Document zoJajxD5VxZnrBXkKDZM55JVn

data search on vca for craig elgut Order nuafcer 901U9-13326S-HIZ -001-001 page 1 set 3 with 363 of 363 item I tea 1 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALTTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEH YEAR 6188 GEN CORR DON CHEMICAL COMPANY'S COTflENTS ON THE CARB 1990 DRAFT TECHNICAL SUPPORT DOCUMENT "PROPOSED IDENTIFICATION OF VINYL CHLORIDE AS A TOXIC AIR CONTAMINANT" HAMCINS NC.DOH CHEH) DON CHEM.TO BARBARA COOK CARB) 1990, JULY 3 VCM(CANCER)RISK ASSESSMENT)HUMAN)EFFECTS) ANIMAL) 199 Itee 2 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGZN DATE DESCRIPTORS akmwee HELD TERMS REVIEH YEAR 6165 gen report PROPOSED IDENTIFICATION OF VINYL CHLORIDE AS A TOXIC AIR CONTAMINANT: NONE.NONE) NONE) 1990. MAY VINYL CHLORIDE)AIR)DETERMINATION)EFFECTS)TOXICITY) CALIFORNIA AIR RESOURCES BOARD) 1995 DRAFT REPORTS PART A-C Item 3 ACCESSION NUTBER 6103 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT BUA REPORT ON VINYL CHLORIDE AUTHOR/AFFILIATION NONE,NONE) ORIGIN CMA,TO R.K.HINDERERt BF6)) DATE 1989, DECEMBER 28 ABSTRACT ECOLOGICAL ASPECTS OF THE PRODUCTION, ENTRY INTO, OCCURRENCE AND DISTRIBUTION OF VCM IN THE ENVIRONMENT. DESCRIPTORS mwmmumm VCM)INHALATION)ORAL)EFFECTS)TERATOGEN) REVIEH YEAR 1995 Item A ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 6102 GEN REPORT RECOMMENDATION FOR THE REVISION OF THE AMBIENT AIR GUIDELINE FOR VINYL CHLORIDE 20S67Q02 BFG51921 data search on vcn for craig elgut Order nuttier 901119-133295-NIZ -001-001 page 2 set 3 with 363 of 363 items AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEN YEAR PARK C,D0H CHEMICAL C0 DON CHEMICAL CO,TO ONTARIO MINISTRY OF THE ENVIROftfENTt DR. M. LU5IS ) ) 1989 AUGUST 30 FOUR CONCERNS NEED TO BE ADDRESSED IF DOCUMENT IS TO BE USED AS A BASIS FOR REGULATION. THE CONCERNS ARE AS FOLLOWS: LACK OF DISCUSSION ON INCORPORATION OF LOH-DOSE PHARMACOKINETIC IPK) INFO) LACK OF DISCUSSION OF RISK ESTIMATES THAT HAVE BEEN OERIVED FROM EPIDEMIOLOGY DATAlINTERNAL INCONSISTENCIES IN THE REPORTING OF ATOIENT CONCENTRATION OF VCM IN COMPARISON TO EMISSION LEVELS AND POTENTIAL HUMAN RESULTS. VCMtCAS.NO.75-01-9)EPIDEMIOLOGY)RXSK ASSESSMENT>AIR SAILING) 1993 Item S ACCESSION NUMBER 9085 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MORTALITY AND CANCER INCIDENCE RESULTS OF THE EUROPEAN MULTI-CENTRIC COHORT STUDY OF HORKERS EMPLOYED IN THE VINYL CHLORIDE INDUSTRY. AUTHOR/AFFILIATION NONENONE I ORIGIN IARC) DATE 1989 ABSTRACT CONTAINS INTRODUCTION AND DISCUSSION AND CONCLUSIONS. DESCRIPTORS *** VCMvEPlDEHIOLOGY HUMAN>EFFECTS>CANCER>M0RTAL1TY) ANGIOSARCOMA REVIEN YEAR 1998 Item 6 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIQN ORIGIN DATE DESCRIPTORS mutual HELD TERMS COMMENTS REVIEW YEAR 9070 GEN CORRESPONDENCE COM1ENTS OF THE VINYL INSTITUTE ON ATSDR'S TOXICOLOGICAL PROFILE FOR VINYL CHLORIDE. NONE,NONE) NONE,TO EPA) I960 VCM)EPA)ACUTE)TOXICITY)CHRONIC)CANCER)MUTAGENXCITY)BIRTH DEFECTS VINYL INSTITUTE) RKH(90) SEE AN83337 1998 Item 7 ACCESSION NUTCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mntiiaiui HELD TERMS 9069 GEN REPORT HEALTH EFFECTS IN CHILDREN EXPOSEO TO VINYL CHLORIDE: FINAL REPORT ZISKIND RA,NONE)SHXTH D.NONE)SPIVEY G,NONE)ROGOZEN MN0NE) NONE,FOR EPA CONTRACT NO.68-2986) 1981, JANUARY VCM)EFFECTS)AIR SAMPLINGlOCCUPATZONAL EXPOSURE jDISEASE REPRODUCTION) SCIENCE APPLICATIONS INC) 20867003 BFG 51922 data *arch on vcm for craig elgut Order number 901119-133245-NIZ -001-001 page 3 eat 5 with 363 of 363 itane REVIEW YEAR 1996 Item 8 ACCESSION NUtCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *** HELD TERMS KHIC INDEX NUTBER REVIEW YEAR 4068 6EN PAPER REVIEW OF FINAL REPORT ON "HEALTH EFFECTS IN CHILDREN EXPOSED TO VINYL CHLORIDE" WILSON R,HARVARD UNIVt NONE,FOR EPA REFERENCE NO. SA1-068-81-569} 1981, JUNE 18 EFFECTS>VCM| SAUGUS ELEMENTARY SCHOOL} 05215 1996 Item 9 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mm miKM HELD TERMS REVIEW YEAR 4061 GEN PUBLICATION CUTANEOUS HAEMANGIOENDOTHELIOMA: A POSSIBLE LINK WITH CHRONIC EXPOSURE TO VINYL CHLORIDE. DAVIES MFP.NONElCURTIS M,NONEVNONAT JHT,NONEI BRITISH J OF INDUSTRIAL MEDICINE,VOL 47 NO.l PP.65-67| 1990 VCM)CANCER}HUMAN}EFFECTS}PVC} HEMANGIOENDOTHELIOMA} 1998 Item 10 ACCESSION NUTBER 4047 FILE LOCATION GEN DOCUMENT TYPE CORRESPONDENCE TITLE OR SUBJECT AUTHOR/AFFILIATION SUTtlARY AND FINAL STATUS REPORT OF CHA VINYL CHLORIOE PANEL ACTIVITIES. GAFFEY HR,NONE} ORIGIN MONSANTO,H.R.GAFFNEY TO SUSAN HOHEiCMA)} DATE 1989 ABSTRACT FURTHER HORK TO RESOLVE THE POSSIBILITY OF MISOIAGNOSIS OF 37 DEATHS TO DETERMINE WHETHER THEY HERE ACTUALLY LIVER AND BILIARY CANCER OR ANGIOSARCOMA IS NOT FEASIBLE. DESCRIPTORS * VCM}HUMAN}EFFECT$}CANCER}EP1DENIOLOGY}ANGIOSARCOMA}LIVER} HELD TERMS BILIARY} REVIEW YEAR 1998 Item 11 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 4004 GEN PUBLICATION CLINICAL MANIFESTATIONS IN VINYL CHLORIDE POISONING 20867004 BFG51923 data eearch on vca for creig elgut Order nudMr 901119-133Z95-KIZ -001-001 page 9 set 3 with 363 of 363 items AUTHOR/AFFILIATION SUCIU I,N0NE tPRODAN L,N0NE)ILEA E,N0TO)PADURARU A,NONE)PASCU L.N0NE) ORIGIN At*4ALS OF THE NEH YORK ACADEMY OF SCIENCES,PP .53-69) DATE 1970 ABSTRACT IN THE 72 CASES ADMITTED TO THE CLINIC THERE HERE 27 POSITIVE HEPATIC TESTS, HITH GOT AND SPT OVER NORMAL IN 18 CASES. BSPlBROMOSULFONPHTHALEIN) IN 22 FROM 26 CASES HAD A RETENTION OVER 5 THE PROTEINOGRAM MODIFICATIONS MERE OF THE ACUTE AND SUBACUTE TYPE. HEPATIC BIOPSY SHOTOD CHRONIC HEPATITIS IN 3 CASES. DESCRIPTORS ** VCM)POISONING)OCCUPATIONAL EXPOSURE)ACUTE )SUBACITTEjHEPATITIS) KWIC INDEX NUMBER 05120 REVIEH YEAR 1996 Item 12 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *** KHIC INDEX NUTOER REVIEH YEAR 9003 GEN PUBLICATION TWO POSSIBLE CASES OF ANGIOSARCOMA OF THE LIVER IN A GROUP OF SMEDISH VINYL CHLORIDE-POLYVINYL CHLORIDE WORKERS BYREN D,NONE)HOLTOERG B.NONE) AM4ALS OF THE NEW YORK ACADEMY OF SCIENCES,PP.299-250) 1979 RECENT (JULY 1979) EXAMINATION OF THE PAHTOLOGIC SPECIMENS BY TUMOR SPECIALISTS HAS CONFIRMED IKE DIAGNOSIS OF HEHANG10SARC0MA OF THE LIVER IN BOTH CASES. IN CASE 2 HONEVER, THERE IS A PROBABLE COEXISTENCE OF A HEPATOCELLULAR CANCER OF BOTH LON AND HIGH DIFFERENTIATED TYPE. VCM PVClANGIOSARCOMA) LIVER)CANCER)OCCURATIONAL EXPOSURE ) 05122 1996 Item 13 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS whhh KHIC INOEX NUMBER REVIEH YEAR 9002 GEN PUBLICATION INTERIM RESULTS OF EXPOSURE OF RATS, HAMSTERS, AND MICE TO VINYL CHLORIDE KEPLINGER ML,INDUSTRIAL BIO-TEST LABS)GOODE JM,SAME)GORDON DE,SAME)CALANDRA JC,SAME AhMALS OF THE NEH YORK ACADEMY OF SCIENCES,PP.219-229) 1979 IN THIS STUDY WHICH HAS DESIGNEO TO COMPLEMENT MALTONI'S STUDIES, 100 RATS, HAMSTERS, AND MICE OF BOTH SEXES (600 TOTAL PER EXPOSURE GROUP) ARE BEIN EXPOSEO TO EITHER 0, 2500, 200, OR SO PPM OF VINYL CHLORIDE VAPOR 7 H/DAY 5 DAYS/MEEK. MICE HILL BE EXPOSED FOR 9 MONTHS AND KEPT FOR AN ADDITIONAL 12 MONTHS. MORIBUND ANO DEAD ANIMALS (MHEN POSSIBLE) RECEIVE GROSS AUTOPSIES AND ARE PHOTOGRAPHED. THE MAJOR ORGANS OF ALL ANIMALS ARE FIXED FOR HISTOLOGICAL EXAMINATION. IT APPEARS THAT ANGIOSARCOMAS MAY HAVE BEEN OBSERVED IN ONE MALE HAMSTER AND ONE MALE RAT EXPOSEO TO 2500 PPM ANO IN ONE FEMALE RAT EXPOSED TO 200 PPM. NO TUMORS HAVE BEEN OBSERVED IN RATS OR HAMSTERS EXPOSED TO 50 PPM BUT ONE MALE CONTROL HAS FOUND TO HAVE A DERMAL FIBROMA. TUMORS)RATS)HAMSTERS)DERMAL)VCMiHICE > FIBROMA) 05123 1996 20867005 BFG51924 data search on vctn for craig elgut Order nuri>er 90U19-133245-HIZ -001-001 page 5 set 3 with 363 of 363 itens 20867006 BFG51925 Item 14 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTH0R/AFF1LIATI0N ORIGIN DATE ABSTRACT DESCRIPTORS ** KMIC INDEX NUMBER REV1EH YEAR 4001 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER AS THE CERTIFIED CAUSE OF DEATH 1963-73 BAXTER PJ,NONE*FOX AJ,N0NE) THE LANCET,PP.27-28* 1975, JULY 5 THIS COtMJNICATION REPORTS THE RESULTS IN ENGLAND AND KALES. ALL CERTIFICATES KITH AN UNDERLYING CAUSE OF DEATH OF CERTAIN BENING OR MALIGNANT LIVER TUMOURS HERE SCRUTINIZED FOR A DIAGNOSIS OF ANGIOSARCOMA, MALIGNANT HAEMANGIOENDOTHELIOMA, OR KUPFFER CELL SARCOMA. THREE CASES HERE IDENTIFIED. A COMPREHENSIVE FOLLOW-UP OBTAINING A FULL OCCUPATIONAL HISTORY IN EACH OF THESE CASES IS BEING CONDUCTED. ANGIOSARCOMA)LIVER|PVC*VCM)CANCER|OCCUPATIONAL EXPOSURE) 05124 1996 Item 15 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS whhh KHIC INDEX NUMBER REVIEN YEAR 4000 GEN PUBLICATION PREDICTIVE VALUE OF CARCINOGENESIS BIOASSAYS HALTONI C,NONE> ANNALS OF THE NEH YORK ACADEMY OF SCIENCES,PP.431-443I 1970, APPROX THE POTENTIAL ONCOGENIC RISK FOR HAN BY OCCUPATIONAL AND ENVrRGttlENTAL AGENTS HAS SO FAR BEEN IDENTIFIED WHEN THE INCIDENCE OF A PARTICULAR TYPE OF TUMOR IN AN EXPOSED POPULATION HAS BEEN ESPECIALLY HIGH OR ON THE BASIS OF RETROSPECTIVE EPIOEHIOLOGIC STUDIES. ME MUST NON PREDICT ONCOGENIC RISKS TO AVOIO HUMAN EXPOSURE TO SUCH AGENTS. THE THREE MOST IMPORTANT CASES OF ENVIRONMENTAL AND OCCUPATIONAL TUMORS, DISCOVERED AFTER 1970, HERE INDIRECTLY OR DIRECTLY PREDICTED EXPERIMENTALLY. BIOASSAY)OCCUPATIONAL EXPOSUtE )TUMORS)EPIDEMIOLOGY)CANCER)VCH)INHALATIGN)RATS)MAN)MOUSE)HAMSTER) ANGIOSARCOMA) LIVER )BRAIN)LUN6)$UBCUTANE0US) 05127 1996 Item 16 ACCESSION NUMBER FZLE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT 3999 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN A VINYL-CHLORIDE WORKER LEE FI,N0NE)HARRY DS.NONE) THE LANCET,PP.1316-1318) 1974, JUNE 29 A MAN AGED 71 YEARS DIED KITH ANGIOSARCOMA OF THE LIVER, AN EXTREMELY RARE TUMOUR. FDR 20 YEARS HEA HAD BEEN A PROCESS HORKER ZN THE MANUFACTURE OF POLYVINYL CHLORIDE MONOMER. EVIDENCE APPEARS data search on vcm for craig elgut Order metier 90U19-133Z45-NXZ -001-001 page 6 sat 3 with 263 of 363 items DESCRIPTORS hwh KHIC INDEX NUFOER REVIEN YEAR STRONG THAT ANGIOSARCOMA OF THE LIVER IS AN OCCUPATION TUMOUR AND THAT VINYL CHLORIDE IS THE CARCINOGEN. THERE IS NO EVIOENCE THAT THE FINISHED POLYMERIPVC l CARRIES ANY RISK. PVC|VCMlACROOSTEOLYSIS>ANGIOSARCOMAI LIVER >OCC(JPATIONAL EXPOSURE 05120 1996 Item 17 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATXON ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 3985 GEN PUBLICATION DETERMINATION OF 7-(2-OXOETHYL)GUANINE AND N2,3-ETHENOGUANINE IN DNA HYDROLYSATES BY HPLC FEOTKE NtCIITlHALKER VE,SAME>SHEWERG JA,SAME> ARCH TOXICOL * SUPP L 13 PP.214-216} 1989 VINYL CHLORIDE(VC) IS METABOLIZED OXIDATIVELY TO 2-CHLOROETHYLENE OXIDE THAT CAN REARRANGE TO 2-CHLOROACETALDEHYDE. 2-CHLOROETHYLENE OXIDE IS RESPONSIBLE FOR THE FORMATION OF THE MAJOR DNA ADDUCT 7-C 2-OXOETHYLJGUANINE (7-OEG) FORMED AFTER IN VIVO EXPOSURE OF EXPERIMENTAL ANIMALS TO VC (LAIB 1986). HHILE 7-OEG DID NOT CAUSE MISPAIRING IN VITRO (BARBIN ET AL 1905), ANOTHER AODUST, N2,3-ETHENOGUANINEI EG) * FOUND IN DNA OF RAT LIVER AFTER VC EXPOSURE (LAIB ET AL 1965), HAS SHOW TO BE HIGHLY EFFICIENT CAUSING GC->AT TRANSITIONS (SINGER ET AL 1987). UNFORTUNATELY, THE ANALYTICAL EVIDENCE FOR THE IN VIVO FORMATION OF EG PRESENTED BY LAIB ET AL (1985) MAS EQUIVOCAL. HENCE, THE FIRST GOAL OF THIS STUDY HAS TO PROVE OR DISPROVE THE IN VIVO FORMATION OF EG. THE SECOND GOAL HAS TO DETERMINE THE SENSITIVITY NEEDED TO STUDY THE DOSE-RESPONSE RELATIONSHIP BETWEEN VC EXPOSURE AND TARGET TISSUE DOSE MEASURED AS DNA ADDUCTS. NCM HPLC METHODS FOR QUANTIFYING 7-OEG AND EG BY FLUORESCENCE SPECTOPHOTOHETRY NERE DEVELOPED. DETECTION LIMITS HERE 15 AND 1.9 PMOL PER UMOL GUANINE FOR 7-OEG AND EG, RESPECTIVELY. IN THE CASE OF EG, ADDITIONAL QUALITATIVE EVIDENCE FOR ITS PRESENCE HAS OBTAINED BY A HIGHLY SPECIFIC GC-MS METHOD. VCMJDNA JMETABOLISM> DNA ADDUCTSIDMA BINDINGl 1995 Item IB ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 3964 GEN PUBLICATION COMPARISON OF POTENCY OF HUMAN CARCINOGENS: VINYL CHLORIDE, CHLOROMETHYLMETHYL ETHER AND BIS(CHLOROMETHYL)ETHER VAN DUUREN BL,NQNE) ENVIRONMENTAL RESEARCH,VOL 49 PP.143-151| 1969 ON THE BASIS OFTHESE NUMBERS OF CANCER DEATHS, AND THE LEVELS AND DURATIONS OF EXPOSURE, IT IS CONCLUDED THAT VC IS A WEAK HUMAN CARCINOGEN COMPARED TO CME-BCME. VCMCANCERHUHANEFFECTS)BCME> CHLOROMETHYLMETHYLETHER)CME 1999 Item 19 20867007 BFG51926 data saarch on vcm for craig algut Order number 901U9-133245-MIZ -001-001 page 7 set 3 with 363 of 363 items ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *** HELD TERMS KHIC INDEX NUTBER REVIEH YEAR 3964 GEN JOURNAL VINYL CHLORIDE FORMATIN FROM THE THERMAL DEGRADATION OF POLY!VINYL CHLORIDE) HAKEMAN IB,TEWECO CHEMICALS)JOHNSON HR,SAHE> NONE,VOL 2 NO.3 PP.200-203) 1980, SEPTEMBER THE VOLATILE PRODUCTS FROM THE THERMAL DEGRADATION OF POLY(VINYL CHLORIDEHPVC) RESINS AND COMPOUNDS ARE SHOW TO CONTAIN TRACE AMOUNTS OF VINYL CHLORIDE. PVC jVCM^COMBUSTIONITOXICITYJTHERMAL DECOMPOSITION) J OF VINYL TECHNOLOGY) 04819 1992 Item 20 ACCESSION NUMBER 3941 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT COtCUSTION PRODUCTS FORM VINYL CHLORIDE MONOMER AUTHOR/AFFILIATION O'HARA m,BFG)CRIDER LB,SAME)DANIEL RL,DOH CHEM) ORIGIN AIHA,VOL 32 PP.153-156 DATE 1971, MARCH ABSTRACT BY MEANS OF A VARIETY OF ANALYTICAL TECHNIQUES, THE COMBUSTION PROFILE OF VINYL CHLORIDE HONOMERIVCH) HAS BEEN DETERMINED. THIS PROFILE INCLUDES FLAME TEMPERATURES, SOOT CONTENT, AM) A COMBUSTION GAS ANALYSIS. DEPENDING ON THE AMOUNT OF VCM-AIR PREMIXING PRIOR TO COMBUSTION, THE TEMPERATURE OF A VCM FLAME RANGES FROM 950 DEG TO 1466 OEG C. SIMILARLY, THE SOOT OR UFBURNED CARBON CONTENT OF A VCM FLAME VARIES FROM 3 TO 6 HEIGHT PERCENT. AN ANALYSIS OF THE CQPBUSTION GASES FROM VCM REVEAL THE FOLLOHING COMPOSITION: HCL 27,000 PPM) C02 58,100 PPM) CO 9500 PPM) PHOSGENE 40 PPM) AND VCM TRACE. FROM A HAZARD STANDPOINT, THE GROSS QUANTITY OF HYDROGEN CHLORIDE IS THE MAIN SOURCE OF DANGER IN A VCM FIRE. DESCRIPTORS mxkxhjim VCM)C0tBUST10N)T0XICITY)THERMAL DECOMPOSITION) KHIC INDEX NUFBER 00950 REVIEH YEAR 1992 Item 21 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR 3924 GEN JOURNAL COHORT AM) CASE-CONTROL ANALYSES OF WORKERS EXPOSED TO VINYL CHLORIDE: AN UPDATE MJ H,NONE)STEENLAND K,NONE)BROW D,NONE>HELLS V,NONE)JONES J,NONE)SCHULTE P,NONE)HALPERXN N,NONE) J OF OCCUPATIONAL MEDICINE,VOL 31 NO.6 PP.510-523) 1989, JUNE THE ONLY SIGNIFICANT ASSOCIATION BETWEEN DISEASE RISK AND CUMULATIVE DOSE HAS FOR LIVER CANCER AND ClftAJLATXVE DOSE OF VINYL CHLORIDE MONOMER. FURTHER DIVISION OF THE LIVER CANCERS INTO ANGIOSARCOMA IN=12 I AND OTHER LIVER CANCERS (N=7), BASEO ON REVIEN OF DEATH CERTIFICATES AND MEDICAL RECOROS , SHOWED THAT THE DOSE RESPONSE EXISTEO ONLY FOR ANGIOSARCOMAS. VCM)PVC DUST)ANALYSIS)HORKRS)EXPOSURE) 1997 20867008 BFG51927 data search on vca for craig algut Order ntdMr 901119-133Z45-MIZ -001-001 page 8 set 3 with 363 of 363 items 20867009 BFG51928 Item 22 ACCESSION NUMBER 3921 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT INCREASED ALKYLATION OF LIVER DNA AND CELL TURNOVER IN YOUNG VERSUS OLD RATS EXPOSED TO VINYL CHLORIDE CORRELATES WITH CANCER SUSCEPTIBILITY AUTHOR/AFFILIATION LAIB RJ,NONE(BOLT HM,NONE(CARTIER R,IARC(BARTSCH H,XARC| ORIGIN TOXICOLOGY LETTERS,VOL 45 PP.231-239 DATE 1989 DESCRIPTORS mmhmkhm VCM(CANCER)DNA (TRANSPLACENTAL CARCINOGEN(LXVER(EFFECTS( HELD TERNS OKA ALKYLATION) REVIEH YEAR 1997 Item 23 ACCESSION NUMBER 3919 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT l*N6-ETHEN0-2'-DEOXYADENOSINE AND 3 N4-ETHEN0-2-DEOXYCYTIDINE OETECTED BY MONOCLONAL ANTIBODIES IN LUNG AND LIVER DNA OF RATS EXPOSEO TO VINYL CHLORIOE. AUTHOR/AFFXLIATION EDERLE G>NONE(BAR8IN A,NONE(LAID RJ,NONE(CIROUSSEL FNONE(THOMALE J,NONE(BARTSCH H,NONE(RAJEMSKY MF,NONE) ORIGIN NONE,VOL 10 NO.1 PP.209-212) DATE 1989 DESCRIPTORS HHummit VCMlONAjCANCER lMUTAGENICITY) HELO TERMS MONOCLONAL ANTIBODIES)DNA ADDUCTSlCARCINOGENESIS: REVIEH YEAR 1997 Item 24 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HMMsmtit HELD TERMS REVIEH YEAR 3915 GEN REPORT VCM TOXICITY SLM1ARY. HINOERER RK,BFG) BFG( 1988 THIS SUftttRY NAS PREPARED TO ADDRESS IfMJNOTOXICITY ALLEGATIONS. VCM(CANCER(TOXICITY(BIRTH DEFECTS)LIVER)EFFECTS(ANGIOSARCOMA) imUNOTOXICITY )ACRO-OSTEOLYSISl 1997 Item 25 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 3903 GEN REPORT THE MUTAGENICITY AND CARCINOGENICITY OF VINYL CHLORIDE: A HISTORICAL REVIEH AND ASSESSMENT. data search on vets for craig elgut Order mdwr 901119-133295-NIZ -001-001 page 9 set 3 with 363 of 363 items AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS * HELD TERMS REVIEH YEAR NONE .NONE ( NONE.TECHNICAL REPORT NO.31) 1988 VCN(MUTAGENICITY(CANCER ECETOC 1997 Iten 26 ACCESSION NUIBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ! KMC INDEX NUtBER REVIEH YEAR 3882 GEN PROCEEDINGS CONFERENCE TO REEVALUATE THE TONICITY OF VINYL CHLORIDE, POLYVINYL CHLORIDE ANO STRUCTURAL ANALOGUES NONE,NONE( NIH.NITH NIOSH/NIEHS AS COSPONSORS) 1980, MARCH 20 VCM(PVC|HUHAN(EFFECTS(CHL0R1NATED HYDROCARBONS (MICE(RATS( 09763 1991 Item 27 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS nm HELD TERMS KHIC INDEX NUMBER REVIEN YEAR 3860 GEN PUBLICATION THE MUTAGENICITY OF VINYL CHLORIDE AFTER METABOLIC ACTIVATION fUUMJG U,NONE (JOHANSSON A,NONE(RAMEL C .NONE (KACHTMEISTER CA,N0NE> AMBIOiVOL 3 NO.5 PP.199-197) 1979 VCM(METABOLISM(MUTAGENICITY iIN VITROj ACTIVATION 01052 1991 Item 28 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS hhh KHIC INDEX NUIBER 3675 GEN PUBLICATION CONGENITAL CENTRAL NERVOUS SYSTEM MALFORMATIONS, KANAHHA COUNTY, NEST VIRGINIA NONE,NONE) CDC.EPI-76-60-2) 1976, JULY 26 DATA AVAILABLE THROUGH THE BIRTH DEFECTS HONITORING PROGRAM (BOMP) REVEALEO THAT FORM 1970 THROUGH 1979, KANAHHA COUNTY, NEST VIRGINIA-- NHERE 1 OF THE 90 POLYVINYL CHLORIDE PRODUCTION PLANTS IN THE UNITEO STATES IS LOCATED--HAD RATES OF CONGENITAL CENTRAL NERVOUS SYSTEM DEFECTS THAT HERE SIGNIFICANTLY HIGHER THAN NATIONAL BDMP RATES FOR THOSE YEARS. VCM(BIRTH DEFECTS(CNS(TERATOGENICITY (HUMAN(EFFECTS)EPIDEMIOLOGY) 02556 C08G70iO Os On data search on vcm for craig elgut Order rxerfoer 901119-133245-MIZ -001-001 page 10 set 3 with 363 of 363 item REV1EH YEAR 1991 Item 29 ACCESSION NOBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ihhhh KHIC INDEX NUMBER REVIEW YEAR 3873 GEN PUBLICATION THE EFFECT OF MATERNALLY INHALED VINYL CHLORIDE ON EWRYONAL FETAL AND POSTNATAL DEVELOPMENT IN RATS MIRKOVA EN0NE iHICHAILOVA A,N0NE)HI^0VA L,NONENASKO h,NONE I NONE) 1970 THE RESULTS SHOWED THAT VINYL CHLORIDE CAUSED AN INCREASED FETAL MORTALITY AND FREQUENCY OF HAEMORRHAGES AND A DECREASED FETAL WEIGHT. VINYL CHLORIDE WAS TERATOGENIC AT THE CONCENTRATION USED. TERATOGENIC EFFECTS CONSISTED OF EXTERNAL IENCEPHALOCELEI INTERNAL SOFT TISSUE ABNORMALITIES (HYDROCEPHALUS, BRAIN HAEMORRHAGES) AND SKELETAL MALFORMATIONS (DOUBLES OSSIFICATION CENTRES IN THE STERNUM). VINYL CHLORIDE PRODUCED ALSO BIOCHEMICAL AND FUNCTIONAL DISTURBANCES IN THE HOMEOSTASIS OF THE FETAL ORGANISM AND THE OFFSPRING. A DECEASED ACTIVITY OF THE DEHYOROGENASES--G6PDH,SUCDH,I-CDH,MDH,LDH AND AN INCREASED ACTIVITY OF GAMA-GTP MAS ESTABLISHED IN THE FETAL LIVER. VINYL CHLORIDE CAUSED AN INCREASED 66P0H AND I-CDH ACTIVITY IN THE FETAL BRAIN. THE INDEX OF FERTILITY AND GESTATION IN THE PROGENY HAS DECREASED. THE EXCRETORY* DETOXIFYING AND ENZYMIC FUNCTIONS OF THE LIVER* AS HELL AS THE NERVOUS SYSTEM HERE INJURED IN THE THREE GENERATIONS OF THE OFFSPRING. VCM(TERATOGENICITY)FETAL TOXICITY >INHALATIONjEMBRYOTOXICITY) 04056 1991 Iten 30 ACCESSION NUTBER 3870 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THE DYNAMICS OF VINYL CHLORIDE IMNXED ACROOSTEOLYSZS AUTHOR/AFFILIATION MYSLAK Z.NOtElGLUSZCZ M,N0NE ORIGIN UNUfOfM} DATE 1977 ABSTRACT THESE OBSERVATIONS SHOW THAT IN VC-INDUCED OSTEOLYSIS NO REAL LESION OF BONE STRUCTURE OCCURS* AND THAT THE ACROOSTEOLYSIS IS REVERSIBLE. DESCRIPTORS mmMMMM VCN>ACROOSTEOLYSIS>HUMANEFFECTS) HELD TERMS INSTITUTE OF OCCUPATIONAL MEDICINE> KHIC INDEX NUTBER 04057 REVIEN YEAR 1990 Iteti 31 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 3669 GEN PUBLICATION HISTOLOGICAL AND ELECTRON MICROSCOPE STUDIES UPON THE LONG-TERM TOXICITY OF VINYL CHLORIDE IN RATS* WITH SPECIAL REFERENCE TO LIVER CHANGES 20867011 BFG51930 data search on vcn for creig elgut Order ntnber 901U9-133245-HIZ -001-001 page 11 set 3 with 363 of 363 itens 20867012 BFG51931 AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS a****** HELD TERMS KHIC INDEX NUTOER REVIEH YEAR STETKIEHICZ J,N0NE(KOLAKOKSKI J,NONE(ZDRAJK0HSKA I,N0NEiSZENDZIKONSKI S,N0NE) UNCNQHN) 1977 VCM(INHALATION(RATSICHRONIC)EFFECTS(TOXICITYI INSTITUTE OF OCCUPATIONAL MEDICINE! POLANO H 04059 1990 Item 32 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALTTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS ewaamwi HELD TERMS KHIC INDEX NUTOER REVIEH YEAR 3666 GEN PUBLICATION METABOLISM OF VINYL CHLORIDE MONOMER IN THE LIVER OF RATS MISNIEHSKA-KNYPL JMN0NE(TARKONSKI S,NQNE(DRAMINSKI NNONE) UNKNOHN) 1977 VCM (METABOLISM (RATS I LIVER (INHALATION( INSTITUTE OF OCCUPATIONAL MEDICINE!POLANO)> 04060 1990 Item 33 ACCESSION NUTOER 3667 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT AMBIENT HATER QUALITY CRITERIA FOR VINYL CHLORIDE ALTTHOR/AFFILIATION NONE,NOt<l ORIGIN EPA,PB61-117869> DATE I960, OCTOBER ABSTRACT THE LEVELS HHICK MAY RESULT IN INCREMENTAL INCREASE OF CANCER RISK OVER THE LIFETIME ARE ESTIMATED AT 10-5,10-6, AND 10-7. THE CORRESPONDING RECOMMENDED CRITERIA ARE 20 UG/L, 2.0 UG/L, AND 0.2 UG/L, RESPECTIVELY. IF THE ABOVE ESTIMATES ARE MADE FOR CONSUMPTION OF AQUATIC ORGANISMS ONLY, EXCLUDING CONSUMPTION OF HATER, THE LEVELS ARE 5,246 UG/L, 5Z5 UG/L, AND 52.5 UG/L, RESPECTIVELY. DESCRIPTORS xhhmkkk VCM(HATER| KNIC INDEX NUTOER 04065 REVIEN YEAR 1990 Item 34 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 3863 GEN REPORT REVIEH AND AUOIT OF IBT NO. 663-03222, CHRONIC VAPOR INHALATION TOXICITY STUOY HITH VINYL CHLORIDE 1 ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS FOR THE MANUFACTURING CHEMISTS ASSOCIATION BOB HEST,NQNE( NONE,FOR IBT) data search on vcm for craig elgut Order nunber 901119-133245-HIZ -001-001 page 12 set 3 with 563 of 363 itens 208G7013 DATE DESCRIPTORS **** HELD TERMS KHIC INDEX NUMBER REVIEH YEAR 1980, APRIL IS VCM )INHALATION)RATS>MICE)HAMSTERS)CARCXNOGENICITY )CHR0NIC)TOXICITY ) AUDIT>008 WEST ASSOCIATES) 04593 1990 Itea 35 BFG51932 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** KHIC INDEX NUMBER REVIEH YEAR 3662 GEN REPORT EPIDEMIOLOGY STUDY ON VINYL CHLORIDE NORKERS AT SHAHINIGAN PLANT: FRENCH VERSION THERIAULT G>N0NE)ALLARD P,NONE) NONE) I960 VChiEPIDEMIOLOGY)HUMAN)EFFECTS) 04769 1990 Item 36 ACCESSION NUMBER 3B60 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT PATHOLOGY REPORT ON THE BRAINS FROM MICE,HAMSTERS, AND RATS EXPOSED TO VINYL CHLORIDE IN IBT STUDY 663-03222 AUTHOR/AFFILIATIQN NONE,NONE) ORIGIN NONE) DATE I960, MAY 14 DESCRIPTORS ******* VCM)BRAIN|MICE)RATSlHAMSTERS)INHALATION)CARCINOGENICXTY)CHRONIC)TOXXCITY) HELD TERMS EXPERIMENTAL PATHOLOGY LABORATORIES)AUDIT) KHIC INDEX NUMBER 04667 REVIEN YEAR 1990 Item 37 ACCESSION NUMBER 3859 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT VINYL CHLORIDE CARCINOGENICITY BIOASSAYS IBT PROJECT) AS AN EXPERIMENTAL MODEL FOR RISK IDENTIFICATION AND ASSESSMENT IN ENVIRONMENTAL AND OCCUPATIONAL CARCINOGENESIS AUTHOR/AFFILIATION HALTONI C,NONE)LEFEHINE G ,NONE)CILIBERTI A,NONE) COTTI G,N0NE)CARRETT1 D>NONE) ORIGIN NONE,MEETING HELD AT INSTITUT CURIE I PARIS,FRANCE)) DATE 1979, NOVEMBER 10 ABSTRACT ANGIOSARCOMA (1 AT 10 PPM INHALATION AND 1 AT 0.3 MG/HG ORAL AMO MORE AT HIGHER DOSES), EXTRA-HEPATIC ANGIOSARCOMAS, HEPATOMA, ZYfBAL GLAND CARCINOMA, NEPHROBLASTOMAS AND NEUROBLASTOMAS FOUND IN RODENTS EXPOSED TO VCM. DESCRIPTORS ******* VCM)CARCINOGENICITY) ANGIOSARCOMA )ZY)BAL GLAND)RATS)MICE)HAMSTERS) HELD TERMS HEPATOMA)NEPHR06LAST0MA )NCJROBLASTOMA)RODENTS) KHIC INDEX NUtBER 04712 data search on vcm for craig algut Order mdiar 901119-135245-NIZ -001-001 page 13 set 3 with 363 of 365 iiam REVIEH YEAR Itea 30 ACCESSION NLTCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *hhhh HELD TERMS KHIC INDEX NUtBER REVIEH YEAR 1990 3858 GEN PUBLICATION A COMMUNITY VINYL CHLORIDE MORTALITY ANALYSIS STUDY ITURRA H,LAVAL UNIY) NONE,SPECIAL KTG ON TOXIC SUBSTANCES IN THE AIR ENVIRONMENT) 1976 STUDY COMPARES THE MORTALITY PROFILE OF PEOPLE FROM A COftHJNITY EXPOSED TO VINYL CHLORIOE INTO ITS ENVIRONMENT WITH THE MORTALITY PROFILE OF A CONTROL COTMJNITY MATCHED FOR DEMOGRAPHY AND INDUSTRIALIZATION. THE TWO POPULATIONS DO NOT DIFFER BUT FOR MALES AGEO BETWEEN 20 AND 64. IN THIS LATTER GROUP, FIVE CANCER TYPES ARE MORE PREVALENT IN SHAHINIGAN THAN IN DRUMMOtttVILLE. THEY ARE CANCERS OF THE LIVER, THE PANCREAS, THE BRAIN, THE LUNG AND THE BLADDER. MORE STUDIES ARE NEEDED TO ASCERTAIN THE ORIGIN OF THESE CANCERS WHETHER IT IS THROUGH EXPOSURE AT NORK OR IN THE ENVIRONMENT. VCMtEPIDEMIOLOGY|CANCER)LIVER)BRAIN)LLNG)PANCREASt&LADDER) APCA) 04756 1990 Item 39 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS mwh HELD TERMS KHIC INDEX NUMBER REVIEH YEAR Item 40 3857 GEN PROCEEDINGS AN EPIDEMIOLOGY DESCRIPTION OF 10 CANADIAN CASES OF ANGIOSARCOMA OF THE LIVER DELORME F,NONEl NONE,SPECIAL MEETING ON TOXIC SUBSTANCES IN THE AIR ENVIRONMENT) 1976 TEN CASES OF ANGIOSARCOMA OF THE LIVER MERE DIAGNOSED AMONG HORKERS OF A VINYL CHLORIDE POLYMERIZING PLANT IN SHAHINIGAN, QUEBEC, SINCE 1974. AN EPIDEMIOLOGICAL QUESTIONNAIRE MAS COMPLETED BY MEETING HITH RELATIVES AM) FRIENDS OF THE CASES. THE PRESENT PAPER DESCRIBES THE OCCUPATIONAL HISTORY ALONG HITH THE ALCOHOL CONSUMPTION, THE SMOKING HABITS, THE PASSED DISEASES AND OTHER RELEVANT INFORMATIONS OF THESE INDIVIDUALS. FURTHERMORE, IT STUDIES THE RELATIONSHIP BETWEEN THE TIME OF FIRST EXPOSURE, THE DURATION OF EXPOSURE, THE MORPHOLOGICAL ASPECT OF THE HEPATIC LESIONS AND A BRIEF EXPOSITION OF THE PATHOGENESIS OF THE DISEASE. ANGIOSARCOMA)VCM)HU1AN)EFFECTS)EPIDEMIOLOGY) APCA) 04758 1990 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 3856 GEN PAPER HEALTH EFFECTS OF EXPOSURE TO VINYL CHLORIDE IN A CANADIAN COMMUNITY 20867014 BFG51933 data search on vcti for craig elgut Order nuiber 901119-133265-HIZ -001-001 page 16 set 3 with 363 of 363 itetns AUTHOR/AFFILIATION THERIAULT G,LAVAL UNIV* ORIGIN NONE,SPECIAL MEETING ON TOXIC SUBSTANCES IN THE AIR ENVIRONMENT) OATE 1976 ABSTRACT THE PURPOSE OF THE PAPER IS TO DESCRIBE BRIEFLY THE RESEARCHES THAT ARE GOING ON AT LAVAL UNIVERSITY ON THE HEALTH EFFECTS OF EXPOSURE TO VINYL CHLORIDE IN A CANADIAN COf*1UNITYtSHAHINIGAN). THE THREE MAIN STUDIES INCLUDE A DESCRIPTION OF THE 10 CASES OF ANGIOSARCOMA OF THE LIVER FOUND AMONG VC WORKERS IN CANADA A MORTALITY STUDY OF THE COMMUNITY EXPOSED TO VC AND A PROPOSAL FOR A BIRTH DEFECTS STUDY IN THE CONCERNED COMMUNITY. DESCRIPTORS ** VCM(ANGIOSARCOMA*BIRTH DEFECTS(HUNAN*EFFECTS* HELD TERMS APCA* KHIC INDEX NUPfeER 067S7 REVIEW YEAR 1990 Item 61 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FI LIATION ORIGIN DATE ABSTRACT DESCRIPTORS KHIC INDEX NUMBER REVIEW YEAR 3855 6EN JOURNAL MUTAGENICITY OF HASTE PRODUCTS FROM VINYL CHLORIDE INDUSTRIES RAMEL C,UNIV OF STOCKHOLM(RAMJUG U,SAME* J OF TOXICOLOGY AND ENVIROMIENTAL HEALTH,VOL 2 PP.1019-1029* 1977 THE RESULTS SHOWED THAT EDC-TAR CONTAINED DIRECT AS HELL AS INDIRECT MUTAGENIC CONSTITUENTS. VCM(MUTAGENICITY}IN VITRO(EDC >TAR* 06092 1990 Item 62 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIQN ORIGIN DATE ABSTRACT HELD TERMS REVIEW YEAR 3S66 GEN REPORT REASSESSMENT OF LIVER CANCER AMONG VINYL CHLORIDE NORKERS NONE,NONE* NONE,FOR CMA) 1989, FEBRUARY ATTEMPTED FOLLOH-UP OF 37 LIVER CANCER CASES IDENTIFIED IN EARLIER REPORT. INCOMPLETE DATA RECOVERY, BUT INCORRECT DIAGNOSIS IS INDICATED IN SOME CASES KITH A REDUCTION BUT NOT ELIMINATION OF STATISTICALLY SIGNIFICANT EXCESS. VCM * LIVER(CANCER 1 ENSR HEALTH SCIENCES* 1992 lien 63 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFF1LIATION 3833 GEN PUBLICATION TOXICITY OF VINYL CHLORIOE AND POLYtVINYL CHLORIQE): A CRITICAL REVIEW WAGONER JK,NONE| 20867015 BFG51934 data search an vcn for craig elgut Order number 901119-133245-NIZ -001-001 page 15 set 3 with 363 of 563 items ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ENVIR0M1ENTAL HEALTH PERSPECTIVES,VOL 52 PP.61-661 1963 THE TARGET ORGANS FOR VC NOHCLEARLY INCLUDE THE LIVER,BRAIN AND THE LUNG, AND PROBABLY THE LYMPHOHEHATOPOXETIC SYSTEM.THE EVIDENCE FOR A CARCINOGENIC RISK HAS BEEN EXTENDED TO JOBS ASSOCIATED HITH POLY<VINYL CHLORIDE) EXPOSURE. CASES OF LIVER ANGIOSARCOMA HAVE BEEN REPORTED AMONG INDIVIDUALS EMPLOYED IN PVC FABRICATION FACILITIES AND AN EPIDEMIOLOGICAL STUDY HAS DEMONSTRATED A SIGNIFICANT ASSOCIATION BETWEEN EXPOSURE TO PVC DUST ANO THE RISK OF LUNG CANCER MORTALITY. CASES OF ANGIOSARCOMA OF THE LIVER ALSO HAVE BEEN REPORTED AMONG INDIVIDUALS LIVING IN NEAR PROXIMITY TO VINYL CHLORIDE-POLYCVINYL CHLORIDE IPLANTS. AN ASSOCIATION BETWEEN PVC DUST AND PNEUMOCONIOSIS ALSO HAS BEEN DEMONSTRATED. ON THE BASIS OF FINDINGS, PRUDENT CONTROL OF PVC OUST IN THE INDUSTRIAL SETTING IS INDICATED. wwitJuni VINYL CHLORIOEPVC DUSTlLUNGS1CANCER)AOL) PNEUMOCONIOSIS1 1996 Item 64 ACCESSION NJTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILXATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEH YEAR 3797 gw CORRESPONDENCE report on the 1986 industrial direct discharges lan q,nor>e) NONE,TO BFG> 1988 AQUATIC TOXICITY iMUTAGENICITY EFFECTS VCMj BROCK UNIV) AQUATIC >TOXICITY | 1990 in ONTARIO: RESPONSE TO COMMENTS BY RK KINDERER. Item 45 ACCESSION NUtCER FILE LOCATION DOCUMENT TYPE TITLE OR SIAJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS KHIC INDEX NUtBER REVIEH YEAR Item 46 3763 GEN PUBLICATION ACROOSTEOLYSIS AND ASSOCIATED CUTANEOUS LESIONS IN TWO WORKERS INCURRED IN THE CLEANING OF AUTOCLAVES. CORDIER JM,NONEiFIEVEZ C,NONE)LEFEVRE MJ,NONESEVRIN A.NONEJ NONE,VOL.4 NO.l) 1966 TRANSLATION ACROOSTEOLYSISiVCH CAHIERS DE MEOECINE DU TRAVAIL) D4791 1996 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 3645 GEN PUBLICATION DISTRIBUTION OF PRIMARY CANCERS OF THE LIVER IN THE PROVENCE OF QUEBEC 20S6701S BFG51935 data search on vest for craig elgut Order number 90U19-1S3Z45-NIZ -001-001 page 16 set 3 with 363 of 363 item AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS **** HELD TERNS KHIC IN0EX NUFBER REVIEW YEAR JACOB PJ,N0NE(THERIAULT OP >NQNE( NONE,VOL 112 PP.305-307* 1975 VCM|HUMAN(EFFECTS(CANCER(LIVER(ANGIOSARCOMA) CNA J(CANADIAN MEDICAL ASSOCIATION J) 01650 1996 Item 47 ACCESSION NUMBER 3561 FILE LOCATION gen DOCUMENT TYPE report TITLE OR SUBJECT cohort and ease-control analyses of workers exposed to vinyl chloride - en t*>date. AlfTI I0R/AFFILIATION wu wnone)teenland knone)brawn d,none(wells v,none)jones j >none)*chulte p,none(helperin wnone) ORIGIN niosh, to bfg) DATE ABSTRACT 1988 there was an association between vea and liver cancer, however, there was no relationship between vea or pvc and brain or lmg cancer DESCRIPTORS cancer (liver ibraimltrigiangiosarcosia(vcn(pvc(hLman)af facts (apidaeiology REVIEW YEAR 1990 Itan 48 ACCESSION NUt-CER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ww REVIEW YEAR 3478 GEN CORRESPONDENCE VCH FOUND IN TOBACCO SMOKE ROEtCR CN,N0NE ( KELLER AND HECKMAN) 1968 IARC VOL 38 LISTS VCH IN TOBACCO SMOKE. VCNiTOBACCO SHOKE)COCUSTION)CANCER)TOXICITY) 1996 Item 49 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE REVIEW YEAR 3376 gen publication update to vinyl chloride Mortality study. 0AHAR KSDOH CHEN (BOND GG,DOH CHEN (MCLAREN EA,SAME ISABEL FL ,SAME[LIPPS TE,SAW,C0QKRR,SAME) journal of ocopatiansl Medicine, vol.30(6) pp.648-9) 1988 vcm (hunen (effects (epideniology(cancer (chronic 1996 Item 50 ACCESSION NUTOER 3375 20867017 BFG51936 dal* starch on vcm for craig elgut Order number 901119-133245-HIZ -001-001 page 17 set 5 with 363 of 363 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEN YEAR GEN PUBLICATION TOXICITY OF VINYL CHLORIDE-POLYVINYL CHLORIDE:A COMPILATION OF PAPERS PRESENTED AT A NYAS WORKSHOP VELTMAN G.NONE(LANGE CE.NONE(LILIS R.NONE(MILLER A>NONE(SUCIU I, NONE(BERK PDiNONE(SAKABE H.NONE) HYATT RH.NONE(CREECH JL.NONE(MARSTELLER HJ.N0NE( HEFNER RE.NOtClOSTER G.NONE(JAEGER RJN0NEt HAGNER ER.NONEiPRODAN L.NONE( VOLKHEIMER G.NONE(POPPER H.NONEiMALTONI C.NONE(KEPLINGER ML.NONE( NICHOLSON HJ.NONE(HEATH CH.NONEtSCHNEIDERMAN MA.NOTE(BYREN D.NONE( MANCUSO TF.NONE(VAN DUUREN BL. NONE)THOMAS LV.NONE(GAY BH.NQNEl SCHWEITZER GE.NONE(CORN M>NONEjROHE VK.NONE(PERKEL G,NONE BELICZKY L.NONE) JOHNSON CA.NONE(DOLL R.NONE(HEIHAW1) H.NONE( ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,VOL 246 PAPERS PRESENTED AT A WORKSHOP SPONSORED BY NYAS.ACS.NIEHS.NIH.SOCIETY FOR OCCUPATIONAL A HEALTH(MAY 10-11.1974) 1975. JANUARY 31 VOLUME CONTAINS FOUR PARTS: TOXICOLOGICAL INVESTIGATIONS OF VINYL CHLORIDE-POLYVINYL CHLORIDE VIA CLINICAL STUDIES. EXPERIMENTAL STUOIES.PATHOLOGY(CARCINOGENESIS ASSOCIATED WITH VINYL CHLORIDE VIA EXPERIMENTAL STUDIES. EPIDEMIOLOGICAL STUOIES.PATHOLOGY (ENVIRONMENTAL CONSIDERATIONS ( CONTROL AND MANAGEMENT. EPIDEMIOLOGY (VINYL CHLORIOE (VCM (PVC (TOXICITY (CARCINOGENICITY (MORTALITY ( 1996 Item 51 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTIIOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEN YEAR 3374 GEN PUBLICATION CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER.POLYIVINYL CHLORIDE) AND .STRUCTURAL ANALOGS: ENVIR0M1ENTAL HEALTH PERSPECTIVES (EHP) COMPILATION OF PAPERS PRESENTED ON VC PVC AND STRUCTURAL ANALOGS HAXHEILER PJ.NONE(KALTONI C.NONE(SUZUKI Y.NONE(GROTH DH.NONE(RADIKE MJ.NONE(HEHIR RH.NONE(HAGNER JC.NONE(INFANTE PF.NONE(HEBER H.NONE) COOPER HC.NONE(FALK H.NONE(BAXTER PJ.NONE(TAWURRO CH.NONE) WHEELER RN.NONE( JONES JH.NONE(CHIAZZE L.NONE(MOLINA G.NONE(MASTRANGLO G.NONEjLILIS R,NONE( JOHN JA.NONE (RICE JH.NONE (FABRICANT JD.NONE (HATCH M.NONE (OWtllCK HF.NONE) VIAFB4A NJ.NONE(CHU KC,NONE( APFELDORF R.NONE(HATTIS D>NONE( ENVIROMCNTAL HEALTH PERSPECTIVES.VOL 41 CONTAINS PAPERS FROM NIH CONFERENCE MARCH 20-2111980)( 1981. OCTOBER CONTAINS MOST EXTENSIVE ANIMAL RESEARCH ON THE CARCINOGENICITY OF VCM EVER PUBLISHED. DOSE-RESPONSE CURVES CAN BE EXAMINED BY SITE ANO TYPE OF TUMOR. BY ROUTE AND SCHEDULE OF EXPOSURE. AND BY SPECIES AND STRAIN OF ANIMAL. THE UPDATED EPIDEMIOLOGIC STUDIES PRESENTED IN THIS VOLUME OF MORTALITY AMONG WORKERS EXPOSED TO VC REINFORCE THE LABORATORY FINDINGS OF MULTISITE CARCINOGENICITY. DATA DEMONSTRATING THE MUTAGENIC AND TRANSPLACENTAL EFFECTS OF VCM ARE ALSO UPDATED ANO SUMMARIZED. THE CARCINOGENICITY OF PVC OUST IS EVALUATED BOTH EXPERIMENTALLY AM) EPIDEMIOLOGXCALLV IN THESE PROCEEDINGS. THE RESULTS ARE NOT DEFINITIVE. TOXICITY (VINYL CHLORIOE (PVC (RATS(MAN(EPIDEMIOLOGY(CARCINOGENICITY(INHALATION(MOUSE(LUNCS(EFFECTS( PVC DUST(RISK ASSESSMENT(VCM$ PNEUMOCONIOSIS: 1996 Item 52 ACCESSION NUMBER 3352 20867015 ,? G 5 1 9 3 1 CD data surch on vcm for craig elgut Order rndwr 901119-133295-HIZ >001-001 page 18 set 3 with 363 of 363 itaeis FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERNS REVIEH YEAR gon report report on the 1986 industrial direct discharges in Ontario.. lan q,nonet NONE T0 BFG) 1988 Master thesis draft AQUATIC TOXICITYthUTAGENICITYtEFFECTS|VCM) BROCK UNIV) 1990 Itea 53 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mwhh REVIEH YEAR 3351 gen publication fellow-1^) study on the carcinogenicity of vinyl chloride end vinylidene chloride in rets ebd Mice: tueor incidence end Mortality subsequent to exposure, hong cb,none)winston jmnonetthornburg lpnonetlee cc,none) J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,VOL.7 pp.909-929) 1981 vca)cenoer)RAT)effects 1996 I tan 59 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR 3350 gen report miawiiy risk assessment. downs td,nonet NONE,VOL 37 PP.118-129) 1978 VCM)HUMAN)RATS)EFFECTS)CANCER)RISK ASSESSMENT) TEXAS REPORTS ON BIOLOGY t MEDICINE) 1996 Item 55 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS KMXMmm HELD TERMS REVZEH YEAR 3337 gen report toxicological profile for vinyl chloride. none ,none ) NONE,FOR EPA> 1988 VCM)HUMAN)EFFECTS)RATS) TECHNICAL RESOURCES INC) 1990 208S7019 BFG51938 data search on vcm for craig elgut Order nuifaer 901119-133245-MIZ -001-001 page 19 sat 3 with 363 of 363 items Item 6 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE HELD TERMS REVIEM YEAR 3259 gen publication development of techniques to monitor for exposure to vinyl chloride: monoclonal antibodies ethenoadenos ine. yoing tl,noneisantella m,none> NONE,VOL 9 NO.6 PP.569-592s 1986 VCM^BIOLOGICAL MONITORING!RISK assessment CARCINOGENESIS! 1996 Iten 57 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 5238 gen publication study of mortality among chemical workers in the kanaiba valley of west Virginia, rinsky ra,none!ott g,none!ward e,noneigraanherg hnone!halperin H,none!leet t,none! american j of industrial medicine, vol 13 pp.629-436! 1988 increase in liver and lympo- and reticulosercoma seen in e cohort of 29,139 Mies, vcm!epidemiology!human!effeets!cencer!liver! LYMPHOPOIETIC! 1996 I ten 56 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 3207 GEN PUBLICATION EFFECT OF VINYL CHLORIDE ON TESTIS IN RATS BI H>NONE J HANG Y,N0NE|M HUANG,NONE !HENG D,N0NE! NONE,VOL 10 NO.3 PP.261-289! 1965 THE AUTHORS EXPOSED MALE RATS TO 0, 10, 100, 3000 PPM VCM, 6HR/D, 6D/9T FOR 12 MONTHS KITH OBSERVATION THROUGH 16 MONTHS. THIS WORK IS NOT HELL REPORTED. THEY INDICATE A DECREASE IN TESTICULAR ORGAN TO BOOY NT RATIO IS DUE TO VCM. HOWEVER, THIS EFFECT NAS SEEN ONLY AT 6 MONTHS, NOT AT THE 3 12, ANO IB MONTHS OBSERVATIONS. THIS SUGGESTS THAT THIS EFFECT MAY BE AN ARTIFACT RATHER THAN VCM-RELATED. THE AUTHORS COULD HAVE PERSUED THIS FURTHER BY COMPARING ORGAN TO BRAIN NT RATIOS. THE AUTHORS ALSO REPORT SEMINIFEROUS TUBULES DAMAGED (DISAPPEARANCE OF SPERMATIDS, SPERMATOCYTS) IN 3 CATAGORIES 10-50, 50-100, AND MORE THAN 100. THERE HAS AN INCREASE IN THE INCIDENCE OF ANIMALS HITH CHANGES AT 100 AND 3000 PPM, BUT THIS INCREASE APPEARED TO BE LIMITED TO LOH GRADE (10-50) CATEGORY BECAUSE THE RELATIVE OCCURRENCE IN THE 3 CATEGORIES DID NOT CHANGE NITH DOSE. THIS IN ITSELF MOULD SUGGEST THAT, IF COMPOUND RELATED, VCM MOULD NOT BE EXPECTEO TO CAUSE AND REPRODUCTIVE BECAUSE THERE IS NO EVIDENCE OF AN INCREASE IN SEVERITY OF DAMAGE HITH DOSE. IF THE AUTHORS HAO PROVIDED INFORMATION ON HHEN THESE CHANGES MERE OBSERVED (3, 6, 12, OR 20867020 BFG51939 dki saurch on vca for craig *lgut Order msnber 901119-133245-WIZ >001-001 page Z0 tai 3 with 363 of 363 itam DESCRIPTORS HELD TERMS REVIEN YEAR 16 MONTHS) IT MIGHT HAVE BEEN EASIER TO DETERMINE THE RELEVANCE OF THESE OBSERVATIONS TO VCM **** VCM>CHRONIC)EFFECTS>TESTESiREPRODUCTION) ECOTOXICOLOGY A ENVIRONMENTAL SAFETYjSPERMj 1996 Item 59 ACCESSION NUTOER 3203 FILE LOCATION gen DOCUMENT TYPE publication TITLE OR SUBJECT increasing evidence of the rise of cancer in workers exposed to vinylchloride. AUTHOR/AFFILIATION smulevich vbnone>fedotova ivnonefilatova vsnone> ORIGIN British j of industrial medicine* vol 45(2) pp.93-971 DATE 1986 ABSTRACT authors allege leukemias and lyephooae in the study group end the absence of angiosarcomas reflect the action of different levels of van. DESCRIPTORS > vcmtangiosarcoaatleuRamie lynphoma>canoer)hinasmeffacts > epidemiology REVIEN YEAR 1996 Item 60 ACCESSION NUmER 3201 FILE LOCATION gen DOCUMENT TYPE report TITLE OR SUBJECT potential effects of vinyl chloride on human offspring, AUTHOR/AFFILIATION none*nonet ORIGIN NONE t DATE 1967 ABSTRACT vos does not cause birth defects or miscarriages* but is of concern as e potential transplacental carcinogen. DESCRIPTORS VCM I BIRTH DEFECTS )REPRODUCTION>EFFECTS)CANCER)}IUMANt HELD TERMS VINYL INSTITUTE% REVIEN YEAR 1996 Itee 61 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS mkkmihui KHIC INDEX NUMBER REVIEW YEAR 3159 gen publication mortality study of workers in a polyvinyl-chloride production plant, duck bw*none)carter jt*none>coobas ej,nonet the lancet* pp.1197) 1975 1 case of angiosarcoma found in a cohort of 2100 workers exposed to vca for ip to 27 years, vcmtangiosareoma liver thtaoanteffacts 02613 1996 Item 62 2G867GZ1 BFG51940 data search on vcm for craig algut Order number 9Q1119-13326S-HIZ -001-001 paga 21 sat 3 with 363 of 363 items ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT KMIC INDEX NLMMER REVIEW YEAR 3166 gan publication angiosarcoma of tha livar among printers. Herbert jt.none) UNKNOtM) 1976 cases identified) possble link to vcm suggested. vcoMar>giosarcoma)livarihLmian)affacts 02331 1996 Item 63 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT HELD TERMS REVIEW YEAR 3129 gen publication vinyl chloride contamination: tha hidden threat, wolf k,none)holland rnonetrajaratnam e.none) NONE.VOL 15 PP.163-166) 1987 discusses vcm in ground water and sanitary landfills VCMlHATER) GROUND HATER)LANDFILL)J OF HAZARDOUS HASTEi 1996 Item 66 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT author/affiliation ORIGIN DATE ABSTRACT DESCRIPTORS MxmntiK REVIEW YEAR 3115 gan report literature search on pvc degredaTION. none,none) NONE,NONE* 1987 no evidence that pvc is degraded in soil or water to vcm)pvc)d0gradBtion)biodegrsdation)Mater 1990 Itom 65 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS imurn 3116 gan correspondence angiosarcoma case report. DRUCMRIGHT JR .NONE) NONE,TO BFGl 1987 angiosarcoma case in a pvc worker, vent *pvc)angiosarcoma*htinaneffacts 20S67OZ2 B ^G 51941 da4a search on vcm for craig algui Order mmfcer 901119-133245-HIZ -001-001 page 22 sat 3 with 363 of 363 iteas HELD TERMS REV1EH YEAR VISTA CHEMICAL CO) 1992 Item 66 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 3113 gen report literature search on the degradation of tee to vcm. none >none) NONE .NONE) 1967 tee is biodegraded to vcm. vcmtrichloroethylene)degrsdation)biodegradationiHATER) DIALOG INFORMATION SERVICES) GROUNDHATER)SOIL) 1994 Item 67 ACCESSION NUHJER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mmkxxww REVIEH YEAR 3112 gen LITERATURE SEARCH literature search vcm/reproductive effects. none.none) NONE .NONE) 1987 vcm)birth defectsi repreductionleffacts 1994 Item 66 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN ' DATE DESCRIPTORS *** REVIEH YEAR 3111 gen publication spontaneous abortions among women employed in the plastics industry. lindbohm m.nanelhemainki k.nona)kyyronan p.none) AMERICAN J OF INDUSTRIAL MEDICINE.VOL 8 PP.579-586) 1985 vcmibirth dsfeett)raproduction)KjRan)effects)apidsmiology)mutagenicity)teratogenicity 1994 Item 69 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 3110 gen publication the use end abuse of tibgmp analysis in epidemiological research. stallone ra.none) preventive medicine, vol 16 pp.163-194) 1987 20867023 BFG51942 data search on vein for craig elgut Order number 901119-133245-HIZ -001-001 page 23 set 3 with 363 of 363 items ABSTRACT critique of infante study of genetic risks of van. DESCRIPTORS mtussss vcmreproducticmbirth defectsiepidemiology)teratogenicity)hunen)effeet*)mutegenicity REVIEW YEAR 1994 Item 70 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS * REVIEW YEAR 3109 gen publication genetic risks of vinyl chloride. paddle (ptnanai the lancet* pp.1079* 1976* eay 15 VCHiBIRTH DEFECTS ^REPRODUCTION *EFFECTS*HUMAN*teratogenicity )mutagenicity)epidemiology 1994 Item 71 ACCESSION NUMBER 3108 FILE LOCATION gen DOCUMENT TYPE pchlicetion TITLE OR SUBJECT genetic risks of vinyl chloride. AUTH0R/AFFILIATI0N infente pf>niosh*wegoner jk*niosh)mc*ichael aj*niosh)wa>oeiler rj*niosh)falk h*niosh) ORIGIN the lenoet* pp.734-735) DATE 1976* epril 3 ABSTRACT AUTHORS REPORT EXCESS FETAL LOSS IN HIVES OF WORKERS EXPOSED TO VCM. HOWEVER* THESE RESULTS ARE QUESTIONABLE BECAUSE OF STUDY FLAWS (SEE MAC MAHON* 1977* VINYL CHLORIDE AND HUMAN REPRODUCTION AND DOWNS ET AL* 1977* VINYL CHLORI0E, BIRTH DEFECTS AN0 FETAL WASTAGE A CRITICAL REVIEW.) DESCRIPTORS *** vc**reproduction)birth defects(mutagenicity*hunan*effects*teratogenicity{epidemiology*FETAL TOXICITY* KH1C INDEX MJtBER 01669 REVIEW YEAR 1994 Item 72 ACCESSION NUt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS muuimm HELD TERMS REVIEW YEAR 3105 gen report literature search on vea ieuiutoxicity. none,none* N0NE*N0NE) 1987 vcm does not cause i--am deficiency. VCM* lM1UNOTaXICITY)IHMUNODEFICIENCY)DIALOG INFORMATION SERVICES) 1994 lien 73 ACCESSION NUt-BER 3098 208S70Z4 BFG51943 11 BFG51944 data search on vest for craig elgut Ordar manber 90U19-133245-MIZ -001-001 page 24 sot } with 363 of 363 itM 20867025 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AimiOR/AFFI LIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEM YEAR GEN GUIDELINES NATIONAL PRIMARY GRIMING HATER REGULATIONS FOR CERTAIN VOLATILE SYNTHETIC ORGANIC CHEMICALS--MONITORING FOR UNREGULATED CONTAMINANTS: FINAL RULE NONE NONE ) FEOERAL REGISTER,VOL 52 NO.130 PP.25690-25717) 1987, JULY 8 THE REGULATIONS SET MAXIMUM LIMITS OF 0.002 MILLIGRAM PER LITER OF VINYL CHLORIDE)0.005 MILLGRAM PER LITER FOR BENZENE,CARBON TETRACHLORIDE, 1,2-DICHLOROETHANE AND TRICHLOROETHYLENE)0.007 MILLIGRAM PER LITER FOR 1,1-DICHL0R0ETHYLENE>0.075 MILLIGRAM PER LITER FOR PARA-OICHLOROBENZEM:) AND 0.2 MILLIGRAM PER LITER FOR 11>1-TRICHLOROETHANE. THE REPORTING REQUIREMENTS REQUIRE PUBLIC MATER SYSTEMS TO REPORT MONITORING DATA TO STATES WITHIN SPECIFIED TIME PERIODS, AND THE PUBLIC NOTIFICATION PROVISIONS REQUIRE EACH PUBLIC MATER SYSTEM TO GIVE NOTICE TO PERSONS IT SERVES IF IT VIOLATES THE MCLS (MAXIMUM CONTAMINANT LEVELS) OR FAILS TO COMPLY WITH THE MONITORING REQUIREMENTS. TRICHLOROETHYLENE>CARBON TETRACHLORIDE>1,1,1-TRICHLOROETHANE>VINYL CHLORIDE)12-DICHL0R0ETHANE> BENZENE>l,l-DICHLOROTHYLENE>DRItttING MATER)MONITORING^CONTAMINANTS) NPDH>PARA-DICHLOROBENZENE) 1992 Item 74 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEW YEAR 3097 gen publication incidence of cencer among vinylchloride and polyvinylchloride workers: further evidence for an association with malignant melanoma, ten berge wf,none> BRITISH J OF INDUSTRIAL MEDICINE,VOL 44 NO.10 PP.718-719) 1987 vcm)cancer)humen>effects MELANOMA) 1994 Item 75 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTIIOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 3096 gen publication exposure to vinyl chloride monomer: report on a cohort study, laplanche a,none>elavel f,none>contassot j-c,rne>lanouziere cnone> BRITISH J OF INDUSTRIAL MEDICINE,VOL 44 NO.10 PP.711-715) 1987 vcm)huaan)effacts >epidemiology>engiosarcona 1994 Item 76 ACCESSION NUFBER FILE LOCATION 2970 gan data search on vcm for craig elgut Order number 901119-I33245-MIZ -001-001 page 25 sat 3 with 363 of 363 item* DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS Jounmaw HELD TERMS REVIEN YEAR publication affects of exposure to vinyl chloride; an assessment of the evidence. doll r,non*) NOtC,VOL 14 NO. 2 PP.61-78) 1986 review and critique of epidemiology studies of vcm exposed populations vcm t cancer >angiosarcoma)huean)effectsepidemiology SCANDINAVIAN J OR WORK ENVIRONMENT t HEALTH) 1996 Item 77 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 2967 gan publication a scientific basis for the riskassessment ofvinyl chloride. NONE .NONE > NONE,VOL 7 PP.120-127) 1987 risk assessments based onanimal and huaaan data are presented, it is concluded that continuous exposure to .001 mg/nl3) corresponds to a risk of 10(-6) per lifetime. vcm;cancer)risk assessmenttRATS)effactsihman REGULATORY TOXICOLOGY t PHARMACOLOGY) 1996 Item 76 ACCESSION NUtOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATI0N ORIGIN DATE ABSTRACT DESCRIPTORS ihhhhh REVIEN YEAR 2963 gen publication risk of angiosarcoma in workers exposed to vinyl chloride as predicted from studies in rats. GEHRXNG PJ.D0H CHEMICAL COlHATANABE PG.SAME)PARK CN.SAME) toxicology and appliad pharmacology, vol 49 pp.15-21) 1979 the predicted incidence of hepatic angiosarcoma using the probit nodal is 1.5x101-6). vcmrat)angiosarcoma)canear)risk assessment 1996 Item 79 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2038 GEN PAPER A MORTALITY STUDY OF VINYL CHLORIDE MONOMER H0RKERS EMPLOYED IN THE UNITED KINGDOM 1940-1974 JONES RD,NONE)THOMAS PGN0NE)SMITH DM,NONE) ICI) 1987, MAY 22 THE MORTALITY EXPERIENCE OF 5,496 MALE WORKERS EMPLOYED FOR AT LEAST ONE YEAR DURING 1940-1974 IN THE UK VINYL CHLORIDE INDUSTRY MAS FOLLOWED THROUGH TO DECEMBER 31, 1964. NON-SECONDARY LIVER TUMORS ACCOUNTED FOR 11 DEATHS, (11/1.94, P<0.001l OF WHICH 7 HERE ANGIOSARCOMAS. ALL 20867026 BFG51945 data search on vctn for craig elgut Order nunfcer 901119-133245-HIZ -001-001 page 26 net 3 with 363 of 363 item 20867027 DESCRIPTORS REVIEW YEAR ANGIOSARCOMA DEATHS OCCURRED IN AUTOCLAVE WORKERS WITH A MEDIAN LATENCY FROM DATE OF FIRST EXPOSURE OF 25 YEARS. A STRONG HEALTHY WORKER EFFECT MAS SEEN. OTHER THAN FOR THE LIVER, NO INCREASED INCIDENCE OF CANCER DEATHS ATTRIBUTABLE TO VCM EXPOSURE NAS FCUND. THERE NAS NO EVIDENCE OF INCREASED MORTALITY FROM CHRONIC LIVER DISEASE. THE INCIDENCE OF DEATH FROM RESPIRATORY DISEASE NAS LOW AND HAS NOT AFFECTED BY PVC DUST EXPOSURE. EPIOEMIOLOGYlVCMWORKERS(EFFECTS V 1995 Item 00 BFG51946 ACCESSION NUtftER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS REVIEW YEAR 2633 GEN PUBLICATION STUDY OF ILLWSSES DUE TO VINYL CHLORIDE SUCIU I ,NONE(DREJMAN I ,N0NE tVALASKAI M,NONE I NONE,VOL 50 NO.4 PP.261-271( 1967 EARLY DESCRIPTION OF THE EFFECTS OF HIGH EXPOSURES TO VCM. VCM(ACUTE (HUMAN(EFFECTS (SKIN(RAYNAUD'S SYNDROME (SCLERODERMA | LA MEDICINA DEL LAVORO( 1995 Item 01 ACCESSION NUt-BER 2700 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT AN UPOATE OF AN EPIDEMIOLOGY STUDY OF VINYL CHLORIDE WORKERS (1942-1902) AUTHOR/AFFILIATION HONG,NONEI ORIGIN CMA( DATE 1986, OCTOBER 17 ABSTRACT THE COHORT CONSISTED OF 10,173 MEN WHO HAD WORKED FOR AT LEAST ONE YEAR IN JOBS INVOLVING EXPOSURE TO VINYL CHLORIDE PRIOR TO JANUARY 1, 1973. THESE HEN HERE EMPLOYED AT 37 PLANTS IN THE U.S., BELONGING TO 17 COMPANIES. OBSERVATION OF THE MORTALITY EXPERIENCE OF THE COHORT NAS EXTENDED FROM DECEMBER 31, 1972 TO DECEMJER 31, 1982. A TOTAL OF 1536 COHORT HEWERS HERE IDENTIFIED TO HAVE DIED. THE OBSERVED MORTALITY, BY CAUSE, HAS COMPARED NITH THE EXPECTED BASED ON U.S. MORTALITY RATES, STANDARDIZED FOR AGE, RACE AND CALENOAR TIME. ANALYSES BY LENGTH OF EXPOSURE, LATENCY, AGE AT FIRST EXPOSURE, CALENDAR YEAR OF FIRST EXPOSURE AND TYPE OF PROOUCTS HERE PERFORMED. THE STUDY CONFIRMED THAT THE VINYL CHLORIDE WORKERS EXPERIENCED SIGNIFICANT MORTALITY EXCESSES IN ANGIOSARCOMA US DEATHS), CANCER OF THE LIVER AND BILIARY TRACT (SMR>641) AND CANCER OF THE BRAIN ANO OTHER CENTRAL NERVOUS SYSTEM ISMR=180). IN ADDITION, THE STUDY ALSO FOUND A SIGNIFICANT MORTALITY EXCESS IN EMPHYSEMA (SMR-179). ON THE OTHER HAND, THE STUDY DID NOT FIND ANY EXCESS IN EITHER RESPIRATORY CANCER OR LYMPHATIC ANO HEMATOPOIETIC CANCER. DESCRIPTORS VCM(PVC(HUMAN(EFFECTS(EPIDEMIOLOGY(ANGIOSARCOMA(CANCER(LIVER(BRAIN(CNS(EMPHYSEMA( HELD TERMS BILIARY TRACT( REVIEW YEAR 1995 Itea 82 ACCESSION NUMBER 2778 data search on vcm for craig elgut Order number 901119-133245-HIZ -001-001 page 27 set 3 with 363 of 363 items 20857 028 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *hhh REVIEH YEAR GEN REPORT MORTALITY STUDY OF 5000 VC MANUFACTURERS ZN NINE ITALIAN PLANTS BELLI ET AL,N0NE) NONE>NONEj 1986 INTERIM REPORT. PVC )VCM)EPIDEMIOLOGY HUHAN>EFFECTS*CARCINOGENICITY ) 1968 BFG5194J Item 83 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT Al/THOR/AFFI LIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEN YEAR 2619 GEN PUBLICATION VINYL CHLORIDE: AN ASSESSMENT OF THE RISK OF OCCUPATIONAL EXPOSURE PURCHASE IFH.NONE(STAFFORD J,NONE)PADDLE GM,ICI| NONE,VOL 25 NO.2 PP.187-202) 1987 ALTHOUGH PRECISE ESTIMATES OF EXPOSURE ARE NOT AVAILABLE FOR THE PERIOOS OF HOST INTEREST, THE PATTERN OF CASES ROUGHLY SUGGESTS THAT EXTREMELY HIGH EXPOSURES HERE NECESSARY FOR THE INDUCTION OF ANGIOSARCOMA OF THE LIVER (ASL). ANGIOSARCOMA)LIVER)VCM)RISK ASSESSMENT >OCCUPATIONAL EXPOSURE) 1992 Item 64 ACCESSION NlfrBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 2615 gen publication incidence of cancer among vinyl chloride end polyvinyl chloride worker* aeeociation with nalicnant melanoma, heldaa* *snone)andersen aa,none)langard s,nona) BRITISH J OF INDUSTRIAL MEDICINE,VOL 44 N0.4pp.278-2BO) 1987 vcm)pvo)ekin)human)effeet* 1995 further evidance for an Item 85 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS COMMENTS 2486 GEN PUBLICATION REVIEH OF PULMONARY EFFECTS OF POLY(VINYL CHLORIDE) AND VINYL CHLORIDE EXPOSURE LILIS R,N0NE) ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 41 PP.167-169) 1981 PVC DUST)PULMONARY FUNCTION)EFFECTS)VCM)CARCINOGENICITY) IMMUNOTOXICITY) RKHI87) DOCUMENT ON SHELVES. BFG51948 11 data search on vcm for craig elgut Order number 901119-133295-HIZ -001-001 page 26 set 3 with 363 of 363 items REVIEH YEAR 1995 Item 66 ACCESSION NUMBER 2965 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THE EFFECTS OF ORGANIC COMPOUNDS USED IN THE MANUFACTURE OF PLASTICS ON THE RESPONSIVITY OF MURINE AND HUMAN LYMPHOCYTES AIFTHOR/AFFILIATION THURMAN GB.NCNEiSIMMS BG,NONE>GOLOSTEIN AL,NONE|KILIAN DJ,NONE) ORIGIN TOX ANO APPLIED,VOL 99 NO.3 PP.617-691) DATE 1976 DESCRIPTORS ** VCM)HUMAN)HICE)EFFECTS) HELO TERMS IMIUNOTOXICITY) COMMENTS RKH187) DOCUMENT ON SHELVES. REVIEH YEAR 1995 Item 67 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS COTVIENTS REVIEH YEAR wmi 2989 GEN PUBLICATION IMMUNOLOGIC EFFECTS OF VINYL CHORIDE IN MICE SIIARMA RPNONE)GEHRING PJ.NONE) AhtULS OF THE NEN YORK ACADEMY OF SCIENCES,VOL 320 PP.551-563) 1979 METABOLITES OF VCM MAY BE REPSONSIBLE FOR THE STIMULATION OF LYWHOCYTE TRANSFORMATION OBSERVED IN SPLENIC CULTURES. VCM)MICElEFFECTS) IFHUMOTOXICITY) RKHC87) DOCUMENT ON SHELVES. 1995 Item 88 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *** HELD TERMS REVIEH YEAR 2962 GEN JOURNAL irtIUNOTOXICOLOGIC STUDIES KITH VINYL CHLORIDE IN RABBITS AND MICE SHARHA RP,NONElYAKEL HO,DON CHEMICAL CO)GEHRING PJ,SAME) NONE,VOL 2 PP.295-299) 1980 THE STUDY INDICATED THAT ALTHOUGH VCM MAY CAUSE AN APPARENT ENHANCEMENT OF ItMJNE REACTIVITY, IT DOES NOT ALTER THE IMMUNOLOGIC REPSONSE TO SIMULTANEOUSLY ADMINISTERED ANTIGENS. VCMjMICEiRABBITSlEFFECTS) IMMUNOTOXICITY | INTERNATIONAL J OF IfMMOPHARMACOLOGY) 1995 Item 89 20867029 li data search on vcm for creig elgut Order nunber 90U19-133245-HIZ -001-001 page 29 set 3 with 363 of 363 items ACCESSION NUMBER 2481 FILE LOCATION 6EN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION GENETIC SUSCEPTIBILITY TO SCLEROOERMA-LIKE SYNDROME INDUCEO BY VINYL CHLORIDE ALTTHOR/AFFZLIATION BLACK CM,NONE(HALKER AE>N0NE(CATOGGIO LJNONE(HELSH KI,NONE(BERNSTEIN LLOYD JONES JK,NONE\ ORIGIN THE LANCET> PP.53-55| DATE 1963 ABSTRACT VARIOUS ANTIGENS HERE OBSERVED IN WORKERS WITH "VCM DISEASE".' S DESCRIPTORS ***i VCM(HUMAN(EFFECTS(RAYNAUD'S SYNDROME) HELO TERMS IMMUNOTOXICITY ( REVIEW YEAR 1995 Item 90 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTIIOR/AFFILIATION ORIGIN OATE ABSTRACT HELD TERMS REVIEW YEAR > 2480 GEN PUBLICATION CHEMICAL INTERACTIONS AND COMPROMISED IMMUNE SYSTEM SHARMA RPN0NE( NONE,VOL 4 PP.345-351( 1984 THE imUNOSTIMULATING EFFECT OF VCM IS DISCUSSED. VCM(HUMAN(EFFECTS(MICEl IH1UNOTOXICITY>FUNDAMENTAL A APPLIED TOX( 1995 Item 91 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR i 2479 GEN JOURNAL HISTOCOMPATIBILITY ANTIGENS (HLA > IN DERMATOLOGY ROWELL NR,NONE( BRITISH J OF DERMATOLOGY,VOL 3 PP.347-357l 1984 VARIOUS ANTIGENS HERE FOUND IN PATIENTS WITH 'VCM DISEASE1. VCM(HUMAN(EFFECTS(RAYNAUD`S SYNDROME( XttIUNOTOXICITY ( 1995 Item 92 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 2478 GEN PUBLICATION THE imUNOTOXICITY OF SELECTED ENVIRONMENTAL CHEMICALS,PESTICIDES AND HEAVY METALS EXON JH,NONE( NONE,PP.355-368( 1984 ul I i 20867030 BFG51949 data search on vcm for craig elgut Order number 901119-133265-HIZ -001-001 page 30 set 3 with 363 of 363 item ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR A REVIEW OF STUDIES INDICATES THAT VCM CAUSES HYPERACTIVE HUMORAL ItflUNE RESPONSES AND APPEARANCE OF CIRCULATING IMMUNE COMPLEXES. VCMiHUMANlEFFECTS)RAYNAUD'S SYNOROME) IftIUNQTOXICITY >UNIV OF IDAHO ) 1995 I tea 93 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 2677 GEN PUBLICATION VASCULITIC PURPURA IN VINYL CHLORIDE DISEASE: A CASE REPORT KAGNAVITA N.NONEiBERGAHASCHI A,NONE(GARCOVICH A,NONEiGIULIANQ G,NONE) NONE,VOL 37 NO.5 PP.362-386) 1986 THE FINDING OF INCREASED CIRCULATING IMMUNE COMPLEXES AND ANTI-SMOOTH MUSCLE AUTOANTIBODIES STRENGTHENS THE HYPOTHESIS THAT IMMUNOLOGIC CHANGES PLAY A ROLE IN THE APPEARANCE OF 'VINYLIC PURPURA*. VCM)HUMAN>EFFECTS)RAYNAUD'S SYNDROMEl IMMUNOTOXICITY 1995 Item 96 ACCESSION NUMBER 2676 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CRYOGLOOUL1WHIA IN RAYNAUD'S PHENOMENON DUE TO VINYL CHLORIDE AUTIIOR/AFFILIATION LANGAUER-LEWOHICKA H,NONE)DUDZIAK Z,NOf* BYCZKOHSKA Z,NONE) ORIGIN DATE INTERNATIONAL ARCHIVES OF OCCUPATIONAL t ENVIRONMENTAL HEALT,VOL 36 PP.197-207) 1976 ABSTRACT RAYNAUD'S PHENOMENON HAS DESCRIBED IN 22 VCM POLYMERIZATION NORKERS. INCREASES IN IM1UN0PR0TEIN AND COMPLEXES HERE OBSERVEO. DESCRIPTORS *** VCN)HUMAN>EFFECTS)RAYNAUD'S SYNDROME) HELD TERMS IrtiUNOTOXICITY REVIEW YEAR 1995 Item 95 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS 2675 GEN JOURNAL IttIUNOLOGICAL MECHANISMS IN THE PATHOGENESIS OF VINYL CHLORIDE DISEASE WARD AM,NONElUONOON S.NONE)NATXINS J,NONEiWALKER AE,NONE>DARKE CS,NONC) BRITISH MEDICAL JOURNAL,VOL 1 PP.936-938) 1976, APRIL 17 IttIUNOLOGICAL INVESTIGATIONS REVEALED THE PRESENCE OF CIRCULATING IMMUNE COMPLEXES IN 19 OF 26 PATIENTS WITH 'VCM DISEASE' AND 2 OF 30 WORKERS WHO MERE EXPOSED TO VCM. VCHtllUMANiEFFECTSlRAYNAUO'S SYNOROME) imUNOTOXICXTY! 20867031 BFG51950 data itarch on vcn for craig algut Ordar nuabar 901119-133265-WIZ -001-001 paga 31 at 3 nith 363 of 363 itan REVIEW YEAR 1995 I ism 96 ACCESSION NUTBER 2659 FILE LOCATION DOCUMENT TYPE GEN PUBLICATION TITLE OR SUBJECT HEPAT0T0XICITY OF VINYL CHLORIDE AND 1,1-DICHLOROETHYLENE: ROLE OF MIXED FUNCTION OXIDASE SYSTEM. AUTHOR/AFFILIATION REYNOLDS ES,N0NEtMOSLEN MT,N0NE)SZABO S,N0NE)JAEGER RjNDNE(MURPHY SD,N0NE) ORIGIN UNCNOMO DATE 1975 DESCRIPTORS KMMMMMM VCM)VDC)METABOLISM)RATS) HELD TERMS HEPATOTOXICITY) REVIEW YEAR 1990 lien 97 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 2651 GEN REPORT A PROPORTIONAL MORTALITY STTJOY OF WORKERS EXPOSED TO VINYL CHLORIDE 1967-76. PASTERNACK BSN0NE) IMtNONN 1976 FIRESTONE POTTSTOM4 STUDY. VCM)EPIDEMIOLOGY )HUMAN)EFFECTS)CARCINOGENICITY 1990 Itan 98 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE HELD TERMS REVIEW YEAR Itan 99 2669 GEN REPORT imUNOPATHOLOGIC OBSERVATIONS IN LIVER ANGIOSARCOMA. ESPINOSA E>N0NE) UNIV OF LOUISVILLE) 1971 VCM i LIVERANGIOSARCOMA) HUMAN) EFFECTS ) IfflUNOLOGIC) 1990 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2666 GEN REPORT EVALUATION OF THE ENVIROTtlENTAL TOXICANTS VINYL CHLORIDE (VC) AND VINYLIDENE CHLORIDE. LEE CC, NONE>WINSTON JM,NONE)PETERS PJ,NONE)BHANDARI JCNONE)HODGSON JR,NONElHAGENSEN JH.NONE) REDDIG TW,NONE>ELLIS ER.NONE) 20867032 BFG51951 data search on vca for craig algut Order readier 901119-133245-HIZ -001-001 page 32 eat 3 with 363 of 363 items ORIGIN DATE NONE,FOR NIEHS) 1977 HELD TERNS REVIEW YEAR MIDWEST RESEARCH INSTITUTE ) 1990 Item 100 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE REVIEW YEAR 2646 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE/POLYVINYL CHL0RI0E WORKERS. SPIRTAS R,N0NE(KAMINSKI R,N0NE( J OF OCCUPATIONAL MEDICINE, VOL 20(6) PP.627-429) 1978 VCH(ANGIOSARCOMA ) HUMAN ( E F FECTS 1990 Item 101 ACCESSION NJICER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE HELD TERNS REVIEW YEAR 2645 GEN REPORT TEN CASES OF LIVER ANGIOSARCOMA EXPERIENCED IN WORKERS EXPOSED TO VCH. DERROD J,NONElLAZARD P,NONE)PIERR C,N0NE|PUECH AM,NONE)RAVIER E,NQNE)RETY J>N0NE)SMAGGHE G,NONE) NONE,AT DUBROVNIK ON 9/28/78> 1978 VCM(HUMAN(EFFECTS(ANGIOSARCOMA 19TH INTERNATIONAL OCCUPATIONAL MEDICINE CONFERENCE) 1990 Item 102 ACCESSION NUTOER FILE LOCATION DOCUMENT TYRE TITLE OR SUBJECT Ai/THOR/AFFILIATION ORIGIN DATE HELD TERNS REVIEW YEAR 2643 GEN REPORT EPIDEMIOLOGICAL STUDY OF VINYL CHLORIDE WORKERS. NC* .NONE) NONE,FOR CMA) 1978, JANUARY VCM(EPIDEMIOLOGY|HUMAN(EFFCTS(CARCINOGENICITY EQUITABLE ENVIRONMENTAL HEALTH INC) 1990 Itan 103 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 2642 GEN REPORT CRITIQUE OF CPSC VCM SINGLE EXPOSURE CANCER BIOASSAY IN RATS AND NICE. 20667033 BFG51952 data search on vcai for craig elgut Order nuiter 901119-133245-WIZ -001-001 page 33 set 3 with 363 of 363 items AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS REVIEW YEAR TOWEL.SON TR,DQH CHEMICAL CO) DOW CHEMICAL CO) 1979 VCM)RATS)MICE)INHALATION)CARCINOGENICITY 1990 Itee 104 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 2941 GEN PUBLICATION MORTALITY EXPERIENCE OF WORKERS IN A VINYL CHLORIDE MONOMER PRODUCTION PLANT. BUFFLER PA.NONE)HDOO S,NONE)EXFLER C,NONE(SUAREZ L>NGNE)KIL1AN DJiNONE) J OF OCCUPATIONAL MEDICINE V0L21I3) PP. 195-203) 1979 VCH)EPIOEMIOLOGYiCARCINOGENICITY)HUMAN(EFFECTS 1990 Item 105 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS whhhh HELD TERMS REVIEH YEAR 2440 GEN PUBLICATION SHORT-TERM INHALATION TOXICITY OF HALOGENATED HYDROCARBONS. JAEGER RJ>N0NE)C0f#40LLY RB.NONElMURPHY SD.NQNE) ARCH ENVIRON HEALTH,VOL 30 PP.26-31) 1975 CARBON TETRACHLORIDEVCM)INHALATION)RATS(LXVER(EFFECTS)l,l-DICHLOROETHYLENE) 11-DIFLUOROETHYLENE)2-CHLOROBUTADZENE)1,1-DIBR0M0ETHYLENE) 1990 Item 106 ACCESSION NUMBER 2430 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ANGIOSARCOMA OF THE LIVER: ANNUAL OCCURRENCE AND AETIOLOGY IN GREAT BRITAIN. AUTHOR/AFFILIATION BAXTER PJ,NONE) ANTHONY PP .NONE (MACSHEEN RW,NONE)SCHEUER PJ.NONE) ORIGIN BRITISH J OF INDUSTRIAL MEDICINE,VOL 37 PP.213-221) DATE 1980 ABSTRACT THE AM4UAL OCCURRENCE OF ANGIOSARCOMA OF THE LIVER IN BRITAIN FROM 1963 TO 1977 HAS STUDIED. 35 CASES HERE CONFIRMED. 8 CASES HERE ATTRIBUTABLE TO THOROTRAST AND 2 TO VCH. ONE CASE APPEARED TO BE ATTRIBUTABLE TO ARSENICAL INTOXICATION. DESCRIPTORS VCH(THOROTRAST)ARSENIC)ANGIOSARCOMA)HUMAN)EFFECTS HELD TERMS ARSENICALS) REVIEH YEAR 1991 Itam 107 ACCESSION NUTOER 2429 2086703^ BFG51953 data search on vcm for craig elgut Order mater 901119-133245-WIZ -001-001 page 34 sat 3 with 363 of 363 iteas FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR GEN PUBLICATION PROPORTIONAL MORTALITY AMONG VINYL-CHLORIDE WORKERS. MONSON RR,NONE(PETERS JH,NONE(JOHNSON tthNQNE) THE LANCET PP.397-3981 1974 A PROPORTIONAL MORTALITY STUDY OF 161 VCM WORKERS IS REPORTED. BILIARY TRACT * LUNG, AND BRAIN WERE NOTED VCMlHUMANiEFFECTSiEPIDEMIOLOGYiCARCINOGENICITY 1991 EXCESS CANCERS OF THE LIVER, Item 108 ACCESSION NUTBER 2428 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT IN VIVO OBSERVATIONS OF SKIN CAPILLARIES IN WORKERS EXPOSED TO VINYL CHLORIDE. AUTHOR/AFFILIATION MARICO HR,NONE(DARKE CS,NONE(ARCHIBALD RMCL,NONE(LEROY ECfNONE) ORIGIN BRITISH J OF INDUSTRIAL MEOICXNEVOL 35 NO.l PP.1-7) DATE 1978 ABSTRACT VCH-EXPOSEO EMPLOYEES FROM A PVC PRODUCTION PLANT IN ENGLAND NERE EXAMINED BY IN VIVO CAPILLARY MICROSCOPY. ABNORMALITIES HERE NOTED. DESCRIPTORS eWKKKKK VCMlPVC$IN V1VO)SCLEROOERMA) HELD TERMS CAPILLARY ABNORMALITIES) KNIC INDEX NUPBER 037S3 REVIEW YEAR 1990 Itea 109 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ** HELD TERMS KHIC INDEX NUPBER REVIEW YEAR 2427 GEN PUBLICATION THE BLASTOMOGENIC HAZARD OF VINYL CHLORIDE (A CLINICO-HYGIENIC AM) EPIDEMIOLOGICAL STUDY). FILATOVA VS,NONE( NONE,VOL 1 PP.28-31) 1982 VCM)PVC)HUMAN)EFFECTS)EPIDMIOLOGY)CARCINOGENICITY GIG.TR.PROF.ZABOL.) 05107 1990 Item 110 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 2426 GEN REPORT MORTALITY AND CANCER MORBIDITY IN WORKERS IN THE SWEDISH PVC-PROCESSING INDUSTRY HOUBERG BN0NE)ELQFSSON S,NONE)HOLMLUND L,NONE(MAASING R,NONE(MOLINA 6NONEiNESTERHOLM P,NONE) ICI,FOR APME MEETING IN SMEOEN) 1979 20867035 BFG51954 data taarch on vca for craig algut Order rxmfcer 901119-133245-HIZ -001-001 paga 35 sat 3 with 363 of 363 item* DESCRIPTORS ******* VCM)PVC)HUMANEFFECTSjEPIDEMI0L0GY)CARCIN0GENICITY KMIC INDEX NUTBER 05101 REVIEM YEAR 1990 Item 111 ACCESSION NUMBER 2924 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT INVESTIGATION OF THE DISEASES PRODUCED BY VINYL CHLORIDE. AUTKOR/AFFILIATION SUCIU INONE>DREJMAN I.NONEiVALASKAI M.NONE) ORIGIN MEDICINA INTERNA (BUCHAREST).VOL 15 PP.967-97B) DATE 1963 ABSTRACT EFFECTS NOTEO: NARCOTIC. EUPHORIA. ANEBRZATION. OYSPEPTIC DISTURBANCES. HEPATOMEGALY. SPLENOMEGALY. ACROOSTEOLYSIS. DERMATITIS. SCLERODERMA. DESCRIPTORS **** VCM)HUMAN)EFFECTS)ACUTE)CHRONIC>SCLEROOERHA)ACROOSTEOLYSIS KNIC INDEX NUTOER 05100 REVIEH YEAR 1990 Item 112 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** KHIC INDEX NUMBER REVIEW YEAR 2423 GEN PUBLICATION THE TOXICITY OF VINYL CHLORIDE AS DETERMINED BY REPEATED EXPOSURE OF LABORATORY ANIMALS. TORKELSON TR.NONE)OYEN F,NO*CROHE VK.NONEt J OF AIHA.VOL 22 NO.5 PP.354-361) 1961 VCmiNHALATIONlGUINEA P1GS)RATS)DOGSRABBITS)CHRONIC)EFFECTS 05099 1990 Item 113 ACCESSION NUMBER 2422 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION GEN PUBLICATION NJTAGENIC EFFECTS OF VINYL CHLORIDE ON DROSOPHIA MELANOGASTER WITH AND WITHOUT PRETREATMENT NITH SODIUM PHENOBARBITURATE. NAGNUSSON J.NONEiRAMEl C.NONE) ORIGIN DATE MUTATION RESEARCH. VOL 57 PP.307-3121 1978 ABSTRACT TREATMENT OF DROSOPHIA HALES WITH 1-20Z VCM IN AIR GAVE AN INCREASED FREQUENCY OF COMPLETE AND MOSAIC RECESSIVE LETALS. PRETREATMENT WITH PHENOBARBITURATE FOR 24 HR CAUSED AN INCREASE IN THE WTAGENIC EFFECT OF VCM. THIS INDICATES THAT THE MIXED FUNCTION OXIDASE SYSTEM CAN BE INOUCEO IN DROSOPHILA. DESCRIPTORS VCHiMUTAGENICITY)IN VIVO HELD TERMS DROSOPHILA) KHIC INDEXNUMBER 05097 REVIEH YEAR 1990 20867036 vT> \0 & vO O daia search on van for craig elgut Order nurfcer 901119-133245-HXZ -001-001 page 36 set 3 with 363 of 363 itens Itee 114 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS hhh HELD TERMS KHIC INDEX NUtBER REVIEH YEAR 2420 GEN PUBLICATION EXPERIMENTAL CHRONIC POISONING HITH VINYL CHLORIDE (MONOCHLOROETHENE). PRODAN LN0NE}SUC1U I,NON(PISLARU V,NONE)ILEA E,NONE)PASCU L,NONEl ANNALS OF THE NEM YORK ACADEMY OF SCIENCES*VOL 246 PP.159-163) 197S VCh EFFECTED GROHTH IN GUINEA PIGS. LESIONS >CRE OBSERVED IN THE LIVER KIDNEYS* SPLEEN* AND LUNGS. VITAMIN C REDUCED THE SEVERITY OF THE LESIONS. REVERSIBILITY OF HEPATORENAL LESIONS HERE OBSERVED HHEN EXPOSURE MAS INTERRUPTED. FIBROTIC LESIONS IN THE LUNG HERE OBSERVED. VCMlINHALATIONtGUINEA PIGS(CHRONIC VITAMIN C) 05042 1990 Item 115 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mwhm HELD TERMS KHIC INOEX NUFBER REVIEH YEAR 2419 GEN PUBLICATION EPIDEMIOLOGICAL STUDIES OF VINYL CHLORIDE HEALTH EFFECTS IN THE UNITED STATES. FALX H,NONE)HAXHEILER RJ,NONE( NONE*VOL 69 PP.303-305) 1976 VCM(HUMAN|EFFECTS)EPIDEMIOLOGY PROC.ROY.SOG.MED.lPROCEEDINGS ROYAL SOCIETY MEDICINE) 05040 1990 Iten 116 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS KHIC IWJEX NUMBER REVIEH YEAR 2417 GEN PUBLICATION CHANGES IN THE ARTERIES IN THE HAND AND FINGERS DUE TO VINYL CHLORIDE EXPOSURE. KOISCHHITZ D*NONE)MARSTELLER HJ,NONE)LACKNER K>NONE)BRECHT G,NONE(BRECHT T*NONE) NONEfVOL 132 NO.l PP.62-6B) I960 VCM)ACROOSTEOLYSIS)HUMAN)EFFECTS FORTSCHR GEB RONTGENSTR NUKLEARMED) 05007 1990 Item 117 ACCESSION NUMBER FILE LOCATION 2416 GEN 20867037 BFG 51956 data search on vcai -for craig elgut Order reedier 901119-133Z45-HIZ -001-001 page 37 set 3 with 303 of 363 itaee OOCUNEKT TYPE TITLE OR SUBJECT PUBLICATION ANGIOSARCOHES DU FOIE CHEZ DES OUVRIERS AYAHT ETE EN CONTACT PROLONBE AVEC LE CHLORURE DE VXNYLE: EPIDEHIOLOGIE ET PROGRAMME DE RESHERCHES CHEZ LES OUVRIERS. AUTHOR/AFFILIATION MARK LN0NE(DELORME F*NON)CREECH JL.BF6) ORIGIN NONE*VOL 104 PP. 1633-1835( DATE ABSTRACT 1975 ALL OF THE 1183 EMPLOYEES OF 01* OF TWO PLANTS HERE TESTED. THREE NEN CASES OF ANGIOSARCOMA HERE DISCOVERED. DESCRIPTORS ******* VCM(ANGIOSARCOMA(HUMAN(EFFECTS(EPIDEMIOLOGY HELD TERMS TOME) KNIC INDEX NUMBER 04989 REVIEN YEAR 1990 Item 118 ACCESSION NUteER 2915 FILE LOCATION GEN OOCUHENT TYPE PUBLICATION TITLE OR SUBJECT CHROMOSOMAL ANALYSES IN VINYL CHLORIDE EXPOSED HPRKERSl RESULTS FROM ANALYSIS 16 AND 42 MONTHS AFTER AN INITIAL SAMPLING. AUTHOR/AFFILIATION ANDERSON D,NONE (RICHARDSON CR,NQME (HEIGHT TM*NONE(PURCHASE IFtUNGNE (ADAMS HGF,NONE( ORIGIN MUTATION RESEARCH* VOL 79 PP.151-162) DATE I960 ABSTRACT THE AUTHORS REPORT THAT A REDUCTION IN EXPOSURE TO VCH HAS ACCOMPANIED BY A REDUCTION IN CHROMOSOMAL ABNORMALITIES IN WORKERS TO LEVELS INDISTINGUISHABLE FROM CONTROLS. DESCRIPTORS wmaaee* VCM(HUMAN(EFFECTS(WORKERS(MUTAGENICITY(CHROMOSOMAL ABNORMALITIES(LYMPHOCYTES HELD TERMS CHROMOSOMES) KHIC INDEX NUMBER 04988 REVIEW YEAR 1995 Itee 119 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS whhh HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2413 GEN PUBLICATION NEUROLOGICAL CHANGES IN VINYL CHLORIDE-EXPOSED WORKERS. STIBLOVA V*NONE(LAMBL VNONE(CHUMCAL 0>N0NE(KELLEROVA VNONE(PASKOVA V*NONE(VITOVCOVA J*NONE> ZLAB L*NONE( NONE*VOL 25 NO.3 PP.233-243) 1981 SOME OF THE NEUROLOGIC MANIFESTATIONS ARE CAUSED BY THE NARCOTIC ACTION OF VCH* SUCH AS CERTAIN SUBJECTIVE COMPLAINTS AND CEREBELLAR AND/OR VESTIBULOCEREBELLAR SYNDROME. THESE SYMPTOMS CAN BE TRANSITORY OR PERSISTENT. CHARACTERISTIC OF VCM ARE PERIPHERAL VASOMOTOR EFFECTS. LESIONS OF THE PERIPHERAL BLOOD VESSELS AND NEURONS HERE NOTED. ABNORMAL EEG HAS DISCUSSED. VCM(ACROOSTEOLYSXS(RAYNAUO *S SYNDROME(HUMAN(EFFECTS J OF HYGIENE *EPIDEMX0L06Y MICROBIOLOGY >lllt1UN0L06Y ( 04963 1990 20867038 BFG51951 data search on vcm for craig algut Order number 901U9-133245-HIZ -001-001 page 38 *at 3 with 363 of 363 items Item 120 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** KHIC INDEX NUMBER REVIEW YEAR 2412 GEN PUBLICATION MUTAGENICITY AND TERATOGENICITY OF VINYL CHLORIDE MONOMER (VCM). CLEtfiESEN J,N0NE( MUTATION RESEARCH, VOL 98 PP.97-100( 1982 VCM (EPIDEMIOLOGY iMUTAGENICITY 1TERATOGENICITY (HUMAN (EFFECTS 04982 1990 Iten 121 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUTOER REVIEW YEAR 2411 GEN PUBLICATION CHEMOTHERAPY OF VINYL CHLORIDE-ASSOCIATED HEPATIC ANGIOSARCOMA. DAFMAHER CLNONE(TAHBURRO CHNONE(YAM LT,N0N( CANCER, VOL 47 PP.466-469) 1981 SYSTEMIC CHEMOTHERAPY NAS STUDIED IN A GROUP OF FOUR PATIENTS MHO HAD VCM-ASSOCIATEO ANGIOSARCOMA. FURTHER INFORMATION IS NEEDEO FOR SPECIFIC RECOTflENOATIONS, BUT CHEMOTHERAPY DOES APPEAR TO BE OF VALUE. VCM(ANGIOSARCOMA(HUMAN(EFFECTS)CHEMOTHERAPY 04981 1990 Itam 122 ACCESSION NUTOER 2410 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CANCER MORTALITY OF A GROUP OF CANADIAN WORKERS EXPOSED TO VINYL CHLORIDE MONOMER. AUTKOR/AFFILIATION THERIAULT G,NONE(ALLARD P,NONE( ORIGIN J OF OCCUPATIONAL MEDICINE, VOL 23(10) PP.671-676( DATE 1981 ABSTRACT THE MORTALITY OF 451 VCM-EXPOSED WORKERS MAS COMPARED HTIH THAT OF 870 NONEXPOSEO WORKERS. THE RELATIVE RISK OF DIGESTIVE CANCER HAS ELEVATED BUT ALSO HIGHER IN THE GENERAL POPULATION. NO OTHER CANCER HAS IN EXCESS. DESCRIPTORS xxxxxn* VCM(HUMAN(EFFECTS(EPIOEMIOLOGY KHIC INDEX NUMBER 04976 REVIEW YEAR 1991 lien 123 ACCESSION NUMBER FILE LOCATION 2409 GEN 20867039 BFG51958 data search on vest for craig elgut Order nunfcer 901119-133245-HIZ -001-001 page 39 set 3 with 363 of 363 items DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mmumukm HELD TERMS KHIC INDEX NUtBER REVIEN YEAR PUBLICATION VINYL CHLORIDE MONOMER-INDUCED DISEASE: CLINICA, RADIOLOGICAL AND ItMJNOLOGICAL ASPECTS. GRAINGER RG,NQNE)HALKER AE.NONE)HARD AH>NONE) NONE.CHAPTER 11 PP.191-214) 1960 VCMHUMAN)EFFECTS INDUCED DISEASE:DRUG.IRRADIATION.OCCUPATION) 04973 1990 Item 124 ACCESSION NUMBER 2406 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION POWER CONSIDERATIONS IN EPIDEMIOLOGIC STUDIES OF VINYL CHLORIDE WORKERS. AUTHOR/AFFILIATXON BEAUMONT JJ.NONEiBRESLOH NE.NONE) ORIGIN AMERICAN J OF EPIDEMIOLOGY,VOL 114 NO.5 PP.725-734) DATE 1961 ABSTRACT WHEN POWER HAS TAKEN INTO CONSIDERATION* THE RESULTS FOR LIVER. LUNG* AND BRAIN CANCER HERE FOUND TO BE CONSISTENT NITH AN ETIOLOGIC ROLE FOR VCH. LUNG CANCER HAS NOT ASSOCIATED KITH VCH. DESCRIPTORS Jcmtxmtlt VCM)HUHAN)EFFECTS)CARCXN0GENIC1TY)LUNG)BRAIN) LIVER) EPIDEMIOLOGY KHIC IMDEX NUMBER 04965 REVIEH YEAR 1991 Item 125 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mhhhm* HELO TERMS KHIC INDEX NUWER REVIEM YEAR 2407 GEN PUBLICATION ANGIOSARCOMA OF THE PENIS WITH HEPATIC ANGIOMAS IN A PATIENT WITH LOW VINYL CHLORIOE EXPOSURE. GHAN0UR-CMAYI+4EHL,NONE |GONZALEZ MS.NONE) CANCER* VOL 47PP.1316-1324) 1981 VCH)ANGIOSARCOMA)BOOY PARTS)HUMAN)EFFECTS PENIS) 04960 1991 Item 126 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FI LIATION ORIGIN DATE ABSTRACT 2402 GEN PUBLICATION AN EPIDEMIOLOGICAL STUDY OF VINYL CHLORIDE EXPOSED WORKERS IN ITALY. BERTZZI PA.NONE)VILLA A.NONE)FOA VNONE)SAIA B.NONE)FADBRI LNONE)MAPP C.NONE jHARCER C.NONE) HAtf40 M.NONE)MARCHI M.NONE)MAR1ANI FNQNE)BOTTASSO F.NONE) NONE.VOL 30 PP.379-397) 1979 AMONG THE EXPOSED HORKERS WHO HAD DIED. A HIGH PERCENTAGE OF TUMORS AS CAUSE OF DEATH HAS 20867040 BFG51959 data search on vca for craig algut Ordar mmbar 901119-133245-NIZ -001-001 page 40 cat 3 with 363 of 363 itans DESCRIPTORS jhhhh HELD TERMS KHIC INOEX NUMBER REV1EN YEAR OBSERVED) 302 HERE OF THE LIVER AND BILIARY SYSTEM. THREE HERE ANGIOSARCOMAS OF THE LIVER. VCM)PVC)HUMAN)EFFECTS)EP1DEMI0L0GY ARH.HIG.RADA.TOXSIKOL.) 04955 1991 Ilea 127 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUTOER REVIEH YEAR 2400 GEN PUBLICATION VINYL CHLORIDE MONOMER LEVELS IN EOIBLE FATS. FUCHS G,NONE)GAFELL BM.NONE)ALBANUS L,NONE)SLORACH S,NONE> NONE,VOL 27 NO.3 PP.134-145) 1975 METHODS FOR ANALYSIS OF VCH IN EDIBLE FAT. VCM)ANALYSXS)FAT VAR FODA) 04634 1990 Itaa 128 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVIEH YEAR 2399 GEN PUBLICATION CHRONIC TOXIC LIVER DAMAGE IN THE CASE OF WORKERS IN PVC PRODUCTION. MARSTELLER HJ.NONEHELBACH HK,NONE)MULLER R,NONE)JUHE S,NONE)LANGE CE,NONE)ROHNER H6,N0NE) VELTMAN GjNONE) DEUTSCH MED NSCHR,VOL 98 PP.2311-2314) 1973 CLINICAL OBSERVATIONS ARE PROVIDED. PVC)VCM)CHRONIC)HUNAN)EFFECTS)LXVER 04633 1990 Itan 129 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS **** KN1C INDEX NLIttER REVIEH YEAR 2396 GEN PUBLICATION TIIE SO-CALLED VINYL CHLORIDE DISEASE. JUHE S,NOtC)LANGE CE.NONEISTEIN G,NONE)VELTMAN GNONE) DEUTSCH MED HSCHRVOL 43 PP.2034-2037) 1973 VCM)HUMANE F FECTS 04631 1990 20Qg7CMl BFG51960 data search on vcm for craig algut Order nuifcer 901119-133245-HIZ -001-001 page 41 set 3 with 363 of 363 itens Item 130 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT HELD TERMS KHIC INDEX NUTOER REVIEH YEAR 2397 GEN PUBLICATION VINYL CHLORIDE AND ANGIOSARCOMA. BLOCK JBiNONE* NONE,VOL 72 NO.9 PP.483-466) 1974 CLINICAL AND PATHOLOGICAL FINDINGS ASSOCIATED HITH ANGIOSARCOMA OF THE LIVER ARE DISCUSSED. DIAGNOSIS ANO TREATMENT ARE CONSIDERED. VCH>ANGIOSARCOMA>HUMANEFFECTS>PATHOLOGY J OF THE KENTUCKY MEDICAL ASSOCIATION 04830 1990 Item 131 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT Al/THOR/AFFILIATTGN ORIGIN DATE ABSTRACT DESCRIPTORS KHIC INDEX NUMBER REVIEH YEAR 2396 GEN PUBLICATION THE VALUE OF PREDICTIVE EXPERIMENTAL ENVIRONMENTAL CARCINOGENESIS AN EXAMPLE: VINYL CHLORIDE. HALTONI C,NONE> AMBIO, VOL 411) PP.16-23) 1975 STUDIES SHOH THAT VCM CAUSES CANCER IN RATS, MICE, AND HAMSTERS I ANGIOSARCOMA ANO POSSIBLY OTHER TUMORS). VCM>CARCXNOGENICITY)RATS)MICE)HAMSTERS)INHALATION)ANGIOSARCOMA)CHRONIC)EFFECTS 04828 1990 Item 132 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS aumuHUt KHIC INDEX NUMBER REVIEH YEAR 2395 GEN PUBLICATION HEPATIC ANGIOSARCONA IN A VINYL CHLORIDE NORKER. SMITH PM,NONE)HILLIAMS DMJ,NONE)EVANS DMD .NON!) BULL.N.Y.ACAD.HEO.,VOL 52 NO.4 PP.447-4521 1976 VCM) ANGIOSARCONA iHUMAN > E F FECTS 04827 1991 Item 133 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE 2394 GEN REPORT 20867042 BFG51961 data search on vcw for craig elgut Ordar nuabar 901119-133245-HIZ -001-001 page 42 3 with 363 of 363 itam TITLE OR SUBJECT AUTHOR/AFFILXATIQN NEOPLASTIC RISK AMONG VINYL CHLORIDE POLYMERIZATION WORKERS. HAXHEILER RJ, NONE(STRINGER HNONE(FALK HN0NE(CARTER C,NONE(JONES J,NONE (WAGONER JK,NOC( ORIGIN NONE.PRESENTED AT NYAS CONFERENCE > DATE ABSTRACT 1975 MARCH 25 PAPER PRESENTED AT NYAS CONFERENCE ON THE EXCESS CANCER INCIDENCES OF THE BRAIN, LUNG, AND LIVER OBSERVATIONS. DESCRIPTORS hhhh VCM(PVC)HUMAN(EFFECTS(CARCINOGENICITY (EPIDEMIOLOGY KHIC INDEX NUMBER 04625 REVIEW YEAR 1990 Itan 134 ACCESSION NUMBER 2393 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEMANGIOSARCOMA OF THE LIVER, CONNECTICUT. AUTHOR/AFFILIATIQN NONE,NONE) ORIGIN CDC,PUBLIC HEALTH SERVICE EPI-74-104-2) DATE 1974, OCTOBER 9 ABSTRACT FROM JANUARY 1935 THROUGH OECEMDER 1973, B CASES OF ANGIOSARCOMA OF THE LIVER MERE REPORTED TO THE COttJECTICUT TUMOR REGISTRY. DESCRIPTORS mum ANGIOSARCOMA *VCH)PVC*HUNAN (EFFECTS KMIC INDEX NUMBER 04823 REVIEW YEAR 1991 Itam 135 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIQN ORIGIN DATE ABSTRACT DESCRIPTORS KMIC INDEX NUMBER REVIEW YEAR lien 136 2392 GEN PUBLICATION EFFECT OF OCCUPATIONAL AM) NONOCCUPATIONAL FACTORS ON THE RESPIRATORY SYSTEM OF VINYL CHLORIDE AM) OTHER WORKERS. GAKBLE J,NONE*LIU S,NONE(MCMICHAEL AJ.NONE(HAXHEILER RJ.NONE) J OF OCCUPATIONAL MEDICINE, VOL 18(10) PP.659-670) 1976 VCM HAS NOT ASSOCIATED WITH CHRONIC RESPIRATORY EFFECTS. VCMlPVC(EPIDEMIOLOGY(HUMAN(EFFECTS*LUNG(RESPIRATORY EFFECTS 04818 1990 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 2391 GEN PUBLICATION RESOLUTION OF DOSE-RESPONSE TOXICITY OATA FOR CHEMICALS REQUIRING METABOLIC ACTIVATION: EXAMPLE-VINYL CHLORIDE. GEHRING PJ,DOH CHEMICAL CO)HATANABE PG,SAME(PARK CN.SAME) TOXICOLOGY AM) APPLIED PHARMACOLOGY, VOL 44 PP.581-591) 1978 20867043 BFG51962 data mrch on vca for craig algut Order nunfcar 901119-133245-HIZ -001-001 page 43 s*t 3 with 363 of 363 item ABSTRACT ASSUMING NO THRESHOLD IN SPITE OF EVIDENCE TO THE CONTRARY, EXTRAPOLATION OF THE DATA DELON THE RANGE OF DOSES CAUSING EXPERIMENTALLY OBSERVABLE RESPONSES PREDICTED AN INCIDENCE OF 0.012 HEPATIC ANGIOSARCOMA IN THE RATS EXPOSED TO 4.6 PPM OF VCM. THEORETICAL EXTENSION OF THE EXTRAPOLATION TO HUMANS AFTER ADJUSTING FOR METABOLIC AND BODY HASS DIFFERENCES HAS UNDERTAKEN. THE THEORETICAL EXTRAPOLATION FOR HAN EXPOSED DAILY FOR 8 HR TO 1 PPM SUGGESTS AN INCIDENCE OF 1.5 PER 100,000,000. THIS THEORETICAL INCIDENCE, ALTHOUGH A LIKELY OVERESTIMATE BECAUSE OF A LESS THAN PREDICTED INCIDENCE IN HEN EXPOSED TO 200 PPM AND GREATER, AS HELL AS EVIDENCE FOR A THRESHOLD IN RATS, IS LESS THAN THAT EXPECTED TO OCCURR SPONTANEOUSLY. DESCRIPTORS ******* VCM(RATS(HUMAN(PHARMACOKINETICS(CARCINOGENICITY(INCIDENCE( KHIC INDEX NUTOER 04816 REVIEW YEAR 1940 Itea 137 ACCESSION NUMBER 2390 FILE LOCATION DOCUMENT TYPE GEN PUBLICATION TITLE OR SUBJECT CHARACTERISTICS OF CASES OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE WORKERS IN THE UNITED STATES. AUTHOR/AFFILIATION HEATH CH,CDC)FALK H,CDC(CREECH JL,BFG( ORIGIN DATE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,VOL 246 PP.231-236) 1975 ABSTRACT A TOTAL OF 13 CASES OF ASL HAVE BEEN DOCUMENTED AMONG VCM WORKERS. AVERAGE LATENCY HAS 20.3 YRS. DESCRIPTORS wmnnuni VCH)PVC>HUMAN)EFFECTS)EPIDEKIOLOGY KHIC INDEX NUMBER 04815 REVIEW YEAR 1991 Item 138 ACCESSION NUMBER 2389 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MORTALITY EXPERIENCE OF A COHORT OF VINYL CHLORIDE-POLYVINYL CHLORIDE NORKERS. AUTHOR/AFFILIATION ORIGIN DATE NICHOLSON HJ,NONEHAtf10ND EC,NONE)SEIDMAN H,NONE (SELIKOFFIJ,NONE) ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,VOL 246 PP.225-230( 1975 ABSTRACT THESE DATA ARE DERIVED FROM EARLY FOLLOH-UP OF INDIVIDUALS EXPOSED FOR 5 OR MORE YEARS TO VCM IN A POLYMERIZATION FACILITY. AT LEAST IT/. OF THE DEATHS THAT OCCURRED HERE CAUSALLY RELATED TO EXPOSURE TO VCM. LONGER PERIODS OF OBSERVATION ARE REQUIRED TO PROVIDE INFORMATION CONCERNING THE FULL SPECTRUM OF VCM-INDUCED MALIGNANCIES AND THEIR INCIDENCE AMONG EXPOSED WORKERS. DESCRIPTORS ******* VCh)PVC)HUHAN|EFFECTS)EPIDENIOLOGY KHIC INDEX NUtOER 04814 REVIEH YEAR 1991 Item 139 ACCESSION NUCBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 2388 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN THE MANUFACTURE OF POLYVINYL CHLORIDE 20867044 BFG51963 data aaarch on vca for eroig algut Onkr nurif 901119-133245-MZ -001-001 pogo 44 3 Mifh 343 of 343 itaaa r 1 AUTH0R/AFFILIATI0N CREECH JL,BF6)JOHNSON tff.BFG) ORIGIN J OF OCCUPATIONAL MEDICINE, VOL 14(3) PP.150-151) 0ATE 1474 ABSTRACT THREE REPORTED CASES OF ANGIOSARCOMA OF THE LIVER SERVE AS AN ALERT TO THE PROBABILITY THAT THIS CONDITION HAY* IN SOME INSTANCES* BE CAUSALLY RELATED TO EMPLOYMENT IN THE MANUFACTURE OF POLYVINYL CHLORIDE RESINS. DESCRIPTORS VCMiPVC > ANGIOSARCOMA)HUMAN)EFFECTS)EPIDEMIOLOGY KMC INDEX NUMER 04411 REVIEM YEAR 1941 Itan 140 ACCESSION NUMER FILE LOCATION DOCUMHT TYPE TTTLE OR SUBJECT AUTH0R/AFFXL1ATI0N ORIGIN DATE ABSTRACT DESCRIPTORS aHH HELD TERMS KMC INDEX NUMBER REVIEN YEAR E387 GEN PUBLICATION CLINICAL ANO MORPHOLOGICAL FEATURES OF HEPATIC ANGIOSARCOMA IN VINYL CHLORIDE HORKERS. MARK L*NQNE)DELORME F,NONE ICREECH JL.NONE)OGDEN Ll>NONE)FADELL EH,NONE)SONGSTER CLNONE)CLANTON J .NONE)JOHNSON M4*NONE)CHRXSTOPHERSON )#1,NQNE) CANCER* VOL 37(1) PP.149-143) 1974 FIFTEEN HALE HORKERS EXPOSED TO VCH DEVELOPED ANGIOSARCOMA OF THE LIVER. VCH)ANGIOSARCOMA)H(JMAN)EFFECTS)EPIOEMIOLOGY) HEPATOMEGALY)SPLENOMEGALY) 04010 1991 Itaa 141 ACCESSION NUKER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS mmw KMC INDEX NUWER REVIEM YEAR 344 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER FOLLOMNG VINYL CHLORIDE EXPOSURE. BLOCK JB'NONE) JAMA* VOL 29 PP.53-54) 1974 ANGIOSARCOMA OF THE LIVER IS REPORTED IN SIX VCM-EXPOSED HORKERS. VCMlANGlOSARCOMA ) HUMAN lEFFECTS) LIVER 04409 1990 I4m 142 ACCESSION NUMER PILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 345 BEN PUBLICATION MMTORIN6 LIVER DISORDERS IN VINYL CHLORIDE MONOMER HORKERS USING GREYSCALE ULTRASONOGRAPHY. MLLIAHS DMJ*NONE)SMITH PMiNONE)TAYLOR KJN.NONE)CROSSLEY IR*NONE)DUCK BN*NQNE BRITISH J OF INDUSTRIAL MEDICINE,VOL 33 PP.152-157) i 1974 1 ULTRASONOGRAPHY SHOMS SOME ADVANTAGES. 20867045 BFG51964 diia March on vcm for craig algui Order raadwr 901119-133245-MIZ -001*001 page 4S Mi 3 with 343 of 343 itM 1 DESCRIPTORS mwrww VCM (PVC (HUNAN I EFFECTS (DETERMINATION (CARCINOGENICITY) LIVER RMZC INDEX NUMBER 04794 REV!EM YEAR 1990 Xtas 143 ACCESSION NIIBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS KHIC INDEX MtER REVIEH YEAR ISM GEN PUBLICATION BREAST CANCER MORTALITY AMONG PVC FABRICATORS. CHIAZZE L.NONElMQNG 0,N0NE| NICHOLS HE.NONE( FERENCE LO,NONE( J OF OCCUPATIONAL MEDICINE* VOL 22(101 PP.477-6791 I960 A CASE-CONTROL ANALYSIS OF BREAST CANCER DEATHS AMONG PVC FABRICATORS IS PRESENTED. THIS STUDY IS AN EXTENSION OF A CROSS-SECTIONAL MORTALITY STUOY OF DEATHS OCCURRING AMONG 17 PVC FABRICATORS (1944 TO 1973). RELATIVE RISK ESTIMATES HERE DERIVED ANO TESTED. ALTHOUGH NO STATISTICALLY SIGNIFICANT RELATIVE RISKS HERE FOUND. A LEAST SIGNIFICANT RELATIVE RISK MOULD HAVE TO BE ON THE ORDER OF THREE TO ONE IN ORDER TO BE DETECTED. THERE DOES SEEN TO BE REASONABLE ASSURANCE THAT VERT LARGE INCREASES IN RISK FOR BREAST CANCER DO NOT EXIST AMONG THESE PVC FABRICATORS. PVC(VCM(CARCINOGENICITY(HUMAN[EFFECTS(BREAST[CANCER(EPIDEMIOLOGY 047B3 1991 Itaa 144 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS mw HELD TERMS KHIC INDEX NUTOER REVIEM YEAR 2363 GEN REPORT REPORT ON m. JOHN GRASSO. EPSTEIN SS.NONE( NQNEBV SAMUEL S. EPSTEIN) I960 TESTIMONY IN GRASSO VS BFG. VCHl ANGIOSARCOMA) LITIGATION) 04723 1990 Ita 14S ACCESSION NUMBER FILE LOCATION Doatexr type TITLE OR SUBJECT AUTHOR/AFFILXATXON ORIGIN DATE DESCRIPTORS mw KMEC INDEX NUMBER 23B2 GEN PUBLICATION COMPARATIVE HAMALIAN METABOLISM OF VINYL AND VINYLIOENE CHLORIDES IN RELATION TO ONCOGENIC POTENTIAL. HATHNAY DE.NONE) ENVUKMCNTAL HEALTH PERSPECTIVES,VOL 21 PP.E5-59) 1977 i VCMlHETABOLISH 04716 2086704G BfG 51965 data search on vcn for craig algut Order mefaer 901119-133245-MIZ -001-001 page 96 sat 3 with 363 of 363 itans REVIEW YEAR 1990 Itan 196 ACCESSION NUTOER 2381 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THE CHEMISTRY AND BIOGENESIS OF THE S-CONTAINING METABOLITES OF VINYL CHLORIDE IN RATS. AUTHOR/AFFILIATION GREEN T,NONE*HATHHAY DE.NONE) ORIGIN NONE>VOL 17 PP.137-150* DATE 1977 ABSTRACT ADMINISTRATION OF SEVERAL VCN HETABLOITES AND CLOSELY RELATED COMPOUNDS TO RATS SHOWS THAT CHLOROACETALDEHYDE AND S-CCARBOXYMETHYL )-CYSTEINE BUT NOT CHLOROACETIC ACID, LIE ON A PATHWAY OR PATHWAYS CONNECTING VCM WITH THIOOIGLYCOLLIC ACID. DESCRIPTORS VChlORALtMETABOLISMlRATS HELD TERMS CHEMICAL-BIOLOGICAL INTERACTIONS* KHIC INDEX NUMBER 09717 REVIEW YEAR 1990 I tan 197 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS WHhhh HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2380 GEN REPORT THE REGULATION OF VINYL CHLORIDE: A CASE STUDY OF THE IMPACT AND IMPLICATIONS OF THE OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970. OUTLAW RC,NONEPERRY CR.NONE* NONE* 1977 VCMJOSHA*ANALYSISl UNIV OF PENNSYLVANIA* 09707 1990 Itan 198 ACCESSION NLt-BER 2379 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT EFFECTS OF VINYL CHLORIDE EXPOSURE ALONE AND IN COtOINATION KITH TRYPAN BLUE-APPLIED SYSTEMATICALLY DURING ALL THIRDS OF PREGNANCY ON THE FETUSES OF CFY RATS. AUTHOR/AFFILIATION UNGVARY GY.NONEiHUDAK A.NONEtTATRAI ,NONE*LORINCZ M,NONE*FOLLY G.NONE* ORIGIN NONE,VOL II PP.95-59) OATE 1978 ABSTRACT VCM HAS FOUND TO CROSS THE PLACENTAL BARRIER. NO TERATOGENIC EFFECT HAS FOUN IN RATS FETAL MORTALITY AND EMBRYOTOXICITY HERE ONLY OBSERVEO DURING THE FIRST TRIMESTER. DESCRIPTORS muimn VCMjRATSjTERATOGENICITYjFETAL TOXICITY*EFRYOTOXICITYj HELD TERMS TOXICOLOGY*PLACENTAL TRANSFER* KHIC INOEX NUtOER 09706 REVIEW YEAR 1990 INCREASED 20867047' BFG51966 data search an vcn for craig algut Order number 90U19-133245-HIZ -001-001 page 47 sat 3 with 363 of 363 itaas 20867C48 ,F G 5 1 9 6 '7 Itan 149 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATICN ORIGIN DATE ABSTRACT DESCRIPTORS whhh KHIC INDEX NUMBER REVIEH YEAR 2377 GEN PUBLICATION MORTALITY EXPERIENCE OF NORKERS EXPOSED TO VINYL CHLORIDE MONOMER IN THE MANUFACTURE OF POLYVINYL CHLORIDE IN GREAT BRITAIN. FOX AJ,NONE)COLLIER PFN0NEi BJIM> VOL 34 PP.1-10> 1977 IN A STUDY OF 7000 PVC POLYMERIZATION NORKERS FOUR CASES OF LIVER CANCER HAS FOUND. TMO HERE ANGIOSARCOMAS. ONLY LIVER CANCERS HERE ASSOCIATED HITH EXPOSURE TO VCM. THE TMO CASES OF ANGIOSARCOMA HERE IN MEN HHO HAD BEEN EXPOSED TO HIGH CONCENTRATIONS OF VCM. VCM(ANGIOSARCOHA(EP!OEMIOLOGY(LIVER(CANCER(HUMAN(EFFECTS 04646 1990 Itea 150 ACCESSION NUBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS hhh HELD TERMS KHIC INDEX NUMBER REVIEH YEAR 2376 GEN PUBLICATION INDUCTION OF GENE MUTATIONS AND GENE CONVERSIONS BY VINYL CHLORIDE METABOLITES IN YEAST. LOPRIENO NN0NE(BARALE R.NONE(BAROMCELLI S,N0NE(BARTSCH H.NONE(BRONZETTI G.NONE(CATNELLINI C. NONE(CORSI C.NONE(FREZZA D*NONE(NIERX R.NONE(LEPORIN1 C,NONE>ROSELLINI D*NONE(ROSSI AM.NONEt CANCER RESEARCH* VOL 36 PP.253-257( 1977 CHLOROETHYLENE OXIDE INDUCED FORHARD MUTATION IN SCH. POtBE AND GENE REVERSION IN S. CEREYISIAE. 2-CHLOROACETALDEHYDE SHOWED ONLY FEEBLE GENETIC ACTIVITY. 2-CHLOROETHANOL HAS COMPLETELY INACTIVE. VCM>HUTAGENICITY(CHLOROETHYLENE OXIDE(2-CHLOROACETALDEHYDE} 2-CHLOROETHANOL(YEAST( 04645 1990 Item 151 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS WWMHMH HELD TERMS KHIC INDEX NUtBER REVIEH YEAR 2375 GEN REPORT VINYL CHLORIDE* BIRTH DEFECTS* ANO FETAL HASTAGE: A CRITICAL REVIEH. DOWS TD,NONE (STALLONES RAiNONE (FRAMtOHSKI RF N0NE (LABARTHE OR .NONE ( N0NE( 1977 VCM(REPRODUCTION(BIRTH DEFECTS(TERATOLOGY(FETAL TOXICITY(HUHANlEFFECTS SPI(SOCIETY OF PLASTICS INDUSTRY( 045B8 1990 data search on va* tor craig elgut Order number 901U9-133245 NIZ >001-001 page 40 set 5 with 365 of 363 item Itee 152 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHQR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS hhhh HELD TERMS KNIC INDEX NUPBER REVIEN YEAR 2374 GEN REPORT TOXICOLOGY* CARCINOGENICITY AND REPRODUCTIVE EFFECTS OF SINGLE AND MULTIPLE EXPOSURES TO VINYL CHL0RI0E IN RATS AND NICE. HEHIR RNN0NE I MCNAMARA BPN0NE(MCLAUGHLIN J,NONE (HIILIGANOA.NONE(BIERBOHER G,NOT(HARDISTY JF* NONE ) NONE) I960 AUTHORS REPORTED AN INCREASED INCIDENCE OF PULMONARY ADENOMAS AND CARCINOMAS IN NICE EXPOSED TO 5000 AND 50*000 PPM VCM FOR ONE HOUR. ANIMALS HERE EXPOSED THEN HELD FOR ONE 18-24 MONTHS. NO TUHORIGENIC RESPONSE NAS OBSERVED IN RATS. VCMVINHALATION)DOSE EFFECTS)CARCIN0GENICITY)HICE)RATS)ADEN0MA)CARC1N0HA) PULMONARY ADENOMAS) CPSC) 04576 1990 Item 153 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELO TERMS KHIC INDEX NUMBER REVIEW YEAR 2371 GEN PUBLICATION COMPARISONM OF THE FATE OF VINYL CHLORIDE FOLLOMING SINGLE AND REPEATED EXPOSURE IN RATS. HATANABE PG.DOH CHEMICAL CO)ZEMPEL JA,SAME)GEHRING PJ.SAME) TOXICOLOGY AND APPLIED PHARMACOLOGY* VOL 44 PP.391-399) 1978 COVALENT BINDING TO HACROMOLECULES NOTED. VCM(METABOLISM)INHALATION)SUBCHRONIC)COVALENT BINDING) MACROMOLECULES) 04321 1990 Item 154 ACCESSION NUMBER FILE LOCATION 2370 GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CHROMOSOMAL ANALYSES IN VINYL CHLORIDE-EXPOSED NORKERS. AUTHOR/AFFILIATION PURCHASE IFHICI(RICHARDSON CR,ICI|ANDERSON DICI)PADDLE GM*ICI)ADAHS HGF*ICI) ORIGIN DATE MUTATION RESEARCH* VOL 57 PP.325-334) 1978 ABSTRACT THERE HAS A SIGNIFICANT INCREASE IN CHROMOSOMAL ABNORMALITIES IN THE EXPOSED NORKERS HHEN COMPARED TO CONTROLS. DESCRIPTORS **** VCH>HORKERS)HUMAN)EFFECTS (CHROMOSOMAL ABERRATION(MUTAGENICITY KHIC INDEX NUPBER 04320 REVIEM YEAR 1990 20867049 BFG 51968 data search on vcm tor craig elgut Order nunber 901119-133245-MIZ -001-001 page 49 set 3 with 363 of 363 item* 20867050 B FG 51969 lien 155 ACCESSION NUrfiER 2369 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEPATO-SPLENIC ANGIOSARCOMA I PRESENTATION OF A REVIEH OF THE LITERATURE. AUTHOR/AFFILIATION LIBESKIND MN0NE)LUGAGNE F,N0NE)MALBRAN J*NONEVILLEMANT J-F,NONE)GUYET-ROUSSET P.NONE) ORIGIN NONE,VOL.I PP.1027-10341 DATE 1977 ABSTRACT THE AUTHORS REPORT THE CASE OF AN ADULT PATIENT KITH ANGIOSARCOMA OF THE LIVER AND SPLEEN.FROM THIS OBSERVATION AND THE OTHER REPORTED CASES (ABOUT 150) IN THE LITERATURE, THE AUTHORS DELIEATE THE CLINICAL FEATURES AM) THE COUSE OF THIS TUMOR. VCM HAS REPORTED AS THE CAUSE IN MOST CASES BUT NOT THIS REPORTED CASE. DESCRIPTORS **** VCM)ANGIOSARCOMA )HUMANEFFECTS)LIVER HELD TERMS GASTROENTEROLOGY CLINICAL BIOLOGY) KHIC INDEX NUTOER 04318 RCVIEN YEAR 1990 Itea 156 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS mmmkm KHIC INDEX NUWER REVIEH YEAR 2368 GEN REPORT LUNG CANCER AT A POLYVINYL CHLORIDE IPVC) POLYMERIZATION FACILITY. FALK H,NONE)HAXNEZLER RJ,NONE)HERBERT J,NONE)KUSCHNER M,NONE)AUERBACH 0*ME)HAKK L,NONE)TAhBURO C,NONE) NONE,NONE) 1979 PVC IS SUGGESTED AS A POSSIBLE ETIOLOGICAL AGENT OF LUNG CANCER. PVC)LUNG)CARCXNOGENICITY)HUMAN)EFFECTS)VCM)EPIDEMIOLOGY 04163 1990 Itea 157 ACCESSION NUIBER FILE LOCATION 2367 GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE AN EPIDEMIOLOGIC INVESTIGATION OF AN EXCESS LUNG CANCER RISK IN A SYNTHETIC CHEMICALS PLANT. NAXNEXLER RJNIOSH)SMITH AH.UNIV OF NORTH CAROLINA>TYROLER HA,SAME)FALK H,NI0SH| NONE,DUBROVNIKYUGOSLAVIA) 1978 ABSTRACT AN EXCESS LUNG CANCER RISK HAS OBSERVED IN A COHORT OF 49B4 MALES EMPLOYED AT A SYNTHETIC CHEMICALS PLANT. PVC HAS SUGGESTED AS THE POSSIBLE ETIOLOGICAL AGENT. DESCRIPTORS whhhhhi PVC)VCM>LUNG)CARCXNOGENICITY)EPIDEMIOLOGY)HUMAN)EFFECTS HELD TERMS XIX INTERNATIONAL CONGRESS ON OCCUPATIONAL HEALTH) KHIC INDEX NUtBER 04162 REVIEH YEAR 1991 data search on vcm for craig elgut Order nuifcer 901119-133Z45-HIZ -001-001 page 50 et 3 with 363 of 363 iiaos 20867051 BFG51970 Item 150 ACCESSION NUMBER 2366 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT PUBLICATION DEVELOPMENT OF HEPATIC ANGIOSARCOMA IN MAN INDUCED BY VINYL CHLORIDE > THOROTRAST AM) ARSENIC. POPPER H >N0NE)THOMAS LB N0NE )TELLES NC,NONE>FALK H ,N0NE)SELIKOFF IJ,N0NE) NONE,VOL.92 NO.2 PP.349-370) 1978 EXAMPLES OF HUMAN ANGIOSARCOMA FOLLOHING EXPOSURE TO VCM, THOROTRAST, OR ARSENIC AM) CASE, INCLUDING CHILDREN* OF UNKN0W ETIOLOGY MERE STUDIED TO ESTABLISH DIAGNOSTIC CRITERIA AND TO STUDY THEIR EVOLUTION. DESCRIPTORS VCNlTHOROTRAST)ARSENIC)ANGIOSARCOMA)HUMAN)EFFECTS HELD TERMS AMERICAN J OF PATHOLOGY KHIC INDEX NUMBER 09146 REVIEW YEAR 1991 Item 159 ACCESSION NUIBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS mm muck KHIC INDEX NUMBER REVIEH YEAR 2365 GEN PUBLICATION EPIDEMIOLOGICAL STUDY OF THE MORTALITY OF WORKERS EXPOSED TO VINYL CHLORIDE (VC) IN THE FRG. REINL HNONEiHEBER H,NONEDREISER E,NONE) UWNOttJ 1977 GERMAN EPIDEMIOLOGY STUDY SHOWS SIGNIFICANTLY ELEVATED SMR'S FOR MANY DISEASES INCLUDING STOMACH, LIVER, LYMPH SYSTEM ANO BLOOO. VCM> HUMANlEFFECTS CHRONIC CARCINOGENICITY 04145 1991 Item 160 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS eaaWHH* HELO TERMS KHIC INDEX NUtttER REVIEH YEAR 2364 GEN PUBLICATION FATE OF 14C-VINYL CHLORIDE FOLLOHING INHALATION EXPOSURE IN RATS. HATANABE PG,DOH CHEMICAL CO)MCGOHEN GRSAME)MADRID EO,SAME)GEWRING PJ,SAME)SAME) TOXICOLOGY ANO APPLIED PHARMACOLOGY, VOL 37 PP.49-59) 1976 VCH)HETAB01ISM) INHALATION )RATS DISPOSITION) METABOLIC FATEDISTRIBUTION) 04125 1990 Item 161 ACCESSION NUTOER 2361 data search on vcm for craig elgput Order rxnfcer 901119-133265-HIZ -001-001 page 51 set 3 with 363 of 363 itaas FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT GEN PUBLICATION EXPERIMENTAL STUDIES ON THE CHRONIC TOXIC EFFECTSOF VINYLCHLORIOE IN RATS. AITTKOR/AFFILIATION SOKAL JA*N0NEiBARANSKIB,NONE)MAJKA J,NONE)ROLECKIRN0NE)MATYCHS,N0NE)0LCZAK G,Ntt)PALUS J NONEiSTETKIEKICZ J,NONE)STETKIEHICZ I>N0NE )HROBLEHSKA K*N0NE) ORIGIN UNKNOtBi* PP.539) DATE ABSTRACT 1970 EXPOSURE OF RATS TO LEVELS OF VCM AS HIGH AS 20>000 PPM FOR 10 MONTHS RESLTED IN BOOT NT DEPRESSION* ORGAN WIGHT INCREASES* BLOOD CHEMISTRY CHANGES* AND MORPHOLOGICAL CHANGES IN THE LIVER. DESCRIPTORS VCmCHRONIC) INHALATIONRATS KHIC INDEX NUTBER 06056 REVIEH YEAR 1990 Iten 162 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALTTIK)R/AF FILIATION ORIGIN DATE DESCRIPTORS mkkmmww KHIC INDEX NUMBER REVIEN YEAR 2360 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN PVC FABRICATORS. BAXTER PJ*NQNE)FOX AJ,NONE) THE LANCET* PP.245-266) 1976* JANUARY 31 VCM > PVC )HUMAN EFFECTS )ANG10SARC0t1A>EPIDEMIOLOGY 06020 1991 Iten 163 ACCESSION NUMBER FILE LOCATION 2359 GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION CONGENITAL CENTRAL NERVOUS SYSTEM MALFORMATIONS AND VINYL CHLORIDE MONOMER EXPOSURE! A COMMUNITY STUDY. ALTTHOR/'AFFILIATION ORIGIN DATE EDMONDS LDN0NE)ANDERSON CE*N0NEiFLYNT JNiNQNE)JAMES LH,NONE) TERATOLOGY VOL 17 PP.137-162) 1976 ABSTRACT INCIDENCE RATES FOR CHS MALFORMATIONS IN INFANTS BORN IN KANAHHA COUNTY* NEST VIRGINIA, 1970-1976* MERE SIGNIFICANTLY HIGHER THAN COMPARABLE US RATES. NO RELATIONSHIP WITH PVC MANUFACTURE NAS FOUND. DESCRIPTORS jhhhhhh* VCMtBIRTH DEFECTS)TERATOGENICITY)HUMAN(EFFECTS)EPIDEMIOLOGY KHIC INDEX NUTBER 06004 REVIEH YEAR 1990 Itee 164 ACCESSION NUBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 2356 GEN PUBLICATION A STATISTICAL ASSESSMENT OF THE QUANTITATIVE UPTAKE OF VINYL CHLORIDE MONOMER FROM AQUEOUS 20867052 BFG51971 data taarch on van for craig algut Ordar mater 901119-133245-WIZ -001-001 paga 52 aat 3 with 363 of 363 itana AUTHOR/AFFILZATIGN ORIGIN DATE ABSTRACT DESCRIPTORS KHIC INDEX NUISER REVIEH YEAR SOLUTION. MITHEY JR.NONE(COLLINS BT.NONEi J OF TOXICOLOGY AND ENVIR0M1ENTAL HEALTH,VOL.2 PP.311-321( 1976 IT HAS CONCLUDED THAT IF THE TOTAL DAILY LIQUID INTAKE CONTAINED 20 PPM OF VCH THEN THE AREA GENERATED UNDER THE BLOOD LEVEL-TINE CURVE. FOR RATS. MOULD BE EQUIVALENT TO AN INHALATION EXPOSURE OF ABOUT 2 PPM FOR 24-HR. VCM) ANALYSIS)RISK ASSESSMENT (DRINKING HATER 03995 1991 Itwn 165 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS KHIC INDEX MUSER REVIEH YEAR Itan 166 2356 GEN PUBLICATION PULMONARY TUMORS IMXJCED IN MICE BY VINYL CHLORIDE MONOMER. SUZUKI Y,NONE( ENVIRONMENTAL RESEARCH, VOL 16 PP.255-301( 1978 NEOPLASTIC EFFECTS OF VCM HERE STUOIED IN LUNGS OF 27 MICE EXPOSED TO VCH AT 2500 AND 6000 PPM FOR 5 ANO 6 MONTHS. PULMONARY TUMARS HERE OBSERVED IN 26 OF 27 EXPERIMENTAL ANIMALS. VCM(INHALATION(CHRONIC (CARCINOGENICITY (MICE (LUNGS (TUMORS 03959 1990 ACCESSION NUWER 2355 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT SUt*IARY OF THE STUOIES CONDUCTED ON THE PHARNACOKINETICS/METABOLISM OF VINYL CHLORIDE IN RATS. AUTHOR/AFFILIATION HATANABE PG.OOH CHEMICAL CO(HEFNER RE.SAME(ZEMPEL JASAME(PEGG DG.SAME(PARK CN.SAMEtGEHRING PJ> SAME ( ORIGIN DON CHEMICAL CO.TO CMAl DATE 1977, MAY 31 ABSTRACT PRELIMINARY STUDIES ON THE FATE OF I(WALED VCH INDICATED TWO IMPORTANT POINTS: 1) VCH NAS METABOLIZED EXTENSIVELY IN VIVO AND 2) THE METABOLISM OF VCH HAS SATURATED AT HIGH EXPOSURE CONCENTRATIONS. DESCRIPTORS miwww VCH) METABOLISM> RATS PHARMACOKINETICS KHIC INDEX NUMBER 03990 REVIEH YEAR 1990 Itan 167 ACCESSION (ODER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2359 GEN PUBLICATION URINARY GLYCOSAMINOGLYCAN PATTERNS IN ANGIOSARCOMA OF THE LIVER. CURRAN KL.UNIV OF LOUISVILLE(KUPCHELLA CE.SAME(TAHBURRQ CH,SAME( 20867053 BFG51972 data search on vcm for craig elgut Order nudter 901119-133245-HIZ -001-001 page 3 set 3 with 363 of 363 item 20867C54 BFG51973 ORIGIN DATE ABSTRACT DESCRIPTORS KHIC INDEX NUMSER RE VIEH YEAR CANCER, VOL 60 PP.3050-3053) 1977 6LYCOSAMINOGLYCANS EXTRACTED FROM 24-HOUR URINE SOECIMENS FROM PATIENTS HITH HEPATIC ANGIOSARCOMA AND FROM NORMAL CONTROLS HERE SEPARATED AS CETYLPYRIDINIUM COMPLEXES INTO HYLUR0NIC ACID, CHONDROITIN SULFATE, ANO HEPARIN FRACTIONS, THEN FURTHER SEPARATED AND CHARACTERIZED. THE CHROMATOGRAPHIC PATTERN OF THE URINARY CHONDROITIN SULFATE FRACTION IN PATIENTS HITH ANGIOSARCOMA OF THE LIVER OIFFERED FROM THOSE OF THE CONTROLS IN THATTHERE HAS A RELATIVE INCREASE IN THE TOTAL AMOUNT OF URONIC ACID IN A HYALURONADASE-RESISTANTFRACTION AND A DECREASE IN A FRACTION SUSEPTIBLE TO HYALURONIDASE DIGESTION. VCM>ANGIOSARCOMA 03938 1990 Iten 168 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIQN ORIGIN OATE ABSTRACT DESCRIPTORS *hhhh KHIC INDEX NUMBER REVIEH YEAR 2353 GEN PUBLICATION THE EFFECTS OF MATERNALLY INHALED VINYL CHLORIDE ON EMBRYONAL AND FETAL DEVELOPMENT IN MICE, RATS, AND RABDZTS. JOHN JA,D0H CHEMICAL CO)SMITH FA,SAME)LEONG BKJ.SAMEiSCHHETZ BA,SAME) TOXICOLOGY AND APPLIED PHARMACOLOGY, VOL 39(3) PP.497513) 1977 NO EMBRYO OR FETAL TOXICITY NOR TERATOGENIC EFFECTS HERE OBSERVED IN NICE, RATS, AND RABBITS EXPOSED TO VCM VIA INHALATION. ETHANOL INHANCED TOXICITY. VCM)RATS)MICE)RABBITS)TERATOGNICITY)FETAL TOXICITY)INHALATION 03901 1990 Item 169 ACCESSION NUM)ER 2352 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ANGIOSARCOMA OF THE LIVER: AN EPIDEMIOLOGY SURVEY. AUTHOR/AFFILIATION BRADY JNONE)LIBERATORE F,NONE)HARPER P,NQNE)GREEMUL0 P,NONE)BURNETT H,N0NE)0AVIES JNP,N0NE) BISHOP N,NONE)POLAN A,NONE)VIANNA N,N0NE) ORIGIN DATE J OF NCI,VOL 59 NO.5 PP.1383-1385) 1977 ABSTRACT FROM 1970 TO 1975 THE AN4UAL INCIDENCE RATE FOR ANGIOSARCOMA OF THE LIVER AMONG RESIDENTS OF NEH YORK STATE (EXCLUDING NYC) HAS 0.25 PER MILLION. A CAS-CONTROL STUDY INDICATED THAT DIRECT EXPOSURE TO ARSENIC, VCM, AND THORIUM DIOXIDE NAS A SIGNIFICANTLY IMPORTANT FACTOR IN THE ETIOLOGY OF THIS DISEASE. DIRECT EXPOSURE TO THESE CHEMICALS COULD NOT BE DEMONSTRATED FOR 19 OF THE 26 PATIENTS. THE FACT THAT 5 OF THESE PATIENTS LIVED NEARER TO VCM FABRICATION OR POLYMERIZATION PLANTS THAN DID THEIR MATCHING CONTROLS LENT SOME SUPPORT TO THE HYPOTHESIS THAT INDIRECT MOOES OF EXPOSURE, NOT SPECIFICALLY RELATED TO OCCUPATION, MIGHT BE IMPORTANT ETIOLOGICALLY. DESCRIPTORS mimii VCM iTHOROTRAST)ARSENIC )HUMAN lEFFECTS) EPIDEMIOLOGY )ANGIOSARCOMA KHIC INDEX NUMDER 03888 REVIEW YEAR 1991 data coarch on vcn for craig algut Ordar numbor 901119-133245-HIZ >001-001 pago 54 sot 3 with 363 of 363 itaos 2G8670S5 Itan 170 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS hhh KHIC INDEX NUtttER REVIEH YEAR 2351 GEN PUBLICATION MORTALITY AMONG EMPLOYEES OF PVC FABRICATORS. CHIAZZE L.NONE{NICHOLS HE .NONE(HONG O.NONE} J OF OCCUPATIONAL MEDICINE. VOL 19(9) PP.623-628} 1977 A CROSS-SECTIONAL MORTALITY STUDY OF 4341 DEATHS OCCURRING AMONG CURRENT AND FORMER EMPLOYEES OF 17 PVC FABRICATORS DURING 1964-1973 IS PRESENTED. AMONG THE HHITE EMPLOYEES* THERE APPEARS TO BE AN EXCESS IN TOTAL CANCER MORTALITY * PARTICULARLY THAT OF THE DIGESTIVE SYSTEM. OBSERVED DEATHS NERE FOUND TO EXCEED THE EXPECTED IN CANCERS OF THE BREAST AND URINARY ORGANS AMONG WHITE FEMALES. DEFICIT MORTALITY HAS OBSERVEO IN CIRRHOSIS OF THE LIVER AMONG HHITE MALES AND FEMALES. PVC)VCM(HUMAN}EFFECTS}EPIDEMIOLOGY (CARCINOGENICITY (ANGIOSARCOMA 03687 1991 Itan 171 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KHIC INDEX NUMBER REVIEH YEAR 2348 GEN PUBLICATION SMOKING AND OCCUPATIONAL CANCERS. HOFFKAM4 O.NONE(KYNDER EL.NONE* PREVENTIVE MEDICINE. VOL 5(2) PP.245-261} 1976 A REVIEH OF THE LITERATURE SHOWS A LACK OF EPIDEMIOLOGICAL DATA FOR THE JOINT ACTION OF OCCUPATIONAL CARCINOGENS (NICKEL. COKE OVEN. GAS WORKERS. VCM, HALO ETHERS. BLAODER CARCINOGENS) AND TOBACCO SMOKE. SYNERGISTIC ANO/OR AOOITIVE EFFECTS HAVE BEEN ESTABLISHED FOR RADON DAUGHTERS AND SOME FORMS OF ASBESTOS. SMOKE(CANCER(NICKLE(GAS(WORKERS(VINYL CHLORIDE}BLADDER}CARC1N0GEN}ETHERS( COKE OVENiHALO ETHERS(SYNERGISM} 03721 1990 Itan 172 ACCESSION NUFBER 2346 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CARCINOGENICITY OF VINYL CHLORIDE AND VINYLIDENE CHLORIDE. AUTHOR/AFFILIATION LEE CC.NONE}BHANDARI JC.NONE(WINSTON JM.NONE(HOUSE W.NONE(DIXON RL.NONE(HOODS JS.NONE} ORIGIN DATE J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. VOL 4 PP. 15-30} 1978 ABSTRACT EXPOSURE OF MICE TO 50. 250. OR 1000 PPM OF VCM 6H/D.50/MC FOR 12 MONTHS PRODUCED A HIGH INCIDENCE OF BRONCHIOLALVEOLAR ADENOMA. MAFMARY GLAND TUMORS. AND HEHANGIOSARCOMAS. EXPOSURE TO 55 PPM OF VDC CAUSED HEHANGIOSARCOMAS AND BRONCHIOLALVEOLAR ADENOMAS. DESCRIPTORS VCM(VDC(CARCINOGENICITY }RATS(INHALATIQN data search on vcm for craig slgit Order mmfcer 901119-133245-WIZ -001-001 page 55 set 3 with 353 of 363 items KHIC INDEX NUFBER REVIEW YEAR 03674 1990 Item 173 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS KWIC INDEX NUTOER REVIEW YEAR 2345 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE/POLYVINYL CHLORIDE WORKERS. SPIRTAS R.NIOSHtKAMINSKI R,NIOSH) J OF OCCUPATIONAL HEOICINE* VOL 20 PP.427-429) 1978 THIS REPORT PROVIDES DETAILS ON 64 CASES OF ANGIOSARCOMA AMONG VCM POLYMERIZATION WORKERS AND UPDATES THE PREVIOUS REPORT OF 26 CASES (JOM 16:809,1974). VCM ) ANGIOSARCOMA) LIVER) HUMAN )E FFECTS 03665 1990 Item 174 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALTTUOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS KWIC INDEX NUMBER REVIEW YEAR 2344 GEN REPORT VINYL CHLORIDE AND HUMAN REPRODUCTION. MACMAHON B,HARVARD UNIV) NONE) 1977, AUGUST 11 VCM REPRODUCTION(BIRTH OEFECTS)TERATOGENICITY)HUMAN)EFFECT FETAL LOSS) 03646 1990 Item 175 ACCESSION NUIBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2340 GEN PUBLICATION EFFECTS OF VINYL CHLORIDE IN MAN A CYTOGENETIC FOLLOH-UP STUDY. HANSTEEN I>lM(tOM)HILLESTAD LfUWNOWOTHXIS-EVENSEN E,UNtNOWfjHELDAAS SS,UN(MM) MUTATION RESEARCH, VOL 51 PP.271-276) 1978 THE MEAN CHROMOSOME-BREAKAGE FREQUENCY FOR THE WORKERS'3.41X) HAS SIGNIFICANTLY HIGHER THAN FOR THE CONTROLS (1.79X) IN THE FIRST INVESTIGATION. IN THE REPEATED STUDY NO DIFFERENCE HAS FOUNO IN MEAN CHROMOSOME-BREAKAGE FREQUENCY BETWEEN THE WORKERS AND THEIR HATCHEO CONTROLS. NEITHER HAS THERE ANY DIFFERENCE BETWEEN THESE BREAKAGE FREQENCIES ANO THE BREAKAGE FREQUENCY FOR THE PREVIOUS CONTROL GROUP. THESE RESULTS WIGHT INDICATE A RELATIONSHIP BETWEEN THE REDUCTION IN EXPOSURE TO VCM AND THE NORMALIZED CHROMOSOME-BREAKAGE FREQUENCY. SISTER-CHRONATIO EXCHANGES HERE STUDIED FOR 16 WORKERS WITH MATCHED CONTROLS IN THE REPEATEO STUOY. A WAN OF 7.6 SCES PER CELL HAS FOUNO FOR BOTH WORKERS AND CONTROLS. BONE-HARROW SAMPLES FRGH 4 WORKERS HERE STUDIED IN THE FIRST INVESTIGATION. THE MEAN CHROMOSOME-BREAKAGE FREQUENCY HAS HIGHER IN THE BONE MARROWS (4.22) 20867056 BFG51975 data search on vets for craig elj^it Order nunfeer 901119-133Z45-WIZ -001-001 page 56 set 3 with 363 of 363 itens DESCRIPTORS REVIEW YEAR THAN THAT REPORTEO FOR NORMAL BONE HARROWS 10.2, 0.9, 1,721 ANO HIGHER THAN FOR THE CORRESPONDING LYMPHOCYTE CULTURES. *** VCM)HUHAN)EFFECTS)CHROMOSOMAL ABERRATION)CHROMOSOMAL ABNORMALITIES )MJTAGENICITY 1990 Item 176 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 2330 GEN PUBLICATION PATHOLOGY OF VINYL CHLORIDE VIOLA PL,UNKNOW) NONE.VOL 61 NO.3 PP.1-7) 1970 THE RESULTS OF THIS INVESTIGATION SHOW THAT ANIMALS EXPOSED TO VCM MAY SHOW DEGENERATION OF THE SKELETON AND CONNECTIVE TISSUE SIMILAR TO HUMAN ACROOSTEOLYSIS OF THE HAND. DEGENERATIVE PROCESSES OF THE PARENCHYMA WERE OBSERVED IN THE BRAIN, LIVER, ANO KIDNEYS. VCM)PATHOLOGY )CHRONIC )EFFECTS)INHALATION)RATS)BONES)KIDNEY)LIVER)BRAIN)ACROOSTEOLYSIS LA MEDICINA DEL LAVORO) 1990 Item 177 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ihhhhh KWIC INDEX NUTBER REVIEW YEAR 2287 GEN REPORT EXCERPT FROM LETTER WRITTEN BY OR E MASTROMATTEO, DIVISION OF INDUSTRIAL HYGIENE, DEPARTMENT OF HEALTH, PROVINCE OF ONTARIO, DATED OCTOBER 13, 1959, REGARDING VINYL CHLORIOE EXPERIMENTS ON SMALL ANIMALS. MASTROMATTEO E.NONEk NONE,TO CROW ATTORNEY) 1959, OCTOBER 13 THIS SUMMARY REPORTS THE RESULTS OF 30 MINUTE EXPOSURES TO RODENTS. MICE)RATS)GUINEA PIGS)EFFECTS)ACUTE)VCh)INHALATION 02721 1990 Item 178 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AITTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS Minimum HELD TERMS KWIC INDEX NUTBER 2286 GEN PUBLICATION ACCIDENTAL POISONING BY VINYL CHLORIDE: REPORT OF TWO CASES. OANZIGER H,UtKNOW) NONE,VOL 82 PP.828-830) 1960, APRIL 16 ACUTE INHALATION EFFECTS FORM VCM NOTED. VCM)HUMAN)EFFECTS)INHALATION)ACUTE CANAD.M.A.J)CANADIAN MED ASSOC J) 02715 20867057 BFG51976 data search on von for craig lgjt Order nunber 90U19-133245-HIZ -001-001 page 57 set 3 with 363 of 363 iteas REVIEH YEAR 1990 Item 179 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS KHIC INDEX NUTBER REVIEH YEAR 2284 GEN REPORT RISK-BENEFIT ANALISIS FOR TOXIC CHEMICALS: VINYL CHLORIDE. WILSON R,HARVARD UNIVt HARVARD UNXV> 1976, AUGUST 25 VCM*RISK ASSESSMENT}ANALYSIS{HUNANIEFFECTS{CARCINOGENICITY 02608 1991 I tea 180 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE HELD TERMS KHIC INDEX NUTBER REVIEW YEAR 2283 GEN PUBLICATION COMMISSION DIRECTIVE OF 29 APRIL 1981 LAYING DOW THE COMMUNITY METHOD OF ANALYSIS FOR THE OFFICIAL CONTROL OF VINYL CHLORIDE RELEASED RELEASED BY MATERIALS AND ARTICLES INTO FOODSTUFFS. UNKNOW >UtNOW } NONE>VOL 24PP.6-11{ 1901, JUNE 24 VCM1ANALYSIS) OFFICIAL JOURNAL OF EEC{FOODSTUFFS{ 02563 1990 Item 181 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT HELO TERMS KHIC INDEX NUTBER REVIEW YEAR 2281 GEN PUBLICATION FATE OF 14C-VINYL CHLORIOE AFTER SINGLE ORAL ADMINISTRATION IN RATS. NATANABE PG.DOH CHEMICAL CO}MCGOWAN GR,SAME{BEHRING PJ,SAHE{ TOX AND APPLIED, VOL 36 PP.339-352} 1976 THE FATE OF VCM FOLLOWING AN ORAL DOSE BETWEEN 1 AND 100 MG/KG HAS CLEARLY DOSE-DEPENDENT. CONSISTENT WITH OUR PREVIOUS STUDIES ON THE FATE OF VCM FOLLOWING INHALATION EXPOSURE IN RATS, THE METABOLISM OF VCM APPEARS TO BE A SATURABLE PROCESS. ( RATS{ORAL{VCM(METABOLISM> DISPOSITION{METABOLIC FATE{ 02579 1990 Item 182 ACCESSION NUMBER 2278 2086*7058 BFG51977 data search on vcm for craig algut Order number 901119-133245-NIZ -001-001 page Sf eat 3 with 363 of 363 itiM TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELO TERMS KHIC INDEX NJIBER REVIEW YEAR HEPATIC ANGIOSARCOMA ASSOCIATED WITH ANDROGENIC-ANABOLIC STEROIDS. FALK HCDC)POPPER H,NCI)THOMAS LB,CITY UNIV OF NEN YORKjISAK KG,NONE) NONEPP.1120-1123) 1979, NOVEMBER 24 A STUDY OF DEATHS FROM HEPATIC ANGIOSARCOMA (HASI IN THE US SHOWED THAT DURING 1966-74 THERE MERE 168 SUCH CASES, OF WHICH 37 (222) HERE ASSOCIATED WITH VCM, THOROTRAST, AM) INORGANIC ARSENIC AND 4 (3.12) OF THE REMAINING 131 CASES HITH THE USE OF ANDROGENIC-ANABOLIC STEROIDS. VCM)ANGIOSARCOMA)LIVER)HUMANEFFECTS)EPIDEMIOLOGY)THOROTRAST) STERIOOS)INORGANIC ARSENIC)LANCET)STERIODS)WALTER REED ARMY MEDICAL CENTER) 02527 1990 Itam 106 ACCESSION NOSER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVIEH YEAR 2273 GEH REPORT QUANTITATIVE RISK ASSESSMENT FOR CtMIUNXTY EXPOSURE TO VINYL CHLORIDE. KUZHACK AM,EPA)MCGAUCHY RE,ERA) EPAi 1975, DECEMBER 5 IT NAS FOUND, USING ANIMAL DATA ANO USING A LINEAR DOSE-RESPONSE MODEL EXTRAPOLATING TO ZERO, THAT THE PROBABILITY OF GETTING ANGIOSARCOMA DUE TO A YEAR OF CONTINUOUS EXPOSURE TO VCM IS 71 CASES PER YEAR PER MILLION PEOPLE EXPOSEO. THE CORRESPONDING PROBABILITY OF GETTING CANCER OF ALL SITES IS 150 CASES PER YEAR OF CONTINUOUS EXPOSURE PER PPH OF VCM PER MILLION PEOPLE. ON THIS BASIS THE PROBABILITY OF GETTING LIVER ANGIOSARCOMA IN HORKERS EXPOSED TO 350 PPH FOR 7 HOURS PER DAY, S DAYS PER MEEK HOULO BE 0.0052 PER PERSON PER YEAR OF EXPOSURE. FROM EPIDEMIOLOGY STUDIES IT NAS ESTIMATED THAT THE PROBABILITY OF GETTING ANGIOSARCOMA AT SOME TIME IN A HORKERS LIFE PER YEAR OF EXPOSURE IS 0.0031. IT IS CONCLUDED THAT THE DIFFERENCE IN RISK ESTIMATES BETMEEN ANIMAL ANO HUMAN DATA IS INDISTINGUISHABLE. VCM(CARCINOGENICITY)ANGIOSARCOMA)HUMAN)EFFECTS)RISK ASSESSMENT 02516 1990 Item 187 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mhhhhj* HELD TERMS KHIC INOEX NUtBER REVIEH YEAR 2272 GEN REPORT REPORT ON A MORTALITY STUDY COVERING EMPLOYEES OF PVC FABRICATORS. NONE,NONE) NONE) 1976, FEBRUARY PVC|VCM)HUMAN)EFFECT$)EPIDEMIOLOGY) ORGANIZATION RESOURCES COUNSELORS INC)FABRICATORS) 02431 1991 Item 188 20867060 BFG 51979 data search on von for craig algjt Order nuifcer 901119-133245-NIZ -001-001 page 60 set 3 with 363 of 363 items 20867061 BFG51980 ACCESSION NUMBER 2271 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION PUBLICATION MORTALITY STUDY OF WORKERS IN THE MANUFACTURE OF VINYL CHLORIDE AND ITS POLYMERS. TABERSHAH IR,NONE)GAFFY HRSAME)TABERSHAM-COOPER ASSOC) ORIGIN J OF OCCUPATIONAL MEOICINE, VOL 1616) PP.509-518) DATE ABSTRACT 1974, AUGUST THIS MORTALITY STUDY OF 8364 MEN DEMONSTRATED THAT CANCERS OF THE DIGESTIVE SYSTEM |ANGIOSARCOMAS), RESPIRATORY SYSTEM, BRAIN, AND CANCERS OF UTKNOTM SITE, AS HELL AS LYMPHOMAS, OCCURRED MORE OFTEN THAN EXPECTED IN THOSE INDIVIDUALS H1TH THE GREATEST ESTIMATED EXPOSURE. EXCESS CANCERS OF THE BUCCAL CAVITY AND PHARYNX HERE INVERSELY RELATED TO EXPOSURE. DESCRIPTORS VCM)PVC)HUMAN)EFFECT)EPIDEMIOLOGY)CANCR)RESPIRATORY SYSTEM)BRAINANGIOSARCOMA HELD TERMS TABERSHAH-COOPER ASSOCIATES INC) DIGESTIVE SYSTEM) KHIC INDEX NUTBER 02376 REVIEH YEAR 1990 Item 189 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS * KHIC INDEX NUTBER REVIEW YEAR 2260 GEN PUBLICATION MUTAGENIC AND CARCINOGENIC EFFECTS OF VINYL CHLORIDE. BARTSCH H,IARC)MONTESANO R.IARC) MUTATION RESEARCH, VOL 32 PP.93-114) 1975 A REVIEH OF CARCINOGENICITY, MUTAGENICITY, METABOLISM, AND NON-NEOPLASTIC EFFECTS OF VCN. VCMICARCINOGENICITY)MUTAGENICITY)METABOLISM>ACROOSTEOLYSIS 02340 1990 Item 190 ACCESSION NUMBER 2259 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT VINYL CHLORIDE DEPENDENT MUTAGETESIS:EFFECTS OF LIVER EXTRACTS AND FREE RADICALS. AUTHOR/AFFILX ATION GARRO JB,CITY UNIV OF NEH YORKJGUTTENPLAN JB,CITY UNIV OF NEH YORK) ORIGIN MUTATION RESEARCH, VOL 36 PP.81-88) DATE 1976 ABSTRACT VCM rft/TAGENICITY IN S. TYPHIMURIUM NAS ENHANCED BY LIVER EXTRACTS AM) RIBOFLAVIN IN THE PRESENCE OF SUNLIGHT. DESCRIPTORS kkmkmms VCM) MUTAGENICITY)IN VITRO)LIVER) HELD TERMS ACTIVATION)RIBOFLAVZN)SUNLIGHT) KHIC INDEX NUTBER 02339 REVIEH YEAR 1990 Item 191 ACCESSION NUMBER FILE LOCATION 2257 GEN data search on vcta for craig elgpjt Order nunber 901119-133295-WIZ -001-001 page 61 set 3 with 363 of 363 item 20667062 BFG51981 DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xkmkki REVIEW YEAR PUBLICATION PULMONARY FUNCTION DEFECTS IN NONSMOKING VINYL CHLORIDE WORKERS. MILLER AtCITY UNIV OF NEW YORK* ENVIRONMENTAL HEALTH PERSPECTIVES.VOL 11 PP.247-2501 ON SHELF)* 1975 VCM*PVC*HUMANS*EFFECTS*PULMONARY FUNCTION 1995 Itee 192 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS whhhh HELD TERMS REVIEW YEAR 2256 GEN PUBLICATION BIOCHEMICAL TOXICOLOGY OF UNSATURATED HALOGENATED MONOMERS. JAEGER RJ,HARVARD UNIV*C0N0LLY RBSAME*REYNOLDS ES,SAME(MURPHY SO.SAME) ENVIRONCNTAL HEALTH PERSPECTIVES.VOL 11 PP.121-128!ON SHELF)* 1975 VCM *1,1-DICHLOROETHYLENE * RATS *ACUTE|LIVER) HEPATOTOXICITY(ENZYMES)1,1-DIBRQMOETHYLENE* 2-CHLORO-l,3-BUTADIENE* 1995 I-tarn 193 ACCESSION NUMBER 2255 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT PRELIMINARY STUDIES ON THE FATE OF INHALED VINYL CHLORIDE MONOMER (VCM) IN RATS. AUTHOR/AFFZLIATION HEFNER RE.DOM CHEMICAL CO*NATANABE PG.SAME *GEHRING PJ.SAME* ORIGIN ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 P.85-95(0N SHELF)* DATE 1975 ABSTRACT CONSIDERING THE RESULTS IN TOTO, IT IS HYPOTHESIZED THAT VCM IS READILY AND EXTENSIVELY METABOLIZED. METABOLISM VIA THE PRIMARY PATHWAY, POSTULATED TO INVOLVE ALCOHOL DEHYDROGENASE, IS SWAMPED BY EXPOSURES TO CONCENTRATIONS EXCEEDING 220 PPM. IN RATS EXPOSED TO CONCENTRATIONS AT ANO EXCEEDING THIS LEVEL, METABOLISM OCCURS VIA A SECONDARY PATHWAY!S). POSTULATED TO BE EPQX10ATI0N AND/OR PEROXIDATION, THESE RESULTS ARE CONSIDERED PERTINENT IN ASSESSING THE POTENTIAL HAZARD AT LOW LEVEL EXPOSURES TO VCM. DESCRIPTORS ******* VCM(METABOLISM(INHALATION *RATS REVIEW YEAR 1990 Item 194 ACCESSION NUtCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2254 GEN PUBLICATION PROPORTIONAL MORTALITY AMONG VINYL CHLORIDE WORKERS. MONSON RR,HARVARD UNIV*PETERS JM.SAME)JOHNSON *M,BFG* ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 PP.75-77!0N SHELF)* 1975 IN A PROPORTIONAL MORTALITY ANALYSIS OF 161 OECEASEO WORKERS IN TWO PLANTS PROCESSING OR PRODUCING VCM, A 502 EXCESS OF DEATHS DUE TO ALL CANCER HAS SEEN. LIVER, BILIARY TRACT, LUNG, AND data search on vca for craig el^-it Order nrnfeer 901119-133265-HIZ -001-001 page 62 set 3 with 363 of 363 itaas DESCRIPTORS REVIEH YEAR BRAIN CANCERS SHOHEO THE GREATEST EXCESS. ******* VCM)HUMAN)CANCER)EFFECTS)LIVER)BRAIN)LUN6 1995 Item 195 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 2251 GEN PUBLICATION OBSERVATIONS ON THE ORAL ADMINISTRATION AND TOXICITY OF VINYL CHLORIDE IN RATS. FERON VJ*NONE)SPEEK AJSAME)HILLEMS HI,SAME IVAN BATTUM D*SAME)DE GROOT APSAME> NONE*VOL 13 PP.633-638| 1975 NO LIVER DAMAGE FROM ORAL ADMINISTRATION OF VCM AS HIGH AS 300 MG/KG, 6 DAY/NEEK FOR 13 HEEKS. VCM(ORAL>SUBCHRONIC(RATS CIVOiCENTRAL INSTITUTE FOR NUTRITION ft FOOD RESEARCH) FD.COSMET.TOXICOL) 1990 Item 196 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS REVIEH YEAR 2250 GEN PUBLICATION THE BIOLOGICAL FATE IN RATS OF VINYL CHLORIDE IN RELATION TO ITS ONCOGENICITY. GREEN T,ICI(HATHHAY DE*ICI) NONE *VOL 11 PP.565-562) 1975 VCN)METABOLISM)ORAL)RATS)IV)IP)RATS) CHEM-BIOL INTERACTIONS) 1990 Item 197 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEH YEAR ! 2269 GEN PUBLICATION MUTAGENICITY OF CHLOROACETALDEHYDE A POSSIBLE METABOLIC PROOUCT OF 1>2-DICHLOROETHANE (ETHYLENE DICHLORIDE)* CHLOROETHANOL (ETHYLENE CHLOROHYDRIN)* VINYL CHLORIDE* ANO CYCLOPHOSPHAMIDE. MCCAFft JUNIV OF CALIFORNIA)SimON VNONE) STREITHIESER D.UNIV OF CALIFORNIA)AMES DN*UN1V OF CALIFORNIA) NONE*VOL 72 NO.8 PP.3190-3193) 1975* AUGUST VCM)MUTAGENICITY)IN VITRO(METABOLITE(CHLOROACETALDEHYDE)EDC(CYCLOPHOSPHAMIDE) CHLOROETHANOL(STANFORD RESEARCH INSTITUTE)PROC.NAT.ACAD.SCI) 1990 Item 198 ACCESSION NUMBER FILE LOCATION 2267 GEN 20867063 BFG51982 data search on vcn for craig algut Order nui6ar 901119-133245-HIZ -001-001 paga 63 set 3 with 363 of 363 itews DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION AN EPIDEMIOLOGIC STUDY OF BLOOO SCREENING TESTS AND ILLNESS HISTORIES AMONG CHEMICAL WORKERS INVOLVED IN THE MANUFACTURE OF POLYVINYL CHLORIDE. AUTHOR/AFFILIATION HYATT RHUNKNOmKOTCHEN JhylMCNOHNtHOCHSTRASSER OL.UNKNOfrftj BUCHANAN JH>UCNCMCAHBELL DR* UNtNOHN^SLAUGHTER JC*UNKN0MN(D0LL AH*UNtNOM ORIGIN ANNALS OF THE NEH YORK ACADEMY OF SCIENCES* VOL. 266 PP.BO-87* DATE 1975, JANUARY 31 DESCRIPTORS WM PVClVCM*HUMANiEFFECTS HELD TERMS CLINICAL CHEMISTRY* REVIEW YEAR 1995 Itam 199 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT REVIEW YEAR Item 200 2245 GEN PUBLICATION HEPATIC DISEASE AMONG WORKERS AT A VINYL CHLORIDE POLYMERIZATION PLANT. FALK H*CDCCREECH JL.BFG(JOHNSON M*BFG|KEY M,CDC| JAMA* VOL.230(1) PP.59-68 1974* OCTOBER 7 11 CASES OF HEPATIC DISEASE INCLUDING ANGIOSARCOMA HAVE BEEN IDENTIFIED AT A VCM POLYMERIZATION PLANT. VCM*PVC*ANGIOSARCOMA*LIVER*HUMANEFFECTS 1995 ACCESSION NUTOER 2244 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CLINICAL AND MORPHOLOGIC FEATURES OF HEPATIC ANGIOSARCOMA IN VINYL CHLORIDE WORKERS. AUTHOR/AFFILIATION MAKK L,UNIV OF LOUISVILLE(DELMORE F*N0NEiCREECH JLBFG*OGDEN LL,UNIVERSITY OF LOUISVILLE*FADELL EH,UNIVERSITY OF LOUISVILLE *SONGSTER CL* UNIVERSITY OF LOUISVILLE (CLANTON J*NONE(JOHNSON m,BFG CHRISTOPHERSON Ml,UNIVERSITY OF LOUISVILLE ORIGIN DATE CANCER* VOL. 37 PP.149-163* 1976 ABSTRACT 15 MALE VCM WORKERS OEVELOPED ANGIOSARCOMA OF THE LIVER. AVERAGE AGES HERE 36 TO SB. EXPOSURE TIME RANGED FROM 6 TO 27.8 YRS (AVG. 16.9 YRS>. DESCRIPTORS whhhhhi VCH*ANGIOSARCOMA(LIVER(HUMAN(EFFECTS* HELD TERMS SUBURBAN HOSPITAL(UNIV OF MONTREAL* MORPHOLOGY* REVIEW YEAR 1995 Iteta 201 ACCESSION NLt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 2243 GEN PUBLICATION LIVER OAMAGE AM) ANGIOSARCOMA IN VINYL CHLORIDE WORKERS MAKK L*NONE(CREECH JL8FG*HHELAN JG.NONE(JOHNSON ttt.BFG* JAMA* VOL. 230 PP.65-68* 20867064 BFG51983 data search on vcm for craig slgit Order nuiiMr 901119-133245-MIZ -001*001 page 64 sat 3 with 363 of 363 itaws OATE ABSTRACT DESCRIPTORS REVIEH YEAR 1974, OCTOBER 7 RECENTLY, 5 CASES OF HEPATIC ANGIOSARCOMA HERE FOUNO IN LOUISVILLE. ALL OF THE PATIENTS HAD HORKED IN A PLANT ENGAGED IN THE PRODUCTION OF PVC. A SYSTEMIC HEALTH SURVEILLANCE PROGRAM NAS INSTITUTED TO DETECT EXISTING LIVER DAMAGE OR ANGIOSARCOMA AND TO FIND EARLY SIGNS OF DEVELOPING LIVER DAMAGE. 11S3 EMPLOYEES MERE TESTED. THO NEH CASES OF HEPATIC ANGIOSARCOMA AM) THREE CASES OF PORTAL FIBROSIS HERE DISCOVERED. ******* VCMIANGIOSARCOMA)LIVER1HUMAN E FFECTS 1995 Item 202 ACCESSION NUWER 2241 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CAPILLARY ABNORMALITIES IN POLYVINYL CHLORIDE WORKERS: EXAMINATION BY IN VIVO MICROSCOPY. AUTHOR/AFFILIATION MARICQ HR,NONE)JOHNSON MN,BF6(HHETSTONE CL,N0NE)LER0Y EC,SAME) ORIGIN JAMA, VOL. 236 PP.1368-1371) DATE 1976, SEPTEMBER 20 ABSTRACT EXAMINATION BY HIDE-FIELD CAPILLARY MICROSCOPY OF THE HANOS OF 152 HORKERS IN VINYL CHLORIDE POLYMERIZATION PLANTS DEMONSTRATED SCATERED, SCLERODERMA-LIKE HXCROVASCULAR ABNORMALITIES IN 21 HORKERS AND ISOLATED CAPILLARY ABNORMALITIES IN 27, AS COMPARED HITH ONLY 3 ISOLATED ABNORMALITIES IN 50 MANUAL HORKERS NOT EXPOSED TO VCM. THIRTEEN OF 17 VCM HORKERS HITH OBJECTIVE EVIDENCE OF VCM-ASSOCIATEDABNORMALITIES (ANGIOSARCOMA, ETC.) HERE OBSERVED TO HAVE HICROVASCULAR ABNORMALITIES. DESCRIPTORS ******* VCMIHUMAN)EFFECTS)PVC) HELO TERMS MEDICAL UNIV OF SOUTH CAROLINA)CONOCO)CXRCULATION) REVIEH YEAR 1995 Itan 203 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS REVIEH YEAR 2240 GEN PUBLICATION IN VITRO SKIN CAPILLARY ABNORMALITIES IN VINYL CHLORIDE HORKERS. HARICO HR,NONE(JOHNSON ffl,BFG)HHETSTONE CL,NONE(LEROY EC,SAME) NONE,VOL 2 PP.235-237) 1976 VCM(HUMAN(EFFECTS) MEDICAL UNIV OF SOUTH CAROLINA(CIRCULATZQN)MICROCIRCULATION) 1995 Itan 204 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTH0R/AFF1L1ATI0N ORIGIN OATE 2239 GEN PUBLICATION GENETIC RISKS OF VINYL CHLORIDE. INFANTE PF,NIOSH)HAGONER JK,NIOSH)MCMICHAEL AJNIOSH)NAXNEILER RJ,NIOSH)FALK H)NIQSH THE LANCET,PP.1289-1290) 1976, JUNE 12 20867065 BFG51984 data search on vcm for craig elgut Order number 90I119-133245-MIZ -001-001 page 65 ut 3 with 363 of 363 item ABSTRACT DESCRIPTORS REVIEW YEAR RESPONSE TO DR. PADOLE'S LETTER TO THE EOITOR.REFERENCES METHOD OF DATA COLLECTION USED IN THEIR STUOY PUBLISHED IN LANCET* APRIL 13, 19761 REFER TO AN-3108). mhhhhw VCM)REPRODUCTIONBIRTH DEFECTS)FETAL TOXICITY)HUTAGEMICITY)HUMAN)EFFECTS) jEPIDEMIOLOGY) TERATOGENICITY 1990 Iten Z05 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN ATE ABSTRACT DESCRIPTORS ***** HELD TERMS KMIC INDEX NUtBER REVIEW YEAR 2Z05 GEN PUBLICATION PHARMACODYNAMICS AND UPTAKE OF VINYL CHLORIDE MONOMER ADMINISTERED BY VARIOUS ROUTES TO RATS. NITHEY JR,NONE) J OF TOXICOLOGY AND ENVIROTtlENTAL HEALTH,VOL 1 PP.381-394) 1976 TO ASSESS THE HARARO PRESENTED BY THE ORAL INGESTION OF VCM, CAM4ULATED RATS MERE INTUBATED KITH 2 I9G/ML VCM IN MATER.VCM UPTAKE HAS VERY RAPID. PEAK CONCENTRATIONS HERE REACHED 10 N1N AFTER DOSING. ELIMINATION APPEAR BIEXPONENTIAL. VCM INHALATION AT 7000 PPM ALSO SI10HS A SIMILAR RAPIO UPTAKE FOLLOWED BY A PLATEAU. BLOOD LEVELS FELL RAPIDLY TO BARELY DETECTABLE LEVELS AFTER 2 HOURS. VCM )PHARMACOKINETICS)ORAL) INHALATION )RATS)DISPOSITION)ELIHINATION DISPOSITION) 01608 1990 Item 206 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KMIC INDEX NUMBER REVIEW YEAR 2203 GEN PUBLICATION MUTAGENICITY OF VINYL CHLORIDE, CHLOROETHYLEtCOXIDE, CHLOROACETALDEHYDE AND CHLOROETHANOL. MALAVEILLE C,IARCiBARTSCH H,IARC)BARBIN A,IARC)CAMUS AM,SAME)MONTESANO R,SAME)CROISY A,NONE) JACKQUIGNON P,NONE) NONEVOL 63 NO.2 PP.363-370) 197S EXPOSURE OF S. TYPHINURIUM STRAINS TA 1530, TA 1535 AND G-46 TO VINYL CHLORIOE INCREASED THE NUTOER OF HIS* REV./PLATE 16, 12 OR 5 TltES OVER THE SPONTANEOUS MUTATION RATE. THE MUTAGENIC RESPONSE FOR TA 1530 STRAIN HAS ENHANCED 7, 4 OR 5-FOLO IN THE PRESENCE OF HUMAN, RAT OR MICE S-9. IN TAI530, CHLOROACETIC ACID SHOWED ONLY TOXIC EFFECTS, HHILE CHLOROACETALDEHYDE, CHLOROETHANOL AND CHLOROETHYLENEOXIDE CAUSED A MUTAGENIC RESPONSE. THE LATTER COMPOUND HAS A STRONG ALKYLATING AGENT. VCM)IN VITRO)MUTAGENICITY) CHLOROETHYLENE OXIDE)CHLOROACETALDHYDE)CHLOROETHANOL) BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMfUNICATIONS) BIOCHEMICAL BIOPHYSICAL RESEARCH C0MJNICATI0N) 01506 1990 Item 207 ACCESSION NUMBER 2201 208S706S BFG51985 data tmrch on vcm for craig elgut Order nuiber 901119-133245-WIZ -001-001 page 66 sat 3 with 363 of 363 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS KHIC INDEX NUtBER REVIEW YEAR GEN PUBLICATION ONCOGENIC AND MUTAGENIC RISKS IN COttUNITIES WITH POLYVINYL CHLORIDE PRODUCTION FACILITIES. INFANTE PF.NONE) NONE* 1975 AUTHOR REPORTS EXCESS CONGENITAL MALFORMATIONS IN COttIUNITIES WITH PVC-PRODUCTXON FACILITIES. VCMjBIRTH OEFECTS*TERATOGENICITY)CNS DEPRESSION*KUMAN*EFFECTSEPIOEMIOLOGY NYASjNEH YORK ACADEMY OF SCIENCE(OHIO DEPT OF HEALTH* 01433 1990 Item 208 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR 2149 GEN TECHNICAL REPORT EVALUATION OF THE REISZNER MINIMONITOR CHARCOAL BADGE AS A VCM MONITOR (PART II) BORN JWBFG* BFG(CORPORATE TECHNICAL SUPPORT STATUS REPORT 6504-64* 1985, AUGUST 12 BRECKSVILLE REPORT OF J.H. BORN CONCERNING DEVELOPMENT AND EVALUATION OF THE REISZNER MINIMONITOR CHARCOAL BADGE FOR VINYL CHLORIDE SAMPLING. ALSO INCLUDES STATISTICAL ANALYSES REPORT OF A.M. FAIRLIE. VINYL CHLORIDEMETHOO*MONXTORING EQUIPMENT* 1991 Item 209 ACCESSION NUTBER 2142 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT FINAL ORAFT CRITERIA DOCUMENT FOR VINYL CHLORIDE AUTHOR/AFFILIATION NONE.NONE* ORIGIN EPA DATE 1982, JANUARY ABSTRACT HEALTH EFFECTS BRANCH/OFFICE OF DRIVING WATER DISCUSSES PHYSICAL AND CHEMICAL PROPERTIES,HUMAN EXPOSURE,PHARMACOKINETICS,HEALTH EFFECTS,RISK ASSESSMENT ANO MCI UNDER CONSIDERATION FOR VCM. DESCRIPTORS MMim VCM*DRINaNG HATERHUNANS*FFECTS*CARCXNOGENICITY*CHRONIC*TERATOGENICITY|MUTAGENICITY PHARMACOKINETICS* HELD TERMS REVIEW YEAR MCLjMAXIMUM CONTAMINANT LEVEL* 1990 Item 210 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2141 GEN EPA REPORT HEALTH EFFECTS ASSESSMENT FOR VINYL CHLORIDE NONE,NONE* 20867067 BFG51986 data aaarch on vca for eraig lgit Order nunfcar 901119-133245-HIZ -001-001 page 67 eat 3 with 363 of 363 item* ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR EPA,REPORT N0.PB86-154475) 1984, SEPTEWER __ DOCUMENT REPRESENTS A BRIEF,QUANTITATIVELY ORIENTED SCIENTIFIC SUMMARY OF HEALTH EFFECTS 0ATA. IT NAS DEVELOPED BY THE ENVIRONCNTAL CRITERIA AND ASSESSMENT OFFICE TO ASSIST THE OFFICE OF EMERGENCY AND REFEDIAL RESPONSE IN ESTABLISHING CHEMICAL-SPECIFIC HEALTH-RELATED GOALS OF REME0IAL ACTIONS. IF APPLICABLE,CHEMICAL-SPECIFIC SUBCHRONIC AND CHRONIC TOXICITY INTERIM ACCEPTABLE INTAKES ARE DETERMINED FOR SYSTEMIC TOXICANTS, OR Ql VALUESARE DETERMINED FOR CARCINOGENS FOR BOTH ORAL AND INHALATION ROUTES. A Ql* NAS DETERMINED FOR VINYL CHLORIDE BASED ON BOTH ORAL AND INHALATION EXPOSURE. VINYL CHLORIDE FOLLOMING INHALATION EXPOSURE HAS BEEN SHOW TO BE CARCINOGENIC IN HUMANS,RATS,MICE AND HAMSTERS. USING OATA FOR TUMOR INCIDENCE IN RATS, A Ql* FOR HUMANS OF 2.5X10-2 (MG/KG/DAY )-l HAS ESTIMATED. NO DATA ARE AVAILABLE CONCERNING ORAL EXPOSURE IN HUMANS AND CANCER RISK. ON THE BASIS OF TOTAL TUMORS IN FEMALE RATS FEO VINYL CHORIDE-CONTAINING DIETS, A HUMAN Ql* OF 2.3 (MG/KG/DAY 1-1 HAS ESTIMATED FOR ORAL EXPOSURE. **** CARCINOGENICITY)VCH)RISK ASSESSMENT)EFFECTS) RAT'S) 1990 Xtm 211 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR 2121 GEN JOURNAL APPLICATION OF THE "FILTER MODEL" TO A RISK ASSESSMENT FOR VINYL CHLORIDE OLSON CS,EPA)SCHAEFFER DJ,NONE) J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,VOL 17 PP.1-22) 1986 THE FILTER MODEL HAS USED TO ESTIMATE THRESHOLDS FOR THE INDUCTION OF CANCER FROM MANY DOSE-RESPONSE SETS FOR INHALATION AND INGESTION EXPOSURE TO VINYL CHLORIDE FOR RAT AND INHALATION EXPOSURE FOR MOUSE. ESTIMATES FOR A VARIETY OF END-POINT COTBINATIONS HERE LOG-NORMALLY DISTRIBUTED OVER ABOUT 2 DECADES FROM ABOUT 1 TO 100 PPM FOR INHALATION EXPOSURE TO RAT AND 0.1 TO 30 PPM FOR MOUSE. HHEN THE DATA IS TRANSFORMED TO "DOSE" (MILLIGRAMS PER KILOGRAM BOOY HEIGHT PER DAY), THE ESTIHATES FOR INHALATION AND INGESTION EXPOSURE ANO ALSO FOR RAT AND MOUSE ARE SIMILAR. ESTIMATES FOR DIFFERENT EXPERIMENTS CARRIED OUT FOR DIFFERENT DURATIONS OF TINE (SINGLE EXPOSURE TO 1 YR) ARE COMPARABLE. SINCE THE THRESHOLD IS AN INTRINSIC PROPERTY OF THE BIOLOGICAL SYSTEM, THE ESTIMATE, EVEN FROM A PROTOCOL FOR SHORT EXPOSURE AND LESS THAN LIFETIME OBSERVATION, CAN BE USED DIRECTLY IN A RISK ASSESSMENT AS THE MAXIMUM SAFE DOSE. VCMiRISK ASSESSMENT)CARCINOGENICITY)EFFECTS)HUMAN)RAT)MICE) 1995 lien 212 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2116 GEN LITERATURE SEARCH CITATIONS FROM THE LIFE SCIENCES COLLECTION DATABASE--VINYL CHLORIDE: TOXICOLOGY 11970-1965) NONE,NONE) NTIS,PB86-856119) 1986 THIS BIBLIOGRAPHY CONTAINS CITATIONS CONCERNING THE TOXICITY OF VINYL CHLORIDE AND POLYVINYL CHLORIOE FOLLOMING SHORT ANO LONG TERM EXPOSURES. METABOLISM, CARCINOGENICITY, ANO TERATOGENXTIC POTENTIAL OF THESE SUBSTANCES ARE CONSIDERED. METHODOLOGY TO QUANTITATE THEIR PRESENCE IN 20867068 BFG51987 data search on vcm for craig elpjt Order number 901119-133245-WIZ -001-001 page 60 set 3 with 363 of 363 items DESCRIPTORS REVIEW YEAR atmospheric dust and body tissues are oiscussed. occupational hazards are also noted. <this UPDATED BIBLIOGRAPHY CONTAINS 231 CITATIONS* 11 OF HHXCH ARE NEH ENTRIES TO THE PREVIOUS EDITION.) ******* VCH(PYC((ttJMAN)EFFECTS(ANGIOSARCOMA (CARCINOGENICITY(ACUTE(MICE(RATS) RABBITS* 1990 Item 213 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERNS REVIEW YEAR 2006 GEN JOURNAL OCCUPATIONAL EXPOSURE AND BRAIN TUMORS MOSS AR>UNIV OF CALIFORNIA* J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH*VOL 16 PP.703-711) 190S EPIDEMIOLOGICAL EVIDENCE OF AN OCCUPATIONAL RISK OF BRAIN CANCER HAS BEEN REPORTED IN FOUR INDUSTRIES HHERE CHEMICAL EXPOSURES ARE LIKELY* MOST RECENTLY IN A SERIES OF PROSPECTIVE STUDIES IN THE PETROCHEMICAL INDUSTRY. HOMEVER* ONLY IN THE CASE OF VINYL CHLORIDE EXPOSURE HAS AN OCCUPATIONAL CENTRAL NERVOUS SYSTEM CARCINOGEN BEEN IDENTIFIED. THIS REPORT REVIEWS THE CONVERGENCE OF EPIDEMIOLOGICAL AND LABORATORY EVIOENCE THAT ESTABLISHED THE OCCUPATIONAL CARCINOGENICITY OF VINYL CHLORIDE* AND DISCUSSES IN DETAIL THE CURRENT EVIDENCE FOR AN OCCUPATIONAL RISK OF BRAIN TUMORS IN THE PETROCHEMICAL INDUSTRY. BRAIN(TUMORS(VCM(HUMAN(EFFECTS) GLIOMAS) 1995 lien 214 ACCESSION NUt-BER 2068 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT EXPOSURE TO VINYL CHLORIOE AND ANGIOSARCOMA OF THE LIVERsA REPORT OF THE REGISTER OF CASES AUTHOR/AFFILIATION FORMAN 0*N0NE)BENNETT BICI(STAFFORD J*SAME(OOLL R.NONE) ORIGIN BRITISH J OF INDUSTRIAL MEDXC1NE*V0L 42 PP.750-753) DATE 1985 ABSTRACT THE ASSOCIATION OF PLASTIC MANUFACTURERS IN EUROPE MAINTAINS A REGISTER OF ALL CASES OF ANGIOSARCOMA OF THE LIVER IASL) RESULTING FROM EXPOSURE TO VINYL CHLORIDE MONOMER (VCM).THIS REGISTER HAS RECORDEO ALL KNOW VCM RELATED CASES OF THE DISEASE HORLDMIDE THAT HAVE BEEN HISTOLOGICALLY CONFIRMED.ALTHOUGH LIKELY TO BE INCOMPLETEIT IS THE MOST COMPREHENSIVE TABULATION OF SUCH CASES AVAILABLE AND*BY THE ENO OF 1984*118 MEN HAD BEEN REGISTERED .THE INFORMATION FROM ANALYSIS OF THE CASES CURRENTLY ON THE REGISTER IS USED TO MAKE AN APPROXIMATE PROJECTION OF THE MJHBER OF CASES TO BE EXPECTED IN THE FUTURE.TME CONCLUSION FROM THIS PROJECTION IS THAT THE INOUSTRY IS REACHING THE HALFMAY STAGE IN THE APPEARANCE OF VCM RELATED ASL. DESCRIPTORS ** VCH (ANGIOSARCOMA (CARCINOGENICITY )HUMAN(EFFECTS)LIVER) REVIEW YEAR 1990 Itee 215 ACCESSION NUMBER FILE LOCATION 2038 GEN 20867069 BFG51988 dais taarch on vcm for craig algut Order ncmfcar 901119-133295-HIZ >001-001 page 69 sal 3 with 363 of 363 item DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS hhhh HELD TERMS KWIC INDEX NUMBER REVIEN YEAR JOURNAL TOXIC EFFECT OF ALIPHATIC CHLORINATED BYPRODUCTS FROM VINYL CHLORIDE PRODUCTION ON MARINE ANIMALS ROSENBERG R,NONE)GRAHN O,NONE)JOHANSSON l-NONE) MATER RESEARCHtVOL 9 PP.607-612) 1975 THE ACUTE TOXIC EFFECTS OF CHLORINATED ALIPHATIC HYDROCARBONS FORMED AS BY-PRODUCTS FROM ONE SWEDISH AND ONE NORWEGIAN PLASTIC PRODUCTION FACTORY,HERE EXAMINED BY EXPERIFENTS KITH COO tGADUS MORHUA),SHRIMP ICRANGON) AND A POLYCHAETE (OPHYRYOTROCHA LABRONICA). THE TOXICITY OF 1, 2-DICHLOROETHAfC--A DOMINATING COMPOUND OF THE BY-PRODUCTS--AND A DISTILLATE KITH HEAVIER COMPOUNDS HERE ALSO ESTIMATED. THE TOXICITY 19BH,LC50 I RATIO BETWEEN THE CONCENTRATIONS OF A SWEDISH BY-PRODUCT ,A NORWEGIAN BY-PRODUCT* AND DICHLOROETHANE HAS 1:9:39. THE EFFECTS OF 1* 2-DICHLOROETHANE*1 * 1*2-TRICHLOROETKANE AND 1*12-TR1CHL0R0ETHENE ON THE REPRODUCTIVITY* AM) ON THE SURVIVAL OF ADULTS OF OPHRYOTROCHA HERE STUDIED. THE REPRODUCTIVITY HAS AFFECTEO BY THESE COMPONENTS IN FAR LONER CONCENTRATIONS THAN THOSE HAVING ACUTE TOXIC EFFECTS ON ADULT SPECItCNS. IN ONE EXPERIMENT SERIES OPHRYOTROCHA HAS EXPOSED SUDDENLY TO THE TEST SOLUTIONS AM) IN A SECOND SERIES THE FIRST PRESENTATION HAS MADE BY A SUCCESSIVE INCREASE OF THE CONCENTRATION OURING ONE HOUR. THE ESTIMATED 96-H LC5Q-VALUES FOR THE TEST HITH SUCCESSIVE INCREASE HERE 1:6-3:1 TIMES HIGHER THAN THOSE FOUND FOR THE TEST NITH SUDDEN EXPOSURE. IT IS SUGGESTED THAT A PHYSIOLOGICAL SHOCK IN THE START OF BIOASSAY EXPERIMENTS MIGHT HAVE REDUCED THE LC50- VALUES IN MANY PREVIOUS TESTS. VCM)EDC)EFFECTS)AQUATIC TOXICITY) 1*1,2-TRICHLOROETHANE) 1,1,2-TRICHLOROETHENE(CHLORINATED HYDROCARBONS) SHEOISH HATER AND AIR POLLUTION RESEARCH LAB 0I020PLBL 1990 Ifen 216 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KHIC INDEX NUFCER REVIEN YEAR 2037 GEN JOURNAL CARCINOGENITY BIOASSAYS OF VINYL CHLORIDE:CURRENT RESULTS MALTONI C*NOTC)LEFEMINE G*N0NE) AM4ALS OF THE NEH YORK ACADEMY OF SCIENCES,VOL 296 PP.195-218* 1975* JANUARY 31 STUDIES SHOW THAT VCM CAUSES CANCER IN RATS,MICE AND HAMSTERS (ANGIOSARCOMA ANO POSSIBLY OTHER TUMORS). ANGIOSARCOMA) VCM* CARCINOGENICITY) RATS) MICE) HAMSTERS) INHALATION) EFFECTS) CHRONIC) LONG-TERM) 01019PUBL 1990 I-tan 217 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2039 GEN JOURNAL THE INFLUENCE OF SOME BYPRODUCTS FROM VINYL CHLORIDE ON ON FEPROOUCTION ON FERTILIZATION* DEVELOPMENT AND LARVAL ND HERRISURVIVAL ON PLAICE*COD ANO HERRING EGGS BRAATEN B,NONE)MOLLERUD FE*NONE)SOLEMOAL P.NONE) 20867070 BFG51989 data search on vcta for craig algut Order rarbar 901119-133295-MIZ -001-001 page 70 set 3 with 363 of 363 iiaat ORIGIN NONE*PP.81-90) DATE ABSTRACT 1972 THE EFFECT OF BYPRODUCTS FROM NORWEGIAN VINYLCHLORIDE PRODUCTION ON FERTILIZATIONEGG DEVELOPMENT AND LARVAL SURVIVAL NAS TESTED. EGGS AND LARVAE OF PLAICE,COD AND HERRING APPARENTLY SEEMED UNAFFECTED BY CONCENTRATIONS UP TO 10 PPM,BUT CONCENTRATIONS OF 100 ANO 50 PPM DELAY AND STOP DEVELOPMENT OF PLAICE EGGS IN AN EARLY STAGE. COD LARVAE SEEMED TO SURVIVE HIGH CONCENTRATIONS OF THE TOXIC SUBSTANCES FOR FAR LONGER PERIOOS THAN DID I ANO II YEAR GROUPS OF SAITHE. DESCRIPTORS VCM) EFFECTS) AQUATIC TOXICITY) HELD TERMS INSTITUTE OF MARINE RESEARCH (NORWAY)) KHIC INDEX NUMBER 01Q16PUBL REVIEW YEAR 1991 Item 218 ACCESSION NUMBER 2031 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT CHROMOSOME ABERRATIONS IN WORKERS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION FUNES-CRAVIOTO F.NONE (LAIBERT B>SAME)LINDSTEN J*SAME) EHREWERG L.UNIV OF STOCKHOLM(NATARAJAN AT* SAME) OSTERMAN-GOLKAR S,SAME) ORIGIN THE LANCET,PP. 459-460) DATE 1975, FEBRUARY 22 ABSTRACT LYMPHOCYTE-CULTURES FROM WORKERS 17 EXPOSED,3 CONTROLS) WERE STUOIED. THE FREQUENCY OF ABNORMAL CULTURES HERE SIGNIFICANTLY HIGHER IN THE EXPOSED GROUP. DESCRIPTORS a mm mm VCM(HUMANS(EFFECTS(CHROMOSOMAL ABERRATIONlMUTAGENICITY1 HELD TERMS CHROMOSOMAL ABNORMALITIES) KHIC INDEX HUBER 01013PUBL REVIEW YEAR 1990 Itea 219 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mcmumn KHIC INDEX NUMBER REVIEW YEAR 2015 GEN JOURNAL COtBUSTION PRODUCTS FROM VINYL CHLORIDE MONOMER O'MARA m,BFG) AIHA 1971* MARCH HCl(PHOSGENE(VCM) 00950PUBL 1991 Item 220 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 1805 GEN PUBLICATION VINYL CHLORIDE-ASSOCIATED DISEASE LELBACH M(*NONE)MARSTELLER HJ.NONE) 20867071 BFG51990 data search on vcm for era if} algut Order timber 901119-133245-HIZ -001-001 page 71 sat 3 with 363 of 363 items ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEM YEAR NONE,VOL 47 PP.1-1101 1981 THIS IS AN EXTENSIVE REVIEM COVERING PRODUCTION,TOXICOLOGY, CHEMICAL AGENTS,PATHOLOGY CONSIDERATIONS,NON-MALIGNANT DISEASE, ANGIOSARCOMA, AND MANY OTHER ASPECTS. PVC iVCMjACUTE (CHRONIC ^CARCINOGENICITY (ANGIOSARCOMA tACROOSTEOLYSISl MUTAGENICITY}METABOLISM) PHARMACOKINETICSl THROtBOCYTOPENIAlUNIV OF BOMt (GERMANY))ADVANCES IN INTERNAL MEDICINE AND PEDIATRICS* IftIUNOLOGYl 1991 Item 221 ACCESSION NUMBER 1001 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MALIGNANT TUMORS OF THE LIVER AND LUNGS IN AN AREA KITH A PVC INDUSTRY AUTHOR/AFFILIATION SARIC MNONEiKULCAR Z.NONEIZORICA M,NONEtGELIC I,NONE* ORIGIN ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 17 PP.169-192) DATE 1976, OCTOBER ABSTRACT THE INCIDENCE OF MALIGNANT TUMORS OF THE LUNG AND BRONCHUS AND OF CYTOLOGICALLY CONFIRMED PRIMARY MALIGNANT TUMOR OF THE LIVER HAS ANALYZED FOR A 4-YR PERIOD IN A CITY WITH SEVERAL FACTORIES, INCLUDING A PVC INDUSTRY. PRIOR TO THE STUDY TWO CASES OF ANGIOSARCOMA OF THE LIVER HERE DIAGNOSED IN WORKERS EMPLOYED IN PVC PRODUCTION. THE STUDY DOES NOT INDICATE THAT THE OCCURRENCE OF MALIGNANT TUMORS OTHER THAN ANGIOSARCOMA IS ASSOCIATED KITH EXPOSURE TO VINYL CHLORIDE. DESCRIPTORS * VCHiPVCiLIVERtEFFECTSiLUNGIANGIOSARCOMAiHUMANlEPIDEMIOLOGY* HELD TERMS INSTITUTE FOR MEDICAL RESEARCH A OCCUPATIONAL HEALTH (YUGOSLAVIA) * REVIEM YEAR 1992 Item 222 ACCESSION NUIBER 1800 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT TUMORS IN PATIENTS WITH ANGIOSARCOMA OF THE LIVER AUTHOR/AFFILIATION VIAFttA NJiNONE* ORIGIN NONE,VOL 95 NO.2 PP.IBS-186* DATE 1981, AUGUST ABSTRACT MOST PATIENTS HITH NELL-DOCUMENTED ANGIOSARCOMA OF THE LIVER HAVE NOT DOCUMENTED EXPOSURE TO ANY OF THESE THREE CHEMICALS (1),S0ME CONSIDERATION SHOULO ALSO BE GIVEN TO THE POSSIBILITY THAT OTHER AGENTS STRUCTURALLY SIMILAR TO VINYL CHLORIDE I SUCH AS CHLOROPRENE,TRICHLOROETHYLENE) MIGHT PLAY A ROLE IN THE CAUSE OF THIS AND POSSIBLY OTHER MALIGNANT DISORDERS. DESCRIPTORS mcwim VCH *ANGIOSARCOMA*THOROTRAST * HUMAN* EFFECTS* HELD TERHS ARSENICALS*ANNALS OF INTERNAL MEDICINE* REVIEW YEAR 1992 Item 223 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE 1799 GEN JOURNAL 20867072 BFG51991 data search on vest for craig elfiAit Order nunfcer 901119-133245-HIZ -001-001 page 72 sat 3 with 363 of 363 itsns TITLE OR SUBJECT P0HER CONSIDERATIONS IN EPI0EMIOL0GIC STU0IES OF VINYL CHLORIDE WORKERS AUTHOR/AFFILIATION ORIGIN BEAUHONT JJ,NIOSH)DRESLOH NE N0NE) AMERICAN J OF EPIDEMIOLOGY,VOL 114 NO.5 PP.725-7341 DATE ABSTRACT 1931 NINE RETROSPECTIVE MORTALITY STUOIES OF WORKERS EXPOSED TO VINYL CHLORIDE HERE REVIEWED TO DETERMINE WHETHER DIFFERENCES IN THEIR HYPOTHESIS TESTING RESULTS MIGHT BE DUE TO DIFFERENCES IN STATISTICAL POWER. WHERE POSSIBLE, THE POWER OF EACH STUOY WAS CALCULATED FOR CANCER OF THE LUNG, BRAIN AND LIVER. WHEN POWER HAS TAKEN INTO CONSIDERATION, THE RESULTS FOR LIVER AND BRAIN CANCER WERE FOUND TO BE CONSISTENT WITH AN ETIOLOGIC ROLE FOR VINYL CHLORIDE. FOR LUNG CANCER, THE DATA NERE NOT CONSISTENT WITH AN ETIOLOGIC ROLE, IN THAT TWO STUDIES WITH VERY HIGH POWER YIELDED NEGATIVE RESULTS. DESCRIPTORS ******* VCM)LUNG (CANCER|HUMAN j EFFECTS ^EPIDEMIOLOGYJ HELD TERMS STATISTICAL POWER) UNIV OF WASHINGTON) REVIEW YEAR 1992 Itaa 224 ACCESSION NUTOER 1796 FILE LOCATION GEN DOCUMENT TYPE BIBLIOGRAPHY TITLE OR SUBJECT THE PHYSIOLOGICAL EFFECTS OF VINYL CHLORIDE AND POLYVINYL CHLORIDE (USERS MANUAL,VOL 1 AND VOL II) AUTHOR/AFFILIATION NONE,NONE) ORIGIN NONE,DEVELOPED DATABASE SYSTEM CALLEO BOYD DOCUMENT SYSTEM (BDS)) DATE 1981 ABSTRACT THE FIELD OF OCCUPATIONAL SAFETY AND HEALTH HAS UNDERGONE AN INFORMATION EXPLOSION OVER THE LAST SEVERAL YEARS. THE PVC SAFETY GROUP OF THE SOCIETY OF THE PLASTICS INDUSTRY, INC. (SPI) HAS ASSEMBLED THE LITERATURE ON RELEVANT RESEARCH FINDINGS APPLICABLE TO THE PHYSIOLOGICAL EFFECTS OF VINYL CHLORIDE (VC) AND POLYVINYL CHLORIDE (PVC). THIS INFORMATION IS EASILY ACCESSIBLE AND CAN BE CONVENIENTLY SEARCHED. ANY INTERESTED RESEARCHER, ADMINISTRATOR OR LEGAL REPRESENTATIVE MAY REQUEST A SEARCH OF THIS DATABASE. THE INFORMATION OBTAINED IN THIS DATABASE NILL BE SUPPORTIVE OF RESPONSES TO GOVERNMENT INQUIRY OR ACTIONS,LITIGATIQN,AND COMPARISON OF SCIENTIFIC RESULTS. DESCRIPTORS * PVC)VCM)TOXICITY DATA) HELD TERMS DANIEL R. BOYD C CO) REVIEW YEAR 1992 Item 225 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1795 GEN REPORT EVALUATION OF MORTALITY IN BFGOODRICII WORKERS: A FOLLOW-BACK STUDY OF MEDICAL RECORDS AMD DEATH CERTIFICATES (FINAL REPORT) NONE,NONE) NONE,FOR BFG) 1974, MAY 17 THIS REPORT (BFGR) SUMMARIZES THE RESPONSE OF TABERSHAH/COOPER ASSOCIATES ITCAI TO A REQUEST FROM B.F. GOODRICH COMPANY (BFG) TO TO EVALUATE THE POSSIDLE ROLE OF VINYL CHLORIDE AS A CAUSATIVE AGENT FOR ANGIOSARCOMA OF THE LIVER IN THEIR HORKERS. MUCH OF THE ACTIVITY CENTERED UPON THE LOUISVILLE (KENTUCKY PLANT WHERE CASES OF ANGIOSARCOMA HAO BEEN IDENTIFIED PREVIOUSLY. AN 20867073 BFG51992 data search on vcm for eraig al^it Order ntafcer 901119-133245-HIZ -001-001 page 73 set 3 with 363 of 363 item DESCRIPTORS HELD TERMS REVIEM YEAR INTERIM REPORT HAS SUBMITTED BY TCA TO BFG ON MARCH 20, 1974. IT SIMMARIZE0 MEDICAL AND INDUSTRIAL HYGIENE RECOMMENDATIONS, AND PROGRESS IN EPIOENIOLOGIC STUDIES. * VCM>EPIDEMI0LOGY)HUMAN)EFFECTS> TABERSHAH/COOPER ASSOCIATES) 1992 Item 226 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEM YEAR 1794 GEN REPORT MEOICAL RECORDS AND INDUSTRIAL HYGIENE STUDIES FOR BFG N0TC>NQNE) NONE,PROGRESS REPORT FOR BFG) 1974, MARCH 20 THIS REPORT DETAILS THE STATUS AS OF MARCH, 1974, OF CONSULTATIVE ACTIVITIES PROVIDED BY TABERSHAH/COOPER ASSOCIATES,INC. TO BFGOODRICH COMPANY MITH RESPECT TO THE MORTALITY AND MORBIDITY ASCRIBED TO THE HANDLING OF VINYL CHLORIDE, ESPECIALLY IN THE BFGOODRICH LOUISVILLE PLANT. RECOIflENDATIGNS AND PROPOSALS ARE ADDRESSED. VCM)EPIDENIOLOGY)HUHAN)EFFECTS) TABERSHAH/COOPER ASSOCIATES) 1992 Item 227 ACCESSION NUMBER 1793 FILE LOCATION GEN DOCUMENT TYPE PROCEEDINGS TITLE OR SUBJECT BIRTH DEFECTS AND VINYL CHLORIDE AUTHOR/AFFILIATION EDMONDS,CDC) ORIGIN NIOSH,CONFERENCE ON HOMEN AND THE WORKPLACE (WASHINGTON)) OATE 1976, JUNE 17-19 ABSTRACT STATISTICAL COMPARISONS ON DISTANCES VARYING FROM ONE MILE TO 10 MILES OF PARENTAL RESIDENCE TO THE PLANT INDICATED THAT THERE MAS NO DIFFERENCE BETWEEN THE CASES AND CONTROL. DESCRIPTORS VCM)BIRTH DEFECTS)HUHAN)EFFECTSEPIDEMIOLOGY) REVIEM YEAR 1992 Item 226 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1792 GEN PUBLICATION VINYL CHLORIOE AND CONGENITAL MALFORMATION NONE,NONE) CDC 1976 IN MARCH 1975, THE OHIO DEPARTMENT OF HEALTH REPORTED AN INCREASED RATE OF CENTRAL NERVOUS SYSTEM (CNSJ MALFORMATIONS IN 3 OHIO COt+IUNITIES WHERE POLYVINYL CHLORIDE (PVC) POLYMERIZATION PLANTS ARE LOCATED (II. THE MALFORMATION RATES HERE DERIVED FROM BIRTH CERTIFICATE DATA FOR 1970-1973 AND HERE COMPAREED WITH SIMILAR DATA FOR THE ENTIRE STATE OF OHIO. THE INCREASE HAS NOT 2U8S7074