Document zoGmBzyOXM361MowY21EogREz

klirck SO. 1972 Ur. W. E. McCormick The B. r. Goodrich Co. 909 8. Malm Street Akron. Ohio 44518 Dr. T. >. Torkoloom Toxicology Specialist Chomlcal Biology Boooarch 1805 BoUdlog Tho Dow Chemical Co. Midland. Michigan 48440 yrM. N. Johnson. M. D. Monsanto Co. 800 Lindbergh Bird. Si. Lovla. MUoonrl 45144 Gentlemen: At Dr. Xcfifcdtcd'f enggoetton X dl senstod tho proposed protocol for tho vinyl chloride Inhalation study with Mr. Carrol Well at Mellon lastUnto. From the brief description I gave him. he had two recommendations the first was to specify that tho strain of rate alee be selected for a low incidence of spontaneous tumors, as wo have already done for tho alee, and tho other wae to oxpeee the mice for 18 moaths instead of 12 mostha. If it le not poeeibto to mso an 18 month exposure spaa for tho mice, then he feelfc they should bo exposed 12 months and retained until the end of the 18 mosSh period. X have also sest a copy of tho protocol to Mr. Weil and ashed for any other comments after he has read it in detail. RS V 0000300 ! 1 xoeoooo ASM 40|Mia IWH IW1WY *r m * **if **rc wwm+oc a * '*a *a *N m !M *t *a n vrnm-i 'JI `UmA ifM) ii*A 'ftfWlMl pw smv i wi Piod pnSM ^ i *iioIm4 m\ hihw 11 ! MfMtte Ml MP fc^m |9imnM Mti Mpua4j9 pra<qMa 9 ! !!" I SU? *0WI a n mw -k *i*v*i *x **a ^)fxOjyf *x `A `IK