Document zoavkwZDo6YJvJoMBV06ZvbGB

-1 - CURRICULUM VITAE NAME: RICHARD JOSEPH KOCIBA CURRENT JOB TITLE: EDUCATION: EMPLOYMENT: BFG41282 Research Scientist 1953-1957 - Our Lady of Lake Huron High School , Harbor Beach, Ml. 1959-1966 - B.S. and Doctor of Veterinary Medicine (D.V.M.), Michigan State University, East Lansing, Ml, U.S.A. 1967-1969 - M.S. Pathology Major, Michigan State University, East Lansing, Ml, U.S.A. 1969-1970 - Ph.D. Pathology, Michigan State University, East Lansing, Ml, U.S.A. Thesis: "Cancer Chemotherapeutic Properties and Toxicologic Effects of Cis-Platinum II Diamminodichloride" 1957-1958 - U. S. Army 1966-1967 - Veterinary Medicine Private Practice, Indiana 1967-1968 - Faculty, College of Veterinary Medicine, NIH Postdoctoral Fellow, Pathology Department, Michigan State University 1970-1974 - Senior Research Specialist, Pathology Department, The Dow Chemical Company, Chemical Biology Research, Toxicology Section 1974-1977 - Group Leader, Pathology Section, Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., (Restructured from Chemical Biology Research) 1977-1981 - Associate Scientist, Dow Chemical U.S.A., Toxicology Research Laboratory, Health and Environmental Sciences, (Restructured from Health and Environmental Research), Pathology Group BFG 00795 -2- EMPLOYMENT (Cont.) 1981 - Senior Associate Scientist, Dow Chemical U.S.A., Toxicology Research Laboratory, Health and Environmental Sciences MEMBERSHIPS: 1986 - Research Scientist, The Dow Chemical Company, Mammalian and Environmental Toxicology Research Laboratory, Health and Environmental Sciences. Phi-Zeta, Veterinary Medicine, Honorary Society Sigma Xi, Scientific Research, Honorary Society Michigan Vetennary Medical Association American Association of Laboratory Animal Sciences American Veterinary Medical Association American College of Veterinary Pathologists Society of Toxicology American Board of Toxicology Board of Trustees, Elsa U. Pardee Cancer . Foundation CERTIFICATIONS: Diplomate. American College of Veterinary Pathologists - 1972 Diplomate. American Board of Toxicology - 1981 APPOINTMENTS: Medical Review Committee, Elsa U. Pardee Cancer Research Foundation BioMedicai Scientific Review Board, Midland Macromoiecular Institute External Rev ewer, NIOSH Criteria Document on Chiomated Benzenes, Dr. David West, National Inst tute of Occupational Safety and Health External Consultant, NIEHS Toxicology Program. National nstitutes of Environmental Health Sciences Program Con'mirtee, Society of Toxicology Annual Meetings External Consultant, World Health Organization, Heaitn Document on Chlorine and Hydrogen Chloride External Consultant, EPA Criteria Document on Dibenzfourans Member Division of Medical Sciences Committee, National Research Council, National Academy of Sciences Adjunct Clinical Professor of Pathology. Michigan State University, East Lansing, Michigan Editorial Board. Veterinary Pathology Journal BFG41283 BFG 00796 3- - APPOINTMENTS (Cont): PUBLICATIONS: PRESENTATIONS: Council Member, Society of Toxicology Michigan Chapter External Consultant, EPA Multimedia Criteria Documents for Chlorinated Dioxins, 1983. Member, National Toxicology Program Technical Reports Review Subcommittee of Board of Scientific Counselors, 1983 Editorial Board, Fundamental and Applied Toxicology. Editorial Board, Chemosphere Journal See Attached. See Attached. Reviewed/Revised: Date:. BFG<I284 BFG 00797 -4- PUBLICATIONS 1. Kociba, R. J. Nitrite Toxicosis in the Ascorbic Acid-Deficient Guinea Pig. M. S. Thesis, Pathology Department, Michigan State University, 1969. 2. Kociba, R. J. and Sleight, S. D. Nitrite Toxicosis in the Ascorbic AcidDeficient Guinea Pig. Toxicol. Appl. Pharmacol. l:424-429, 1970. 3. Kociba, R. J., Sleight, S. D., and Rosenberg, B. Inhibition of Dunning Asitic Leukemia and Walker 256 Carcinosarcoma with CisDiamminedichloro-platinum (NSC-119875). Cancer Chemotherapy Reports 54:325-329, 1970. 4. Kociba, R. J. Cancer Chemotherapeutic Properties and Toxicologic Effects of Cis-Platinum (II) Diamminochloride. Ph.D. Thesis, Pathology Department, Michigan State University, 1970. 5. Kociba, R. J. and Sleight, S. D. Acute Toxicologic and Pathologic Effects of Cis-Diamminedichloroplatinum (NSC-119875) in the male rat. Cancer Chemotherapy Reports 55:1-8, 1971. 6. Kociba, R. J., Gehring, P. J., Humiston, C. G., and Sparschu, G. L. Toxicological Study of Female Rats Administered Hexachlorobutadiene or Hexachlorobenzene for Thirty Days. A Special Release of The Dow Chemical Company, August 1971. 7. Spencer, H. C., McCollister, S. B., Kociba, R. J., Humiston, C. G. Toxicological Studies on a Beryllium Containing Exhaust Product. Published in the Proceedings of the Third Conference on Environmental Toxicology, October 25-27, 1972. Sponsored by SysteMed Corporation under Contract No. F3361-5-70-C-1046 with the Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, Ohio. 8. Spencer, H. C., McCollister, S. B., Kociba, R. J., Humiston, C. G., and Sparschu, G. L. Toxicological Evaluation of a Beryllium Motor Exhaust Product Document AMRL-TR-72-118, 95 pages, Contract No. F3361-5-C1046 withthe Aerospace Medical Research Laboratory, Aerospace Medical Division, AirForce Systems Command, Wright-Patterson Air Force Base, Ohio, 1972. 9. Kociba, R. J., Sparschu, G. L., Leong, B.K.J., and Gehring, P. J. Tissue Response to Ceramic Foam Dust Following Intratracheal and Intraperitoneal Administration. Toxicol. Appl. Pharmacol. 25^45-151, 1973. 10. McCollister, S. B., Kociba, R. J., and McCollister, D. D. Dietary Feeding Studies of Methylcellulose and Hydroxypropylmethylcellulose in Rats andDogs. Food and Cosmetics Toxicol. 11:943-953, 1973. BFG41285 BFG 00798 -5- PUBLICATIONS (Cont.) 11. Johnson, R. L., Gehring, P. J., Kociba, R. J., and Schwetz, B. A. Chlorinated Dibenzodioxins and Pentachlorophenol. Environmental Health Perspectives, Experimental Issue 5:171-175, 1973. 12. Norris, J. M., Kociba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G.,and Gehring, P. J. Toxicological Evaluation of Fire Retardant Chemicals: Fall Meeting Am. Soc. Pharmacol. Exp. Therap. The Pharmacologist 15:394,1973. 13. Norris, J. M., Ehrmantraut, J. W., Gibbons, C. L., Kociba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G., Jewett, G. L., Crummett, W. B.,Gehring, P. J., Tirsell, J. B., and Brosier, J. S. Toxicological and Environmental Factors Involved in the Selection of Decabromodiphenyl Oxide as a Fire Retardant Chemical. Appl. Polymer Symposium No. 22, 195-219,1973. 14. Norris, J. M., Ehrmantraut, J. W., Gibbons, C. L., Kociba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G., Jewett, G. L.t Crummett, W. B.,Gehring, P. J., Tirsell, J. B., and Brosier, J. S. Toxicological and Environmental Factors Involved in the Selection of Decabromodiphenyl Oxideas a Fire Retardant Chemical. J. Fire and Flammability/Combustion Toxicology 1:52-57, February 1974. 15. Kociba, R. J., McCollister, S. B., Park, C. N., Torkelson, T. R., and Gehring, P. J. 1,4-Dioxane: (I) Results of Two-Year Ingestion Studies in Rats. Toxicol. Appl. Pharmacol. 2Q:275-286,1974. 16. Torkelson, T. R., Leong, B.K.J., Kociba, R. J., Richter, W. A., and Gehring, P. J. 1,4-Dioxane: (II) Results of a Two-Year Inhalation Study in Rats. Toxicol. Appl. Pharmacol. 2Q 287-298, 1974. 17. McCollister, S. B., Kociba, R. J., and Gehring, P. J. Studies on the Acute and Chronic Oral Toxicity of 0.0-diethyl-0-(3,5,6-trichloro-2-pyridyl) Phosphorothioate. Food and Cosmetics Toxicol. 12:45-61,1974. 18. Schwetz, B. A., Norris, J. M., Kociba, R. J., Keeler, P. A., Cornier, R. F., and Gehring, P. J. Reproduction Study in Japanese Quail Fed Hexachloro-butadiene for 90 Days. Toxicol. Appl. Pharmacol. 2Q:255266, 1974. 19. Kociba. R. J., Leong, B.K.J., Jersey. G. C., Quast, J. F., and Gehring, P.J. Induction of Esthesioneuroepitheliomas in Rats Exposed to Bis(chloromethyl)ether. Lab. Invest. 22:12, 1975. BFG41286 BFG 00799 -6- PUBLICATIONS (Cont.) 20. Kociba, R. J., Torkelson, T. R., Young, J. D., and Gehring, P. J. 1,4Dioxane: Correlation of the Results of Chronic Ingestion and Inhalation Studies With Its Dose-Dependent Fate in Rats. Proceedings of the Sixth Conference on Environmental Toxicology, AMRL-TR-75-125, 345354,Dayton, Ohio, 1975. 21. Norris, J. M,, Kociba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G., Jewett, G. L., Gehring, P. J., and Mailhes, J. B. Toxicology of Octobromobiphenyl and Decabromodiphenyi Oxide. Environ. Health Perspectives 11:153-161, 1975. 22. Kociba, R. J., Frauson, L. O., Humiston, C. G., Norris, J. M., Wade, C. E., Lisowe, R. W., Quast, J. F., Jersey, G. C., and Jewett, G. L. Results of a Two-Year Dietary Feeding Study with Decabromodiphenyi Oxide (DBDPO) in Rats. Combustion Toxicology 2:267-285, 1975. 23. Hefner, R. E., Jr., Leong, B.K.J., Kociba, R. J., and Gehring, P. J. Repeated Inhalation Toxicology of Diphenyl Oxide in Experimental Animals. Toxicol. Appl. Pharmacol 22:78-86, 1975. 24. Fishbeck, W. A., Langner, R. R., and Kociba, R. J. Elevated Urinary Phenol Levels Not Related to Benzene Exposure. Journal of the American Industrial Hygiene Association 36:820-824. 1975. 25. Kociba, R. J., Keeler, P. A., Park, C. N., and Gehring, P. J. 2,3,7,8Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-Week Oral Toxicity Study in Rats. Toxicol. Appl. Pharmacol. 35:553-574. 1976. 26. Kociba, R. J., Kalnins, R. V., Wade, C. E., Garfield, E. L., and Fishbeck, W. A. Elevated Urinary Phenol Levels in Dogs Treated with Salol. Journal of the American Industrial Hygiene Association, 32:183-191, 1976. 27. Schwetz, B. A., Humiston, C. G., Kociba. R. J., and Jersey, G. C. Results of Subchronic Toxicity Studies on HCI-Tailored Hydroxypropyl Methyl Cellulose in Rats and Dogs. Amer. Chem. Soc., Div. of Polymer Chemicals, Series 17,1:6-11, 1976. 28. Kociba, R. J., Keyes, D. G., Jersey, C. G., Ballard, J. J., Dittenber, D. A., Quast, J. F., Wade, C. E., Humiston, C. G., and Schwetz, B. A. Results of a Two-Year Chronic Toxicity Study with Hexachlorobutadiene in Rats. J. American Industrial Hygiene Association 3fi:589-602, 1977. 29. Kociba, R. J., Schwetz, B. A., Keyes, D. G., Jersey, G. C., Ballard, J. J., Dittenber, D. A., Quast, J. F., Wade, C. E., and Humiston, C. G. Chronic Toxicity and Reproduction Studies of Hexachlorobutadiene in Rats. Environ.Hlth. Perspectives 21:49-53, 1977. BFG41287 BFG 00800 -7- PUBLICATIONS (Cont.) 30. Gross, P., Kociba, R. J., Sparschu, G. L., and Norris, J. M. The Biologic Response to Titanium Phosphate. Arch. Pathol. Lab. Med. 101:550-554. 1977. 31. Schwetz, B. A., Smith, F. A., Humiston, C. G., Quast. J. F., and Kociba, R.J. Results of a Reproduction Study in Rats Fed Diets Containing Hexachlorobutadiene. Toxicol. Appl. Pharmacol. 42:387-398, 1977. 32. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S. D., Hummel, R. A., and Humiston, C. G. Results of a Two-Year Chronic Toxicity and Oncogenicity Study of 2,3,7,8-Tetrachlorodibenzo-pDioxin(TCDD) in Rats. Toxicol. Appl. Pharmacol. 46:279-303. 1978. 33. Leong, B.K.J., Kociba, R. J., Pernell, H. C., Lisowe, R. W., and Rampy, L. W. Induction of Pulmonary Carcinoma in Rats by Chronic Inhalation of Dust from Pulverized Asbestos Pipe Covering. J. Toxicol, and Environ. Hlth. 4:645-659, 1978. 34. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M,, and Gehring, P. J. Long-Term Toxicologic Studies of 2,3,7,8-Tetrachloro-dibenzo-p-Dioxin (TCDD) in Laboratory Animals. Annals of New York Acad, of Sci. 22Q:397-404, 1979. 35. Braun, W. H., Sung, L. Y., Keyes, D. G., Kociba, R. J. Pharmacokinetics and Toxicologic Evaluation of Dogs Fed 1,2,4,5-Tetrachlorobenzene in the Diet for Two Years. J. Toxicol, and Environ. Hlth. 4:727-734, 1978. 36. Rampy, L W., Leong, B.K.J., Jersey, G. C., Quast, J. F., Kalnins, R. V., Keyes, D. G., and Kociba, R. J. A Long-Term Inhalation Toxicity and Carcinogenicity Study of Vinyl Benzyl Chloride in Rats and Mice. Proceedings of the 8th Annual Conference on Environmental Toxicology, AMRL-77-97, Conference Proceedings, Page 211-231. Air Force/56780/6, March 1978. 37. Schwetz, B. A., Quast, J. F., Keeler, P. A., Humiston, C. G., and Kociba, R. J. Results of Two-Year Toxicity and Reproduction Studies on Pentachlorophenol in Rats. Ed. by K. Rango Rao (1978), Plenum Publishing Corp., New York, NY. 38. Kociba, R. J., Keyes, D. G., Beyer, J. E., and Carreon, R. M. ToxicologicStudies of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Rats. Proceedings of 10th InterAmerican Conference on Toxicol, and Occup. Med. Developments in Toxicology and Environmental Science 4:281-287, Elsevier Publication, 1979. BFG41288 BFG 00801 -8- PUBLICATIONS (Cont.) 39. Barrow, C. S., Kodba, R. J., Rampy, L. W., Keyes, D. G., and Albee, R. R. An Inhalation Toxicity Study of Chlorine in Fischer 344 Rats Following Thirty Days of Exposure. Toxicol. Appl. Pharmacol. 42:77-88, 1979. 40. Kociba, R. J., Keyes, D. G., Lisowe, R. W,, Kalnins, R. P., Dittenber, D. A., Wade, C. E., Gorzinski, S. J., Mahle, N. H., and Schwetz, B. A. Results of a Two-Year Chronic Toxicity and Oncogenic Study of Rats Ingesting Diets Containing 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T). Food and Cosmetics Toxicol. 17:205-221, 1979. 41. Murray, F. J., Smith, F. A., Nitschke, K. D., Humiston, C. G., Kociba, R. J., and Schwetz, B. A. Three-Generation Reproduction Study of Rats Given 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in the Diet. Toxicol. Appl. Pharmacol. 58:241-252, 1979. 42. Keyes, D. G., Kociba, R. J., Schwetz, R. W., Wade, C. E., Dittenber, D. A., Quinn, T., Gorzinski, S. J., Hermann, E. A., Momany, J. J., and Schwetz, B. A. Results of a Two-Year Toxicity and Oncogenic Study of Rats Ingesting Diets Containing Dibromoneopentyl Glycol (FR-1138). J. Combustion Toxicology 7:77-98, 1980. 43. Smith, F. A., Murray, F. J., John, J. A., Nitschke, K. D., and Kociba, R. J. Three-Generation Reproduction Study of Rats Ingesting 2,4,5-Trichloro phenoxyacetic Acid in the Diet. Fd. Cosmet. Toxicol. 19:41-45. 1981. 44. Leong, B.K.J., Kociba, R. J., and Jersey, G. C. A Lifetime Study of Rats and Mice Exposed to Vapors of Bis(Chloromethyl)Ether. Toxicol. Appl. Pharmacol. 58:269-281, 1981. 45. Henck, J. W., New, M. A., Kociba, R. J., and Rao, K. S. 2,3,7,8Tetrachlorodibenzo-p-Dioxin: Acute Oral Toxicity in Hamsters. Toxicol. Appl.Pharmacol. 52:405-407, 1981. 46. Kociba, R. J. and Schwetz, B. A. A Review of the Toxicity of 2,3,7,8Tetrachlorodibenzo-p-dioxin (TCDD) with a Comparison to the Toxicity of Other Chlorinated Dioxin Isomers. Spring 1981 Meeting of Central States Association of Food and Drug Officials. J. Assoc. Food and Drug Officials Quarterly Bulletin, 4(3):168-188, 1982. 47. Kociba, R. J. and Schwetz, B. A. Toxicity of 2,3,7,8-Tetrachlorodibenzop-dioxin (TCDD). Presentation at Symposium entitled "Metabolism and Pharmacokinetics of Environmental Chemicals in Man". Sarasota, Florida, June 7-12,1981. Proceedings in Drug Metabolism Reviews, 15(3):387-406, 1982. BFG41289 BFG 00802 -9- PUBL1CATI0NS (Cont.) 48. Kociba, R. J. Morphologic Considerations in the Detection of Immune Suppression in Routine Toxicity Studies. Chapter 6, in Vol. II ot Textbook entitled Immunologic Considerations in Toxicology, edited by R. P. Sharma. CRC Press, 1981. 49. Nitschke, K. D., Kociba, R. J., Keyes, D. G., and McKenna, M. J. A Thirteen Week Repeated Inhalation Study of Ethylene Dibromide in Rats. Fundam. Appl. Toxicol. 1:437-442, 1981. 50. Kociba, R. J., Leong, B.K.J., and Hefner, R. E., Jr. Subchronic Toxicity Study of 1,2,4-Trichlorobenzene in the Rat, Rabbit and Beagle Dog. Drug and Chemical Toxicology 1(3): 229-249, 1981. 51. Cook, R. R., Kociba, R. J., and Langner, R. R. Environmental Health Criteria for Chlorine and Hydrogen Chloride. World Health Organization. 1982. 52. Sharma, R. P., Kociba, R. J., and Gehring, P. J. Reversal of Immunologic and Toxicologic Effects of a Single Exposure of 2,3,7,8Tetrachlorodibenzo- p-Dioxin in Mice. Trace Substances in Environ. Health, 12:473, 1979. 53. Dodds, J., Abt, D., Bloor, C., Bowie, W., Fox, J., Gorham, J., Jones, A., Kociba, R. J., Loan, R., and Talbot R. Specialized Veterinary Manpower Needs Through 1990. National Research Council, National Academy of Science Press, 1982. 54. Kociba, R. J. and Mullison, W. Possible Toxicologic Interactions with Commercial Mixtures of Two Pesticides. Down To Earth !Q:1, 1984. 55. Kociba, R. J. Proceedings of Symposium Public Health Risks of the Dioxins. October 19-20, 1983, Rockefeller University. William Kaufmann, Inc., Los Altos, California. 56. Kociba, R. J. Evaluation of the Carcinogenic and Mutagenic Potential of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and other Chlorinated Dioxins. Banbury Report 18. Biological Mechanisms of Dioxin Action. Cold Spring Harbor Laboratory, New York, 1984. 57. Sharma, R. P., Kociba, R. J., and Gehring, P. J. Immunotoxicologic Effects of 2,3,7,8-Tetrachlorodibenzo-p-diodin (TCDD) in Rabbits. J. Environ. Path. Toxicol, and Oncol. 5:321-328, 1984. 58. Kociba, R. J. Critique of Proposed Methodology for Assessment of Target Organ Toxicity (Human Health Effects). EPA Workshop. December 3-4, 1984, Cincinnati, Ohio. BFG41290 BFG 00803 -10- PUBLICATIONS (Cont.) 59. Kociba, R. J. and Keyes, D. G. Squamous Cell Carcinoma as a Spontaneous Neoplasm of Rodent Tongue. ILSI Monograph Series on Pathology of Laboratory Animals. Vol. Ill, Digestive System. T. C. Jones, U. Mohr and R. D. Hunt, Eds., Springer-Verlag, New York, 1985. 60. Kociba, R. J. and Cabey, O. Comparative Toxicity and Biologic Activity of Chlorinated Dibenzo-p-dioxins and Furans Relative to 2,3,7,8Tetrachlorodibenzo-p-dioxin (TCDD). Chemosnhere 14: 649, 1985. 61. Kociba, R. J. Aspects of Dioxin Issue. Concluding Summary-Toxicology & Epidemiology. Chemosohere 14: 649,1985. 62. Park, C. N. and Kociba, R. J. Statistical Evaluation of Long-Term Animal Bioassasy. Chapter 17 in Carcinogen Testing. Edited by H. Milman and E. Weisberger. Noyes Publications, 1985. 63. Kociba, R. J. Evaluation of Global Literature for Definition of DoseResponse Relationship for Hexachlorobenzene (HCB) Toxicity. International Symposium on Hexachlorobenzene. June 24-28,1985, International Agency for Research on Cancer, Lyon France. 64. Gorzinski, S. J., Nolan, R. J., McCollister, S. B., Kociba, R. J. and Mattsson, J. L. Subchronic Oral Toxicity, Tissue Distribution and Clearance of Hexachloroethane in the Rat. Drug & Chemical Toxicol. 8, 155, 1985. 65. Kociba, R. J. Summary and Evaluation of the Toxicity and Biologic Activity of 2,7-Dichlorodibenzo-p-dioxin. Special Release of The Dow Chemical Co. to Industry Task Force on MCPA Research Data. 1985. 66. Miller, R. R., Young, J. T., Kociba, R. J., Keyes, D. G., Bodner, K. M., Calhoun, L. L., and Ayres, J. A. Chronic Toxicity and Oncogenicity Bioassay of Inhaled Ethyl Acrylate in Fischer 344 Rats and B6C3F1 Mice. Drug & Chemical Toxicol. 8:1, 1985. 67. Kociba, R. J. Review of the Toxicology of 2,3,7,8-TCDD and Related Compounds. 5th International Symposium on Chlorinated Dioxins and Related Compounds. Abstract #78, 1985. 68. Kociba, R. J. et al. Issues Pertaining to Proliferation and Differentiation in the Carcinogenic Process. Proceedings of Workshop on Toxicity, Tumor Promotion and Carcinogenesis. 1985. 69. Jori, A., Bonaccorsi, A., Gorattini, S., Kociba, R. J., and O'Flaherty, E. J. Toxicology of Halogenated Dibenzofurans in Animals and Humans. Que Hee, S. Ed. Monograph, 1985. BFG41291 BFG 00804 -11 - PUBLICATIONS (Cont.) 70. Kociba, R. J. Summary and Evaluation of Toxicologic Data on Decabromodiphenyl Oxide Flame Retardants. Document prepared for release by Brominated Flame Retardants Industry Panel. December, 1986. 71. Kociba, R. J. Analysis of the Animal Toxicity Studies of 2,3,7,8Tetrachlorodibenzo-p-dioxin (TCDD) Used in Derivation of Lifetime Exposure Control Limit Recommendations for Humans. American Chemical Society Symposium Series. 1987. 72. Bond, D. M., Kociba, R. J. Keyes, D. G., Wall, J. M. and S. K. Weiss. Results of a One-Year Dietary Toxicity Study in Beagle Dogs Administered Cyhexatin. The Toxicologist. 6:Abst. 197,1987. 73. Kociba, R. J. Key Factors in the Intrepretation and Extrapolation of Data Derived from Chronic Organ Toxicity Studies in Laboratory Animals. Am. Conf. Chemical Labelling. March 1987 Proceedings. 74. Gorzinski, S. J., Kociba, R. J., Campbell, R. A., Smith, F. A., Nolan, R. J. and D. L. Eisenbrandt. Acute, Pharmacokinetic, and Subchronic Toxicological Studies of 2,4-Dichlorophenoxyacetic Acid. Fund. Applied Toxicol. 9:423, 1987. 75. Kociba, R. J. Issues in Biochemical Applications to Risk Assessment: How Should the MTD be Selected for Chronic Bioassays? Environ. Health Perspect.. 1988. 76. Lomax, L. and Kociba, R. J. Hematologic Lesions Induced in Laboratory Animals. International Life Sciences Institute Monograph on Pathology of Laboratory Animals. Hematopoietic System. T. C. Jones, U. Mohr and R. D. Hunt, Eds. Springer-Verlag, New York, 1988. 77. Kociba, R. J., Keyes, D. G. and Williams, D. M. Follicular Hyperkeratosis, Induced, Rabbit Ear. International Life Sciences Institute Monograph on Pathology of Laboratory Animals. Integumentary System and Mammary Glands. T. C. Jones, U. Mohr and R. D. Hunt, Eds. Springer-Verlag, New York, 1988. 78. Pinkerton, M. N., Kociba, R. J., Petrella, R. V., McAllister, D. L, Willis, M. L., Fulfs, J. C., Thoma, H. and 0. Hutzinger. Investigation of the Comparative Toxicity of Combustion Products of High Impact Polystyrene (HIPS) with and without Decabromodiphenyloxide/Antimony Trioxide (DBDPO/Sb203) as a Flame Retardant Using 2,3,7,8Tetrabromodibenzo-p-Dioxin (TBDD) and 2,3,7,8Tetrabromodibenzofuran (TBDF) as Positive Controls. Seventh Intern. Symp. on Chlorinated Dioxins, Las Vegas, Nev. 1987. BFG41292 BFG 00805 -12- PUBLICATIONS (Cont.) 79. Betso, J. E. and R. J. Kociba. Hazard Communication: The Case for Category IV "Cancer Information". The Toxicologist. 8:58, Abstract 229, 1988. 80. Pinkerton, M., Kociba, R., Petrella, R., McAllister, D. Willis, M., Fulfs, J., Thoma, H. and O. Hutzinger. The Comparative Toxicity of Combustion Products of High impact Polystyrene (HIPS) with and without Decabromodiphenyloxide/Antimony Trioxide (DVDP0/Sb203) as a Flame Retardant Using 2,3,7,8-Tetrabromodibenzo-p-Dioxin (TBDD) and 2,3,7,8-Tetrabromodibenzofuran (TBDF) as Positive Controls. The Toxicologist. 8:212, Abstract 844, 1988. 81. Betso, J. E. and R. J. Kociba. Hazard Communication: The Case for Category IV "Cancer Information". Regulatory Toxicology and Pharmacology. 8:219-225, 1988. 82. Kociba, R. J. Review of the Animal Toxicity Data on 2,3,7,8Tetrachlorodibenze-p-Dioxm (TCDD) Used for Derivation of Lifetime Exposure Control Limits for Humans. Proc. of Technical Assoc. Pulp and Paper Industries. Environmental Conf. 1988. 83. Nitschke, J. D., Burek, J. D , Beil, T. J., Kociba, R. J., Rampy, L. W., and M. J. McKenna. Methylene Chionde: A 2-Year Inhalation Toxicity and Oncogenicity Study in Rats Fundamental and Applied Toxicology. 11:48-59. 1988. 84. Kociba, R. J. Toxicologic Ejects on Bone Marrow, Thymus and Related Tissues of Hematopoietic System International Life Sciences Institute Publication. 1988. 85. Kociba, R. J. and Kociba. G J Assessment of Toxicologic Effects Upon Bone Marrow and Reiateo T ss-es ILSI Monographs of Pathology of Laboratory Animals. T C Jo^es Editor. Sprager-Verfag, New York. 1989. 86. Pinkerton, M.N., Kociba. R J Petrella, R. V., McAllister, D. L, Willis, M. L., Fulfs, J. C., Thoma, H.. Hutz rger O A Preliminary Report on the Investigation of the Comparative Toxicity of Combustion Products of High Impact Polystyrene With and Without Decabromodiphenyloxide/Antimony Trioxide as a Flame Retardant Using 2,3,7,8-Tetrabromodibenzo and 2,3,7,8-Tetrabromodibenzofuran as Positive Controls. Chemosphere, Vol. 18, Nos. 1-6, PP 1243-1249. 1989. 87. Hanley, T. R., Jr., Calhoun, L. L. Kociba, R. J., and Greene, J. A. The Effects of Inhalation Exposure to Sulfuryl Fluoride on Fetal Development in Rats and Rabbits. Fundamental and Applied Toxicology 13, 79-86, 1989. BFG41293 BFG 00606 -13- PUBLICATIONS (Cont.) 88. Kociba, R. J. Rodent Bioassay for Assessing Chronic Toxicity and Carcinogenic Potential of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Biological Basis for Risk Assessment of Dioxins and Related Compounds. Banbury Report No. 35. Cold Spring Harbor Laboratory Press. 1991. 89. Hotchkiss, J. H., Banco, M. J., Busta, F. F., Genigeorgis, C. A., Kociba, R. J., Rheaume, L., Smoot, L. A., and Sugiyama, H. The Relationship Between Botulinal Toxin Production and Spoilage on Fresh Tomatoes at 13 and 23 C Under Passively-Modified and Controlled Atmospheres and Air. J. Food Protection. 55:522-527. 1991. 90. Kociba, R. J. The Use of Material Safety Data Sheets to Communicate Information. Journal of the American Veterinary Medical Association. 202:1548-1549, 1993. BFG41294 BFG 00807 -14- PRESENTATIONS 1. Kociba, R. J. Effects of Platinum Compounds on Transmissible Murine Tumors. International Symposium on the Bacterial, Viral and Antitumor Activities of Platinum Compounds, September 1970. 2. Kociba, R. J. Pathologic Effects of Platinum Compounds in Rodents. International Symposium on the Bacterial, Viral and Antitumor Activities of Platinum Compounds, September 1970. 3. Kociba, R. J. Induction of Olfactory Neuroepitheliomas by Exposure to Bis(chloromethyl)Ether. Presented at the 1973 Meeting of the American College of Veterinary Pathologists, November 1973. The following four papers were presented at the 13th Annual Meeting of the Society of Toxicology, Washington, DC, March 1974. 4. Kociba, R. J., McCollister, S. B., Park, C. N,, Torkelson, T. R., and Gehring, P. J. 1,4-Dioxane Toxicity as Determined by a Two-Year DoseResponse Study in Rats. 5. Torkelson, T. R., Leong, B.K.J., Kociba, R. J., Richter, W. A., and Gehring, P. J. Lack of Manifestation of Toxicity in Rats Inhaling 111 ppm 1,4Dioxane for Two Years. 6. Rampy, L. W., Norris, J. M., Humiston, C. G., Kociba, R. J., and Gehring, P. J. Toxicological Properties of 2,3,5-Trichloro-4-(N-Propylsulfonyl)Pyridine. 7. Norris, J. M., Humiston, C. G., Schwetz, B. A., Kociba, R. J., Jersey, G. C., and Wade, C. E. The Toxicological Properties of 4-((4,8-Dimethyldecyl)oxyl)1,2-(Methylenedioxy)-benzene, and Insect Juvenile Hormone Mimic. 8. Kociba, R. J., Leong, B.K.J., Jersey, G. C., Quast, J. F., and Gehring, P.J. Induction of Esthesioneuroepitheliomas in Rats Exposed to Bis(Chloromethyl) Ether. Presented at 64th Annual Meeting of International Academy of Pathology (United States-Canadian Division), New Orleans, LA, March 5,1975. The following three papers were presented at the 14th Annual Meeting of the Society of Toxicology, Williamsburg, VA, March 9-13,1975. 9. Kociba, R. J., Keeler, P. A., Park, C. N., and Gehring, P. J. 2,3,7,8Tetrachlorodibenzo-p-dioxin (TCDD). Results of a 13-Week Oral Toxicity Study in Rats. 10. Leong, B.K.J., Kociba, R. J., Jersey, G. C,, and Gehring, P. J. Effects from Repeated Inhalation of Parts Per Billion of Bis(chloromethyl)Ether in Rats. BFG4l295 BFG 00608 -15- PRESENTATIONS (Cont.) 11. Norris, J. M., Kociba, R. J., Humiston, C. G., and Gehring, P. J. The Toxicity of Decabromodiphenyl Oxide and Octabromobiphenyl as Determined by Subacute and Chronic Dietary Feeding Studies in Rats. The following two papers were presented at the 15th Annual Meeting of the American Industrial Hygiene Association, Minneapolis, MN, June 1-6, 1975. 12. Fishbeck, W. A., Langner, R. R., and Kociba, R. J. Elevated Urinary Phenol Levels Not Related to Benzene Exposure. 13. Leong, B.K.J., Kociba, R. J., Jersey, G. C., and Gehring, P. J. Effects from Repeated Inhalation of Parts Per Billion of Bis(chloromethyl)Ether in Rats. 14. Kociba, R. J, Toxicity of Vinyl Chloride. Presented at the 1975 Spring Seminar of the Midwest Veterinary Pathologists Meeting, Indianapolis, February 28, 1975. 15. Kociba, R. J. Toxicologic Pathology. Presented at the Armed Forces Institute of Pathology Course on Pathology of Laboratory Animals, Washington, DC, September 15-19, 1975. 16. Kociba, R. J., Torkelson, T. R., Young, J. D., and Gehring, P. J. 1,4Dioxane: Correlation of the Results of Chronic Ingestion and Inhalation Studies with Its Dose-Dependent Fate in Rats. Presented at the 6th Conference on Environmental Toxicology, Dayton, OH, October 21-23, 1975. 17. Kociba, R. J., Keeler, P. A., Park, C. N., and Gehring, P. J. 2,3,7,8Tetrachlorodibenzeno-p-Dioxm (TCDD) 13-Week Oral Toxicity Study in Rats. Presented at the Fall Scientific Meeting of the Midland Section of theAmerican Chemical Society, Midland, Ml, November 8, 1975, 18. Kociba, R. J., Kalnins, R. P , Wade, C. E., Garfield, E. L., and Fishbeck, W. A. Elevated Urinary Phenol Levels in Beagle Dogs Ingesting Salol. Presented at the 15th Annual Meeting of the Society of Toxicology, Atlanta, GA, March 1976. 19. Leong, B.K.J., and Kociba. R. J Effects in Rats and Hamsters from Chronic Inhalation of Asbestos Pipe-Covering Dusts. Presented at the Annual Meeting of the Amencan Industrial Hygiene Conference, Atlanta, GA, May 16-21, 1976. BFG41296 BFG 00809 -16- PRESENTATIONS (Cont.) 20. Kociba, R. J., Keyes, D. G., Jersey, G. C., Ballard, J. J., Dittenber, D. A., Quast, J. F., Wade, C. E., Humiston, C. G., and Schwetz, B. A. Results of a Two-Year Chronic Toxicity Study with Hexachlorobutadiene in Rats. Presented at the Fall Scientific Meeting of the Midland Section of the American Chemical Society, Midland, Ml, October 30, 1976. 21. Kociba, R. J. Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Rat. Presented at the Scientific Meeting of the American College of Veterinary Pathologists, Miami, FL, December 1-4,1976. The following two papers were presented at the 16th Annual Meeting of the Society of Toxicology, Toronto, Canada, March 1977. 22. Kociba, R. J., Keyes, D. G., Jersey, G. C., Ballard, J. J., Quast, J. F., Wade, C. E., Humiston, C. G., and Schwetz, B. A. Results of a Two-Year Chronic Toxicity Study with Hexachlorobutadiene (HCBD) in Rats. 23. Braun, W. H., Sung, L. Y., Keyes, D. G., and Kociba, R. J. Pharmacokinetics and Toxicologic Evaluation of Dogs Fed 1,2,4,5Tetrachlorobenzene in the Diet for Two Years. 24. Kociba, R. J. The Toxicology of TCDD. Presented at the Winter Meeting of the Midwest Association of Veterinary Pathologists, Purdue University, March 1977. 25. Kociba, R. J., Schwetz, B. A., Keyes, D. G., Jersey, G. C., Ballard, J. J., Dittenber, D. A., Quast, J. F., Wade, C. E., and Humiston, C. G. Chronic Toxicity and Reproduction Studies of Hexachlorobutadiene in Rats.Presented at a Symposium on Compounds Similar to Vinyl Chloride, National Institute of Environmental Health Sciences, Bethesda, MD, May 1977. The following six papers were presented at the 17th Annual Meeting of the Society of Toxicology, Hyatt Regency Hotel, San Francisco, CA, March 12-16, 1978. 26. Barrow, C. S., Kociba, R. J., and Rampy, L. W. A Thirty-Day Inhalation Toxicity Study of Chlorine in Fischer 344 Rats. 27. Smith, F. A., Schwetz, B. A., Murray, F. J., Crawford, A. A., John, J. A., Kociba, R. J., and Humiston, C. G. Three-Generation Reproduction Study of Rats Ingesting 2,4,5-Trichlorophenoxyacetic Acid in the Diet. 28. Kociba, R. J., Keyes, D. G., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Hummel, R. A., and Humiston,C. G. Results of a Two-Year Chronic Toxicity and Oncogenicity Study of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Rats. BFG41297 BFG 00810 - 17- PRESENTATIONS (Cont.) 29. Rampy, L. W., Kociba, R. J., Balmer, M. F., Keyes, D. G., Schuetz, D. J., and Yakel, H. 0. Results of a Two-Year Inhalation Toxicity Study of Hydroxyethyl Acrylate (HEA) in Rats. 30. Watanabe , P. G., Kociba, R. J., Hefner, R. E., Jr., Yakel, H. 0., and Leong, B.K.J. Subchronic Toxicity Studies of 1,2,4-Trichlorobenzene (TCB) in Experimental Animals. 31. Sharma, R. P., Kociba, R. J., and Gehring, P. J. Immunotoxicologic Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Laboratory Animals. 32. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S.,Hummel, R. A., and Humiston, C. G. Results of Chronic Toxicity of TCDD in Rats. Presented at the Spring Scientific Meeting of the Midland, Michigan Chapter of the American Chemical Society, 1978. 33. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., and Gehring, P. J. Long-Term Toxicologic Studies of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Labortory Animals. Presented at the New York Academy of Sciences, June 21-30, 1978, New York, NY. 34. Kociba, R. J., Keyes, D. G., Beyer, J. E., and Carreon, R. M. Toxicologic Studies of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Rats. Presented at 10th Conference on Toxicology and Occupational Medicine, University of Miami, FL, October 23-25,1978. The following four papers were presented at the 18th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 11-15, 1979. 35. Jersey, G. C. and Kociba, R. J. The Importance and Results of Proper Morphologic Evaluation of the Nasal Turbinates in Inhalation Toxicity Studies. 36. Watanabe, P. G., Kociba, R. J., Keyes, D. G., Carreon, R. M., and Yakel, H. 0. Acute and Subchronic Toxicity of a-Picoline in Rats. 37. Gorzinski, S. J., Nolan, R. J., Kociba, R. J., Karbowski, R. J., Wade, C. E., Morden, D. C., and Hermann, E. A. Results of a Subchronic Dietary Study of Hexachloroethane in Rats with Preliminary Data on Clearance from Selected Tissues. 38. Kociba, R. J., Keyes, D. G., Wade, C. E., Kalnins, R. P., Lisowe, R. W., and Dittenber, D. A. A Two-Year Chronic Toxicity and Oncogenic Study of 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) in Rats. BFG41298 BFG 00811 -18- PRESENTATIONS (Cont.) The following two papers were presented at the 19th Annual Meeting of the Society of Toxicology, Washington, DC, March 10-13, 1980. 39. Nitschke, K. D., Keyes, D. G., Kociba, R. J. A Ninety-Day Inhalation Toxicity Study of 2-Methyl-3-Butyn-2-ol in Rats and Mice. 40. Keyes, D. G., Kociba, R. J., Schwetz, R. W., Wade, C. E., Dittenber, D. A., Gorzinski, S. J., Quinn, T., Kalnins, R. P., Hermann, E. A., Momany, J. J., and Schwetz, B. A. Results of a Two-Year Chronic Toxicity and Oncogenic Study of Rats Ingesting Diets Containing Dibromoneopentyl Glycol (FR-1138). The following two papers were presented at the 20th Annual Meeting of the Society of Toxicology, San Diego, CA, March 1-5, 1981. 41. Nitschke, K. D., Kociba, R. J., Keyes, D. G., and McKenna, M. J. A Thirteen- Week Inhalation Toxicity Study of Ethylene Dibromide in Rats. 42. Gorzinski, S. J., Kociba, R. J., Wade, C. E., Morden, D. C., Keyes, D. G., and Schwetz, B. A. 2,4-D((2,4-Dichlorophenoxy) Acetic Add): Results of a 13-Week Feeding Study in CDF Fischer 344 Rats. 43. Kociba, R. J. The Toxicity of Dioxin Compounds. Presented at the 1981 Spring Meeting of the Central States Association of Food and Drug Officials, Grand Rapids, Ml, May 5-7,1981. 44. Nitschke, K. D., Kociba, R. J., Keyes, D. G. Thirteen-Week Repeated Inhalation Study of Ethylene Dibromide in Male and Female Rats. Presented at the Dow Spring Scientific Meeting, April 1980. 45. Keyes, D. G., Kodba, R. J., Henck, J. W., Blogg, C. D., Schuetz, D. J. Methyl Chloroacetate (MCAC): Results of an Eleven-Day Repeated Inhalation Toxicity Study in Rats. Poster presentation given at Michigan State University, East Lansing, Ml, May, 1981. 46. Kodba, R. J. and Schwetz, B. A. A Review of the Toxicity of 2,3,7,8Tetrachlorodibenzo-p-dioxin (TCDD) with a Comparison to the Toxicity of Other Chlorinated Dioxin Isomers. Spring, 1981 Meeting of Central States Association of Food and Drug Officials, Grand Rapids, Michigan, 1981. 47. Kociba, R. J., and Schwetz, B. A. Toxicity of 2,3,7,8-Tetrachlorodibenzop-dioxin (TCDD). Presentation at Symposium entitled "Metabolism and Pharmacokinetics of Environmental Chemicals in Man". Sarasota, FL, June 7-12, 1981. BFG41299 BFG 00812 -19- PRESENTATIONS (Cont.) 48. Kociba, R. J. Laboratory Studies on the Identification of Environmental Causes of Cancer. Presentation at 1981 Annual Meeting of United Cancer Council, Midland, Ml, October 22-24, 1981. 49. Kociba, R. J. Toxicological Studies of TCDD and Related Dioxin Isomers. International Symposium on Chlorinated Dioxins and Related Compounds. Arlington, VA, October 25-29, 1981. 50. Gorzinski, S. J., Jersey, G. C., Wade, C. E., Hermann, E. A., McCollister, S. B., and Kociba, R. J. Butyl and Methyl Acrylate: 13-Week Oral Toxicity Studies in CDF Fischer 344 Rats. Presented at 21st Annual Meeting of the Society of Toxicology, Boston, MA, February 22-26,1982. 51. Keyes, D. G., Kociba, R. J., Henck, J. W. Nasal Mucosal Response Induced by a Respiratory Irritant. Presented at the 21st Annual Meeting of the Society of Toxicology, Boston, MA, February 22-26, 1982. 52. Kociba, R. J. Career Opportunities In Toxicologic Pathology. Michigan State University, Department of Pathology, Lansing, Michigan, February 16, 1982. 53. Kociba, R. J. Establishment of Adequate Margin of Safety for Chemical Carcinogens. Midwest Air Pollution Control Association Meeting, Southfield, Michigan, April 7, 1982. 54. Kociba, R. J. Carcinogenesis Testing in Toxicology. Midwest American Chemical Society Short Course, Northwood Institute, Midland, Michigan, June 14 and 15,1982. 55. Kociba, R. J. Overview of the Animal Data Available for Asssessment of Carcinogenic Potential of TCDD and Other Chlorinated Dioxins. Rockefeller University Symposium, New York, October 19 and 20, 1983. 56. Kociba, R. J. Pathologic Lesions Encountered During the Conduct of LongTerm Mammalian Toxicity Studies. University of Illinois, October, 1983. 57. Kociba, R. J. Evaluation of the Carcinogenic and Mutagenic Potential of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Other Chlorinated Dioxins. Banbury Conference Center, Cold Spring Harbor, New York, April 2-4, 1984. 58. Kociba, R. J. Overview of the Animal Toxicity Data on Chlorinated Dioxins. Ohio State University, April 24, 1984. BFG41300 BFG 00813 -20- PRESENTATIONS (Cont.) 59. Kociba, R. J. Laboratory Studies for the Detection of Carcinogenic Potential. Medical Education Conference, August 29,1984. Midland Hospital Center, Midland, Michigan. 60. Kociba, R. J. Critique of Proposed Methodology for Assessment of Target Organ Toxicity (Human Health Effects). EPA Workshop. December 3-4, 1984, Cincinnati, Ohio. 61. Kociba, R. J. and Cabey, 0. Comparative Toxicity and Biologic Activity of Chlorinated Dioxins and Furans Relative to 2,3,7,8-TCDD. 4th International Symposium on Dioxins, Ottawa. Canada, September, 1984. 62. Kociba, R. J. Concluding Summary on Aspects of Dioxin IssueToxicology and Epidemiology. 4th International Symposium on Dioxins. Ottawa, Canada, September, 1984. 63. Kociba, R. J. Evaluation of Global Literature for Definition of DoseResponse Relationship for Hexachlorobenzene Toxicity. International Agency for Research on Cancer. June, 1985. 64. Kociba, R. J. Review of the Toxicology of 2,3,7,8-TCDD and Related Compounds. 5th International Symposium on Dioxin. Bayreuth, FRG. September, 1985. 65. Kociba, R. J. Case Examples of Morphological and Mechanistic Studies of Hepatic and Renal Carcinogenesis. Workshop on Toxicity, Tumor Promotion and Carcinogenesis. Aspen, Colorado. July, 1985. 66. Kociba, R. J. Review of the Toxicology of 2,3,7,8-TCDD and Related Compounds. 5th International Symposium on Chlorinated Dioxins. Beyrouth, FRG, September, 1985. 67. Kociba, R. J. Analysis of the Animal Toxicity Studies of 2,3,7,8Tetrachlorodibenzo-p-dioxin (TCDD) Used in Derivation of Lifetime Exposure Control Limit Recommendations for Humans. ACS Annual Meeting, New York, NY. April, 1985. 68. Kociba, R. J. Overview of the toxicity of the Chlorodibenzo-p-dioxins/ Furans and the Basis for Extrapolation from Animals to Man. National Council for Air and Stream Improvements. Chicago, IL May, 1986. 69. Kociba, R. J. Overview of the toxicity of the Chlorodibenzo-p-dioxins/ Furans and the Basis for Extrapolation from Animals to Man. Canadian Paper & Pulp Association. Toronto, Ontario, Canada. September, 1986. BFG41301 BFG 00814 -21- PRESENTATIONS (Cont.) 70. Bond, D. M., Kociba, R. J., Keyes, D. G., Wall, J. M. and S. K. Weiss. Results of a One-Year Dietary Toxicity Study in Beagle Dogs Administered Cyhexatin. The 26th Annual Meeting of the Society of Toxicology. Washington, DC. Feb, 1987. 71. Kociba, R. J. Historical Perspectives on the Rationale for Selection of the Maximum Tolerated Dose (MTD) for Chronic Animal Studies. The 26th Annual Meeting of the Society of Toxicology, Washington, DC. Feb, 1987. 72. Kociba, R. J. Key Factors in the Interpretation and Extrapolation of Data Derived from Chronic Organ Toxicity Studies in Laboratory Animals. Spring 1987 Meeting of the American Conference of Chemical Labeling. Washington, DC. March, 1987. 73. Kociba, R. J. Toxicity of Combustion Products from Plastics Containing Brominated Flame Retardants Relative to the Toxicity of Brominated Dioxins and Furans. U.S. Industry User's Meetings. Washington, DC. 1987. 74. Kociba, R. J. Toxicity of Combustion Products from Plastics Containing Brominated Flame Retardants Relative to the Toxicity of Brominated Dioxins and Furans. VCI Industry User's Meeting. Frankfurt, Federal Republic of Germany, 1987. 75. Kociba, R. J. Selection of the MTD for Chronic Bioassays. Natural Institutes of Environ. Health Sciences Meeting. Research Triangle Park, NC, 1987. 76. Kociba, R. J. Application of Risk Assessment to Toxicologic Data. Toxicology Information Roundtable. Annual Meeting, Midland, Ml, 1987. 77. Pinkerton, M., Kociba, R. J., Petrella, R. et al. Investigation of the Comparative Toxicity of Combustion Products of High Impact Polystyrene (HIPS) With and Without Decabromodiphenyl Oxide/Antimony Trioxide (DBDPO/Sb2C>3) as a Flame Retardant Using 2,3,7,8-TBDD and 2,3,7,8TBDF as Positive Controls. Dioxin '87 Meeting, Las Vegas, Nev., 1987. 78. Betso., J. and R. J. Kociba. Hazard Communication: The Case for Category IV" Cancer Information" 27th Annual Meeting of the Society of Toxicology, Dallas, Texas, 1988. 79. Pinkerton, M,, Kociba, R. J., Petrella, R. et al. The Comparative Toxicity of Combustion Products of HIPS With and Without Decabromodiphenyl Oxide/Antimony Trioxide (DBDP0/Sb203) as a Flame Retardant Using 2,3,7,8-TBDD and 2,3,7,8-TBDF as Positive Controls. 27th Annual Meeting of the Society of Toxicology, Dallas, Texas, 1988. BFG41302 BFG 00815 CURRICULUM VITAE BARRY LESTER YANO EDUCATION: EMPLOYMENT: 1965-1970 -University of Minnesota, St. Paul, Minnesota- B.S. 1968-1972 - University of Minnesota, St. Paul, Minnesota - D.V.M. 1975-1981 - University of Minnesota, St. Paul, Minnesota - Ph.D. 1972- 1973 - Intern, Department of Small Animal Medicine, University of Minnesota St. Paul, Minnesota. 1973- 1975 - United States Air Force, Base Veterinarian 1975-1980 - Veterinary Medical Associate, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota. 1980-1984 - Project Leader - Pathology, Health and Environmental Sciences,Toxicology Research Laboratory, Dow Chemical, U.S.A., Midland, Michigan. 1984-1989- Research Leader - Department of Pathology, Mammalian and Environmental Toxicology Research Laboratory, Health and Environmental Sciences, Dow Chemical Company, Midland, Michigan. 1989-present- Research Associate- Department of Pathology, Mammalian and Environmental Toxicology Research Laboratory, Health and Environmental Sciences, Dow Chemical Company, Midland, Michigan. BFG41303 BFG 00816 JOB DESCRIPTION: 2- - Provides professional expertise in the areas of pathology, clinical pathology, and toxicology as needed to design, conduct, interpret, and report safety assessment studies conducted by the Mammalian and Environmental Toxicology Research Laboratory. MEMBERSHIPS: CERTIFICATION: American College of Veterinary Pathology Society of Toxicologic Pathologists Phi Zeta (Veterinary Honor Society) 1982 American College of Veterinary Pathologists AWARDS: 1972 - Outstanding Achievement in Small Animal Medicine 1972 - Outstanding Achievement in Small Animal Surgery 1972 - Minnesota A.V.M.A., Outstanding Senior 1978 - Charles Louis Davis, D.V.M. Foundation Scholarship Award in Veterinary Pathology PUBLICATIONS Gray, G. W.; Yano, B. L.,: A Study of the Actions of Methampyrone and of a Commercial Intestinal Extract Preparation on Intestinal Motility. Am J Vet Res 36(2):201-208, 1975. Osborne, C. A.; Engen, M. H.; Yano, B. L.; Brasmer, T. H.; Jessen, C. R.; Blevins, W. E.: Congenital Urethrorectal Fistula in Two Dogs. JAVMA 166(10):999-1002,1975. Osborne, C. A.; Hammer, R. D.; Resnick, J.; Stevens, J.; Yano, B. L.; Vernier, R. L.: Natural Remission of Nephrotic Syndrome in a Dog with Immune-Complex Glomerular Disease. JAVMA 168(2):129-137, 1976. Johnston, G. R.; Osborne, C. A.; Wilson, J. W.; Yano, B. L.: Familial Urethral Ectopia in the Dog. JAAHA 13:168-170,1977. BF41304 BFG 00817 12/7/95 -3- Osborne, C. A.; Stevens, J. B.; Yano, B. L.: Hypercalcemic Nephropathy, Spontaneous Animal Models of Human Disease, Vol. 2, pp. 290-292, Academic Press, Inc., New York, NY, 1979. Segedy, A. K.; Yano, B. L.; Jeraj, K.: Sacral Spinal Cord Agenesis in a Kitten. JAVMA 174(5):510-512, 1979. Jeraj, K.; Ogbum, P.; Johnston, G.; Edwards, W.; Yano, B.; Brunson, D.; Wallace, L.; McGrath, C.: Atrial Spetal Defect (Sinus Venosus Type) in a Dog. JAVMA 177(4):342-346,1980. Yano, B. L.: Feline Insular Amyloid. Ph.D. Thesis, 1981. Yano, B. L.; Johnson, K. H.; Hayden, D. W.: Feline Insular Amyloid: Histochemical Distinction from Secondary Systemic Amyloid. Vet Path 18(2):181-187,1981. Yano, B. L.; Hayden, D. W.; Johnson, K. H.: Feline Insular Amyloid: Incidence in Adult Cats with No Clinicopathologic Evidence of Overt Diabetes MeUitus. Vet Path 18(3):310-315,1981. Yano, B. L.; Hayden, D. W.; Johnson, K. H.: Feline Insular Amyloid: Association with Diabetes Mellitus. Vet Path 18(5):621-627,1981. Yano, B. L.; Hayden, D. W.; Johnson, K. H.: Feline Insular Amyloid Ultrastructural Evidence for Intracelullar Formation by nonendocrine Cells. Lab Invest 45(2):149-156,1981. Jeraj, K.; Yano, B.; Osborne, C. A.; Wallace, L. J.; Stevens, J. B.: Primary Hepatic Osteosarcoma in a Dog. JAVMA 197(10):1000-1003,1981. O'Brien, T. D.; Osborne, C. A.; Yano, B. L.: Clinicopathologic Manifestations of Progressive Renal Disease in Lhasa and Shih Tzu Dogs. JAVMA 180(6)658-664,1982. Yano, B. L, Hayden, D. W.; Johnson, K. H.: Occurrence of Secondary Systemic Amyloid in the Pancreatic Islets of a Cat. AJVR 44(2):338-339, 1983. Landry, T. D.; Gushow, T. S.; Yano, B. L.: Propylene Glycol Monomethyl Ether: A 13-Week Inhalation Study in Rats and Rabbits. Fundam. Appl. Toxicol. 3:627-630, 1983. Hanley, T. R., Jr.; Calhoun, L. L.; Yano, B. L.; Rao, K. S.: Teratologic Evaluation of Inhaled Propylene Glycol Monomethyl Ether in Rats and Rabbits. Fundam. Appl. Toxicol. 4(5):784-794, 1984. BFG 00818 12/7/9 5 BFG41305 -4- Hanley, T. R., Jr.; Yano, B. L.; Nitschke, K. D.; John, J. A.: Comparison of the Teratogenic Potential of Inhaled Ethylene Glycol Monomethyl Ether in Rats, Mice and Rabbits. Toxicol. Appl. Pharmacol. 75:409-422. 1984. Landry, T. D.; Yano, B. L.: Dipropylene Glycol Monomethyl Ether: A 13-Week Inhalation Study in Rats and Rabbits. Fundam. Appl. Toxicol. 4:612-617,1984. Lomax, L. G., Stott, W. T. Johnson, K. A., Calhoun, L. L., Yano, B. L. and Quast, J. F: The Chronic Toxicity and Oncogenicity of Inhaled Technical-Grade 1,3-Dichloropropene in Rats and Mice. Fundam. Appl. Toxicol. 12:418-431, 1989. Albee, R. R., Mattsson, J. L., Yano, B. L. and Chang, L. W. Neurobehavioral Effects of Dietary Restriction in Rats. Neurotics and Terat 9:203-211,1987. Fox, T. R., Schumann, A. M., Watanabe, P. G., Yano, B. L., Maher, V. M. and McCormick, J. J. Mutational Analysis Of The H-ras Oncogene In Spontaneous C57BL/6 X CH3/He Mouse Liver Tumors and Tumors Induced With Genotoxic and Nongenotoxic Hepatocardnogens. Cancer Research 50: 4014-4019,1990. Yano, B.L., Dittenber, D.A., Albee, R.R. and Mattsson, J.L. Abnormal Auditory Brainstem Responses and Cochlear Pathology in Rats Induced by an Exaggerated Styrene Exposure Regimen. Toxicologic Pathology 20 (1): 1-6,1992. Stott, W.T., Yano, B.L., Williams, D M., Barnard, S.D., Hannah, M.A., Cieszlak, F.S., and Herman, J R. Spedes-Dependent Induction of Peroxisome Proliferation by Haloxyfop, an Arloxyphenoxy Herbicide. Fundamental and Applied Toxicology 28: 71-79,1995. ABSTRACTS AND ORAL PRESENTATIONS Yano, B. L. Effects of Two Veterinary Drugs on Intestinal Motility. (1970). The 51st Congress of Research Workers in Animal Diseases, Chicago, IL. Yano, B. L., Campbell, R. A., Cieszlak, F. S., Bama-Lloyd, T., and Battjes, J. E. (1990). Dietary Chronic Toxicity And Oncogenidty OF Haloxyfop Herbidde In Dogs, Rats and Mice. Sodety of Toxicology, Miami Beach, FL. BFG41306 BFG 00619 12/7/95 -5- Quast, J. F., Yano, B. L., Dietz, F. K., Marler, R. M. and Hayes, W. C. (1990). Subchronic And Reproductive Toxicity And Teratology Of Haloxyfop Herbicide. Society of Toxicology, Miami Beach, FL. Breslin, W. J., Cieszlak, F. S., Zablotny, C. L., Corley, R. A., Yano, B. L. and Verschuuren, H. G. (1990). Developmental Toxicity Of Inhaled Dipropylene Glycol Monomethyl Ether (DPGME) In Rabbits And Rats. Society of Toxicology, Miami Beach, FL. Stott, W. T., Yano, B. L., Williams, D. M., Barnard, S. D., Hannah, M. A. and Cieszlak, F. S. (1990). Species Dependent Induction Of Peroxisome Proliferation By Haloxyfop, A New Herbicide. Society of Toxicology, Miami Beach, FL. Fox, T. R., Schumman, A. M., Yano, B. L., Watanabe, P. G., Maher, V. M. and McCormick, J. J. (1990). Mutational Analysis Of The H-ras Gene In B6C3F1 Mouse Liver Tumors Induced With Nongenotoxic Hepatocarcinogens. Society of Toxicology, Miami Beach, FL. Yano, B.L., Schultze, G.E., J R Szabo, J.R., Corley, R.A., Cosse, P.F. and Billups, L.H. (1991). Subchronic Dietary Toxicity Of 2,4D Add, 2,4-D Amine Salts And 2,4-D Esters In Rats. Sotiety of Toxicology, Seattle, WA. Richardson, R. J., Yano, B. L., Kayyali, U. S. and Randall, J. C. (1992). Potentiation of Organophosphate Neuropathy: Preliminary Histopathology and Demonstration of Clinical Potentiation by an Organophosphinate. Society of Toxicology, Seattle, WA. Kirk, H. D., Yano, B. L., Haut, K. T., Verschuuren, H. and Breslin, W. J. (1992). Tripropylene Glycol N-Butyl Ether 13-Week Drinking Water Study in Fischer 344 Rats. Sodety of Toxicology, Seattle, WA. Crissman, J. W., Long, P. H., Yano, B. L. and Everitt, J. L (1992). Spontaneous Renal Tubular Tumors and Atypical Hyperplasia in Two Strains of Rats on 90-Day Studies; Comparison to Hereditary Renal Carcinomas in the Eker Rat. Society of Toxicologic Pathologists, Phoenix, Arizona. Yano, B. L. and Mattsson, J. L. (1992). Tissues Selection for TSCA/FIFRA Neurotoxiaty Guideline Studies. American College of Veterinary Pathologists, San Diego, CA. Vet Path 29:5,445,1992. Zielke, G. J., Yano, B. L. and Breslin, W.J. (1993). 2,3,5,6Tetrachloropyridine: Combined Repeat Dose an BFG41307 1 2/7/95 BFG 00820 6- - Reproductive/Developmental Toxicity Screen in Sprague-Dawley Rats. Society of Toxicology, New Orleans, LA. Albee, R R., Mattsson, J. L., Yano, B. L., Beekman, M. J. and Spencer, P. J. (1993). Ototoxicologic and Neurotoxicologic Evaluation of Rats Exposed to Styrene. Society of Toxicology, New Orleans, LA. Mattsson, J. L.Albee, R R, Yano, B. L., Bradley, G. J., and Spenser, P. J. (1995). Neurotoxicologic Examination of Rats Exposed to 1,1,2,2Tetrachloroethylene (Perchloroethylene) Vapor for 13 Weeks. Society of Toxicology, Baltimore, MD. Yano, B. L., Mattsson, J. L, and Jeffries, T. K. (1995). 2,4-D Herbicide (2,4-Dichlorophenoxyacetic Acid): One-Year Oral Neurotoxicity Study in Fischer 344 Rats. Society of Toxicology, Baltimore, MD. Jeffries, T.K., Yano, B.L., Stott, W.T., Ormond, J.E., Battjes. J.E., Charles, J.M., Cunny, H.C., Wilson, R.D., and Bus, J.S. (1996). Dietary Chronic Toxicity /Oncogenicity of 2,4-Dichlorophenoxyacetic Add (2,4-D) in Rats. Sodety of Toxicology, Annaheim, CA. BfG41308 BFG 00821 1 2/7/95 -1 - CURRICULUM VITAE NAME: KENNETH EDWARD STEBBINS CURRENT JOB TITLE: EDUCATION: EMPLOYMENT: INDUSTRIAL PATHOLOGY TRAINING: RESEARCH EXPERIENCE: TEACHING EXPERIENCE: Research Leader 1980 - B. S. Medical Technology - Michigan State University 1984 - D.V.M. - Michigan State University 1987-88 - Pathology Residency, University of Pennsylvania, School of Veterinary Medicine 1976 - Byron Center High School, Byron Center, Michigan 1984-85 - Pet Veterinary Clinic, Grandville, Michigan - veterinarian in private small animal practice 1989-present - Project Leader - Pathology Section, The Toxicology Research Laboratory, Health and Environmental Sciences, The Dow Chemical Company 1988 - Three month externship at E. I. du Pont de Nemours and Co., Inc., Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware Co-Investigator in the project entitled "Ultrasonographic Evaluation of Tendon and Ligament Injuries in the Horse: Correlation with Gross and Histopathologic Findings". Supported by a grant from the Grayson Foundation 1985-88 - University of Pennsylvania. Assistance with laboratory teaching of Core Pathology. Assistance with instruction of senior veterinary students on large and small animal necropsy rotations. BFG41309 BFG 00822 TEACHING EXPERIENCE (Cont.): HONORS AND HONORARY SOCIETIES: PROFESSIONAL SOCIETIES: CERTIFICATIONS: PUBLICATIONS: ABSTRACT: 2- - 1987-88 - Philadelphia College of Pharmacy and Science. Lectures to undergraduate toxicology students in "Principles of Pathobiology" course. Upper and lower digestive systems, bone and connective tissue. 1988-89 - Cornell University. Instruction of veterinary pathology residents in diagnostic pathology C. L. Davis Foundation Scholarship in Veterinary Pathology, November, 1987 Merck Award (for highest GPA in my freshman veterinary class) Michigan State University, 1981 Membership in Society of Phi Zeta, the National Honor Society of Veterinary Medicine, for ranking in the top ten of my junior veterinary class, Michigan State University, 1983. American Veterinary Medical Association American College of Veterinary Pathologists Charles Davis Foundation American College of Veterinary Pathologists 1988 See Attached See Attached Reviewed/Revi sed: Date: n?s~ BFG41310 BFG 00823 3- - PUBLIC ATIONS 1) deMadron, E., Helfand, S. C., Stebbins, K. E. Use of Chemotherapy for Treatment of Cardiac Hemangiosarcoma in a Dog. JAVMA13Q. (7):887891 (1987). 2) Stebbins, K. E. and McGrath, J. T. Meningio-angiomatosis in a Dog. Veterinary Pathology 25. (2):167-168 (1988). 3) Stebbins, K. E. Polycystic Kidney and Liver Disease in an Adult Persian Cat. Journal of Comparative Pathology 100:327-330 (1989). 4) Foodman, M., Giger, U., and Stebbins, K. E. Immotile Cilia Syndrome in a Dog. Journal of Small Animal Practice (1989). 5) Stebbins, K. E., Morse, C. C., and Goldschmidt, M. H. Feline Oral Neoplasia: A Ten Year Survey. Veterinary Pathology 26 (2V.121-128 (1989). 6) Sweeney, C. R., Stebbins, K. E,, Schelling, C. G., Beech, J., and Schilling, D. A. Hypertrophic Osteopathy in a Pony with a Pituitary Adenoma. JAVMA 125 (1 ):103-105 (1989). 7) Rowland, P. H., Valentine, B. A., Stebbins, K. E.t and Smith, C. A. Cutaneous Plasmacytomas with Amyloid in Six Dogs. Veterinary Pathology 23 (2):125-130 (1991). ABSTRACTS Breslin, W. J., Zielke, G. J., and Stebbins, K. E. (1992). Developmental toxicity of monoethanolamine (MEA) in rats following dermal exposure. The Toxicologist 12, 102. Abstract No. 323. ^G413^ BFG 00824