Document zo7YxpRdpX13Nay6NrJ5jwr17

od mew erence : ! des Lis, Cove de: L.S. Cove Sisels 223-6SE 13 ha L.J. Hals V. Catewens W. Caldwe ll 1.8; Kraan L.C. Krogh Sisear 223-6SE Eon J.E. Long Siosh 220-2E Wi Fetersen W.H. Petersen Bistess 223-6SE wi: Soom W.F22.2233--S66cS5oEEwn -- EES MINNESOTA MINING & MFG. CO. MIHN|SOTA MINING & MFG. CO. RRo. JJ.. SSEEFFFFLL -- 223366--22A4 aCnl~v _W_iWlimlmlinnggttoonn,~ DDeellaawwaarree comm: CpOeMaPsAoNnYi:EL: PERSONNEL: tod. D LAZENIE - 236)o@a~n 1122//55//77~5 ~ J.D. LAZERTE - 2~6-1 E. 1. auone E. I. duPont dupont duPont Her Moneure, l[enry Moncure, Jr. Jr., RRFeelssueeoaarrr.o~shharMMoaannnaaggBeeirrv,., oPfeerv~eyerr~hPluTmtnmieerr,H, oToHHmneepssooeobauisrrFaocclnhhrueotrSSreouustcps+aeerrHrbvvaoiisnsskooerrlD,;liv.FLFallbuusoo.rrooccaarrbboonn SMHiiinkkee'reKKiraa~tppa,lliaa.lnn~ ]",~--~RTT,oooHxxxoilimcccooooplllooologryplimissesttrt,.s| HHHaaasss~kkeeellllll LLLaaabvvsee. Jim Terrll[, Toxlcolog~st, Haskell Labs. aLLL.nitJ. oIwlaaelss SDE A foe L. S. Cove J. E. Long FDFCDuCucEfP-cLoo1aInn4uUtt3se iiI1sannor tc(chhooTeoiR~n.accTeTee~erpJ.fnfnolelesododsSnniebfaaflKbbkleoouuuuttssueseeddtthheeiiinnn,ppHoaMassoarssrrisisbhvthlaiaaeew cottnootxp"vaiiDDccucutsstteelwffeieffetseeshs.cc,ttssPPrrFoooooccffoeedsssst" boercoatuastee.of its possible use in, or in (ontact with, food HpHtehroenonrodyyuucnteMNsoo.noncfcuurrTeeuroeonmnpphhaaKssiiinzzeeddfoottdhhaattdrpddLuuiPPcoounntttioirLses.nnooattndaaddavvcooseccnaaittliiynngg 'rrfrFFTteeeohoehcerercccoyooomgmmuaunnmmnmwsiieeeozznnuFFeeddlDO.ossdARftthhTaccaTaaieglglttkafaeoeiilawnnorrttsshanahTettnnceycycK.eenssauuccivcanacffennhhoorrfononuuvoTlTosoetetedue..ffnlolacSoiooponvnnTpTnehthln.ereiKKe.yyo.c)laitddnioaoHaHfoollroowslnnbreos-oest-tvaaa-e~ptpaerppippnr,llold,lainainnccatnaahcae;tettovyiyouatooatnnlid4ffsslsobii,oyllieeaaenndd PttToohheyysSuupwpcppoooourrlbttd their llke their FoBition. in the tc haw~ defensive Dositlon in the cient That a information event that a provien available problem wiHHd1ieoet0tnenhhsrrsyy F6aCGrG0S-iiei-s1bab0es4rs0.soo33nn aaarinrriedeed.ppTooTerrefttfleeloddonn ocnn K tt(oocxsoitncottiattiyyninssgttuudd0il.ee5ss38 ccaaFrrorrriieeedd) oouuSttome (containing 0.25~ FC-143) some 10-15 years ago. Siw acute tostettys AAccuuttee ocrraall ttooxxiieciittyy:: TTFF19eCCe.f--rld11ioa44enp3$--KFS---teAAu-oUd~"rDyIrni.nno66oo77ncc00ruuopmeutgtsa/"tkgf.ed a ater of OoS(bubobssFeerrasvvcoaauvttteiierooannltsso::xtiecsiwEFEtteenneylLll:dggaa~nrrtEggfeelddo2o2iufr055o%%rliodtitiThaThvveeyeeeserffursllscsrs,ootodfnnunnadttcuuyprprvKKooallntot((toon22dd55er-t-tewhp3a3ahpr0t0eereesennsedd.ggsii//fennkketShggggdii:))mn.eeauussppooTdnnhitteihhtesewwhhiioccfhh asaSt(pEhupoRerpfpfeFoaaasLtocreivetevvaaddeennrrtt.atb.olofobbtae"ObetosOhdt4aheyenrdffos)wuuennlwwccfseettlhrriiuteeooonnrowwrooooarrfftsssiueeotrthhfeewtatahchsaotssnnauunrr4tffFP.aCa8Oc-cwie1eav44sa33aa:.tctuthtseeiidvvWW.iiiictettoyhyhnTthorFooiffoC-sl-11ttt4hho3e3ef tD33hi.te5S. elsidvITnearrlaolt]loabncLoaadstyehTs"uwcethhihegehLteinnnielraraav.rtigieeonmTeehwnneattsoste4ihf.fte8eercsvttssubwytaahsseacurchteoeevnveterrrsoariltebbcliotecf but did require "much time". The other sub acute effect Exhibit 1124 11112244..00000011 Swatonzess 3MA10024380 BRi TE ts ner + 15, ses Field Letter ",. k.J. Seffl EE..II.. DDuuPPoonntt -- .2/5/15 ky Pa~;e 2 le Eieinss of al sresaa es) noted was lne reduction in sleeping times of rats treated with Tora titionioSlee Lig of igpropene ren pentathoL thus indicating possible rapid de-toxJflcatlon of the pre mnSning poets rly spr drug by ~,ne test group. Further details of this study will be RI TLE dlscusze~' on a one-to-one basis b~t~ee:] H. ~.l~man_~and J. Long. Barer sping ts wnstniones Torion stmpelaber hie oun ar DuPont claims that unsintered Teflon dispersion which does not Joe hpi en metgnes Torin gigolo wpe sg contain FC-143 does no~ p~oduce the above ~ted sub acute effects. Er A a Therefore they desire defe[~slve !n?ormation and want to know to RE what extent 3M will be willing to provide them with information Tr ET te why 10mrorias Sen vith snfetin on FC-143 relative to possible inhalation toxicity--sub acute, and BREE RRS ~ata with which to establish an oral "no effect level". Ey It was agreed that J~:n Long and , H~q~ry ~man ---- would get back to- LI Et Dn rt Ee egme pp gether regarding the details of their" tests to date. Subsequently Saher Feganvon SilofuitLanty up swe, Singlets Jim will determine what tests he de<~ms advisable and make his recomBTine0e0 ntSee,hoS rebon wiT m some bIe Soom Bboanneie 00 heBER mendations to the Co,~:~.rcial Chemicals Division who in turn will eormmunlcate wlth duPont as to what our program, if any, will be. 4&/ itt . 11112244..00000022 Pl -- 3MA10024381