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a n d w el f ar e a g en c y OF PUBLIC HEALTH EDMUND G . BROWN, Governor July 175 IStlt ion,, ':rising Grotip en Lead Centat&naiion tiers of .ksalih fducation, and Welfare Y;-:.'by6IicColtuomalb2tiha6,PSOarelkrilvwoicaey ' lev x'oad over the third draft of the Three-City* Study and first .;:ii vo coraepnpdeayresatoanhdeymouorviangssvoecriyatwesellca*sti this very ercimleoc and important ;f boXtydobulridivene aisfeswomceworhramt itnscooncppiaegtee 2in0syTohepitnrieosntiaaenRdtIowfotuhled qsuugegsteisotnthe ^edition of two paragraphs (Xamsending copies of4this letter to Dr* Kobe aid Dr* dorten in order to expedite their reactions if any* to those oorrvouts) Host of the crperiiasntal work on uptake and excretion of lead has teen carried out with inorganic load compounds The relationship of load DLkyla to the total body burden is not as i&oroughly investigatod. .oo.H"frhgjiraasttnaminiscotsllbpooehaaceddaruicecsoxemspaaopmsovuupernleredysshoaa(vfsfosealroiblaedpdeisnrcoaueplkxsopsyriotlcissone,ndoseotfoafthpstheia^egcpeiosinfldi7lce9ivacanitdintoudna3lasa0onuwadnnictdstoh'nofaacfnbetlnheisteerVsa*etIio-n3-3 on page dl). Fron animal experimejitation and the relatively rare occupational ;closures in nan it is likely that lead levels in the brain and central nervous systemAny to eem extent reflect the exposure to lead alkyls* It is also tliougiii that urinary lead levels ray reflect changes, if of sufficient nsgni* tude, in lead alkyl exposure and that blood lead levels are relatively less sensitive* ' There has been a very modest amount of work on lead concentrations in the various organs in the body compared to the study of blood lead levels* Ijtnotroliixsulvmaotcacodlyndvittehinoeinemanltagwdnaoittruakdinoegnohlfeyatphdoetchboeonsdicysenhthteraraettiionbnloooifndleltareidae*d.olreIgvtanewslsoourfledpfbeleerscodtneasspirw-aibthle varying degrees of exposure to ataospheric lead in order to provide further 'tests of this assis^ticn* phrasOenpthegebo22dy bliunredelnitofthloeadsenitnenacewsatyawrthinicgh sNugogeevsitdsentchea*t*,#theucsoesnctshnetration of load in ooveral organs of the body have been tested extensively* As I read the preceding material I have the impression that it refers to experimental exposure, but it could refer to occupational exposure as well* Dr, John H, Ludwig Page- 2 July 17, 196h alascu:b;dsatritutotecfloarrifthyevsheanttesnigcehttobewthhiocuhgahttteonftiaosnanhaasmbbeiegnuidtyrawInwaosulfdolsluogwgse*st I'fcPrraoa:!thtieleremlaantyivoeblsyersvcaatinotnysoobfsetrhveatbiolonosdolfoaledadlevcoenl caenndtriattsiontrenindsv,aarniodus organs of t:ie body, there is no reason to think that uniformexposures at laodeut levels ever a long period of tine load to a progressive increase in storage of lead in the body.'* In the section on Lead Intoxication the comments concerning blood ab normalities indicate that blood abnormalities do net occur- unless intced.cation occurs* I believe this viewis at variance with previous statements ao.mofeatDcrrtoiodnKcotehoolleslewaehdnodesaxthipdeosseiunrneeayaffreebecitntet"eTterhfeeetreeedanrcbleyiewisnticthrfeinathdseeindg^ussartiounfraaratyiobnpioocorhpfehhmyerimcinaoslg.l"obin . .'This is a paraphrase but 1 believe that tho essence of the statement is s.:.Ie-.tctriirosenctt)hocofuIagnnhtIvtiteehmwat6otf,hewthieithsarasltiaestesectmtireoennatcIhtieo%andioinutolgdasBnuiogucghneedsmtesitcihraealbCaledrdietixetiproionasuotroef Ettohxipsloesaudre. would bo the increase in the body burden of lead in the various organa of the body, dince it is nearly ir;Bx>ssibla to aterrnins this in a systematic afatshthioonparmesoenngtlatringoe fnoumr bperrascotifcpaeloppulerp,oistesi.s not easy to use such a criterion Probably the next change which riiiirt be detectable would be a raid iinntethrfeeruernincaerywipthorhpheymritnast*opoiesis which would bo reflected in an increase :b\s an indicator related to tho body burden of lead wo have chosen in icnrettihosintsu*dsytui-dteoydweixdoaumnldointheafbeveleololadthdlaettaodthaolletevlereaaldtsioaennxdspoiasnlusroheesmtoloikgelexolabyminitnome eubteraibneoanlircsyomulneataneddredex for this reason porphyzdns were not examined.* ' The section on Biological Studies lias teen much improved and this ob vfaiobuleslyVIre-p0re-1seanntds VaIs-ubCs-t2antotiaplreesffeonrtt*the1dfiisntrdibiuttioobnjeoctfioanlalbolef ithne sub jtyepcotss oexfamsrionhejdoeitns 1e9x0am6iannedd oanllthoefsethetwsouobcjeccastsioenxsa,maisnetdheinta1b96le3 bdeoceasuisnedtihceate, iesmpsluoybesetsanatnidalClyitydiHffeearlethntD. epTahretmseunbtjeemctpsloiynee1s9w63hoisneclrmud&enb17lo6opdelsetadoflfeicveels altaoehnrfaeeydathftlhaiilnnelsgthettwhooiesofmeplcpoo"orwaneppssueespslqialtoeutniiseonnntachntehoda.eftoItCtrhaaibnetnhlgrceeeei*rsne"hnfaaoisTtnrhiebebderieeinetnfwqcfealeuureeesndsinitom1tn9tihp5no6aruotftaiponttohhndroetm1iion9f,ni6nI3sH*aicbelaeTbtnlwoinheodeovytcaebocd,luoducrnimdrttieenronaisbnteiounsfte these two tables, be deleted. tain Tthhooucgohlutmhen hcoemadmienngt iinsdtirciavtiinagl,thTaatbltehseVlIe-ftGh-a1n2d, 1s3er,ieansdolfitt,hdreoencootlucmonns rsehfoeurlds btoe badlodoedd,. and the right h'and series to urine.* These column headings KE . -' ' . ' Dr* John H* Ludwig Page 3 Joly 17, 1961* fSohleloawrIait,nwDgoiirunelddcitvboeirdoaupfaplMsrewecdhiioactaealdsEsiidsfutceaadctkilnoacnv,oloKudragiepsrhesaresnFetocouofnudtlahdteiobnsetuHindoyc*lsupditeDadrl*atonMdathrCteilninic, OPeamklaannde!ntoDr*ProFgrreadmesricBkr*Al*ilSllcihaaarlReso,thMroeedkic,aMi. eDdiirceacltDori,reScotourthoerfnthCealHifuogrhneisa AHeiracltrhafDt eCpaorrtpmoernatt*ion! and Dr* Morris Grover, Health Officer, Pasadena City I hope that these cements will bo helpful* Sincerely, AJoibrsMPio*llGutoioldnsmMitehd,icKa*lISUt,uHdieeasd cci Mr* Join Maga Dr. Robert llcrtou Dr. Robert Kehoe K Z 000471 a