Document zo15yxO01v572z8EQQZ5740R0

CONFIDENTIAL World Register of Cases of ANGIOSARCOMA OF THE LIVER (ASL) DUE TO VCM REVIEW DATE FEBRUARY 1991 ^p Collated by: J. R. Drumwright, M. D. Vista Chemical Company Manager Medical 900 Threadneedle Houston, Tx. USA Telephone (713) 588-3044 Fax (713) 588-3107 Tlx 794557 CH* LIVER ANGIOSARCOMA CASES CIRCULATION OF REGISTER BAGSHAW Dr I M N BAND Or P R BARRAT Dr G BAXTER Dr P 3AYLAC Dr BEUEC Dr BENECH Dr N BENNETT Or B 8ERTAZZI Dr P BEYNON DUS BISHOP Dr C BORRELLI F E BRAUN Or C L J BROGDEN M E BROUN Or N G BYREN Dr David CAMPION Or Catharine CARTER Dr J T CHIOZZINI Or Giorgio CLARKE Dr E A CONTASSOT Or J C COWLES Dr Sally DELORME Or F DEPLAN Dr F DIETZ Dr H U DOLL Prof Sir Richard OCMBROUSKI S L S OOORNBOS Dr N ORUMURIGHT Dr J R DUPONT G EMMINGER H ERNST Dr U EVANS Dr A E J FALK Dr H FAVRE Or FIELDING Miss C CONFIDENTIAL FEBRUARY 1991 Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Colmtoia, Vacouver, Canada AECRP, Cosaantry, France University of Caafcridge UK Atochem, Chaurty, France Rhone Poulenc, Aierviliars, France Naphtachteie, Lavera, France ICI Hitlhouse, UK Inst of Occupational Health, Milan University, Italy ICI Rincom, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhaai, The Netherlands ICI Rvrteom, UK Shell, An Den Haag, The Netherlands Nobel Industrier, Smdsvall, Sweden Health l Safety Executive, Bootle, UK EMAS, London, UK Ospedsle Uatoerto I, Venice, Italy Ontario Cancer Foundation, Toronto, Canada Atocheai, Saint-Fons, France Shell Oil, Houston, Tx. USA Quebec, Canada Atochasi, Jarrie, France 8 F Goodrich, Akron, Ohio, USA Imperial Cancer Research Ftrtd, Oxford University, UK Dow Cheeriest, Midland, Michigan, USA DSM, Seek, The Netherlands Vista Chaarical, Houston, Texas, USA APMC, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chearischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Centers for Disease Control, Atlanta, Georgia, USA Atocheai, Hontluel, France ICI Mftlbank, London, UK CMA Oil947 FILLINGE J FINCHAM Ms Shirley FOA Prof v FORMAH Dr 0 FRASE $ U FRIEDEL Dr H P GAFFEY Dr U GIlllGAM Dr. R. GIUDICE Dr S GOTTESMAN Or R T GOUGH M GROtSMAM D HAMILL DP PW HILLMAN Dr 0 W HOWARD Or J 1C HOUE Susan R. HOWE Or W HUMPHRY Dr M F JOHNSON Roy N KAIPERT Dr J H KALNAS Or J LAGAST Dr H LANHAM Dr John LANOUZIERE Dr CLaudine LAURENCE-JONES Sir C LEE Dr F I LEESER Or Jenny LELSACH Prof Or UK LEVEQUE Dr G LEVI SON Prof Dr D A LEWIS or P LIGO Dr R N LO MARTIRE Prof N LUSS R D LUSSATO Dr Josette MALTONI Prof C MATTIUSSl Dr R MELTON B MIDOLETON D MOKKA Mr MONTESANO Dr R MOTTI Or A A MUNOT Dr K A MUNOZ MOUTON Or M MacSUEEN Prof RNM NAKAMURA Dr S NORTHROP Or H L OSMAN Or J OUEN Dr R PADDLE DrSH Solvay, Brussels, Belgiun Alberta Cancer Board, Edmonton, Canada Inst Industrial Medicine, Milan, Italy Inperial Cancer Research Fund, Oxford University, UK OiversiTech General, Akron, Ohio, USA Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monsanto Co, St Louis, Missouri, USA Occidental, Dallas, Tx, USA Montedipe, Venice, Italy The Vinyl Institute, Wayne, NJ, USA Centre for Risk Management, Washington Electrochemical Industries, Acre, Israel Mamill Associates Inc. Annapolis, Md, USA Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand CMA, Washington DC, USA I Cl Runcorn, UK ICI Australis, Melbourne, Australia GenCorp, Fairlawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland tnperial Oil, Sarnia, Ontario, Canada Solvay, Brussels, Betgiu* Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, Franca Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK ICI Runcorn, UK University of Bom, West Germany CDF Chimie, AZF, Bully-les-Mines, Franca Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port da Bouc, France Institute di Oncologia, Bologna, Italy Envelope Returned no Address Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Nasta Oy, Espoo, Finland IARC, Lyon, France ICI Duperial, Buenos Aires, Argentina University of Massachussetts, Antoerst, Me. USA Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo, Japan ICI America*, Wilmington, De, USA Health t Safety Executive, Bootle, UK Harpenten, Harts, Ok USA ICI Central Medical Group, Alderley Park, UK jaii,, CMA 011948 PAOJET Dr Christian# PARIS Or A PATERSON Dr J C PINAUD R PIRASTU Or Roberta POSSBERG Dr J PUECH Or AN PURDHAM Dr J RAMBAUO Or J RICHARD Or A ROBSON Mrs D ROSA Dr HS RUTY Dr J SALG Dr Joyce A SCHIPPER Or H SCHUCKMANN Or F SERONNC Dr D SGOURIS Or G SIGRIST Or J SIMONATO Or L SMITH Prof Allan H SMITH Or P M SPIRTAS Dr R STAFFORD Or J STAHNECKER Or E SULAIMAN Or TACHECI Dr H TAM8URRO Prof CH TENKHOFF Or N TEPPER Or L B TERUIESCH Or B THERIAULT Or Gilles THIIS'EVENSEN Or E TOMATIS Dr L TONER H P VAN OER MERUE Or H J UALTEMATE H UEJDL1NG S 0 WELLMAN Dr J WEN Or C P WILLIAMS Or DMJ WILSON Prof R YORK J ZOBER Or M A Atochem, Serquigny, France Rhone - Poulenc, Roussillon, France ICI Runcorn, UK Petroquimica Colombians, Carkagena, Columbia Istituto Superiors di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Petroquimiea, Salvador, Brazil Atochem, St Auban, Franca NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechat, Frankfurt, Germany Diamond Shamrock, Dallas, USA EKO Chemicals, Thessaloniki, Greece Shell Chimie, Berre L'Etang, France University of Podua, Italy University of California, Berkeley, USA llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafcn, Germany Arabian Petrochemical Co, Saudi Arabia Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Morsk Hydro, Porsgrunn, Norway IARC, Lyon, France Society of the Plastics Industry, Washington OC, AECI, Sasolburg, South Africa BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenwgsind, Sweden Goodyear Tire A Rubber, Akron, Ohio, USA Chevron, Houston, Tx., USA BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgiua BASF, Ludwigshafen, Germany Fran: J. R. Drunwright, M. 0., Vista Chemical Coepany 900 Threadneedle, Houston, Texas, USA CONFIDENTIAL Register of Cases of Angiosarcoma of the Liver Due to Vinyl Chloride Review Date - February 1991 As you're aware, Dr. Brian Bennett left ICI on September 30,1990. The responsibility for maintaining the ASL Register was passed on to me. All data has been reviewed, updated and prepared for the 1991 Register based on information supplied by Dr. Bennett. Your suggestions for change, additions/deletions for the future Registers will be appreciated. i Respectfully Submitted, ^ jjR. D _. PREFACE: Acknowledgements, Significant Changes, Comments & Requests 1) The four new cases in the Register are: Australia 01; Germany 40; Italy 08 & 09. The Australian case is the first notified from that country. (Currently, two cases in the US are under review for confirmation of diagnosis.) 2) There have been no deletions for the 1991 Register. 3) Amendments from previous Register include new page for Australia; Table 2: Total Western Europe cases increased to 99 with world total to 161 cases of ASL; Table 4A, 4B, 4F, 5, 6, 7, 12: Recalculations due to new cases . 4) Based on current data, the following cases are still alive: France 15 & 28; US 33 & 36. If new information is available for these cases, please advise me. 5) Thanks are in order for new cases, information/clarification and reports to: Drs. Friedel; Johnson; Northrop; Lagast; Richard; with special thanks to B. Bennett. 6) Research: I respectfully request that each recipient of the Register continue to keep me informed of any new cases, etc. and/ or provide me with the name and address of the appropriate individual who can supply the necessary details. (A blank sheet is enclosed at the end of the Register to assist you in reporting the appropriate information.) Also, please continue to provide any relevant information about earlier cases, factory data, etc.) as well as individual retirements, changes of address, etc. for the Register mailing list. From: J. R. Drumwright, M.D., FACOM Manager Medical Vista Chemical Company P.O. Box 19029 Houston, Texas 77224 USA Telephone (713) 588-3044 Telex (713) 588-3107 LIVER ANGIOSARCOMA CASES (REVIEW DATE - FEBRUARY 1991) INDEX Table Sequence Australia............................................................................................................................................... 1 Belgium................................................................................................................................................ 2 Canada............................................................................................................................................... 3-4 Czechoslovakia.................................................................................................................................... -5 France..............................................................................................................................................6-11 Germany........................................................................................................................................ 12-19 Italy............................................................................................................................................. 20-21 Japan................................................................................................................................................. 22 Norway............................................................................................................................................... 23 Spain................................................................................................................................................. 24 Sweden............................................................................................................................................... 25 UK.................................................................................................................................................26-29 USA............................................................................................................................................... 30-38 Y ugoslavia............................................................................................................................................. 39Incidence of Cases per annum (Table 1)........................................................................................40 Distribution of Cases by County (Table 2)....................................................................................41 Pattern of Cases by Factory (Table 3)...........................................................................................42 Latency Periods (Table 4A)............................................................................................................. 43 Distribution of Latency Periods (Tables 4B-4H)......................................................................44-50 Annual Geographical Incidence (Table 5)..................................................................................... 51 ASL Case Numbers by year of Death (Table 6)...........................................................................52 ASL Case Numbers by year of first exposure (Table 7).............................................................53 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8)........................ 54-55 USA PVC Producers - Start-up Dates vs ASL Cases(Table 9)............................................ 56-57 Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10)....................................... 58 East European PVC Producter - Start-up Dates vs ASL Cases (Table 11)...............................59 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12)..........................................60 South & Central American PVC Producers - Start-up Dates (Table 13)........................................ 61 Austra/Asian PVC Producers - Start-up Dates (Table 14).......................................................... 62 Middle Eastern PVC. Producers - Start-up Dates (Table15)......................................................... 63 Number of PVC Factories in the World (Table 16)..................................................................... 64 Blank form for notifying new cases...............................................................................................65 CMA 011951 J MISMUU 1 COUMTV ANB tffflEME m 2 turn m 1BillALA i MIC Of lain * conn 5 fACIQRT 6 FIRST VC uposuc LIVER Anoiosarcaw Caves fttvicw dale febcwry 1991) 7 MIC Of 01AMOK IS B ACC AT 01 AMOS IS 9 IEAAS Of amu TO 01AMOS IS ID IEAAS Of EtfO SUAE It OAIE Of DEATH 12 HISTOLOGICAL CONf IAHAIIOH IS ESTIMATED EXPOSURE LEVEL 14 OCCUPATION -- 15 16 OTHER CAREER H1GML1GNIS OTHER C0MHERTS n p ICI Botany July 1965 April 55 25 10 April Teft AwtrftlU *su 1990 1990 Low Hediue PVC Uareho us ShifUan July65 to Mat.67 (20 aonths) Autoclave Cleaner Mar.67 to Aug.75 (8 years 5 ontlii) Letter; Or Nf Ikapfiry, Chief Medical Officer, ICI Australia, June 1990 j CMA 0 1 1 9 5 2 1. J BEIGJUN ;-- COUNTRY AHO REFERENCE HO 01 2j NAME OR OAIE Of INITIALS 1IR1H 12.01.1} 4 COMPANY totvay 02 SR 29 09 60 Solvay n > O 1IVER Anglosarcoitia Cases - (Review Date February 1990 sn 6 7 0 9 10 rrrn 12 13 H 15 16 FACTORY FIRST VC INPOSURE DATE Of DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE 10 DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISlOtOGtCAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHUGHIS OTHER COMMENTS Jwppe oo.or.so 00.05.76 63 10 17 29.06.76 Yes High Autocleaner Driller in a Hepatic tests U yrs foteidry In Oct 1974 19561960 (2 yrs) were noneat. exposed to Polyuorker Farmer 200 ffm 3 yrs (15 yrs) Retired Feb 1975 for 6 hr* Work in glass Hospitalised per day knd. i cheml- Nay 1976 end cal industry certainly Complete under 500 ppm Clinical and career detaiis irtj6 to 9a* are given in a paper by autoclaves Mublet et at 1969-1972 in Arch. Belg. exposed to Med. Soc., 30-200 pp> Nyg. Ned. 0 hr* per Irev. Med. day.In Leg. 25a 1977 pages autoclaves 601-622 1972-1976 exposed to 50-200 ppa in euto- cleve rows 1976-100 PI* 1975- 50 PI* RETIRED 1 Eeb 1975 jeaeppe 20 00 62 00.10.79 59 17 9 23 10 05 Yes OB.62-01. 63 01.67 -10.71 200 ppei Bh/day 06.63-12. 66 < 200 PE* Autocleaner Fireman since 5 yrs 5 athi 10 71. Operator 3 yrs 9arths. 1st sign iuly 79: Thoracic pain 07.79. Hepatic teats altered 10.79. Poaitive echogrephy 11.79. Hepatectoory 02.80. Chemotherapy. Information given in letter 12 Nov 1984 from Or De Sloover. t 'O cn J CANADA Sheet 1 1 COUHIAT AND REFERENCE NO CANADA 01 2j NAME OR DATE OF INITIALS IRTN 1S.12.1J 02 OA.OJ.H 0] 20.00.19 04 OS.04.19 OJ 07.OS.11 ot IS.12.19 07 09.11.19 00 13.0S.20 09 19.07.21 LIVED Angiosarcoma Cases - (Review Date February 1991) DM - MONTH TEAR All dates use LK system 4 C0H9WT s FACTORY 6 MAS! VC EXPOSURE 7 DA1E OF DIAGNOSIS 0 AGE AT DIAGNOSIS 9 TEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS Of EXPOSURE 11 DA1E OF DEATH 12 [ 13 HISTOLOGICAL { ESTIMATED CONFIRMATION EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS HtWIiusa 1944 1955 41 11 11 02.09.55 Yes Reactor cleaner Operator Smoker polymerisation 1943 1957 43 14 14 21.12.57 rei 1 ^ |1941 1902 42 21 20 23.03.02 1 lei | Maintenance, Operator ni1iurtght, pipefitter Operator, foreman Worked overtime Smoker Worked overtime Non-smoker 1945 1907 40 22 22 21.01.60 r | Reactor cleaner Operator, foreman, water cooltng wit Worked overtime Smoker 1944 I960 57 24 05 05.07.60 1947 1971 51 Yes | 24 2] 10.04.71 Reactor cleaner Reactor cleaner Water cooltng Worked unit overtime Smoker Maintenance, millwright Worked overtime Smoker * 1940 1972 S3 20 25 24.12.72 Yes Reector cleaner Machine shop operator and poly unit Worked overtime Smoker 1901 1973 53 12 05 12.06.73 Yes Reactor cleaner Maintenance in pi ant machine shop 25 yrsl Smoker 1946 1974 S3 20 26 04.09.74 " Furnace op. pipefitter maintenance ________________ 1_____________ Worked overtime Smoker * Paper by Or f DELORME in Annalas d*Anatomic pathologique Paris, 1970 Vol 23 No 2 pplOHU claims this case had both a hepatoma and ASL simultaneously. O * > -o v\ CANADA Sheet 2 1 - I COUNTRY AND REFERENCE HO NAME OR INHIALS DATE Of aitTN CANADA ID 16.05.15 LIVED Angiosarcoma Cases (Review Date February 1991) PAT - HQNIH - YEAH AH dates use UK system 4 COMPANY 5 FACTORY 6 71 0 FIRST VC DATE OF AGE AT EXPOSURE DIAGNOSES DIAGNOSIS 9 10 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE 11 DATE Of DEATH 12 HISTOLOGICAL confirmation u 14 ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMHENIS Sheuinigei 1955 1976 61 21 14 00.04.77 Yes Reactor cleaner furnace op. maintenance, packaging Ex-smoker u LG 11.I0.2S Gulf Ihauinigai i 1941 Nov AS 60 42 5 05.04.06 Yes Nigh 1943 47 Operator t Supervisor VC Plant et 1 rad 1972 (Age 47) Letters from Dr Fernand Delorme, Pathologist & H ftibeao, 1FG 12 1C 14.09.20 Gulf Shewinigari IKS Mar 02 61 57 27 11.01.02 Yes High 1945-55 Retired 1972 Letters from Autoclave (Age 52) Dr Fernand Operatort Delorme, PVC Resins Pathologist A tt Bibeau, BFG Low 1955-65 VC Manufacture Medina 1965-72 Autoclave Operator, PVC Resina 1] ss 10.06.26 EG Niagara 1957 1907 60 10 21 26.1.07 Yet 1957*70 Poly Cieanar Retired I960 Informal ion tie!land High & Operator (Age 54) from Dr H U Dieti, 1970 00 SiDcrvisor BFG, 1968 Low CMA 0 1 1 9 1 ___________ ____________ i -- I tn CHECHOSLOVAKIA LIVES Angiosarcoma Casas - (Review Date February 1991) 1 COUNTRY AND REFERENCE NO 23 NAME OR OAIE Of INITIALS l?H A COMPANY 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE Of DIAGNOSIS a AGE AT DIAGNOSIS 9 10 VEAAS OF EXPOSURE 10 DIAGNOSIS VIMS OF EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS CZECHOSLOVAK1A 01 2fl.06.2S Stilt Co Novaky 01.07.3/ 26.12.73 45 16 16 24.1Z.73 Yes Autoclave Cleaner IARC letter bf 1-4-32 giving details froai Prof A David of Centre Ind Hygiene and Occ diseases. 02 ot.or.2T State Co Novtky 01.11.30 27.11.66 37 14 15 26.11.66 Yes Autoclave Cleaner IARC letter of 1-4-32 gave soaiewhat altered dates for this case. 1 have accepted the changes since the dates cone froa Prof A David of the Centre of Industrial Hygiene and Occiput ional Diseases. My dates cone originally treat XIOSH. CMA 0 1 1 9 5 & f 5 FRANCE Sheet I ---------- ; 2i COUNTRY ANO REFERENCE NO NAME OR DATE Of INITIALS BIRTH 01 N 15.04.24 02 SIN 05.00.11 01 NAV 06.01.Z0 M NOR 22.01.27 05 29.01.10 A COMPANY RP PCUK RP PCUK PCUK LIVER Angiosarcoma Cases (Review Date February 1991) 5 FACTORY Roustlllon 6 FIRST VC EXPOSURE QQ.Ql.A6 7 DATE OF DIAGNOSIS 18.02.67 B AGE AT DIAGNOSIS 43 9 TEARS OF EXPOSURE TO DIAGNOSIS 21 10 11 YEARS Of DATE Of EXPOSURE 0EA1H 19 19.02.6/ Srignoud 06.07.59 15.01.75 61 16 12 24.01.75 St Font 00.00.46 15.01.75 55 29 29 29.06.75 Irignoud 19.10.49 16.01.76 49 26 26 04.01.76 Srignoud 18.01.65 11.05.76 58 11 11 13.05.76 12 HISTOLOGICAL CONFIRMATION Yet Yes (NIOSH no cooanenO vet Yet Yet 11 U 15 16 ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COHHCHTS High Autoclave worker and cleaner 19 yrt Ref. Ravier et al Arch. Hal. Prof. 1 30 n' 3 Nov 25 p 1/1-12/ High 2 yrt on onoMr 10 yrt on polywHat ion Italian origin Ref. G Sonneton et al "Nouvette prttte medicale" 5 Nov 19// p 735 High Potyworker: 10 yrt at autoclave cleaner. Compounding 1 yrt VCN production Ref. Rely et 16 yrt. al Arch. Mai. Italian POU. Prof. 1 3/ n' Shepherd. 6 June 71 Sawyer. Nason p 551-555 High Noncmer production worker B yrt. PVC nitration IB yra High Polyworker 11 yrt UThoracotomy Ref. P Coudere 9th Feb 19/6 et al "Semaine costal det hospitaut angiosarcoma 10 Septenfere 2)Scfntigraphy 19/6 found ASL Previously had 1 Haemorrhage bone from ASL angiosarcoma*1 4)Right Also Hepatectomr PilichoNski et al **ta Houvelie Presse Kedtcale 7th July 1979 Page 2485. CMA 0 1 1 9 5 7 t 6 FRANCE Sheet 2 1 2jA COUNTRY AND fiEFHEKCi NO NAME OR JMIUALS DATE Of aiRin COHHOV 06 Pa H.04.J* wuc 07 Gift 26.0*.{7 ftp 00 ft 01.M. Sotvsy 09 RFX 08.10.1* ftp li LIVER Angiosarcoma Cases - (Review Date February 1991) 16 FIRST VC FACTORY EXPOSURE ri trout oi.oi.se 7 DATE OF OtAGNOSIS 12.08.78 ft AGE At DIAGNOSIS 42 9 YEARS OF EXPOSURE TO DIAGNOSIS 1ft 10 TEARS OF EXPOSURE 11 DATE Of DEATH 12 HISTOLOGICAL CONFIRMATION ii 11.09.76 (NIQSN says 12.09.76) Tts *o$1 fcubtn 01.07.10 After 26 22 02.07.76 Tea death (NIOSH no 111 OSH comment) eaya 00.07.76 favao* 21.01.17 01.12.71 *2 10 19 30.01.77 Yes St Iona 10.01.*0 26.04.76 61 28 28 21.12.77 Yes ii u 15 16 ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Moderate (1950-1960) 2 yr f i 1tratIon 10-11 yre polyworker and works lab? This man had AOt prior to AS. Am. de Mai. Prof. July 4 77 p 645 ft 6, AOL was found In 1971 five yrs before ASL High Plant for* men In pot ymerIsatton 1972-6 admin section in St Auban Died of sept i catena Smalt liver lesion found after autopsy Moderate 6 yre pecker 0 autoclave clnr 14 yre autoclave worker Had been tunnel worker previously Very Nigh 1S- 1966 Letter Etpoture 1966-1976 Pol ymer* 10 yrs In teat ton sulphuric operator, acid factory, autocleaner, storekeeper ft autoclave general maintenance services Operated 4.76 for removal of tumour from 1Iver and died after second surgical operation for bilio bronchial fistula Paper by Dr Rety et si in Archives de Melades Professionals Vol 40 No 6 1979 pages 741-3. * o -o * LI 00 7 FRANCE - Sheet ] 1 23 COUNTRY MR) REFERENCE NO NAME Oft INITIALS OATE Of IlftTN 10 VP 24.05.19 4 COMPANY IP 5 FACTORY St font LIVER Angiosarcoma Cases - (fievleu Dace February 1991) 6 7 "8 9 10 r~,, FIRST VC EXPOSURE 00.12.56 OATE OF DIAGNOSIS 10.01./a AGE AT DIAGNOSIS 58 TEARS OF EXPOSURE 10 DIAGNOSIS 21 YEARS OF DATE OF EXPOSURE DEATH 21 10.01.70 n1 15.02.12 P St Font 00.01.41 I2.08.7B 66 32 it U.11.7B 12 16.08.14 PCUK Bngnoud 09.02.49 00.05.29 65 30 27 23.06.79 1] 19.01.11 lolny Tavaux 21.09.63 26.06.79 40 16 11 22.08.79 U HJ n 3 05-04-24 Chloe Chheie (Fomerly *P) St fons 1941 00.07.81 57 18 16 29.07.81 12 HISTOLOGICAL CONFIRMATION Yes Yes Yet Yet Yet 13 14 15 16 ESTIKAIED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS High Autoclave cleaner 10 yrt in mechanical engineering industry 1946-1956 Died of pulnonary CMbolltM 5 days after surgery Nigh 1941 * 1946 pofpaerisatIon general purpose worker. 1946*1972 VCM syntheele (HC1 & Acetylene) foreewn (gent de naftrite) 1972 retired High Moncseer production end polymer* 1 eat Ion operator Autoc leaner 2 yrtg Autooperator 9 yrtg Copoi yeert 4 yrt 2 yrt as cycle Cigarette Mechanic. smoker until 10 yrs at 1974. Ill alt anaaieller In of 1977 due to sanitary ware Oesophageal Manufacture varices. Surgical intervention 25.05.79 (right hepatectonry) Very High 1943*1975 1975-1979 1943*1975 Alt types of Maintenance and jobs on work tntemin Manufacture ently 1 Maintenanci 1975* 1979 in VCH Poly Process <1 u * 8 FRANCE Sheet 4 1 2s4 5 COUNTRY AND REFERENCE NO NAME OR iHITIALS DATE Of BIRIN COMPANY FACTORY IS OEP 01.01.37 CMo* Ctilata (fwatrty (P) fit Fone 16 cm 13.07.22 Chlo* Chtat* (Foratrly P> St font 1 17 NAR 22.02.23 Chloe Chi tale (Formerly ftP) St Fora LIVER Angiosarcoma Cases - (Review Date February 1991) 67 FIRSI VC DATE OF EXPOSURE DIAGNOSIS 07.07.33 2S.09.S2 s 9 10 1, AGE AT TEARS OF TEARS OF DATE OF DIAGNOSIS EXPOSURE 10 EXPOSURE DEATH DIAGNOSIS 43 27 27 Alive 17.10.41 03.01.S3 61 41 36 oi. . as 17.06.40 03.04.S3 60 34 20 03.04.03 12 11 14 13 16 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 01 HER C0MMEH1S Tea High*20 yr Autoclave Moderate cleaner 7 yra 1955*1962 autoclave operator 1962-1982 Left Hepetectomy 1981. J C Contaaaot Letter* of 5 10 81 and 29 7 88. Tea High'll yr* Pol ymeriset* Moderate* ton Proceaa Low * 5 yrt Man Maintenance Worker Retired Jan 1979. J C Contaaaot letter* of 5 10 1981 and 25 7 64. Health fi Safety Agent Tea High * Autoclave Other sector* Retired 21 yra Cleaner of St Fona 01.01.79 1946-1921 Factory 1971- J C Contaaaot 1978 Letter of S 10 1981 IS R H.07.42 Solvay fevauK 09.09.63 21.03.S4 42 21 21 27.12.04 21.03.84 High-12 yra Autoclave Low - 9 yra Cleaner o 3: > o 1 >0 O' o 9 09.01.84 Right Hepatectoaiy 05.05.6424.09.84 chemotherapy for lingnetaataai* : partial remitaion. 08.64 - liver recurrence. 10.64 - Lirg: evolution of the disease FRANCE Sheet 5 LIVER Angiosarcoma Cases - (Review Date February 1991) 1 COUNfRT AHO REFERENCE NO FRANCE 19 20 21 22 21 I3 n NAME OR DATE Of INilIALS 61R1N 4 COMPANY 56 7 0 FIRST VC DATE OF AGE AT FACTOR! EXPOSURE DIAGNOSIS DIAGNOSIS HA2 IS.12.12 Atocham flrfgnoud 07.04.59 26.10.04 52 U 02.01.21 Atochtt rlgnoud mi 22.12.OS 63 Pa 01.10.40 RP SEP Hontlucon 1959 03.06.56 45 RL 11.00.20 Atoehem St Aiban 01.09.50 05.11.07 59 DO 02.02.22 Atoehem St Foot 1944 1900 61 9 10 11 12 13 14 is 16 TEARS OF EXPOSURE 10 DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL COMFIRMAIION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OIHER COMMENTS Autoclave operator and 25 25 06.11.55 Tes High c leaner Myocardial infarct Ion 1960.Coronary bypass 1961. Letter from Or Contessot 5.4.66 Portal 34 22 26.12.65 Tes Nigh Autoclave In other parts fibrosis from operator and of factory 26.04.74. The cleaner since 1946 illness was diagnosed as presunably work related on 20.04.74. Letter from Or Contessot 05.04.66 27 4 26.06.S6 res Nigh Autocleaner Maintenance Hepatic test 4 year* worker May 64 normal. Hepatic test May 66 showed abnormalities. Letter from Dr iarrat 16.07.66. 29 26 00.09.00 Tes Nigh 12 years 1956-70 Autoclave worker. Low 14 years in 1970 64 Control Room Letters from Dr Contessot, Atoehem 2.12.67, 29 7 66, 24.01.89 44 20 21.09.69 Tes High Autoclave Cleaner t all PVC production jobs Partial Mepatectomy, Apr 66, Chemotherapy Information from Or J C Contessot Atochem, 1966/69 o x o O' i 10 France Sheet 6 LIVER Angiosarcoma Cases * (Review Date February 1991) 1 2i COUNTRY AND NAME OR DATE Of REFERENCE INITIALS ilRIH NO HA 06.12.26 25 M 02.03.30 4 COMPANY AtochM Solway 5 I^ 1 if IAS! VC fACTOAV |EXPOSUAE 1 e 9 10 YEARS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS 10 EXPOSURE DIAGNOSIS 11 DATE Of DEATH 12 13 14 HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS irignoud 1943 1906 02 43 33 01.12.66 Yes High PVC Product on - 2 years HCV Detecti* n - 3 years PVC Product on Maintenance - 30 years Liver transplant Hay 1988. Infonsstion fron Dr J C Contassot, Atochem, 1988/89 lavauR 1902 I960 36 26 23 07.03.60 Yes 11 yetn) Polycleaner High) * S years Polyfloor * 6 years 12 yctrt Control R001 1 tow 12 years Prleury L lvtr Tunur Hetestettt lung, bytin, boot, spleen, kldhey. Information fro* Or H Legett, totvey, Aoveefcer 1968 26 W 29.11.40 Solvay Favaua 10.04.03 23.10.66 48 23 IS 02.11.60 Yes Nigh Autoclave 12 year* Cleaner low for IS 3 years years Died by haemorrsgic nature of the tuaour. No surgery, letter from Dr H Lagast. Solvay, 28.4.89. n RC 1929 Atocheei SI Font 1954 19U 39 34 30 00.01.89 Yes 1934-74 Autoclave High Cleaner and 1974-64 all PVC low product ion Job* Notified by Dr Contessot, A toehen, Dtccdwr 1989 2B JG 1920 Atochea SI Font 1942 1989 63 42 20 Alivt Yea 20 years 10 years High Monomer analysis (labs) 10 years product ion PVC Notified by Dr Contessot, Atochem, Dtcedier 1989 o 3: o >0 O' M < n GWtM*< Sheet 1 1 COUNTRY AMO REFERENCE NO GERMANY 01 2i NAME OR DATE OF INITIALS SIRIN oo.oo.so 4 COMMIT 4 UVtt Angiosarccma Cases - (Devieu Oate February 19911 5 FACTORY A FIRS! VC EXPOSURE 7a OATE OF AGE AT DIAGNOSIS DIAGNOSIS 9 TEARS Of EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE 11 DATE Of DEATH 12 HISTOLOGICAL CONFIRMATION ii ESTIMATED EXPOSURE LEVEL 14 . OCCUPA1 ION 4 01.10.56 19.09.60 10 12 12 25.01.49 Ye* (NIOSH) Polyworker 15 OVHER CAREER NIGHLJGHIS iT OTHER COMMENTS 02 00.00.11 4 4 It.10.52 25.09.20 19 11 11 It.12.21 Yes OHOSH) Polyuorker 01 00.00.10 12 12 09.06.52 00.01.21 tl 21 16 10.10,73 Te* (NIOSH) Filling Reported under peat it Ida non polymer aerosol cans isation with VC workers in NIOSH list Of 31.3.77. This of course ii strictly correct. However 1 wonder whether this awn hed high exposure to VCM in his con filling operation? 04 00.00.10 0 0 16.0t.52 26.11.2t 44 12 17 25.11.2t V* (NIOSH) 200-300 ppa Polyworker t 195B mi Clinical but high temporary eutocteener details In during 1 yr eutocteaner for 1 yr paper by utoe leaner total el si Virchows Arch A hath 1976 172 p 195-201 O 3 > O >0 0- 1 w 12 GERMANY h(_i 1 23 COUNTRY AMO REFERENCE HO MANE OR DATE OF INITIALS 1RTM GERMANY 05 00.00.36 {KIOSK give* li Cm 06) 4 COMPANY h 06 (KIOSK give* l Cm* 05) 0) 00.00.32 r 00.00.26 s OS 00.00.17 4 LIVER Angiosarcoma Cases - (Review Dale february 1991) 5 IACI0RY ii 7 67 FIRST VC DATE OF EXPOSURE DIAGNOSIS 02.06.60 10.12.73 16.12.62 00.00.75 6 AGE AT DIAGNOSIS 38 43 9 YEARS OF EXPOSURE 10 DIAGNOSIS 13 13 10 H 12 YEARS OF DATE Of HISTOLOGICAL EXPOSURE DEATH CONFIRMATION 05 16.12.74 Yes (NIOSH) 12 09.01.75 Yes 13 U ' ESTIMATED EXPOSURE LEVEL OCCUPATION BG Chemie seys "chemistry (borator Ian In the Techno* logical Research Department" (NIOSH says assistant factory chemist which may be wrong translation) PVC * Manu facture Shift Leader 15 16 OTHER CAREER HIGHLIGHTS OTHER COMMENTS Confirmed Reported under non-polymer isation workers in NIOSH list of 31.3.77 and 1.7ft. 1 don't think this is a correct cl ess If teat ion by NIOSH. The man may have been Involved in VCM polymerisation in pitot plant or in main ptant. e 15.06.54 12.11.75 49 21 21 13.11.75 Yes (KIOSK **y* 12) 4 19.02.54 06.04.75 58 20 20 25.12.75 Yes PVC Manu facture and ail work I net autocleaning 12 yrs (195464) Foreman lech Oev 6 yrs 0967-1975) 1 Polyworfcer 1 O 3: > o O' A 13 GERMANY Sheet 3 1 COUNTRY AND KfCITKCT NO GERMANY 09 2j NAME OR DATE Of INITIALS BIRTH 00.00.34 10 CNIOSH gives as Case 11) 00.00.S6 11 (MIOSH give* Cast 10) 12 00.00.29 00.00.56 4 COMPANY 2 2 a A EIVER Angiosarcoma Cases - <Revieu Date february 1991) 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE Of DIAGNOSIS a AGE AT DIAGNOSIS 9 10 YEARS Of EXPOSURE TO DIAGNOSIS YEARS Of EXPOSURE 11 DATE Of DEATH 12 HISTOLOGICAL CONFIRMATION 15 kT'-i 15 ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 01 HER COMMENTS 2 20.02.61 16.06.26 41 15 15 Z4.03.7a Yes High peaks 12 yrs poly* worker incl 17X auto* clsve cleaning Control room 1 yr 2 01.01.61 00.01.22 40 16 10 02.05.22 Yts High peaks 10 yrt poly- worker incl 1 rX auto* clave cleaning a 10.10.5$ 20.06.22 47 21 22 26.06.22 Yet High 3 yrs auto* clave cleaner 19 yrs filter operator 4 00.00.61 00.10.22 59 16 6 02.10.22 Yes 7 PVC Manu facture Autoclave worker for 6 yrs T0/7D Conf i nned Average exposure first 9 yrs ISO ppm, occ 1000 ppsi. Nest 3 yrs ava 75 ppm. Last, yr av 35 ppm Average tKpostst first 9 yrs 150 ppm, occ 1000 ppm. last yr av 75 ppm. CUtt letter of 21.04.7A n 3; 3 o >0 CK ut 14 GEftHANV Sheet 4 1 COUNTRY AND REFERENCE HO i] 2i NAME OR DATE Of INITIALS tllTN 00.00.14 k COMPANY r (14) 15 (NIOSH give* thii as Cm* 13> 00.00.29 ilVEFE Angiosarcoma Cases - (Review Date February 1991) s FACTORY 7 6 HAST VC EXPOSURE 00.00.60 7 DATE OF DIAGNOSIS 00.04.70 0 AGE AT DIAGNOSIS 65 9 TEARS OF EXPOSURE TO DIAGNOSIS 16 10 11 YEARS OF DATE Of EXPOSURE DEATH K 19.05.70 1? HIS10L0G1CAL CONFIRMATION Yes 13 ESTIMATED EXPOSURE LEVEL K OCCUPATION Nat an ArtgioserccMM In his letter of 21 12 01, Hr Friedet aid this was a "Ptattenepi' the! Ear 1 inoa Der Speiserohre" (a carcinosis of the oesophagus) not attribut able to vat t not recognised as an indust rial disease 0 19.10.51 09.10.70 49 25 25 21.10.70 Yes T Autoclave cleaner and worker. Orier operator. Later shift leader 15 j 16 OTHER CAREER | HIGHLIGHTS OTHER COMMENTS !f U Rest {letter of* 30th June 1960 {enclosing data froe Mr H P Friedet {of 6G Chemie f U Rest letter of 30th June 1960 enclosing date f real H P Friedet of BG Cheatie withdrawing this case Angiosercoeie conf i need 09/79. $aae detail of this A also cases 9, 13, 15, 16 1 17 given in HRU Report for 1976 n 3; o o O' O' 15 GfDFMN7 Shett 5 1 COUNTRY AMO REFERENCE MO it 2s NAME OR DATE Of INITIALS tins 00.00.2] u (HIOSD gives as Cast IS) 00.00.]/ IS 19 O x > o 00.00.1] 00.00.2S A COMPANY 4 A s A 5 FACTORY A A s A LIVED Angiosarcoma Cases - (Devieu Date: February 1991) 6 7A 9 10 n 12 h iT^i 15 16 FIRST VC DATE OF AGE AT EXPOSURE DIAGNOSIS DIAGNOSIS 10.01.ss 07.0S.7S (Lelbach lulpected DSL at Feb 19/S laparolaoy) ss TEARS OF EXPOSURE TO DIAGNOSIS 25 TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 20 07.00.7B Tea High Autoclave ASL and worker till Heptoeeltular 1964. Carcinoma Leader and aiaster OTHER CAREER HIGHLIGHIS OTHER COMMENTS Angiosarcoma con Mrned, full detail* of illness since March 1975 given in NRU Med Insp Rep for 197A. Different deteils given in "VC Associated Disease" by Lelbach and Hersteller (19151) p71. 01.11.il 1A.Qfl.7A At 16 It 2S.08.70 Tea High Autoclave No Angiosarcoma worker confirmed. Annual report of the North Rhine Westphalia Medical Inspectorate for 197A pages 547-577 gives full details. Vinyl chloride disease diagnosed 02-02 n. Oesophageal varices. Radiological ly confined aero osteolysis. OO.OO.S5 2S.12.79 66 24 21 25.12.79 Yes Autoclave Worker ia.io.sA 00.OB.79 sc 2S ia 22.02.BO Yes High Autoclave Dr Besche Hetestasing Worker letter of ASL 15-04 62 to __________ Dr W G f Adams I >0 O' 16. 's! GERMANY Sheet 6 1 COUNTRY AMO RE TERENCE NO 21 22 21 24 2S (26) 22 L1VC.II Angiosarcoma Cases ( Review Date: February 1991) 2 i4 5 6 2 a 9 10 u 12 \S 14 IS 16 NAME OR DATE Of FIRST VC DATE OF INITIALS SIRIN (XMPJUK rocioof EXPOSURE DIAGNOSIS 00.00.15 4 4 14.02.61 00.04.B0 00.00.11 4 00.00.21 4 4 01.01.62 00.00.20 pronounced clinical liver tynptoaa) 4 16.10.61 20.00.00 00.00.22 0 0 1055 26.01.20 00.00.20 0 0 1060 11.10.02 AGE AT DIAGNOSIS 65 66 50 52 54 TEARS OF EXPOSURE 10 DIAGNOSIS to IS 19 24 11 YEARS Of EXPOSURE DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 11 10.10.00 Yes High Autoclave Haemangio Worker Endothei i<eae of liver 1 rlth Metastaset 13 19.06.80 Yes High Autoclave Haemangio Worker end Endothei i< me worked in ol 1 ver iith drying chop Hetastase 11 06.12.01 Tea ! High Autoclave Chargehartd, Hetastasing Worker subsequent ly ASL | Foremen 21 20.00.01 (e* [ High Cheaiatry 1 (>100 ppa) Uorker 12 2S.05.8J Yea I High Autoclave f C >300 ppm) Cleaner OTHER COHHENlS Dr Besche letter of 1S-04-82 to DrUGf Adams Dr Besche letter of 13-04-82 to Dr U G F Adams Dr Besche letter ol 13-04-82 to Dr U G F Adams Primary hepatoceller care inoma; proliteration of the sinusiodal cells with sinusoidal ectasia. Friedel letter 23.12.86. Prof Eder (Munich) letter 22.0S.B1. Friedel letter 19.04.85. 00.00.21 0 0 I960 20.00.01 50 21 11 14.01.01 Ye* j Nigh Polyclave i 1 ------------- I1 Worker end Autoclave Cleaner | Deleted or advice of Dr fenkhof December 19i .9; AlcoholIc Cirrhosis,1 not VCH eat octeted. 00.00.20 4 4 1055 10.01.01 55 20 10 02.01.04 Yet 1 High Autoclave Cleaner tilt ________ l__________ 1972 Prof Setaeir (Munich) letter 22.06.83. Friedel letter 19.04.85 Lei bach. Friedel letter 19.04.85 O 3>: o t >0 OCO 17 GERMANY Sheet 7 l COUNTRY AND REFERENCE 0 28 29 JO 11 12 33 LIVER Angiosarcoma Cases (Review Date February 1991) 2 34 5 6 name or DATE Of FIRS! VC Mil IMS IRIK COMPANY FACTORY EXPOSURE 21.11.21 2 2 01.10.60 7 DATE OF DIAGNOSIS tt.oa.as a AGE AT DIAGNOSIS 61 9 YEARS OF EXPOSURE 10 DIAGNOSIS 21 10 11 YEARS OF DATE OF EXPOSURE DEAIH 25 25.00.65 12 13 14 HJSIO LOGICAL CONFIRM* A! ION ESIIMATEO EXPOSURE LEVEL OCCUPATION Yes High Procete worker 1974*04 Ot.10.60 31.03.54 PVC product ion, agitator area 00.00*22 2 2 1962 15.02.81 61 21 19 15.02.04 Yes High Chemistry worker 00.00.17 4 4 1951 02.01.80 .02 29 25 25.05.0) Vet High Potyworker Shift leeder 00.00.21 a a 1953 10.06.85 61 32 20 31.01.06 Ye* High Autoclave cleaner 00.00. U 0 0 1955 00.04.81 55 30 21 11.02.86 Yes High Polyworker Autoclave cleener 00.00.12 8 1951 19.08.81 62 30 21 21.05.81 Yet High Autoclave Cleaner, Cheatitry Worker 00.00.M 4 4 1956 11.05.81 51 29 16 17.09.05 Yet Nigh Shift leeder 00.00.24 4 4 I960 18.2.21 49 5 4 16.10.84 Ye* High AutocI eve Cleener 15 01NER CAREER HIGHLIGHTS 16 01 HER COMMENTS Arruel VCM screening 24.04.05; no complaint, no ebnoraellty detected. 1970 two'thlrds gestrectoay for ulcers. 1971 Coronary thrombosis 1903 femoral 1^)1 antat i on 1904 Pulmonary eflbolisa and pleuropneutonie. Lender* letter* 10.09.65 end 04.02.02. Jtacmangioserkoma. Friedel letter 23.12.06. N eeaang i os er k ana. Friedel letter 23.12.06. Haemeng i osarLoom. Friedel letter* 23.12.06, 15.11.09 i Fendel 16.2.09. Heemangioserkana. Also Developed Choi angiosarcoma, friedel letter* 23.12.06, 15.11.09 and Fendel 16.2.09 Letter from Or friedel 15.11.09 Letter fro* Dr friedel 15.11.09 1975 dicease of liver parenchyma; at last 001. Letter from Or friedel 15.11.09 o 3 > OI 'O (b -o 18 Sheet A LIVER Angiosarcoma Cases (Review Dale February 1991) 1 23 4 5 A 7 8 9 to n 12 13 M 15 16 cvurnr ako aefEttNCF. mi H 57 St St 40 NAME OM ntriroF COMPANY FACTORY INITIALS turns 44 ff.ff.U ff.ffii 4 4 4 4 ft.ff.fi 4 4 ft.ft.ft 4 4 HOST VC EXPOSURE ms 1 Ht itu IHt Ifft HATE OF DIAGNOSIS 19 017* AGE AT DIAGNOSIS ST YEARS OF EXPOSURE 10 DIAGNOSIS 25 1X4 NS OF EXPOSURE 25 ff.ff.U 59 l* * li.4S.ti *4 54 It 041414 44 II 5 24.4t.t7 4T It 4 DATE OF DEATH 14,42.14 ItlSTO LOGICAL CONFIRM AT10N Yet 45.49.t* U.49.U Yet Yet 45.ll.t4 Yet lt.4i.lt hi ESTIMATE D EXPOSURE LEVEL llltk Hit* nith Hlfk OCCUPA TION Antedate Warier Lai. Ant. s*** Leader at the etfMiirn later on Mthe AimMer <4mariere Cleaner Amtoeiafe CDaner OTHER CAREER tUGHUG HTS OTHER COUUEN1S Letter from Dr Friedel 15.11 19 and Reformation from Dr. TenXhoffDec.lt LaMar from Dr. Frle4ttlS.ll.t9 Letter from Dr. Fried*! ISM.lt Pension from 74-44 10% tour on 104% Letter from Dr. Friedel IS lt.lt and Informationfrom Dr. Ttnkkoff Dec It Pentlon from 72-tT Later on choianglnartomo, XhtoioflcoOf confirmed. Letter* from Dr. Frfait IS.ll.lt and 27 5 94 o 3: > 0 M o 19 MUD Sheet t 23 COUNTRY AND reference HO HAW OP. OA1E Of INITIALS SIRIN 01 (On Ml OSH supple* entary list) LG 13.06.34 4 COWAN) RANSAC 5 FACTOR! Hire Venice 02 SE 03 VG 11.11.79 Montedison Porto Nirghtri 14.01.70 Solvey Ferrara 04 FB 70.07.17 ANJC Ravenna OS G panesin 19.01.17 PANSAC l i LIVER Angiosarcoma Cases - (Review Date February 1991J 6 FIRST VC EXPOSURE 00.00.63 7 DATE OF DIAGNOSIS 19.04.71 8 AGE AT DIAGNOSIS 16 9 VEAAS OF EXPOSURE TO DIAGNOSIS 06 10 YEARS Of EXPOSURE DA IE OF DEA1N 03 16.04.71 00.00.37 11.17.77 43 li 06 27.12.72 00.01.31 10.07.75 55 22 21 10.07.75 00.04.39 00.01.81 41 21 21 30.03.81 00.00.67 07.01.83 46 16 6 06.04.81 .2 u 14 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION ?Yes PVC Reg eat ruder Yes Polyworker li OTHER CAREER HIGHLIGHTS OTHER COHHENTS Primary tieuur nay have been pericardii*. Not homo geneous with other cases. 4* * * res High Autocleaner 1972*5 did 8 yrc 0951- a variety of 61) Autoclav f jobs operator including 12 yra (1961 PVC packing. 72) * Vet 12 yrs - 1 yr Never cleaned Very High Hoocaaer operator autoclaves. See paper by fta 5 yrs * CNIAPP1N0 et Non-smoker. Med it* 20 yr* - l Med Lavoro Consumed Autoclave Vol 6 (1962) little 4 yr* * operator A pp 555*563 alcohol. No Low other duties AOL. In suspens ion polymer isation. Area Foremen in seme Dept since 1975. Te* Nedi i-T teg extruder High 1967-1975 Conmerciel Pept 1976- 1981 $ Rag!ialinga telex of 2 Aug 1981 * Sec Hal ton! Hed dl lavoro Q pW5, 1974. Further details in letter from Dr Montessno ol I ARC on April 1st 1987. ** Alto see Maltoni and Aondtnelta In Acta Oncologies Vol 1 1980 pages 35 - 49. n 3C > 'll SI ** 20. HALT Sheet 2 1 2 1 ^ ;-- s 6 LIVER Angiosarcoma Cases - (Review Date February 1991 > 7 a 9 10 IT 12 14 COUNTRY AND NAME OR DATE OF REFERENCE INITIALS BIRIN NO COMPAMY FACTORY HRS! VC EXPOSURE YEARS OF DATE OF AGE A! EXPOSURE TEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE Of DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPA1ION LEVEL OTHER CAREER HIGHLIGHTS ' 16 01 HER COMMENTS 06 GZ 21.06.16 Hont*41 (on Porto 01.10.60 06.12.BS 49 25 25 15.02.66 Yes High PVC Marchers, 1960-71 manufacture Venice Medina 11 yeara aa 1971-74 Autoclave Low cleaner 1975-65 1960-71. 14 yeara in Controi Room 1971 65 Lettera (roa Dr Chionini, Venice, 22.09.67 and 11.01.66 07 AP 09.02.2S Hoptolw lerni 1950 21.01.66 60 oa U.L. 01.06.16 E.V.C. Ravenna 02.10.61 10.07.69 Italy jourM D-D. Cooperative Ravenna fr?7J 04.06.44 65 . Candtano Italy r26 22 05.04.66 Yea 1956 74 Maintained Nigh VC Hachiner (not operating or cleaning autoclaves) I1974-60 VC level a Medina reduced froi 1973/74 Infonaatfon froa La Medicine del lavoro, Italy, Vol 79 No.1 Jan-Feb 66, and Dr Benetta, Eni Cheat. 26 26 21.09.69 Yea 1961*66 autoclave *02.10.*61 - 02.04.'65 >100 ppe cleaner for 1967-72 16 Months* 100-200 autoclave roa operator 1973- 71 and reactor 20010pp. area 1976-7B operator 501pp. 1979-89 is H.64.W Yea '5pp. 1W2-BF"'1 helper in {Retired 20G5ppm reactor area 11.01.*65 1962A5 <5pp b9ger j___________I_____________ I___________I__________ I___________I___________I__________ I_________ l__________ I--------------------- 1__________ i-------------------- 1. o 3. > 'O Nl U 21 JAM* ilVEft AngiosarccMa Cases (Neview Dale february 1991) 1 2 3 4 5* 7 a 9 10 11 12 u 14 15 16 COUNtRY AMO KfHENCE MO MANE OR DATE Of INITIAL* SIRIN CGHMOT FACIORY FIRST VC DATE OF EXPOSURE DIAGNOSIS AGE AT OIAGNOStS YEARS OF EXPOSURE 10 DIAGNOSIS VEAJtS OF EXPOSURE DATE Or DEATH HISTOLOGICAL CONFIfiMAIION ESIINA1ED EXPOSURE LEVEL OCCUPATION DINER CAREER HIGHLIGHTS OTHER COMMENTS 01 loaaji 01.ae.22 Mitsui Nsaoya 00.04.51 24.10.25 S3 22 13 24.10.75 Yes PVC Assoc 13 yra auto Mori Tostsu says not clave known. cleaner Japan 1964 - 1 iaea assigned to Indicated different on 25.10.75 work since exposures Nod ill often t health 3000 pfsa up to 1974 Japan 1ines 25.10.75 t Japanese PVC Assoc letters of 31.03.7a 4 30.11.a7 02 SC 02.0B. 19 Kantgsfudt i Otiha oo.ii.sa 10.00.76 12 17 13 10.0fl.7t Yea Not known In polywer- Chtaical IsatIon work Including autoclave cl toning Japanese PVC Association letters of 31.03.76 t 30.11.67 01 IS 01.09.10 Kiltuf loatsu Nagoya oo.07.as 26.01.05 54 20 5 14.09.as Yea High 5 years Autociova cleaner Letter Iron Dr Nakanure, Japanese PVC AssociatIon 30.11.87 o > O 'C SI w 22 NORWAY LIVER Angiosarcoma Cases - (Review Date February 1991) 1 23 COUNTRY AHO KfHEHCE NO NAME OR DATE Of INITIALS HIM 4 COMPANY 5 FACTORY 6 FIRST VC EXPOSURE i ~i 2|a 1 9 DATE OF ! ACC AT DIAGNOSIS j DIAGNOSIS 21.12.21 | 56 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRM IE ON 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMER'S 01 AH 25.1Z.1S Norsk Hydro Ktroy* 00.03.30 1 1 1 1 l 1 1 1 i j 22 21 04.01.72 Yes Nigh Foreman A Autoclave ipervltor Confirmed by Dr ItiifsEvensen of HR. At APHE Htg of 9 June 1976 Hr P Rangnes stated that AH had been a meatier of s start-up team. VCH A PVC were made in sine building. The VCH was made from acetylene 1 1 1 1 1 1 1 1 tr 6 T T 0 VWO I 23 SPAIN LIVER Angiosarcomi Cases - (Revieu Dace February 1991) 1 2 i 4 s6 7 a 9 TO 11 12 15 u 1* COUNIAY AND REFERENCE NO NAME QA DATE Of INITIALS HATH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS Of EXPOSURE 10 DIAGNOSIS YEARS OF EXPOSURE DAlE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS 01 MCG 2t.0J.A0 Hltpavlc 01.02.64 10.11.09 w 2S u 09.11.89 Yes Hioh Autoclave Fro* 1.1.28 Cause of death: 12 years Operator production of aut t i pi e 12 yeara. hydrogen cerehral peroxide haemorrhages. Medina late* No Metastasis, 1 year 1 year letter fro* Dr Lagast, Solvay, 04.01.90 o 3 > '0 Si LI 24. SUEDEM IIVER Angiosarcoma Cases - (Review Date February 1991) ; COUttfRT AND REFERENCE NO z1 NAME OR DATE OF INITIALS BIRTH 01 NU 02 IL Z1.D6.2T 27.11.11 OS NE 04 At 10.06.10 16.11.14 OS 12.05.19 4 coifAm Kemanord Kemanord Keawnord Keawnord 5 FACTORY 6 FIRST VC EXPOSURE lundtnll 14.06.51 Sundtval l 00.01.61 SundsvaLL 00.05.47 Sundsvalt 00.00.46 Sundtval 1 11.05.64 T DATE OF DIAGNOSIS 20.10.70 00.06.72* 16.03.76 12.05.77 22.11.00 8 ACE A1 DIAGNOSIS 43 6) 65 62 61 9 TEARS OF EXPOSURE 10 DIAGNOSIS 19 27 29 11 16 10 11 TEARS OF DATE OF EXPOSURE DEATH 16 20.10.70 27 16.00.72 21 19.03.76 11 12.05.77 16 22.11.00 12 HISTOLOGICAL CONFIRMATION Tes Tes Tes Tes Tes 13 14 , 15 ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER NtGNllGHfS Nigh Polyworker VCM product ion Nigh Nigh Polyworker 1946-1956 polymerfsation worker (12 yrs) i 19561977 foreawn (19 yrs) Nigh - 6 Veers Low - 10 Tears 1964-1970 centrifuge operator 1970-1960 drier operator 16 01HER COMMENTS Mr Sjoelin's letter of 26 March 1970 confirm IL was a monomer worker who was heavily exposed, probably even more so than s normal reactor cleaner In first 12 yrs of employment had been heavily exposed. In 1974, liver abnormal i ty and necrosis diagnosed. Data confirmed in Dr D Ryren letter 16.6.77 to CEFIC Letter of 2nd Nov 1961 from Or David Ryren * In bit letter of let April 1962, Dr Montesano of I ARC tiyi Sweden*e Notional Board of OS Health 91 vet 20 02 70 as date of diagnosis tor Case 01 and IS-OS-72 for Case 02. CMA 0 1 1 9 7 6 25 UK Sheet l 1 COUNTRY AND REFERENCE HO 23 NAME OR DATE OF INITIALS OIRJH 4 C0HPU2 LIVER Angiosarcoma Cases - (Review Date February 1991) 5 FACTORY 6 FIRS! VC EXPOSURE 7 DATE OF DIAGNOSIS 6 ACE At OlAGNOSIS 9 YEARS OF EXPOSURE TO OlAGNOSIS 10 YEARS OF EXPOSURE 11 0A1E OF 0EA1H 12 HISTOLOGICAL CONFIRM It OH 15 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION ii OTHER CAREER HIGHLIGHTS 16 OIHER COMMENTS UK 01 UJ 20.0*.01 ICI Hillhout* 04.04.44 01.12.22 21 20 22 03.12.22 Yes 100 ppa 1944-2 VCM (Foi t (Fon 6 1942-6 Orfer Collier Collier 1946*61 paper nys paper Autoclave 21.12.22) says operator 23.12.22) 1961*66 Drier let and Harry Lancet 29-06-24 pages 1316-6 (02) 0] 6JV 02.06.12 *P tarry 00.02.66 00.12.24 32 w JSt 21.06.20 ICI Hillhouse 26.04.34 00.06.29 39 Dubious fabrication case 09 1.1 24.12.24 Yea High Autoclave cleaner Exposure limited to 2.66 - 9.69 23 10 12.10.29 Yes Hedlia- 1954-5 Pre-war fish high egging packer Plant 1939*45 army 1933-6 vehicle Drier Plant maintenance 1956-6 1945*54 Autoclave fish packer worker 1956-61 Chargehand Drier Plant 1961-22 Foreman C 2/3 Plant Ot Nl Vi UK - Sheet 2 UVER Angiosarcoma Cases - (Review Date february 1991) 1 2 i 4 s6 1 e 9 10 11 12 15 K 15 16 COUNTRY AHO REFERENCE HO NAME Oft DATE Of INITIALS IRIH CONFM* FACTORY FIRST VC EXPOSURE DATE Of DIACHOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS Of EXPOSUAE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPA1ION OTHER CAREER HIGHLIGHTS 01 HER COMMENTS RR M.0J.I4 W> tarry oe.oi.st 00.10.re 45 26 21 19.11.79 Yes 1951-52 Polycleaner 1952*55 Lite* 1955*60 Polyfloor 1960*64 Poly Chargedand 1964*70 Charging operator 1970-72 Drier operator Further information 1969 from Dr P H Saith and Dr D M J Uillians 06 CEP 1031 IP iarry 1962 09.01.60 46/9 16 12 09.01.60 Tec 7 yn Poly Floor Operator 5 yrs Greaser on Poly floor fur ther information 1969 from Or P H Smith and Dr 0 M J Uiltime or RG6 26*04.20 IP Berry 1963 00.00.BO 60 17 e.2 13.06.60 Yes Polycleaner 1963*5 Recovery 1965-1971 Further inform ation 1969 from Dr P N Smith l Dr D H J Williams at MIN OO.OS.24 IP tarry 19.09.50 22.it.ei S2 31 O 3 >i ______ _______ I >0 Si QD 27 24 2S.12.ei Yes 1950*1956 1950-51 1930-1946 Further 500 ppm Autoclave Motor Mechanic information 1966*1974 operator 1946-1950 1969 from 200 wm 1951-1957 Operator on Or P H Smith Chergeman Acetylene and Or 0 M J autoclave Production Williams building Plant 1957-1974 Shift supervisor autoclave building * Never cleaned autoclaves but sipervisor's Job entailed entering autoclaves to inspect then UK 3 1 23A country and Kruewf HO NAME OR OATS Of INITIALS SIRIN COMPANY 09 EEGP 02.05.21 IP 10 GJ1 u.H.tr If 5 FAC10AY Rarry tarry LIVER ni)iosrcoM Cases (Review Dale February 1991) 67a 9 10 11 FIRST VC EXPOSURE 15.02.SO DATE Of DIAGNOSIS 02.03.63 AGE A1 DIAGNOSIS sa YEARS OF EXPOSURE 10 DIAGNOSIS 33 YEARS OF DATE Of EXPOSURE DEA1H 29 24.02.63 22.04.66 01 OS 64 12 16 4.2 16.OS.64 12 13 14 15 16 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTNER CAREER HIGNLIGNIS OTHER COMMENTS Yes Mediua Polyworker 2 years on Acrylonitrile Resin Plant. Alao prior to 1950. 4 years RAf Maintenance. 5 years Motor car peintstiop. 2 years in Graving Dock. Yes High - 11 Polycleaner Heavy goods Information Months (500 1966-67. vehicle driver given in ppm), low* Spray-drier uitil final 16 Months bisttr 1967- Hines. let ter 16.06.64 fro (50 ppm). 66. Dr D N J Medina - low-down Willi BAS 21 Months stripper (200 ppM} operator 1966*70. 11 GLP 08.05.28 6P Itrry 19.12.6S 02.06.05 57 19 16 02.06.85 Yes High Polycleaner 1965 -69 1965-66. Med 69-79 Service Low 79 62 operator 68-69. Poly Operator 69-79. Leading Hand 79-62. 12 J1 24.01.12 IC1 HlUhouae 16.09.S7 03.06. as 40 20 20 06.12.85 Yes Low 1957-59 Spare Man, High 59-74 bagging low 74-65 floor 1957-59. Autoclave Operator 1959-65 letter of 04.06.65 Dr Paul Smith and letter of 04.06.65 Dr D M 0 Evans Oesophageal haemorrhage due to oesophegeal varices due to Angiosarcoma of liver Letter 26.06.65 Or f I Lee O 3: > oi 'O S( 'O 28 UK - Sheet 4 LIVER Angiosarcoma Cases - (Review date: february 1991) 1 2 i 4 56 7 89 10 11 12 13 14 15 16 COUNTRY AND NAME OR DA1E Of REFERENCE INITIALS BIRTH NO C0HPM7 FACTORY ffRST VC EXPOSURE TEARS OF DATE OF AGE AT EXPOSURE TEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATN HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE ATION LEVEL OCCUPATION u MJ 02.0S.4t BP tarry I960 Jan 86 37 it s 02.06.86 Yes High Polycleaner 1968-69 Low Central Depot 1969-70 High Polyfloor 1970*1971 OTHER CAREER NiGNLIGHIS 01 HER COMMENTS Moved to Remained wall, working Acrylonitrile actively, until Jan 1986 Plant until left IP 1983a Manager of ic A s$ Ltd at Cardiff Airport 1983*86 14 GS IS.06.4 P tarry 07.07.66 27.0t.t7 45 21 11 01.12.88 Ye* ID aonths Polycleaner Nish 1966-67 10 years Polyfloor conitmt worker at tine* Hediia between but on 1968*1982 inter* mittent Job* lettera from Dr DMD Evans, Pathologist, Pensrth, Walts and Dr DMJ Williams, BP, Barry IS CP 21.OS.2 IP tarry 19S6 1988 66 12 16 01.05.tt in 9 years Poly cleaner 8 1 Information from Nigh Operator > Or D M J Williams, BP, and 5 year* 61 ou 8 Recovery Dr Paul Smith, Pathologist 1988. ftediu* 2 year* Operator Utility ^periods J Intermittent Lou Operator > 16 RT 25.OS. 2 ICI Hillhouse 1963 1988 66 25 12 12.11.SO Tes 1 year ) Packer Low ) 9 years) High ) 2 years) Low ) Autoclave Operator 17 M 14.01.SI ICI Nil Lhoust 00.04.63 1989 58 26 25 17.09.09 Ye* 1963-63 Packar Low 2 months 1963*74 ) Nigh ) Autoclave (11 year* t) Operator 1974-88 ) 25 year* low (14 year* >) l___ Nepatlc flbroti* 1974 Oesophageal varices Porta-caval shunt 1973 Information from Dr 6 Bennett, (Cl, and Dr F 1 Lee, Blackpool Victoria Hospital 1988. Information from Dr I Bennett ICI, and Dr f 1 lee, Blackpool Victoria Hospital, 1989. o 3: > o 'O to o 29 USA Slicet I LIVES Angiosarcoma Cases - (Review Oate February 1991) UK system of dates DAT - HON IN - TEAS 1 COUNTRY AMO reference NO 2 NAME OR INITIALS i DATE Of MIRTH 4 COMPANY 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE ST DIAGNOSIS 0 ACE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS Of EXPOSURE 11 DATE Of DEATH 12 NU10L0GICAI CONFIRMATION 13 14 ESTIMATED EXPOSURE LEVEL OCCUPATION 15 01 MEM CAREER HIGHLIGHTS 16 OIHER COMMENTS 01 Earl 17.10.2] 070 Louie 09.12.4ft 01.01.71 49 24 21 05.03.73 Yes Parks villa Pot Cleaner (liock Jama 1974) p 53 History given lollIng Stone in Annals MY Art ACAD SCIENCES Ref 1 NY Acad Vol 329 (1979) ol Sc Syep page 190 In 1974 Paper by Also liock 1 1 Cottine of Jama 1.7.74 OSHA P5S 02 10.00.1) EG louta- 15.11.55 00.05.70 17 14 u 27.09.71 Yes villa (NIOSN says 20.09.71) 01 Eduard 25.OS.15 IFG Louie 2ft. 11.45 10.12.71 SO 20 20 19.12.71 Yet Dinwiddle villa Pot Cleaner <Cf liock) Pot Cleaner (Cl liock) Louisville Courier Journal 02-09-10 Ref 1 Also liock JAMA 1.7.74 P 51 Ref 1 Also liock 04 15.01.24 EG Louis 06.07.52 19.Oft.67 41 15 15 07.01.6A Yes ville Pot Cleaner (Cl liock) Ref 1 Also liock 05 25.01,12 REG Louis 19.06.44 09.04.64 52 20 20 09.04.64 Vet ville Pot Cleaner (Cl liock) Ref 1 Also liock 06 * 21.11.20 EG Louis- 17.01.62 00.02.74 45 12 12 24.07.75 res Austin villa Jones? US Air Force Pot Cleaner (Cl liock) Ref 1 * Louisville Tiies 23.7.75 Retired April 1974 Also liock 07 Charles 01.05.22 UCC S Charle 27.Oft.44 00.00.60 45 24 17 21.01.60 Yes 1 Smart ston Ref 1 00 06.05.20 Goodytar Niagara 07.10.46 00.00.61 41 15 15 29.00.61 Yes Ref 1 - CMA 0 1 1 9 8 1 f 30 USA - Sheet 2 1 2) COUNTRY AND REFERENCE HQ NAME Oft INITIALS OATE at IJftIH 09 Raymond oe.ii.it Gettta- Mngirl 10 u.oe.is 11 22.0S.09 12 Francis A 12.11.11 lichaw 11 Richard 01.12.21 Eduard Clandanln 4 COMPANY 56 FIRST VC FACTORY EXPOSURE ofg louit- 2B.0S.AS villa Goodyear Niagara 12.06.SI Goodyear Niagara 14.10.46 Firestone Potltown 1S.02.A9 Pa UCC S Char la 11.12.42 ston LIVER Angiorcona Cases - (Review Date: February 1991) 7a 9 10 11 DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEAAS Of EXPOSURE DATE OF DEATH 01.05.2A AS 29 24 11.05.25 OO.OS.6S ss 12 12 10.OS.AD oo.os.ro A1 25 25 16.03.20 02.05.69 so 20 19 02.05.69 00.OS. 24 52 52 26 02.04.24 UK syste* of dotes DAY - HONIH * YEAR 12 11 14 15 " 16 ' HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 01 HEX COMMENTS Tat 2000 ppa Ref 1 has wrong Figure* re First exposure. Looisvllle Tines 29.10.74, 12.5.25, 10.3.26 Taa Ref 1 Vat Ret 1 Taa Nigh 10 yrt 10 yra aa Utility t Ret 1 * letter raactor op. Service op. of 26 April (not cleaner logger 1920 froa - aaparata Dryer op. Russell A Park craw cleaned Stripping op. to J T Seawall autoclaves} 3 yra prior of MCA service in tyre plant Tea 2000 ppm Charleston Daily Hall 21.2.25 (14) (1$) n 3 > O 'O 00 M 31 Never diag nosed as ang iosarcoma of liver. Inform al Ion given in letter 22 Hay 1964 from i A Salg. Accountant; ASL - No evi dence of VCM exposure. USA ' Sheet_3 ---------- ; 2 3A COUNTRY AND REFERENCE NO NAME Oft INITIALS DATE Of (IN COMPANY 16 04.11.27 MG Howard 3 FAC(OAT Louis villa 6 FIRST VC EXPOSURE LIVER Angiosarcoma Cases (Review Date: February 1991) 7 8] 9 10 u DATE Of DIAGNOSIS ACE Al DIAGNOSIS " YEARS OF EXPOSURE 10 DIAGNOSIS TEARS Of EXPOSURE DATE Of DEA1H 06.05.50 00.00.69 41 TV 04 27.03.69 LHC System of dates DAY MONTH - TEAR 12 13 <4 15 16 HJSTOtOGICAL CONFIRMATION Yes ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 1951-4 VCH polymer isation From 1954 Table 4 in onwards in Wagoner Army and othar Testimony to service. US Senate 46-50 Army Confirmed fn M N Johnson Itr 07.06.76 louii- Yes i/ Peerenboam 06.0$.11 0FG villa 21.06.$$ 11.10.r4 41 19 19 16.10.60 on It.10.74 but no post-mortem 16.10.60 Dr M N Johnson letter of 24.2.81 con firmed death 6 years after diagnosis 16 Chart 1* 22.04.20 MG Arthur Avon Lake 15.09.54 00.00.75 46 21 13 02.11.7$ Yes 13 yn Navy autoe leaner 6 yrs on Eatol Tyra Stora plast Utter 1 Carbosat operation ConfUeed in M H Johnson Ur 07.06.76 Also Rolling Stone mag. 15.01.76 19 Virgil 00.00.1$ UCC Chrtat Ian t Charle 00.00.41 19.06.7$ ston 60 12 12 06.04.76 Yes 2000 ppa a 11.00.17 Goodyear Niagara 00.00.55 10.01.76 $0 21 10 30.01.76 Yes Hi 11lewsport Sin Gatette 21 June 1975 Charleston Deity Mail 21.7.75 NOtSM latter of 2$.10.79 21 Chester 02.09.00 UCC S Charle 00.12.46 Early 77 67 30 22 02.01.77 Yes Hinkle ston 26 yrs with UCC at SC Retired News release 23.2.77 o a: > o CD (4 I 32 USA Sheet 4 I LIVER Angiosercooa Cases * (Review Date: February 1991) UK system of dates DAY - HGN1H - YEAR i 4 56 7 a 9 10 U 1z U 14' ' IS 16 COUNTRY AMO REFERENCE NO 22 KANE OR DATE Of INITIALS IAIN 02.10.2J COMNUIT FO FACTORY loot*villa FIRST VC DATE OF EXPOSURE DIAGNOSIS 11.07.4r 00.01.76 AGE A1 DIAGNOSIS 52 YEARS OF EXPOSURE 10 DIAGNOSIS TEARS Of EXPOSURE DATE Of DEATH HISTOLOGICAL CONFIRM! ION 29 20 04.12.76 Tee ESIIHA1ED EXPOSURE LEVEL OCCUPATION 21 (24) 00.00.2J Great fItchburg 0R.09.SR 06.04.n 50 15 14 American Hass. Chemical Company Del a ed 1990 fay i Rennett: Hot englo arcomer but confirmed C lolangfoaarcoa i 06.04.7J Yea i\ OTHER CAREER HIGHLIGHTS OTHER COMMENTS LouisviHe limes 26.1.76 said He uas the 10th AS victia at RelLa lane of whom A had died fay 26.1.76 In hla letter of 16.09.61 Dr H N Johnaon confirms thit is the case described by Dannaher laiturro S Yam in Feb 1960 Am J Medicine VoL 70 p26Q (25 > ster confirmed in R Kaminski Let lemo m\ from r*g er of 5 Nov wber 1960 1l_!___________ _____________, ____________ _______________, R N Wheeler letter of 20/2/79 and Rose Kaminski Letters of 26/2/79 end S/11/60 o 43 CD > 33 l(9(R Angiosarcoma Cases {Review Date: February >991) UK system of ctates OAT MONTH- TEAR USA Sheet S 1 23 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE Of IJtlM 26 John ferry 02.07.2) 4 COMPANY FO 5 FACTORY touisville 6 FIRST VC EXPOSURE 03.10.47 7 DATE OF DIAGNOSIS 00.00.77 to 2 years af ter death> s AGE At DIAGNOSIS 52 (death) 9 YEARS Of EXPOSURE TO DIAGNOSIS 20 (death) 10 11 YEARS OF DATE OF EXPOSURE DEATH IS 11.02.75 12 13 14 HISTOLOGICAL CONFIRM! ION ESTIMATED EXPOSURE LEVEL OCCUPATION Yes Exposed In Various jobs saeie degree in pvc to 22 plants froa chewiest* cold rocai to but noln paste exposure recovery to was to VCH, PVC charging probably operator to high paate charging. IU August 1965. Tenalnated dpioyeent Jan 1966 15 OIHER CAREER HIGHLIGHTS 16 OTHER COMMENTS R (sainski letter of 26/2/79 and Prof, laeburro letter of 9/1/79 22 J L 11.05.It ucc Forrest S Charle 01.07.41 30.11.70 ston 62 37 20 25.11.7S Yes (NIOSN say* 27 and C Daily Nail 25) High Operator to 10.10.76 Exposure in R N Wheeler bulk and itr of 4 Jan dispersion PVC 1979 and enufecture Charleston Daily Mail 3D.11.7S and R (aninski 26/2/79 26 11.04.17 ucc S Charle oo.oa.44 03.11.7S SI 34 33 03.11.78 Yes ston A Kaminski lattar o( 6/4/79 29 12.10.07 ucc S Chart*' 00.OS.42 00.03.SO 72 36 16 01.05.SO Yet aton R (Minski Letters of 19th Jltis 19B0 6 5th Nov 19B0 30 UVN 22.07.22 Temeco Flealngta 11.06.64 30. 12.60 Cbssricals 56 17 15 30.12.60 Yes 6 * Unknom Maintenance 9 - Minlwal Mechanic 6 yrs Elsewhere 1* yra Softer house Operator 9 yra O 3 > O >0 0u0 34 USA Sheet 6 LIVER Angiosarcoma Cases * (Review Oate: February 1991) IRC System of dates Day - Month - Tear , 2 i A 56 7 6 9 10 n 12 i) u 15 16 COUNTRY AND REFERENCE NO NAME OR DATE Of INITIALS KIN COMPANY 0a.ll.2J ucc FIRST VC DATE OF AGE AT FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS S Charle 12.OS.46 oi.oa.si ston 57 YEARS Of EXPOSURE TO DIAGNOSIS 35 TEARS Of DA1E OF EXPOSURE DIAIH 13 02.04.02 NISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPAT JON OTHER CAREER HIGHLIGHTS OT HER COMHCN1S Tes High (Out Chemical From 1959 to Dr Decay not as high Operator in 1976 Aliphatic letter as reactor charge Chemicals 16.10.01 and cleaner reactor operator and R N Wheeler would from July 1976 tetter of experience) to dote 9.11.01. Worked aa Foreman Also Or Decey labourer Aliphatic letter of from Chemical 07.03.03 re Jtn 1941 Opera!Ion date of death. to May 19/6 and may v have cleaned reactors in that time m C U Giroux 22 02 08 Monsanto pringfLtl< 1 15-10-51 0007-79 Hess 71 ]} S Ferguson oa-io-2? FG Jnr loullvlll 0* 09-i* 110502 H 20 14 w-os-ao An autopsy The death 1940-1951 (in PVC was done and certificate Various jobs su toe lave immediate gave in polymer area) cause of Mr Giroux' manufacture death given usual BUIVAR as occupation LUSTRES "Angiosarcoma* aa "kettle 1951-1964 operator* Various Jobs In in and "chemicels round PVC industry". autoclaves 1964-1973 Various clericsl jobs in PVC polymer issti ?n Facility/ Retired 01-03-73. 20 2a Alive Yes 1954-74 Multiple I High jobe J 1975-02 including ] low Poly 1 Operator * ] Polycteener.1 Information given in letter of 24 February 1902 from Or Walter C Barnet of Monsanto Springfield to Or A Hum of Monsanto Europe. Prof teeburro letter of 12 Aug 1902 Dr M N Johnson letter of 20 Feb 1903. o 3: > o o 1 CO O' 35 Page US* * Sheet 7 . "1 2 i 4 5 LIVER Angiosarcoma Cases * {Review Date: February 1991) a9 10 11 12 ,1 r UK system of dates - DAT - MONTH - TEAR 15 16 C0UN1RY AND NAME Oft DATE OF REFERENCE 1N1UA1S IRTN NO COMPANY FACTORY FIRST VC EKPOSUtE TEARS Of DAIE OF ACE AT ENPOSURE YEARS OF DIAGNOSIS DIAGNOSIS 10 ENPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL ESTIMATED CONfIRH- ENPOSURE OCCUPATION AMON LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS u Hr lyriai 29-OI-M BFS loultvilli 1955 011162 46 27 TO 01.06.61 Yes 1955-/4 High 1975-62 Low Poly Operator * Autoclave Cleaner 1955-65 1965 laft Dr N N Johnson latter of 3 Nov 1962r RFC to 26 Feb 1963 and 9 August 1964. becoata a Ctergyaan. 15 09-01-12 occ 1 Chart*' 23-07-44 18-07-01 71 19 14 10-07-01 Yea High froa ton 1944 to 1955. Hed front 1955-1956 U M.G. 27-00-12 *h# Gwwa Ashtabula M-D6-56 21-08-61 Price lira and tufcbar Co SO 27 27 At iva Yes Moderate 1956-56 labourer 1956-57 prod helper 1957-/0 operator 1970-75 electrician 1975-63 operator If J Payton 29.08.29 6FG loulivilta 1951 06.0fl.54 31 22 06.00.64 Yet High Worked regularly In PVC area In the early days was a reactor cleaner 1953-75. 18 ju* 2B.0S.22 Air Catvart 00.02.61 19.01.64 Products City 61 i_________ 20 20 26.10.63 Yet Nigh Normal 1963-1962 progression fro* helper to senior operator, cleaned reactors, stripping 1 recovery areas as well as charging operator. o 3: > Or D*cey letter ol 5 September 1901. 1 U Laundrie tetter of 12 Sept 1963: spotted at aedfeel May 1963. Testing coanenced May 1963 Roy N. Johnson letters Feb 6 March 1990 Inforaetlon given in letter 09.06.64 fro* Dr M H Johnson Thrd cytopenla and leukopenia since 1976. Gold treatment for arthritis 1976. Under Dr.1 a care about 6 snnths before death, had passed standard physical ensainat1 on 3 aonths earlier. J. Herr lettera of 22.10.64 and 23.01.65. o 00 SI 36 USA Sheet I LIVER Anglos dr cava Cases ` (Review Date: February 1991) UK sy&ten of dates OAT - MONTH - TEAR 1 2 3 4 56 7 89 10 .1 12 13 K 15 16 COUNTRY ANO NAME OR DATE Of REFERENCE INITIALS BIRIN MO COMPANY FACTORY FIRST VC EXPOSURE TEARS OFF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTHER CAREER HIGHLIGHTS 01 HER COMMENTS 39 J NMict *7.04.IS P*ntMO PaataIt 1960 March 1964 AS 40 p p 24.10. U RFC Gilacr louiavllla 22.03.42 1967 72 Never in hospital for any chronic or 24 23 9,06.84 Yea Low 29.09.60 Worked acute asdics! problem. Death certificate May 66 before tates cause of death cardio-pulnonary Vinyl 1960 arrest secondary to engiosercoaa of fabrication with US 1Iver. Plant Air totter of 15.07.86 froa John i Ertel High May 66 - Force, of Pentaeote with letter of 24.02.86 Aug 70 Uni ted froa Dr Auerbach, Pathologist. Utility Wool Resin Dyers Operator and (fnc Jut 66 Okanita - Sep 67 Reactor Operator) Low Sep 70-82 Honowr Operator Low 198283 Mill Operator, Calendar Shop, until retireaent 45 34 03.01.07 let High Cheatcal 1942'1974 Worker 1942-45 Low 1975*1976 foreman i 1945-76 LaMar froa Dr Oteti, IFG, 10.3.17 1 41 1 luckl* 2.02.13 Goodyaar Ml agar* 1949 falls 1907 72 30 27 20.00.07 Ttt Nigh 1949-65 Retired tetters froa Prof TaRurro Cheafce! Op. 1977 University of Louisville, 1987 Shift Sup/ (At* 62) and Dr C A Johneon, Goodyear, 1906 foreaan, PVC Realn Production Nedi us 1965-77 HF Plant [Left PVC area for 6 i lonthe in I1 *65) _____________i ____________i ____________________________________________ -- o 3: > o *0 00 00 37 USA Sheet 9 LIVER Angiosarcooa Cases - {Review Date; February 1991 > UK systoa of dates DAT * MONIH ' TEAR 1 2 3 4 56 7 09 10 ii 12 13 14 15 16 COUNTRY AMO MANE OR DATE Of REFERENCE INITIALS ilftlM MO cemm FAC10RY fiftsr vc EXPOSURE FEARS OF DATE Of AGE AT EXPOSURE TEARS OF OIAGMOSIS OIAGMOSIS 10 EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL ESTIMATED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS 42 HcHul Ian 02.01.41 01 In Attorn t 00.04.60 00.04.02 41 14 6 09.07.02 Vet Niflh Labourer in Pot aree: pot cleanou regularly Latter Iron Or Pttar Hnlll 11.04.09 41 J ft oa.o.2i GtnCorp Athttbult 14.04.11 26.11.00 67 Sued (foraarly Ohio Central lira) 11 20 10.01.09 Ye* PVC Rea in Retired letters Iroa Roy N Johnson, GenCorp Plant: 01.01.fl4 Qft.Q5.09 and 30.05.89 ttiRh Maintenance Cleaner 1.6 yeara Shift Medina Mechanic 2 year* Plant Lou Electrician 24.10 yeera CMA 0 1 1 9 8 9 38 YUGOSLAVIA LIVER Anjiosarctw Casts - (Review Date February 1991) 1 2i COMMIT AMD NAHE Oft OAIE OF REFERENCE INHIAi* IR1N MO 4 corARY t6 1 e9 10 11 12 13 14 it TEAMS OF MAST VC DATE OF ACE Al EXPOSURE TEAMS OF FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS 10 EXPOSURE DIAGNOSIS DATE Of OEATH HISTO LOGICAL ESflHAIED CONFIRM EKPOSUDE OCCUPATION ATION LEVEL OTHER CAREER HIGHLIGHTS 16 OTHER COMENIS YUGOSLAVIA 01 OS.04.14 Juo Vlnll Split 00.00.S3 00.04.21 to 20 20 00.04.23 Yea SAftIC t el peper Env Health Perspective Vol 17. pp 109*192 1976 02 It.11.31 Alga Spill 00.00.SO 12.02.23 42 21 ie 12.02.23 Tes* VCH Vlnll Production in hie letter of 1 Oct 1970, Or Spirtas of NIOSN changed the atetus of Ceae 02 to VCH production e^ioyee. Dr Spirtes also notified e new Ceae 01 aieo a VCH production 01 21.12.11 **0 Split 04.06.54 11.01.26 45 22 22 11.01.76 les* VCH worker. Vtntl Production 04 11.06.10 JUftO Split 1t.12.S0 oi.09.re 40 20 10 01.09.re Tea Vinll ftoea Kaafnafci letter of 19 June I960 end IAIC latter of 1 April 1962 n a>: o >o o 39 Incidence of ASL Cases Per tana - By pate of Death IABLE 1 (Review Date - February 1991) 1955 ................................................................................... 1 6 ...................................................... 0 7 ................................................................................... 1 8........................................................................................... 0 9................................................................................... 0 1960 ................................................................................... 0 1 ........................................................................................... 1 2 ........................................................................................... 1 3 ........................................................ 0 * ........................................................................................... 2 5 ................................................................................... 0 6 ...................................................... 0 7 0 9 1970 t 2 3 4 5 ................................................................ It 6 ......................................... II 7................................................................................... 8 0.......................................................................... 10 9................................................................................... 5 1980 .................................................................................... 10 1 ................................................................................... 5 2 ................................................................................... 3 3 .................................................................................... 10 4 .................................... 8 5 ......................................................................................8 6 ................................................................ It 7 ................................................................................... 3 >O 3C 8 ................................................................................... 7 9 ................................................................................... 5 Total 153 BOIES 1 Does not include Italian 01. 2 The 1977 total now excludes OS24, Chotangiosarcoaia: deleted. 3 . The 1982 total now excludes G26 Alcoholic Cirrhosis: deleted. 4 Does not include the following who are still alive, so far as known: Fr15 and 28, US33 and 36. % 66TT0 f 40 TABLE 2 (Review Date - February 1991) Distribution of ASL Cases by Country (These are listed in descending order of number of cases.) USA U Germany Franca UK Canada Sweden Italy Vugoslavia Japan Czechoslovakia Belgiim Norway Spain Australia Total 39 ** ***** U ***** 28 ** 16 13 5 **** 8* 4 *** 3 2 2 1 1 161 ie Uestem Europe North America Best of World Total 99 52 10 -- 161 * Omit itOI - atypical case of PVC bag extruder. ** Includes Fr15 and 28, USJJ 6 36, who are still *** Includss one monomer worker. '*** Includes two monnamr workers. '*** Excludes 826 and US 26: deleted. alive, so far as known. n 3. I > O <i 41. O K) Pattern of AS( Cases bv Factory TABU 3 (Review Date - February 1991) (a) W Europe Of the 99 case* In If Europe, SO have occurred in clusters at 10 factories. Of the 38 German cases, 34 have occurred In clusters at 4 factories. ASL Cases Oynamit (now Huls), Iroisdorf, Germany BP, Barry, UK Atochem (formerly Chios Chimie, formerly RP), St fons, France Waclcer, Burghausen, Genaany Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvalt, Sweden ICI, .MUhouse, UK Sotvay, Tavaua, France CUH/Nuls, Marl, Germany Lonta, Uatdshut, Genaany 19 11 11 10 8 5 S 5 3 3 60 NS: There are 32 pre 1962 PVC plants in W Europe; 20 of these have had ASl cases (Ref Table 6) <b) N America Of the 32 cases in N America, 41 have occurred at four factories out of a total of 55 factories. In N America 41 plants have not had ASL cases. ASL Cases 6FG, Louisville, US BFG, Shawlnlgan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 9 _5 il N8: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 A 10) (c> Rest of World Nine of the cases are believed to be in one cluster of 4 and two clusters of 2 cases. Australia 1 9 _1 10 CMA 0 1 1 9 9 3 I 42. (Review Date - February 1991) TABLE 4A Latency Periods (Fears from first Exposure to Diagnosis) Country No of Cases Total Years Averaoe U Eurooe Belgiua 2 35 17.50 France 28 795 28.39 * Germany 38 783 20.61 * Italy 8 172 21.50 Norway 1 22 22.00 Spain 1 25 25.00 Sweden 5 122 24.50 UK 16 376 23.50 * 96 2267 23.61 U Europe Average N America US 39 1002 25.69 * Canada 13 314 24.15 * 52 1316 25.30 N America Average Rest of World Austral ia 1 25 25.00 Czechoslovakia 2 30 15.00 Japan 3 59 19.66 Sumaarv Yugoslavia II Europe 4 10 96 85 199 2267 21.20 20.00 Rest or World Average 23.61 N Axwrica 52 1316 25.30 Rest of Uorld 10 161 199 3845 20.00 23.88 * World Average * Of the countries with > 10 cases, France, USA 1 Canada have an average latency period above world average; Germany 1 UK below world average. CMA 0 1 1 9 9 4 f 43. DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - February 1991) 0-9 yrs 10-H yra 15-19 yrs 20-24 yrs 25-29 yrs 30-34 yrs 35+ yrs Austral ia Belgiua Canada Czechoslovakia France Geraany Italy Japan Norway Spain Sweden UK USA Yugoslavia 1 1 --------------------- 1 --------------------- \ 2 3 5 2 12 1l 1 4 3 10 5 12 to 6 46 4 12 2 3 12 1 1 2 21 5 1 63 3 7 9 6 66 4 Total 1 Average Latency Period (Table 4A) ' 25.00 2 17.50 13 24.15 2 15.00 28 28.39 38 20.61 a 21.50 3 19.66 1 22.00 1 25.00 5 24.50 16 23.50 39 25.69 4 21.20 TOTAL 2 14 36 37 39 19 14 161 23.88 -S 6 6 T T 0 VWO I 44 TABLE 4C (Review date February 1991) LATEHCT PERIOD OF ASL CASES TABULA1ED BY TEAR OF FIRST EXPOSURE MAX POSSIBLE LATENCY PERIOD 51 49 48 47 46 42 41 37 36 32 31 27 26 22 21 17 16 TEAR OF FIKSPOSURE 1939 1940 41 42 43 44 45 46 47 48 49 1950 51 52 53 54 55 56 57 58 59 I960 61 62 63 64 65 66 67 68 69 1970 71 72 73 74 TOTAL LATENCY PER100 (NO Of TEARS) ARITHMETIC MEAN OF LATENCY PER 100S 37,21,37,41 32,38,45,47** 38,14,32,42,45 28,11,24,20,24,34,39,44 27,22,28,29,37 21,29,31,26,28,15,23,30,35 29,24,29,28 28,24,34 30,26,20,38 26,22,31,19,23,14,33 19,28,17,28,34,29 21*,15 25,23,22,20,31,22,32,30,23 21,21,25,25,21,28**, 22,34,34 22,23,24,14,19,21,27 27**,24,28,30,33 21,12,27**,32,29 19,17,15,13,16,28,30 298 * 37.25 8 886 > 28.58 31 559 = 25.41 22 1010 * 24.04 42 18,18,15,17,20,29,28, 16,21,25,27 13,18,21,25,24,25 15,16,16,16,19,19,12,28 13,18,17,12,18,21.26 16,17,20,21,25,25,26 16,17,25 11,19,20 9,18,21 16 18,5,18,14,19 13,16 13 626 - 19.56 32 347 19.23 18 11$ = 14.50 8 161 CASES 3846 = 23.89 161 '1 I | 1 l | | 1 1 1 I R I VIOLA [I I 1 | I | MALIONI [ GOODRICH I I CMA 0 1 1 9 9 4 * Aerosol can filler G 03. " The following ere stilt stive, so far as known fr IS and 28, US 33 and 36 45 MBit 4D (Review date February 1991) LAIEHCT PER IOCS Of RSI CASES 1ABULAIED BIT TERR Of FIRS1 EXPOSURE AMC GEOGRAPHICAL LOCATION MAX POSSIBLE LATENCY PER ICO 51 49 46 4? 46 42 41 37 36 32 31 27 26 22 21 VEA> Of flRSl EXPOSURE 1939 1940 1 2 3 4 5 6 7 8 9 1950 1 2 3 4 5 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 LATENCY PERIODS IN WESTERN EUROPE NORTH AMERICA 37,41 47** 38,45 26,44 27 21,29,31,33 29 21,37 32,38,45 14,32,42 11,24,20,24,34,39 22,28,29,37 26,28,15,23,30,35 24,29,28 28,34 30,26 26,22.31 19,28,34,29, 21* 24 20,38 19 17,28 15 25,22,32,30,23 21,21,25,25,34,34 22,23,24,27**24,28 30 21,12,32,29 19,17,15,13,26 23,31 21,28** 14,19,21,27 27** 30 18,18,29,28 16,21,25,27, 13,18,21,25,25 15,16,16,16,19,19,21 13,18,17,16,21,26 15 24 12 12 16,17,21,25,25,26 16,25 11,19 9,18,21 16 20 17 18,5,18,19 13,16 14 ROU 23,14 22,20 22 16 17,20 20,25 VIOLA 1970 2 17 MALUM] 3 TOTAL CASES 99 52 __10_ Aerosol can filter G 01. Itie following are still alive, so far as known fr15 and 2t, US33 and 36. 46 PLANT TROISFORF W GERMANY LOUISVILLE USA SHAUINIGAN CANADA BARRY UK ST TONS FRANCE BURGHAUSEN W GERMANY START UP DATE 1954 19*07 ms (1941?) 19*8 1939 1933 TABLE 4 E (Review Date February 1991) LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) 12,13,16,16,18,19,19,21,23,75,78,29,29, 5,23,16,34,18 12,14,15,19,19,20,24,27,28,28,28,29,29, 31,45 11,12,14,21,22,23,24,24,26,28,42,37 NO OF CASES 18 15 12 AVERAGE LATENCY PER100 20.22 24.53 23.66 9,17,18,28,31,33,18,19,18,21,32 11 22.18 21,28,29,37,38,27,41,34,44,34,47 17,21,22,25,24,13,21,32,30,30 11 34.53 23.50 10 t 1 | I [ | [ [ I n 3 > O I >0 >0 CD 47 (Review date February 1991) TABLE 4F LATENCY PER 100 OF ASL OSES TABULATED BY FEAR Of FIRSI EXPOSURE AMO SPECIFIC PLBUT <10 OR MORE CASES) YEAR Of FIRST EXPOSURE IROISDORF LOUISVILLE SHAUINtGAN W GERMANY IMA CANADA BARRY UK SI FOHS BURGHAUSEN FRANCE U GERMANY 1939 1940 1 2 3 4 5 6 7 21 20 28,29,27 29,28 14,42 11,24 22,37 26,28 24 37,41 47 38 44 29 a 9 1930 1 2 3 4 5 6 7 24 19 29 IS 23 21,25,34 23,28 12,29 13 31 28 14,19 23 31,33 28 28,34 34 27 32 21 25,32,30 21 22,24,30 17 8 9 I960 1 14,16,19,19 12 2 18 12 18 21 3 17 4 5 19 6 9,18,21 7 8 5,18,19 18 9 16 13 1970 1 2 1 11 ________ ________ _______ ______ __ >0 48 *0 (Review date February 1991) PLANT T*9ti fS START-UP DATE LATENCY PERICO OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES AVERAGE PERIOD S CHARLESTON USE 19197 24,30,32,32,34,35,17,30,39 9 301 * 33.44 9 BR1GNOUO FRANCE mo 11,16,18,26,30,25,34,45 8 25.62 SUNOSVALL SWEDEN ms 16,19,27,29,31 5 24.4 NIAGARA FALL: USA TAVAJX FRANCE HILLHOUSE UK SPLIT YUGOSLAVIA 1K7 m3 1940 T9S0 15,17,21,23,38 19,16,21,26,25 (ie FR26) 28,25,20,25,26 (ie UK17) 20,20,22,23 5 22.8 5 107 * 21.4 5 5 U2 26.4 5 4 21.25 O >3C O M Pj o o o 49 (Review date February 1991) IABLE AH LATENCY PER 100 OF ASL CASES TABULATED BY TEAR Of FIRST EXPOSURE AMD SPECIFIC PLANT <4-9 CASES) YEAR OF S CHARLESTON MIGNOUD FIRST EXPOSURE USA FRANCE SUNOSVALL SUEDEH NIAGARA FALLS USA IAVAUK FRANCE HILLHOUSE SPLIT UK YUGOSLAVIA 1959 1940 1 2 3 4 5 6 7 37 32,38 32 24,34,39 30,35 45 27* 31 15,23 29 28 8 9 1950 1 2 26,30 34 19 38 17 23* 3 20 4 25 22* 5 21 8 7 19 28 8 9 1960 1 2 18 16,25 20 26 3 16,21,25 25,26 4 16 5 11 6 7 8 9 1970 1 2 'Norwtuer worker I CHA 012001 50 TABLE 5 (Review Date - February 1991) Annual Incidence of ASL Cases (Date of Death) by Geographical Area Western Europe North America ! 1953 7 i 1961 \ 2 4 !7 98 ! 1970 !1 2 * 4 j 85 !7 8 9 ! 1980 !1 2 ! 4I 5 ! 67 1 ^1 1 1 4 1 '1 3 8 6 8 7 5 8 5 7 i8 7 10 J0 8 ___________ 2___________ ________ i__________ 1 1 1 1 1 5 2 1 i i 4 2 4 3 2 2 4 3 3 2 1 3 1 Rest of World 1 3 1 2 1 1 Annual Total 1 1 1 1 2 1 5 3 2 3 5 8 5 11 11 8 10 5 10 5 3 10 8 8 11 3 7 5 Emulative Total Key Events 1 2 3 4 6 7 12 13 17 20 25 33 38 49 80 88 78 83 93 98 101 lit 119 127 138 141 148 ____ m_______ Viola Hsltoni Goodrich TOTAL | 97* * j 50** |_________ 10 j 153 * OMits It 01 bag extruder * Doee not Include the following who are still alive, so far as known: Fr15 and 28, US33 t 36 NOTE: G28 and US24 deleted. O 3 > O w o o 51 w TABLE 6 (Rnviow Dm* Febcuary 1991) ASL CASE NUMBERS BY YEAR OP DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING >011 KEY EVENTS 1955 6 7 S 9 I960 1 2 3 4 5 6 7 S 9 WESTERN EUROPE PI G1 Vula Mitaa* Goodrich TOTAL 1970 1 2 3 4 5 6 7 > 9 19S0 1 2 3 4 5 * 7 S 9 1990 Swl G2 Nl,Sw2.UKlja G3* G4,G5,UK3 F2JG,06,G7,GSJ3 Bl.F4,F5,F5,F7,3w3 Faj9,G10,Gll.al2Jw4 F10.F11,G9,G13,G15 G16.G17 F12JU3,UK4,UK5,G11 UK6,ur7,G19^w5,G20,G21 R4F14,UKS,GZ2,G23 UKD9J5,F17JB2,G24,G251G30 UK10JH6.F18,G27,G29,G35 UKll.UK12J19J>20,G2i,G33, G34 F21.UK13J6Jff.G31.G32. a36.G37.G3S.G39 F25JW,UK14,UK15.UK16.G40 F22JP23J<24J27Jpl,UK17> 1SJ9 97** ** Doc* not inchid* *a fatloviaR who an nil afiva, nfiraakaovn: F15 and 2S, US33 and 36 NOTE; G26 and US24 delaad NORTH AMERICA Cl Cl USS a USS C4.C3.US4.US7.US10 US12.US16 US11 C6.US2 C7 CS.US1.US3.US23 C9.US13 US6.US9.US1I.US26 US19.US20.US22, C10.US21 US27.US2S US17.US29.US30.US32 US31.US42.C12 US3S.US34.US38 US37.US39 CI1 US40.US4I.C13 US43 50" REST OF WORLD Cz2 * Yl.Y2.Czl X*p2.Y3 Y4 3*3 AnaOl 10 52 CMA 012003 IfllLI 1 (Review date February 1991) ASt CASE MOWERS BY YEAR Of FIRST EXPOSURE AMO GEOGRAPHICAL LOCAllow mjflWlHS ItiQI) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST Of WORLD 1939 40 1 2 3 4 5 A 7 S 9 50 1 2 3 4 5 6 7 S 9 60 1 2 3 4 S 6 7 0 9 fr11,Fr16 Fr2fl Fr14,Fr24 l*1,fr23 Su2 Fr1,Fr3,Sw4 Sw3 Fr9, Fr17 Fr12,Fr4 fr 7, NT, UKB, 1*9 Su1,(*5,Fr20,G30 63 G15,lt3,631,633,636 G7,60,G19,630,fr27,l*4 C11,C16,G1S, ErK** G23,620,632 FRIO, 61,634,1*15 Fr6f64,lt2,62,1*12 Fr6,01,fr22,1t7 Fr2,lt4,Fr19,Fr21 G5,G13,G2S,620,lt6 G9,610,612,G17,620,622 It.00, 66,1*6,621,02,629,Fr25 Fr13, 1*7, Fr1B,UK16, 1*17, Fr26 SwS.Spt FrS.UKII 1*3, 1*10,1*14 !t5 1*13,635,639 624,637 C3.US27 US13. US29.US40 C2,US19,C11 Cl,C5,US5,US7,US20,US35 C4,US3,US9,C12 C7,C9,USA,US11,US21,US11 C6,US22,U$26 US1 US12.US41 US16 US10, US12 Y2, Cz2 US4 CIO, US37 Japt.Vt US10,US33" Y3 US2,US17,US20,US34,US43 US36** CIS US23 Czl Jp7,Y4 US39 CO USA US30 US30 lap! Aus 01 US42 Viola 70 1 2 It 09 Haltoni 1 Total 99 52 10 fro o s ro vw a * Aerosol can filler (Cl) ** FrIS, Fr20, US31 4 36 are still alive, so far as known 53 SOOCIO vwo START-UP TEAR 1931 1 1933 ] 91938 J 1939 1 1 1940 j | mS | 1946 1 1948 I I 1949 1950 1951 1952 1953 1954 COUNTRY MANE Ueat Cenanny Meat Geraany Italy Franca Uni tad Kingdoa Uni tad Kingdu Sweden Franca United Kigndoa Ueat Geraany Belgiua Franca Franca Holland Norway Switzerland Italy Italy Auetria Franca Italy Spain United Kingdon Ueat Geraany Ueat Geraany 1955 Spain IABIE B UESTERM EUROPE PVC PRODUCERS - START-UP BATES VS ASt CASES (CHITTING G--03r. I- t- 08i, *I*t --09') COMPANT NAME LOCATION ASL CASE NUMBER BASF LutAiigshafen Review Date February 1991 TEAR OF 1ST EXPOSURE ' Hacker Burtftausen 04,07,11,15,23,24 25,31,32,33 57,54,55,53,55,69,60,53 55,53 Montecatini Acna Rhone-Poulenc/ Chioe/Atochea St Fona 03,09,10,11,14 15,16,17,23.27,20 46,48,56,41,43, 55,41,48.44,54,42 ICI/EVC ICI/EVC Runcorn (closed 1940) Nil(house 01.04,12,16,17 44,54,57.63,63 Keaanord/Nobel Sundavall (Stocky)k) 01,02,03,04,05 51,45,47.46.64 Rhone-Poulenc Roussi lion (Closed 1-1-07) 01 46 RP Cheat/ICI/EVC CUH/Huia Sorry Marl 03,05,06,07,00,09 10,11,13.14,15 09,10,29 66,51,62,63,50,50 66,65,68,66,56 61,61,62 Solvay Jeneppe 01,02 58,62 PGUK/Atocheai Rhone-Poulenc/ CNlow/Atochea Shell Norsk Rrignoud St AtRan Pemis, Rotterdan Berova. Porsqnm 02,04,06,06,12,19 20,24 07.22 01 59,49,65,58,49,59, 51,43 50,50 50 Lenza/lCI/EVC Sins Nontediaort/ Noplafan Nontedison/EVC Terni 07 50 57,60 Nalvic/Solvay Solvay Solvay Rio Rodino BXL/RIP7NQ8SK Hocchat Porto Nartftera Hallain Tavatai Ferrara Nemani Ayctiffe Gendorf 02,06 00,13,10,25,26 03 18 57,63,63,62,63 53 55 Oynaait/Nuis (aince 1.1.09) Troiadorf 01,02,08,12,16,17 19,20,21,22,27,30 34,35,36,37,38,39 56,57,54,61,55,61, 54,61,62,61,55,51 56,68,53,69,54,68 Monsanto Iberia Honzon 1 Torrelavega 54 9 0 0 2 1 0 VMO | START-UP TEAR COUNTRY NAME TABLE 8 MESTERH EUROPE PVC PRODUCERS - STABT-lIP DATES VS ASL CASES (OMITTING 603, It OB, It 09) COMPAMT WANE LOCATION ASL CASE NUMBER 1956 1958 1960 1961 9I 1965 1 | 1 1966 111 iwr 1968 1969 1970 1971 1972 1976 1977 1982 \ im . Ml 1*dl 1 Spain West Germany Italy Uest Gernany Portugal Frwtce Italy Italy Heat Gernany West Gernany France Spain Greece Belgium Uhitad Kingdom Italy Italy United Kingdom Spmin Sweden Finland Holland France Spain West Germany Caigsa Hispevic/Solvay Solway ABIC/SC Ravenna EVC Lonxa/ICl/EVC Cires tbone-Poulenc Paul Pensac Wacfcer Hoechst Atodiem Rio Rodino Esso Pappas Oadiphil Vinatex/Norsk Rtamnica/EVC SIR ICI/EVC Hispavic/Solvay Kcaanord/Norsk BP Otem Pckema OSH Soc Art O'vinyt (CDF) Honsanto Iberia ICI/EVC i * Laboratory Worker in Research Department Rheinberg Ravenna Waldshut Oporto Hantlucon Ferrandira Hire,Venice Cologne )Knapsack(Frankfurt Balan Miranda de Ebro Oiavata Salonika Antwerp Stavelcy Cagliari Sardina Porto Torres Sar Runcorn Hartorel1 Stenungsund Raglan Ray Svartback Reek Liaburg Maiingarbe Tarragona Voelapp UiIhetmshaven t 01 M 06.13.28 21 OS 05* 55 Review Date February 1991 TEAR Of 1ST EXPOSURE M1 59 62.60.60 59 67 60 (Review date February 1991) TABLE 9 USA pVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP | COMPANY NAME | LOCATION | ASL CASE r' j YEAR OF i 1 YEAR _ 1939? |*UCC 1 | S Charleston 1 NUMBER 1 1st EXPOSURE (07,13,19,21,27 (99,92,93,96,91 | Dow 1 128.29.31.35 | Midland (made 1 1 Saran copolymer)___1 199.92.96.99 mo? | *8FC | Louisville |01,02,03,09,05, |98,55,95,52,99, 1996 _ 1*UCC/Dow 1997 ... 1 Goodvear 1998 | Firestone/ 1 Occidental | Uniroyal 1950 | Monsanto 1 ______________________ |06,09,16,17,22, (62,95,50,55,97, 126.33.39.37.90 197.59.55.53.92 1 Texas Cltv (Partially closed 1977) 1 Niagara Falls 108.10.11.20.91 196.51.96.55.99 | Pottstown 112 199 11 | Painesville 1 (closed 1975) 1 1 | Springfield | 32 (51 1952 1 Dow 1 (Closed 1975 ______i___ :_______________ 1 Midland (No PVC since c 1975) 1 BFG 1 Avon Lake 118 159 1953 1959 1 Diamond/BFG 1 Deer Park | General Tire/ ** | Ashtabula 1 DiverslTech 1(Closed 1983. 1 (36,93 (56,55 ReoDened 1986 bv Vveen) 1956 1 Air Products 1 Pensacola (Pace) 1 1 Atlantic Reflnlne 1 Brooklvn(Closed late 1960s) 1 Borden 1 Conoco 1 Leominster (Closed 1989) 1 Hebronville (Closed 1975) 1 BFG | Great American 1 Nlaaara | Fitchburg 1 123 | 58 1957 l Plastics 1 Hooker 1 Pantasote 1 Atlantic Tublne | Tenneco/ 1 (Closed 1983) ______ l___________________ 1 Hicksville (Closed 1980-81) 1 Passaic(Closed 1989) 39 160 1 Cranston (Closed 1967) | Flemington NJ | 30 | 59 1958 1 Occidental 1 Kevsor Centurv | Air Products j 1 (Closed 1985) 1 1 Saueus. Cal _______ 1____________________l__ | Calvert City(Paducah) 38 163 1 (Closed March 1982 Re-oDened October 1983) J_____ - ... . _ Continued 56. TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES r --------------- 1 START-UP| COHPANY NAME LOCATION ASL CASE YEAR OF YE&R 1960 BFG NUMBER Long Beach, Cal (No PVC now. 1st EXPOSURE 1962 1963 Borden Tgnn6gZQiiisntal Conoco/Vista Formerly shown as Watson) llllopolis Burlington NJ X _L Aberdeen. Hiss_____ |_ Stauffer Long Beach. Cal (Closed 1982) 1965 Conoco/01in Assonet, Mass | 42 68 EthyL (Closed by Qlin 1975) Baton Rouge (Closed 1984) 1966 Diamond/Ceorgla Delaware City Xulf_____________________ Cen Tlre/Pantasote Ht Pleasant W Va i(Closed 1982) 1967 _BE_ Stauffsr/FgEBgsa, Allied/Robintech/ Georgia Pacific___ Henry. Ill X Delaware City (Sold to Formosa 1981) Painesvllle, 0. (No PVC made by Robintech. GP converted to polystyrene)______ Hooker/Occidental Burlington NJ X im Fires tone/Occidental Perrwllle (Closed 1982) 1969 .mi 1972 MSL Goodyear/BFG Cpiwsp/Viata Nat Starch Pedricktown NJ X PUaysains X Oklahoma Cltv X Heredosla. Ill_____ L X2ZX 1974 Itersisa, Atlantic Tubing/ Springfield X Cranston R1 (Closed 1962) 1975 Tallvrand--------------- Shinlssh.. certain-tsssl. Georgia Pacific/ ________ I________ Freeport. Tex X Lake Charles Plaquenine, La | Georgia Gulf--------- _______________________________ L Tenneco/Occldental Pasadena. Tex X 1979 Firestone/ Addis (formerly shown as n Occidental 31 1983 Fgrmgsa- Plaquemlne) 1_______ Point Comfort. Text 1986 Vvgen ** Ashtabula. Ohio____ L _______ t tO * My databank has n information on UCC before 1946 or BFG before 1950NB O O ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. 09 Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. 57. (Review date February 1991) TABLE 10 (START-UP YEAR CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES COMPANY NAME LOCATION ^ ASL CASE NUMBER I YEAR OF 1st EXPOSURE 1943 (1941?) 1951 Goodrich | Shawinigan (Formerly Gulf) j (Formerly Shawinigan Chenicals) (Formerly Canadian Resins & Chemicals) 101,02,03,04,05 144,43,41,45,44, (06,07,08,09,10,|47,46,61,46,53 (11,12 (43,45 II _)------------------------------------------1-------------------------------------------- Monsanto II La Salle (Closed 1975) 1957 Goodrich Welland (Niagara) 13 57 1966 Esso (Imperial Oil) Sarnia 1979 I | Diamond Shamrock Alb/ BF Goodrich I Fort Saskatchewan | (Review date February 1991) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES r I START -UP| COUNTRY NAME | COMPANY NAME 1 YEAR___1| IPre 19391 East Germany 1 State Company 1 1941 IRussia 1 State CoroDS 1 1950 lYueoslavla___ (Jueo Vlnil____ 1 1951 ICzechoslovakialState Comps___ 1 1955 1 East Germany 1 State Comes 1 1956 1 Rumania 1 State Couds 1 1957 (Poland 1 State Couds (Rumania (State Comps 11 1 1958 (Rumania 1 1959 (Hunearv 1 State Comos (State Comps 1 1961 (Rumania (State Comes 1 1963 lYueoslavla (Obis 1 1965 1Buiearla I 1967 1 Poland 1 1969 IRussia 1 1970 1Rumania (State Couds (State Comps 1 State Comps 1 State Comos 1\ 1 ' 1972 1 1975 IRussia 1 State Comos lYueoslavla___ IVinilolastlka ICzechoslovakialState Coups IRussia (State Comos 1 1976 lYueoslavla (Hip 1 1977 1 Rumania i_________ jState Comos | LOCATION l 1Schooau (Vladimir et al (Split INovakv IBitterfeldt 1 Icechlm (Osweicim (Dworv) |Tirnaveni ITurda IRlsnov IBerente Borsod 1Borzestl 1Skoole 1Varna ITarnow IDIeriinsk IRlmnicu Vllcea IVoleoerad t Zadar INeratovlce IKalush Area 1Pancevo |Rimnlcu Vllcea | ASL CASE 1 NUMBER 1 1 101.02.03.04 101.02 1 1 1 1 1 l 1 1 1 1 1 1 1 l 1 1 1 I | _________________ | YEAR OF 1 1st Exposure 1 1 153.50 54.58 157.50 1 1 1 1 1 1 1 1 1 l l 1 1 1 1 1 1 1 1 CMA 0 1 2 0 1 0 t 59. Table n (Review data Fdmuiy 1991) JAPANESE PVC PRODUCERS - START UP DATES VS ASL CASES 34 PtonriM I doa4 - TNIM 60 CMA 012011 (Review date February 1991) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS |START-UP | i YEAR COMPANY NAME 1 1953 1 Monsanto Mexica 1 1956 1 Policvd 1 1955 1 Geon Do Brazil I 1956 1 Elchlor/Solvav I I960 | Electrochlor 1 Vlclastic t 1961 1 Indupa 1 1965 1 PET Columbiana 1 1966 1 Carburo Da Col | 1967 1 Plastlcos Omeza 1 SOC Paramonea 1 1968 1 Primex 1 1970 | Pollcasa l Petro Dow 1 1971 1 Pollmeros Hex 1 1975 1 Rico Chemicals 1 1976 1 Petrodas 1 1977 1 Indust Resistoe | 1978 | Huls Brasil | Polychem 1 Policvd 1__ 1222__ i, fET ..SaaasflEl | LOCATION 1 i 1 Lecheria (Mexico) | | 1 Mexico Citv (Mexico) | 1 Sao Paulo (Brazil) | 1 Sao Caetano (Brazil) | |Capitan Bermudez(Argentina) 1 1 Mendoz (Areentina) | 1 Cinco Saltos (Areentina) t 1 Cartaeena (Colombia) | 1 Medellin (Colombia) 1 Mexico 1 Paramonea (Peru) 1 Puebla (Mexico) | Managua (Nicaragua) | t | | 1 1 Conception (Chile) | 1 St Martin Puebla (Mexico) I 1 Guvanilla (Puerto Rico) | 1 EL Tablazo (Venezuela) 1 Tlazcala (Mexico) j| Cubato (Brazil) El Salvador | | 1 1 1 Coatzacoalcos (Mexico) | 1 Camacari Bahia (Brazil) ASL CASE NUMBER 1 YEAR OF | 1st EXPOSURE | | | | 1 | | | | | | | t t t | | | l 1 | 1_ 61- (Review date February 1991) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES fH )START-UP COMPANY NAME j YEAR LOCATION ASL CASE NUMBER -- YEAR OF 1st EXPOSURE |Mid 1950s 1 | 1960s 1 |Late 1970s ICI.Australia B F Goodrich ICI Australia ______________ ,_______________________ 1 Botany, Sydney He lbourne Laverton Melbourne 01 65 ___________________ 1_____________________1 ETOZTO VWO I I 62. \ (Review date February 1991) TABIE 15 middle eastern pvc producers START-UP PATES ---------------- --. START-UP DATE COUNTRY NAME COMPANY NAME LOCATION Sept 1986 Saudi Arabia National Plastic Conpany (Ibn Hayan) Arabian Petrochemical Company Hadiant Al-Jubail Al-Sinahyah _______ !____________ _____________ _____________________ 1 CMA 0 1 2 0 1 4 t 63. (Review Date February 1991) TABLE 16 HUMBER OF FACTORIES IH THE WORLD PRODUCING PVC Sfl far as known at 1 January 1991 (See Tablet 8-15 of this ASL Register) Western Europe USA Canada Eastern Bloc Japan South and Central America Australasia Middle East CLOSED OPEN 1 53 20 30 14 - 23 8 26 - 22 -3 __ ^ 22 t 172 64. * COME IIEI1 I A L UERLD REGISTER Of USES Of MKIOSMHXM OF HE UVEA (UU du* to WM 1 23 camay and REFERENCE MO NAME Oft INITIALS DATE Of HIM * COMPAMI 36 7 s 9 10 ii 12 13 H 13 FAcroar FUST VC EXPOSURE TEARS Of DATE OF AGE AT EXPOSURE TEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE OIAGNOSJS DATE Of DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION IEVEL OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS CMA 0 1 2 0 1 6 65.