tori Dow Chemical Company. x orltioal raview of ths Environmental Protection xgeney Risen xz Report on the spontaneous Abortion Effects of Aerial spraying of 2#4,S-T 10. Buffler# P.# Dabarths, D.# and Downs# T.# 1979. Tori us Air Toros* critique of a study protocol for determining deleterious sffsots# if any# in Vietnam veterans exposed to "agent orange" 11. Downs# T.# 1979* Tori pennsoil corporation* Effects of underground exposure on Duval Potash Miners 12. Downs# T*# and Davis, S*# 1979. Pori union carbide Corp. Estimating tertiary effluents from en industrial wastewater pond ucc 074253 KUAivtu i*/tn is; j* lasc mi SENT BYSUTHSC-H SPH rHhb a irnutM rmc -Si1n0"-23-92 $ u:20 ; 11379U877-* 4030502 if $ Ton Dona CV, paga 4 rxportsi continued 13. Downs, T., I960, fori Ths Society of Plsstios Induotrio*. & critical raviav of ths propeaad 1120*8 occupational xposur* standard* for atyran* 14* Downs, T., Shaw, 0., and Hair, F., 19*0. fori Th# Amarioan Mining Congress. Coaaants on th* propeaad m air quality eritaria for airborna carcinogens is. Downs, T., 1980. fort standard Oil company of Ohio. Risk assessment from low-dose exposures to aorylonltril* 1C. Downs, T., 1981. fort ASARCO. fraparad atatanaat to fugat Sound Air Pollution Control Aganoy on community lung eanear risk assessment for araanio amission* 17. Downs, T# 19B1. fort Cameron iron work*. Relationships batwasn hast stress and risk of cardiovascular disease la. Downs, T., 19*2. fori Mr. Michael Pretl, Baltimore, XD. A atatlstioal analysis of the relative risk of PXD among users of the Daikon shield 19. Downs, T, 19*2. fori Mr. R. Manchester, Burlington, vr. A atatlstioal analysis of adjusted relative risks of the CDC Woman1* Health study 20. Downs, T., 1983* fori tmiroyal. Rxpacted oanoar oases and deaths for Dniroyal whit* males. Byi salaotad site, pay status, data, and oumulative ago group 21. Down*/ T,, 1983. fort ASARCO. Comments on the risk assessment methodology used by BPA for high araanio oopper smelters' 22. Downs, T., 19S5. fort Monsanto Chemical Company. Expected leukemia mortality among workers at the Monsanto Chocolate Bayou flent 23. Downs, T., 1967. fort Mr. Craig McClellan, Ban Diego, OA and Mr. Phil Bardberger, San Antonio, TX. Risk of dsath or Injury Involving children riding three wheeled ATVs 24. Downs, T., 1921. fort ASARCO. Comments on risk assessment procedure* us*d for predicting srsanic-lndueed cancer in the vicinity of the Tacoma smelter UCC 074254 r wrriUEfi ia/23lSM 1992 AT H638S02 PACE J> <PH*T0 1 'sISt BY:UThlcH< SPH i10-23-92 ! 1*521 i 71*37844877** 4630502 !8 6 Tom Downs CV# page 5 reports (continued) 25* Downs# T.# 19SS. Fori FDA. Statlftioil accuracy and validity aapaota of fatal ultrasound Dopplar dsvioas 2. Dovns# T# issa. Pori Baron corporation. Conservative risk assaBsna&t for arsaaioal ooontaalnatioa of natural gas 27. Downs, T# 1988. Tori pannsoil Corporation. consarvatlva rlsX aeeeaament of potential contamination in natural gas araanlo as. Downs# T.# 1989. Port Rabsaman Hospital, Jacksonville, ax. Estimated eanoar risks from asbestos exposures 29. Downs# T., 1989. Pori PDA. Sample else aspects of ollnloal trials for altering sex ratios 30. Downs# T.# 1989. Pori PDA. Comments on proposed PDA Ouldelinas for premarket tasting of female barrier oontraeaptivas 31. Downs# T.# 1989. Pori PDA. comments on the Interoeed absorbable adhesion barrier premarket application 32. Downs# T.# 1989. Pori Pannsoil Corporation. statistical critiques of 'white oilsi a 90 day feeding study in rats11 and "White oilsi a repeat 90 day feeding study in female rats11 33. Downs# T. # 1990. FOrx PDA. Comments on the Genesis fetal recorder 34. Downs# T.# 1990. Pori PDA. Statistical review of position paper on the preaarket approval criteria for ambulatory toeodynamometor used as an aid in the diagnosis of preterm labor 35. Downs, T.# 1990, Pori PDA. Review of Medela nipple stimulation device for oontraotlon stress tests 38. Downs# T.# 1990. Pori PDA. comments on the statistical analysis la support of the Kealthdyne uterine eotlvity recording system UCC 074255 l`iTr-,llfflWSBWr* " ``*"*110-23-92 TWl rM~ 7137944877- 4630502 ;# 7 Tom Downs CV, page c RETORTS (continued) 97. Downs, T., I960. Ton FDR. Clinical dots review of iMltbdya* tjftn 77 uterine activity recording system 3S. Downs, V., 1990. Tort DUFont Chemical Company. Rsviv of appsals court dscisloa rs DeLuca versus Xarrell Dow vharmaoautloals 39- Downs, T., 1990. Ton xr. stsvo Dillard, Houston, rx. asvisw of Dsnssns risk asssssasnt artlolss 40 DOWDS, T., 1990. Fori FDA. Coonants on the statistloal analysis and elinioal utility of tno Hsaltkdyns 8UAM systsa, witn revisions enolossd vita latter to FDA dated 9 Oot 90 41. Fhilpott, F., Davis, s. Downs, T. and Schroeder, a., 1990. Fort AMOCO and Monsanto Chemical Company. Evaluation of long-term water quality trends in Chocolate Bayou 42. Buffler, F., feurau, X, Downs, T., Friohard, 8. and Rosas, A., 1990. Fori XBX. Exposure to ydts and reproductive outcomes i Xeta-analysis of epidemiologic studies 49. Downs, T., 1991. Fori FDA. Review of olinioal studies and labeling for XY-FAP selfadministered screening device for cervical cancer 44* Downs, T., 1991. Fort FDA. Review of elinioal statistics in the PXA for the Advanced Medical systems BOAX 41. Downs, T., 1991. Fori FDA. Review of Cook chorionic villus sampling set UCC 074256 r RCCeiVEfi 18/23 IS: 32 ISM SENT BYiUTHSC-H SPH HI itb3UMl2 10*23-92 rMM. a ; U<22 irniMw i" 7137 944877-* 4630502 U8 Tom Downs CV, poor* 7 CURRENT RESEARCH ACTIVITIES! 1. Leukemia incidence in Southeast Texas (funded by NCI) 2. Angular-angular regression methodology (no funding) 3* Risk factors for isuksmis in Tmi (funded by NCI) 4. Risk assessment msthodology (no funding) s. statistics of hypsrplanss in n-epaoe (no funding) ,4. VDT exposures and adverse pregnancy outcome (funded by IBM) 7. Hiv-associated GN8 lymphomas (proposal to HXH) a. cancer in rubber workers (expert witness) 9. Safety and Efficacy of Ob-Oyn devices (consultant to FDA) 10. skin keratoses and chemical exposures (funded by XCX) 11. statistics of long-term animal cancer bioaseays (no funding) 12. Evaluation of cluster of lymphoma oases (funded by NASA) 13. Asbestos levels in ohildren'e lungs (funded by MCI) 14. Statistical methods for meta-analysis (no funding) 15. Southwest Center for Occupational Health and safety (member) 14. Toxicologic aspects of*risk assessment (associate faculty) 14. Health of petrochemical plant workers (funded by Phillips) 17. Public perception of risks (no funding) 12. Multivariate methods in Public Health (no funding) UCC 074257 `t oIrrnriturbny1`S0t7S23 cl-f^i'32SPH1992 AJ *bJt4S*;2io-23-S2 P;ASu6 :239 :(PHiMUJ rttM. 9i i M9Y011R4?.* 1(4ACn4 ; 9 To Downs CV, page t PUBLICATIONS l 1. Gannon, J. and Downs, T. Programming rivsr do calculation*. Water and Sewage works Journal, Kerch, lt<$. 2. Downs, T. The von xisss distribution! dsrivsd distributions, regression theory, and soma applications to meteorological problems. Ph.D. Thasis, univarsity of Michigan, Ann Arbor, 1961. S Downs, T. Boas relationships among tha von Mists distributions of dlffarant dimensions. Blomstrlfca S312if, 1*65. 4* Downs, T. Liebaan J., and Romberg, H. Tha atatiatioal treatment of angular data in vaotoroardiography. Znt vaotoroardiograpby 1S65, X. Hoffnan and R. Taynora, aditors. North-Holland, Amatardam, 1*66, p.2S6. 5. Liabaan, J., Downs, T*, Roabarg, H. and Agusti, R. statistical treatment of angular data in vaotoroardiograpby. Tha Aaarioan J of cardiology 17x126, 1666. 6. Liabaan, J., Roabarg, H., and Downs, T. Tbs Prank QRS VCG in the Prematura infant. Vaotoroardiograpby, 16(5, X. Hoffman and R. Teymore, editors. North-Kolland, Amsterdam, 1966, p.272. 7. Downs, t. Quality Control. Tbs Handbook of Biochemistry and Physios. Henry Damn, editor. world Publishing Company, Cleveland, 1666. a. Eats, 8., Haipie, x. Downs, T. and ford, A.8. Long-Term Course of 147 Patients with fracture of tha Hip. surgery. Gynecology and Obstetrics 124H216, 1667. 9. Downs, T. and Gould, L. Boms Relationships Between the Normal and von Miaee Distributions. Biometrlka 54ICB4, 1967. 10* Adams, M., Downs, and Dsuble, h. Nursing Referral Outoome for Poet-Koepitalised Chronically 111 patients. American J. of Public Health SBUOl, 1965. 11. weir, w. and Downs, T. The optimum Time for Conception. American J. of fertility 19X64, 1966. 12. Young, li. and Downs, T. Testing ths Signlfloanee of Agreement Among Observers. Journal of Speech and Hearing Research 1H5, I960. UCC 074258 Sent byiuthschh sph............. ; 10-23-82 ; u:23 7137844077* 4630502 ;io Tom Down* CV, p9 9 PUBLZCXTIOXS (continued) 13* Sreenvisan# V. # Llebman# J.# Linton, D. and Downs# T. Posterior Mitral Regurgitation in Girls possibly duo to Posterior Papillary Muscle Dysfunction. Pediatrics 42i276# mi. 14. Jaffa, J., Fereky# L. and Downs, f. Parantaral Thsrapky in tka Management of Mechanical Renal Trauma. The Journal of Urology 100(133# 1962. is. Kata, a., Ford# X., Downs, T. and Xdaae# X. Okroaio Dlaaaaa Claaaifioatioa in Evaluation of Kadioal Cara Programa. Madioal Cara 7*139# 1969. 15. Downs, T. and Llabuan, J. statistical Methods for VOO Directions. Trans, on Blo-nsd. Bnglnaaring 16(37# 19S9. 17. Rats, S. # Dwons# T# Cask, H., Grots, n. and Ford# X. Prograss in Development of tka Znds* of XDL. Tka Oarontologist 10120# 1970. 18. Doarokuk# c.# Downs# T.# Matthews, L. and Lough# K. X Matkod for Vantilatory xaasuranonts in aukj sots Ons Month to Fiva Ytari of Xga. normal Results and - obsarvations in Dissaea. Padiatrie Rasaarek 3il65, 1970. 19. xarkus# B., Blanknar# X. and Downs# T. Relocation Strass and tka Xgad. interdleoipl. Topics Gerontology 7<S0# 1970. go. Ready# J.# Bsoses, w; and Downs# T. Tongue Rolling Xmong Twins. Journal of Keredlty 68(2# 1971. 21. iilabman# J.# Downs# T. and Fledge# A. The Frank and XoFee Vaatorcardiogram in normal Children. Vectorcardiography# 1970. I. Hoffman# R. Hamby and X* Classman, editors. WorthHolland# xmstardam. 1071# F. 423. 22. Downs T# Liabman# J. and KaoXay# W. statistical Methods for Vaotoroardiogram Orientations, Vectorcardiography# 1970. I. Hoffman# R. Hamby and 8. Glassaan# editors. Morth-Holland# xmstardam# 1971# p* 216. 23. Markus# 8# Blanknar, X.# Bloom# K. and Downs# T. The impaot of Rsloeation upon Mortality ratss of Znstitutionalias Xgad Parsons. Journal of Garontology 26(4# 1971. 24. Rats# S.#- Ford# X.# Downs# T.# Adams, M. and Rttsby# D. The Effect of Continued Cara. United State Department of Bduoation and Welfare# 1972. 23. Downs# t. orientation statistics. Biomatriks 59(662# 1972. UCC 074259 Sent BY^utHsc-^ sph no-23-82 ; 14:24 ; immm-* 4030502 ;#u Tom Downs cv* page 10 PUBLICATIONS (continued) 2<. Markus, x. Blenkner, x.* Bloom, H. mad Dwons# T. dome Moteo mad Their Association with Post-Rslooatien Mortality Among institutionalised Aged Persons, Journal of Gerontology 2713, 1972* 27. Koir, T, and Downs# T. Myocardial Reactive Hypermiai comparative effeete of edenosine# ATT, ADP* and AMP. American J- of Thyaiology 22214, 1972. 28. Nielsen* M., Blenkner, X.# Bloom* M. and Downs, T. Oldor Persons aftor xoopitaliBatloaf A ooatrollod Btudy of Homo Aido Service. Amorioan J. of PUblio Health 42tl094, 1972. 29. strong# w.# Down*# T.* Xtlebaan, J* and Liabowts* X. Tho Normal Adoloooont miootrooardiogram. Amaarioan xaart Journal 83U15, 1972. 30. Downs* T. Rotational Angular Corralatlona. Biorhythms and Human Reproduction. M. Parrln at al# editors. John Xllay S Bone# New Tort. p. 97# 1974. 31. Smolensky, x.* Kraft# z.* sotharn# R# Downs, T., Biflar* C. and Mealy# S. Oiroadian Rhythmloity in Heart Rata and Duration of cardiac Cycle (F-F interval) in Donor and Recipient cardiao Tissue of Heart Homograft patients. Texas Reports on Biology and Medicine 33x53$, 1975. 32 Severe, R., Heal* R. and Downa* T. Time as a Paotor in Atmoapherlo Sampling. Ameriean Industrial Hygiene Aaaoo. J. 38x134# 1977. 33. Downs* T. Community Risk Aeeeeement. Texas Reports on BtaScgy and Medioine 37X118* 1978. 34. Davie* b.* Downs* t. and Cray* w. Ammonia In Tsxaa streams during Low Plow from Kunieipal Wastewater, water Resouroeea Bull. 1411417, 1978. 35. Hayes, J. end Downa, T. Beaeonal Changes in an Isolated Population of culex Plplens Quinguefaaelatue <Dlpterat Culioidae)i A Time series Analysis. J Msdleal Entomology 171 S3, 1980. 36. Downs* T. Problem Ranking, mi Health Bffeote of Photovoltaic Technology, stang et al, editors, vrooeedinge of a Workshop at Brookhavea National Laboratory# p. 270* 1980. UCC 074260 SENT Br:UTHSC-H SPH T10-23-82 ;14:25 7137944877* 4630802 ;i2 Tom Downs cv, pag* n publicatioxs (continued) 57. Downs, T. mnd Frankowski, it. Influsncs of Rapair Proossas* d Doss--Rasponsa Models. Drug Metabolism Reviews 13x837, 1*81. 38. ciessn, P., Payne, A., Snyder, 0. and Downs, T. Mortality and znfluanaa. J. ofxnreetioue Disease 146x313, 1782. a*. Casssrly, D., Davis, R. and Downs, T. Sorption of Organic* p olanastrua caprieornutum. Tatar Raaaaroh 17fistX, 1783. 40 Downs, t. Book Review of oaomatry and Biological Tima by A.T. Winifroa. Biometrics 37x837, 1783. 41. Downs, T. An Aaaasa&ant of various Dose-Response Modala in tha Datannination of Risk. Zm Raw Approaches to Tonicity Tasting and Thair Application in Busan Risk Assaaaaa&t. A.P. Li, editor. Ravan Praaa, Maw York, 1788. 43 wkaalar, w., Cherry L., Downs, T and Ran, X. Mltotio inhibition and Anauploidy Induction by Katurally Occurring and syntktie Batrogana in Chinaaa Jamatar calls in Vitro. Mutation Research 171S31, 178C. 43. Downs, X., Crane M. and Xim, X. Mortality among Workers at a Butadiene Facility. American J. of Industrial Medicine 121311-337, 1787. 44. Downs, T. Projective Angular Regression. Submitted for publication 45. Davis, E., Sullivan, B. and Downs, T. Dotsrminatlon of cellosolva and Chlorex Concentrations Inhibitory to industrial Waats Stabilisation Pont Treatment Efficiencies. Water Soie&oe Technology 2lil833-i83C, 1987. 4d. Buffler, p.. Downs, x., Christensen, B. at al. The Incidence of Leukemiae and Myalodyaplasia in Adult Males Residing in the Upper Texas oulf Coast. Submitted for publication 47. Burau, X., muffler, p,. Downs, T. et al. Asosztainment and Evaluation Methods for a Large Epidemiologic study of Adult Leukemia incidence in the upper Texas Quiff Coast. Submitted for publication 48. Downs, T. Bioatatiatioal Approaohaa for Modelling U-ahapsd Dose-Response curves and study Design Considerations in Assessing the Bloligloel Effects of Low Doses. Proosedlngss Workshop on Biological iffeets of Low Dossa. l.J. Calabrese, editor. Lewis Publlshsrs, Ann Arbor, 1773. UCC 074261 SENT BY s UTH5C-H SPH J10-23-S2 J 14525 J . 7137844071- 4630502 iftU To* Dovns CY, pig 12 PUBLICATIONS (continued) 49. Downs# t and Grant# X. A Kati-Aaalytio Hathod for Assessing Dosa-Basponsa in studiaa of Association. Ssamplaipassivasmoking and lung canear* Subaittad for publication so. Burau# B# Bufflar# p., Dovns# T. at al* A Meta-analysls of apldaaiologlo studios of VDT Uss and Fragnaney Outcomes. Subaittad for publioation. ii. Downs# T> # crana# X.# Via# I. at al* Mortality among Workers axpoaad to Aorylonitrila# styrsna# and Butadianai An update* Subaittad for publioation* 82. Cooper# 8.F# Downs# -T.# Burau# X. at al. A survey of Xaratosas among Paraquat Workers and a Nonexposad Priand Reference croup* Subaittad far publication* ucc 074262