Document zopLdzK9oKKpgG4rL1DyMo6dg

AR226-2885 E. I. du Pont de Nemours and Corr.iny Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 Study Inltiated/Completed T///J^.r5//Or\Ur\ - ~/i /1 11i//J oorO Material Submitted by CD&P Dept. Jackson Lab SKIN IRRITATION TEST ON RABBITS Procedure: Six male albino rabbits were clipped free of hair on the trunk and lateral area and placed in FDA-type stocks. Doses of 0.5 ml undiluted test material were applied to intact skin under 1 1/2" x 1 1/2" 12-ply gauze squares. Rubber sheeting was then loosely wrapped around the trunk and secured with adhesive tape. After 24 hours, the rabbits were removed from the stocks, the patches taken off and the reactions observed. Observations were also made at 48 hours. Results: 24-Hour Observation 48-Hour Observation Erythema Mild 3/6 Slight 3/6 Mema None 1/6 Slight 4/6 Mild 1/6 Erythema Mild 1/6 Slight 4/6 None 1/6 Edema None 6/6 Company Sanitized. Does not contain TSCA CBI 1 Summary:! IrrittiS ln ised mild to slight skin irritation in 24 hours and mild to no hours when tested on the shaved intact skin of rabbits. ln, TM i * B?t*rlal lB * "lld 8kln irritant. In the event of skin contact, good Rdustrial hygiene practice would be to wash thoroughly with soap and water. Approved b y i y ______ raid L. Kefinedy .CliiAf,; Acute Investigations Section PAijrg ' vj Study Director: 0. L. Daehiell LOate Issued: July 23. 1980 N.B. E-21090, p. 6T\ I Report No. 561-80 ^ -2 Company Sanitized. Does not contain