Document zdyYoLwLOaNwOOb2pdn0YnEnn

E* I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 239-81 MR NO Haskell No. 14,008 Study Initiated/Comnlgtrf 477781-4/9/8l Material Submitted by Polymer Products Department Experimental Station SKIN IRRITATION TEST ON RABBITS . f1* aale,New Zealand White rabbits were clipped free of hair on lelt lateral frea aBd P^ced in FDA-type stocks! Doses of 0.5 gm of 1/2" flal were applied ** aqueous paste to intact skin and 1 1/2" x*? ' if Pi 8Si*e Squares were ecured over treated areas. Rubber sheeting Af?eih24 ii86ly uraPPS around the trunk and secured with adhesive tape. 5 reooved froa the 8ccks, the patches taken off and the reactions observed. Observations were also made at 48 hours. Results; - '-- ------------------ -- ------ :--- 24-Hour Observation Erythema Edema 1/6 Slight 5/6 Negative 6/6 Negative 48-Hour Observation Erythema Edema 6/6 Negative 6/6 Negative S t s ' " - H* - 1- Company Samfzed. Doesp^ c*>nan T?r e I Report by: -Q^inrvm jjxl^Zl Lyrin S. Silber Technician Reviewed by: 0. Louis Dashiell Study Director LSS.-jtd Date Issued: April Report No. Approved by: _ ____ ______________________________ Gerald L. Kennefly . Chief, Acute Investigations Section m