Document zoGNa27JRm7jJ9zXjKBE8wQVg

AR226-2759 gnn nu POUT USE ONLY K I du Pont de Nemours and Company HHaasekke.llll ^U kiki mtono SJoad> TNeowkarlck>o lWDelaware 19711 " Study Inltiated/Completed 1/1/B - 11/3/ Material Submitted by c oiymer" rroduc.ts Dept. Washington Works Parkersburg, W. Va. ORAL LD50 TEST IN RATS P r o cedure The tealt mater:Lai, lntragastrlc intubation in single g ^ u r o f ^ ^ o u n r a d u l t CrltCD determine the initial dose S M 'tbl S e t e s i - 8 ^ s u r v i v i n g rats were weighed and observed during a 14-day recovery period and ?hen sacrificed. Resultat Dose Average Body (ma/kg) Weight (g) 25.U0 242 l As received Average Doae (ml) 4.IB Mortality Ratio 0/10 LD50 > 25,000 mg/kg Clinical Signsi 25,U0U mg/kg Congestion and slight initial weight loss (1 rat) after dosing. c" r i s - ' * conrgestion Ind sli. g.ht. _w__eji^gUhi .t llAodscs (inn fotfne rat. * ei6"8observ,i"*CB - -1 -jgCACB1 noicoo^ Does S anW*ed deacha. Report by: L iiU Lon Rinckle Technician Approved by: Gerald L. Kennedy Chief, Acute Investigations Section LSHt!ujdry8Director: n0 L Dashiell 22, 1980