Document zo1ZqoXd0nG3wy4pgxmLGVo10
Biochemical Research Laboratory THE DOW CHEMICAL COMPANY
f
a .ToVT oy TiL- :^crrY a*' ^dtiS--U3safi2UEB
OUKYiY
Work *# . C;:u.
T* Ale Boport
Chock
j-i-ir-tfc) rt..b,
It- .
Baodaroost oaft B&SGart (toloao ocses, l*flf
p. 104} g^yo tlw ftllocdag
{eitofl frac ToetfliiaX
Popor 272* 1921, D# Da DopcTtoQOt Of Interior, Dorm
of ninco).
BBSS*
# Jaasa-a^-- (Boa ..One, ^1CQ*
Slight ays^taoo eftor oovural boaro of closure*
Wntttrara Concentration tliGt OOO fc
Is&aod for 1 boar
serious
diCtirbCHOC.
Rapidly festal for avon abort
I espoouro.
1570 to 3UD
S130 to 4700 19,000
\ i
Ttio follOsilr<i ttbla of ooncontrutiono of "Oor.-oLo '.ocorCijit; to t:oir of', -oto end tlae ~f oapoturo Is t .-:oa froa tbe tablo dn im \xi In *:.,ooiiauical Sn^nacriiit?* (1935) * (Cited by Drowning, 2.027, p# 11).
Concer.i;r.t ion of ton-ol vapour in air (;tpo) 19,000
3,000
0,100 to 4,700
2,-370 to 2,120
100
Sffooto
Fatal In vezy aU>ri tlafe
IXiCk^-orooo tdth ox/o juroo Of 1/- -
1 liOCET.
Uaxtaaa oonocctr tioa 0* of 1/C to 1 tiaur*
di it onsptSBa with cjpOOUroseveral hoora. tleriusjBa conooa'ir t- jd. nllo^nil...
auufuu
nO 136607 OONFTDFNTIAV.
-Ci 1* *
iii-L,
: . .1 i u.
TIG.l-i
0;.. ,c 6
i'lio l'ollo iiij t.hl^9 Li* ii--i iUi (Ul~)
o t.
ro j 1 ouo O i
.itii '.atil
O.X i C x* wit L i.-
CX - - i i * J.ai A*
(oxtoti L^- 1907 -j 17): :o utn,Jt
. oi. D i.o t t ji,/
i I*.io o. 1j_, OOil 1
yt l lJ_ kJ .
j t Uj.*
i ;o ;A
t -i*. 1
lou
itor
Li Jit rcocltj
Do on i. l-coele
i'urtlior irooroso
61
1 .,0 >;
J i.OUi'j
-j X * i.Oui'ii
:6
1 -. , 500
... iij.-i'w
a. -uj-', u - anatom
._nuuua -
-
0 hours
olow r^co'i/o.y
-
/. h.uro
DoUtL
x Lor
6 hours.
j ii
.9,000
V0 ..iHUl-o . * Jii! y Jtj
9.
i. iui
-i0 uiuu tui;
1>0 lain.
Dio- rucjvor/
DO 1 3 6 6 2 8 C O N F ID E N T !
Li MjLaaio 1 TIL.1-4
i. Li O \J
k*
Xj .
The lethal - >. ... --a Ji.ia ' ... a.J;tr..C:.U2ia a'u t,i . Jii in i.!.
l'i i j.ro. ninvJ,
1`JLV (. .
J\ .
LI 1 .
-l alio. in... c Ola t-.iiuu
.`nl i la
L .Li 1 0. i. /I.
L.j.an J .1
TTav i Liu ^OiicOii ijiv.*fcjLCui 1. l> JLl
or
Lieu
-.6 .: , 0- >0
La: arm. (1009)
I.ii UU Cats Cuta
:i?o
Ui la uO
LO
l..,000 10,000
0,000
iuhnur (19 al) Luiniami (191..)
(1015;.)
LO(jo
liG
...,000
Luit; (1915)
ituL ai ca
4..1 t/0^. fi iL^Ux L>
, , 00
LoLuaim (101; )
llN ^aU N O O
639901 00
1>
x'J
Aui____1 Uicu C, tn
Lt-i-ix-J-u {, .1 aooll .. *Jv,> til' . - t.
/ . t Ll1"-* bJ .^ i-JU \
t LU L
LxlO Aj.L L
v)l* L L Lx )
Jjl. lb r .ij iU l (
t1 ,, vuO
( -.fOO) (1.,100}
Tine 7
G *,01.11*a G ..ouru u ,to a -- a
a. . uCt
On.au u >,l euhc
Louia
Onau, oi Cotiuo r^..^ Loua
LijjLb n. i c-uls
iJue
i'Oj -i a
- , rck L ,:oi\ lory
i^i'orotiCu
.JA..oorci tor, 19;..
Arch. Lyy ., burl. 106,
lbD ti
it
"Jilu la" "AniaALu'* "/jaiu. lo:> bo^a
1G-1G OU > o
Cat a Cut a C;:ta Cuba
LI an Li an
LO bO 00 60
lo * >0 * uO
C L:\ioa
t J-O)
(-. ,700) (17,, .00)
(1- ,-^o)
(0, .00) (o, ,00) (1-^100) (1 ,100)
( -, 700) (0 00-
'* -0)
( 0, -OOlb, 900)
't-'U ,inuto.j "foT.lu., u. lay i.xuacloa:' ut . .rnutea Oonu. i. -ion:.
10 ..-inul^xiii Uncoil, . u i ou,.j;uau . 0 .-Lnutca boat!
* . . ..lUO tluul. ( 1/ltoU U y Jiixiilt-oii, 19:0, ,, ->,nj)
tt H tt tt
linailton, 19 t-9, fj ou
ho bourn G bourn
ILaru.. oiu a.. cot Conylotc in.rcoaia
la j.LLnutua bare ao
1 hour
Con lute
rejoin
LJinan
(Uitod. by uanilton, luofl
p. -ibb-lb?)
00 ,_,xmicua Haui -^uanoas .xiu a on. ua. oil u.. koura" Loan ol conociauannas
* ,\j' . .LiriX tiOj
,J*. .Cl i o oi Lr-->ii } .
. urolL.^t, 1`jOo, J . x'l. i.JC cun. jl# ao;;-io.
hi- cre.iic V TIG.1-4
0^
rc:
_.e-ootoe :.::'ooiiro3
There n. vc not -eon . .rent nuu-LC oi
orroriiionts ro. ortee in v.-ic.'. 1 bor'.to.-y ni;o 1- .. ve
boon ,iven re_: j ...toe c: .ioeuro z
ooii'. ene Vo,';ors.
_n ..t to .;t h. s been a: .tie to rj:;c lit the 1
ri
i*4*
LI
w3
*s<- <J . in th o hollo; :inj thble. mX i.*:Ur. i tool.:1 ;i oca
.. X V, *
. ^j.
4.+ W
' * on:
j- T ;nt
-ot
a
-*i.Lk i- ron ilcG ore -O 0- n
_ VII.I1
*
--
-30
cent
. uni 1-tu oo..i ii . zi. vii J
t.. ;a;r ' - ^ r_ - H
0. J o'S3
_ VO nt
ty ioel
on.orn:.V' yi**'
f'* 14^4
^e*'"-\' -4V.T*JJP
oo
^
3^63^
OF NT I
CONF T.
hr t
I ]'. p
IJog
>->; */l
* *L /
*
(7.0)
O! 'll.1
:.M0
Length of drily . n o;r.:i'c
16-00 hours
: .a. j- ' dally <j O'.'M'- :c
7
To fc;l 1 7
(BM) 1055 10-BO hours 7 7 :
( .6)
015 10-00 hours
7
7
7-10
G hours
!/ y
o1 o
S3 hj
(MG)
000 8 hours
M4
-99v M/v,'00
0q
Bloc'cnicM hose-roh L-oBor." tory
T I,C;.
1-4=
/*
vet '.'OVC'VCG
Ornhuef' . ' Ms, . crl- h tchc-lor,
n tirni,
ID BO, i Inal
v.hnvsr, Mi i'-t
-.r.oit v-n
incoordin M .a.
ol, h t
t. 1 tchln.,, .'it f 1 t 0 : utj
ij. ' i.-vi; vci v -
.'Ub Council,
sA-y o: .aM. 1th
y. 101.
clonic ; o o - M.-e
My
Incjcruin tlvn, c oil:-bio, to- ' t i )i .
''
j j O 0 i j .1 1 V. : 0 U- C O n fc oil M tty rnd
- n. no.
tT
Ln rv I v u d t'O -; 1 lout. (; MU.
Lj'lc'nr, 1C . rc1 . ;.o:.oi
i.-tK I
Oi
M* r, ML
(jjroi.mn.*,, 3
i. 10)
Ty IcM Moor
icc-ur:. >: ! . ol o:i;;:mln.-.
Y:: nt, >r c- ri
:: -'.7 5, o;
: Milh rt, : >lri;w kuI.;
.eto" in t
j J l.-V . -ViC
`O-' iuc, i
ill- IS.
f'
VM- u. j
; v -* - / y
- |y J. .
;.0 . Vi j ij i*. j i-j
?: C j `w
V
17 V u ys *f t1./ ^ ,/ *-j
10 ' - > , k_-
o-:
rj-_ d L.,,-1.
.^.0 ' - ,/ 'j
iXx" i*l v-*i. J. d -
J li y - Iy*jCl k.^i ^
,, .' obj 0J, vw
'iwj1
' ' c
1.; -id i,Oc. . J>1
# '. ;y
o..ix
;tuo,
A. * 1,. X T' -lit W V>
0!
j .3. . y v>"* U i X*XO
i, i-c ivo yiic-o .'X
o^ijiiltivc - Hood
uUl'U ' *5 t.XX tw ti^T
(.}.
'>OlS\lL'i,)
Ini, IL 0 .
(i.o ^Xi-uJEarc)
(v.J oXXw'O;>u._ c}
(iiG -wlJ udUl't,*)
TIC.1--1
. ; .0C 6
O l*Cfl t L. I 'L-ii . t - j i* j
AnlnUs ji u
{ 1 G)
A.V1-, <-'* Lm
.....
J.i-l
hOO oOu
a GO 1000
Lv-ix ;ii,. oi a.'iily ..:_oo;ao
V l.oui-i* V ..Ju.G
/ ilOLtl G 7 j.>Jlll'G
..J.
V* 11/ Taliil
^ . . v) ^- i 1^. OL*
-J. - < j.
v 1- U u
t ` 5* 1 ,. , w
^ J^
71 - /g
`iX u../o
jjA J. GOt
j.. aii,.. jji uU
ojii. ., 1
tj.'onir. Lial 0 ti'.yy i i tor tea.ia tion ol' o;.. oxure.
Xj l>OGO|) oXUl ...
KUO 111.
iiUUCOiMJlii.U.
ijt.:, t)..
Iicf-1-c..oo
: iCOoi'U j 0 . .' . 100.., ]>cn. ol olx;oiilntj. Til- In.uistivU
lia.lth
Cjnsc v: ncy
Xj toj'ioSj
Ciucin-j ti, Ohio
li jel.xiicul r.o^: rc,, Laboratory
na.i-i 9
dodo of tction
In "'Out o voieoniu_ the eiii -- of foot of ben..olo is uoon tin. centric. nervous s/stan, v;Lilo in chronic yoieonin the nost rovero ..eycrer ti n f- .iy.c occur in the lienuto :oiotic rvoten.
.notations fr.aa
- +- "f * > 'A -- n V*n *1
^
Va VW
-i
' )^p '
.olO'.r to' rubstidate tills rtatenxit.
"In .cues ..-enroll . on sonan. one sai;t,,,.o to
-.u.. .... . u v v 1,; -- r a a o 7 .'. estruct.vo of.. cot u on
the ceutr--.il nervous system, .hxroeo in chronic ban xlo . oi-onin... tf- 'relatively .11 ht moo*+t>s on die ccr.tnJL :i .'rvme mete . re not ,t .11 o : i r jle n r- * ' s - --a-*-
-f'-y
o.. tho iw. :cnm-\tive c._n,;ou mourri..
;.... .x:r. co xi-mio
,, sue i. In .cue- , oi.-oni:. , ' .e. ol .
oor# ~I..,_yo neurot j.J.u ..:r,, 1 t r s
(- .tc.xiar, cTj * TJ * J - ln' tw '/nJ --.. -,
--'-ta-
.--^ -
-<
.
^
W . ..
. - . r.` --
J -/ r.
Tt
J - -* ^
J _ V_r
** ,n -
- U. fcX ^ ^ i O |
V, -7u) a ^C-
-- S / .
t -- *-
?ITv
i:Ci :f Luh. dxti xi
jo.:::ola am;, our u.on -nix 1.- i~- th t o_ .. mien oinn,
.itl: . emmet oil otic noure-irrit.xt effect, as evidenced
oy xuscle fritc.-iu.,, .onvu^sinx, ,mor..l trexor, state
o: hy. t to id. city of th- .-oay n moeul cion (lr.tu ..;lor,
19.7) , onjus. in n:_ny a a on. a
ooxli r ri.d-u d-shv. od
. nm: ition of cho t;JLl. (1
:......9)
7>0 1 366^F> CONFIOENTTAl
Biochemical Hoscurch Luborato T16.1-4 fago 10
"A toodc action upon the heart Id also postul .toil by Ilahun and Hoi'f (1934), proGreoclvo unozenia of the myocardium, nd a sensitisation of tho myocardium to the offccts of adrenalin, so that doatii nay occur from ventrlcul r fibrillation. (Cited from Brownin^, 19C7, p. 17)
"____Tho offoot% of clironlc benzene poisoning
Id to cause a Iocs of rod blood corpusclos, resulting in profound mania; . loss of tho elements :;nu oubst sices In
the blood \;hics are concerned in bloou clotting, r:suiting in hemorrhago; md a loss of v/hito blood cells .aid of the substances in ahe blood scrum ; hie.. arc concernaa in defending tho body against bacterial infection" (Ihsail ton, 19I;9, p. 470), (Hamilton, 199, p, 475-479 presents a great deal jf szporinontcl cvidoncc uhich substantiates tho . .hove statement),
.ran t:.u \.ork a. a .great number jf invest!.y tors it is certain tn ; nn.olo is 1 .uccsornn (evident p...rti oul,../ly in ._onic empomros), .vi urou is.. nc v only tie oircul tin, leucocytes in tho blood, but .loo tho
-rcnciiyci-tons cello or the bonc-marro*.;, sloen au lymph ,d..nds. h pcrcntly tl is destructive orfeet ^.s more pronounced on tno myelocytic th tar lymph tic elements. In addition thero is a loso obvious uifect on tho erythrocytes, rao to injury oi tme orythroblastio tioo'io in the dono-nurrov and an initial stinul ting effect on tho .onc-marrov; i.ith a resultin,, leucocytosis.
oo 13663^ CONF TDF.Nt^ AF
liocmauical .'.oscare., iio. i-*n
- CU'CJ 11
nory
.ou n * Q .1 Vo -- 1`JJLdZlZOO
u.; on Clu ..mi:_to. OX1--'t C `J
nature or -Ills action, ita suocioicity
} r'
la-.
initial attack are still andetouninod.
vi-cnco for m oint of
Hold ntucies
recently , very sen'loco resort of carefully
conducted study of industrial ronsone o::;osuro ....s _son
;'uslisLcd ..o folio-..s:
fo'.iiitcfi,
n. .plains, ... f. Cfr mic ..270curt;
00 .mrmono (lom.ol). I. f :o luuurvrl 1 .is mts. -7. Xnd. -0 -- j^l# j*~*s---dt, , I/O. luntor, . T. CIronic . .mo cure ro 0:1..one
(Ij-U-oI). II, Tlx Clinical . ffecos. 7, Inti. r;y. <j To:;.
^1, I71-led, loro. ..ollory, T. a., >.1.1,
. , . cm iriokl.y,
. J.
fir mi j m.orure 10 .oa.aaa (for. >1). III. . / irxlo, ,c
.. ItiL a
" T-*
'r ^
n^-.- i
j
v*` -
. -L. |
t',_r"7t7 'V'n
<- v* * j
-- *" *J
j. . _~^
j::. a-uve.
m- ..s.i;cd.
_ul clinical n. _ 0 m . : or-- sr;-..-- . ore
-1G ` j l1 " ^ _ ,1
-- . u i lo -in -0 of
iso C'.rflfull.,-
/ 'J 1.
urtner, .i-tolo ,ic .... z ,
To.: 1C times
.runic
oi.o .mvosuro ns r m._i ously
- 'J
__ .. ^
.W
I :ie ' T'1 T ' A'T* 3 *1 w
H , -- iul
T
^^
"* * *,
, "J ...
... .e . j........... oi sonic: so e.neonor cions
O--J- ^--0-- V 0_.`OO^.w^. .,
i-1 .
^ ) * .... - .
-
.0 hj ^ 1 j v . ,, .."O u
n~ in ...oat
.. y, >--<
to
s .oueu oolo- 0 .i., .1 uro.
00 136637 C0NF1DFNTIAt
iioo'^nicnl + ,;o I- -
rcL loborotc:.
(
clinical (inoiin:.n:_. I
-cry)
/O >OTl c,'.t
,"i v* o 1
w wil ^4* V l* t --, __ J ^ o , i. ^ <Lv */ -
; lollo in
.on e on;i uol jus
di irir. ,
ttTi';ic 'Crumr on
cio jrcxJ
Ori. iwr--
drjocure,
^ ^ v - - c .jI o o d
j- --j,, o__ ^
*j, ..lf .. ^,, o -- d --j
-out: ..olyct.iouii;:; l.jjsciiiw. or loucc-ioi^ '.ioou
icturos ( oio--ji' I/-i.n tic or or/.loi..) ; oo.-dno r,,i.r,
re ;J.oc/tooic >: .-icrocytosis; S-.-jj reccnco ,i in- euro
'l-uouoo ill _..: .-i.er. _.o
1 "* f"\ `
1 :
>J___ -- o.__ .., -
.l00`. 1 .. l_-uoo
IT 11 non- , u.
*-* -J
'* on-n
-- ----
-
-1- * ' {f
"
__ -- '. a. ^4, U .. W> -l*
J
o_-n:-:: uooruui; u. on :; o:::; t--iu u or: ciro
;iu our.
or.
> . i.
0 oU . tl W Cr
c
v* . - 1.
DO 1,36638 CONFTDFNTTAI
CCil ese'.rc.: bnuoratory T16.1-4
Host ia:-sort.xit In tb-.: fact tbst cbe rtboln-;-0^ oi;ji..cs continue to develo bter cxie wxcjonurx.; < e censed, t o mcy uoto the authors ..s bollovs:
"Ho _.iscushion ->b t i.O -uieml ,,e> - b en.. quo
; ecu: w>0 vOx -uOd ./It.. - -J '*. J . -*'
* v---- close
;y ob many ob those byyorol .stis norrov.'s, .on./os cd --v--1 J . j ' in .a.tar e _.-_ ..o.o.i/- -invents, ro the
bone -UT/, c lee cribcg by bnrtl ;id (. .0-..) in
wdiua
;oi;.orJ_n ,. .. still tore .ur/risin-, t:.eu ;ii r/b 11/
accidental ..roll dim owlets in tbc ^roloiioOu. 1..Ouiic; between,
ns.osure _nb tie devolouieno o..' syn tor: ir detect, blu sinns ,,re 'neatly observed in the t*.;o conditions. T'n_ no..ors
era no no :orr- then ortnroso tboir nrr.t event tb. t . single
volatile ory/mie cnaiicul, -c --iy lisuinntco vie :ne
r -o ,ir...tor;- or ot o
Lf.L ' * -y v
i:i c.t. .olo io
..o ..moot . bier. _ ro res; .; ,r uonebs aid i,va;
h.- n: :ounrc b .s
it
rs
jon ' *"_i `" j <
\/ *
t) on ,u:;c rodneed ...nos. _ .,
no c_n
n: osure
r?.bLso .Ujjcaoi ;o ,j nyon- nu- n.:.s :uuc n von
su/orbicidly cases ,, : tre by ord sole ty. c /bio . r_vc been
_ rcsontou. .r obis rrtiol.
t.._ o/:..jtco,. . -V...C, tor
rr.r.t -' ' /otter tor..:,
j - 11
noo ins-me t o. .'..ency *
Tbc dorrso . - :sr 1; si.., tl.o r. idt; o- jro-.vt t ju-jod by
... number i nicotic ..injures,
.. c.ovolo oion: -. rolls
vi::: no counter ,"'rt in ncrm/l donut jut con.non to n
ricty or nli^ejas tutors ore s--ne* .on..
wvio oi
QO 1.36^40 CONFIDENTS
Biochemical Booor.rcfc, l.barctory Tlo.1-4
?rvo 15
neoplasia arj.c.. tnc ..utitoru nave novor horotcvoro ..rot in such nvrnad loyreo in non-noo;;l antic states. Certainly no norc ravorc.blo oonuitiono Tor the uevclo incur. or noojirsn can oo i: a.joined than rolonyca xlu intense stinui tion oi` reproductive activity ,,nd siuult .uous arrest or in turation.
"Tlio evidence tint chronic miiosure z-j ..mono
produced louoaaia in Inman br-njo
still ineonjl. - . but
it ir rccunul-.tir. a rae .:n_ n valiant aim w;: nd
serious consideration."
Tori colo giegi hi, jiiriQ:r.cc oh ion, eno
..nr/
in laone o.. ""
imuctr. _i cove sure
to bonrono to io-_n n c.o. 10.10 jJ ore cotter on.s Ivon
brio-.::
Bro\ nr:. y To id. city o;. Invar tri.'i ..olvonts, .is
j \.J lo u j w- ' v j Tw id r. ^
'-'rice, ojbcu.u, -j- i.
.viilten, _n.au-tri a o.. vac an
m>
n - - **
amla _l .yQi .g
.j , _ o
`.'r**
n (;..wli..ol) - oi_*_..sin *
.. Z 4 1 V>>( . .. U+-*
I, -..I.-1.;, 001-017, _'JLl.
\
-inul iegort o. ti, Gomittee on bon. el. national
ai'cty council, 10; 0. r1^*. ,b r*t v*. i chilly (r.;.-i eolo y, Im-urti-bl
Medicine, Cliicnyo, 1907,
. 700-76C) li *w0?
rf* >w> a. 1
.-i rl r .ulllj*
on lately oon_Uwoa o_.j .u^.. . v_-- in con.-no
( oenrol) .m. bon. ino. In no earn i-
reva v. or bentone
toiicolo..,/ 4. .o ivl-oa a. on.
00 'I.366'11 CONFTDFNTTAl
no.i-:-
3 10
.1 .j^urci; Ll.,,j-..': jry
_xoa 1 re views vl.w iiiyrcssion - - ^-i.'.ou t.v.t
, -ro.t ..'.any c.:
-_ ben .ovc o 1. ouin .r.ve ;cc-_:toc. _.u
Industry and tint bbere I v; been a considerable mcibci*
oi' deaths. Since in only tow instances is tlore 'uy
indication
,i j* ...
J. V* -- ^
severity o.
..orposurs,
it aoula nos bo
advisable to nil a C-TOful StUd`.' Oi H thODO CaSC3.
Ilovover, the record or do many cooes oa;;h.'.:.si _cd the definite indust-iilai haaard resentcc "by ' on.:one.
The evidence yLvon by the iocc.it clinical
01. ; tholo.,,ieil studies (o. Inc. yj. 1 Ion. _1, 1910)
ah,.oi.ioo n.o iuDi-ioia. nature
Ion. eiio oiDOiicr,,j
, tf . _
_ u^.Ll - - , wu
.Cl .. ' - hi. L.0`Ve,jIi<
.iloitulo h halts
The laitLanni '4.1oi;able o me onto-: .tier, bovo \ a_eh
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no 1.36643 CONFIDENTIAL