Document znLZrvD08x71ER6gJKq3QGnB

^ 4 2 2 - V / 7 6 CANCER PREVALENCE IN SUBJECTS EXPOSED TO PERFLUOROOCTANONIC ACID (PFOA) James Dahlgren MD1, Ayman B Ibrahim M DU' \Raphael Warshaw2, Harpreet Takhar MPH3 1. UCLA School o f Medicine. 2. Comprehensive Health Screening Services. 3. Dahlgren Medical Group I'crthiumnei.Huinic Acid iPFOAi n nun-mad* pcrllunmnctaned v'hcnucal. alan Mewed tn as i d PUJA it 4 kcy i>ni in ihe pnsttuouva o| Tvtlnii t and nthef ilunrivhermcal producianti u btoncrsiaeni ani huvKcumubtc There has been documeu'iitl chrome esfhvuireto PFOAM'Uk resideni* ear 4 plant using PFOA andother lluminaled cunnomanti. Ottr aim era cnaipar* cancer dtunhuuon and cancer prevalence Wt in a ft OA-cspowd pnpidaihut rciutcata1in that ni'ihe industry c* cr rtguftry >bu Irnnt m nccajwooflal cupaacd population and faally 'iboitewnil popalatton iSHPRi We performed a qtwuioaaam: on MMreddcnU living ne a PFOA errng moiwlacturing ptaMoperated by Daprati Cancer Mfiflry dam tern lile PFOA cipoted Oupnat werken war made availabk tfintugh Uaeovery in pndtag iMgattan agaiii Oupmu and w u rm prevjottaly mada available Dm k Im i IAc community for review. The SiHERdata <b used Tercoaipacisna 0the genant population The overall cancerprevalence rat* u higher Dm PFOA-expnred populawon whencompared reihe general population. Cwnparewi ol' cancerprevalence cue* Tenthe industry cancer registrydata. resident data and SEEA Ushown tn Takt I Our findingi indicate that the PFOA exposed rcsidcatial population and PFOA-etprwed w hen ha eievated cancer prevalence iTabte U prostate cancer io ihe resident* was prepontenatehr elevated m ag yonng mal. Cervia and uterine cancer rates in rameo were also higher in Ihemuteni pop*non compared to die U S. gvocral population. The tforibuiiMi ofcancer In the cesidcuis and weaker* 11 diHetent thanexpected. Ofnoie anr ihe (Mian nf eleva#*prevalence mes a f atypical case* tach m S'rm-Hodgkio'i lymph-- u. Leukemia. and Matn Myelon. D ui data tugged* that ecpoeurv 10PFOA may alter cancer diaributton la capotad population(wmhan and midenwt and may be imponam lieh fielt* for an eecc o f cancer casen Results Aro PFOA Lovolo Location (Dfib) 1 1 7 .4.3 Link Hodern. Ohio 2 0.4-3.9 Lubnck. WV a 0.29-0.37 Tuppar* PWno. Ohio 4 o.oa-0.13 Balpro, Ohio 5 0.06-0.1 Mason, WV a 0.0642.07 Pomoroy. Ohio 1.0-5.0 Dupont. Washington a 1.75-1.7 GE Plastico 9 0.05-8.5 66 Private Walls WVA & Ohio * KilimMcd as 2 1 people per houachoid S'-'A Not Applicable Household 4200 3700 4600 6000 4200 1000 N/A N/A 66 Population* 11760 10360 13440 16600 11760 2600 2200 700 190 Figur 1. F tgon 2. Overview of Washington Mark* PtoM U S W orknr 4 o o td n rit sM .i 0 3 5 % 0 TS 9W9 .110% '02 0 1 B 07 111 3 4 .ow rk. .sot 3..WM% .060?! 1 ill 6923 4 899 1M 3 3 b.054* 0.000% i.004% a ll irw n i 4 77 6 9923 9.109* O 999 0.000% 9 .4 3 11 0.199% - -2 .. 599 0^ 34% I.Q6Q* 3.98 SO IS SM s 1 999 0.167% .7 24 4 t7 6683 Qjrr.2%. t N 1.006% 1 2 .0 7 ,' t V-J _M 23 50 1 :m in 3 O SM i* * 44/ 1.423% 5623 0 206 599 M M JH n :M >.014% 2 6 9 9 4469 m i * 0 296 > 060* 2 23 3 5623 1.064* 1 599 >.06Q% 1.09 3 34 t o t a l _____ 309 -- 68.23-- . L S 9 S * ____ m 10-017% 7.06-0* 2 4 62 * Baaed tut Total Cancer Counta ' Bai.nl on SEER First Malignant Primary b'Ignr 3. Wuhlacton Works