Document zdpp1ezZG8kQkz9NmJMd1br1a

/Zf^ COMMON USES: Medical RECENT ACUTE TOXIC DATA:1 NOTICE: 21CFR203, FoodA Drug Admin., Bureau of Drugs, Federal Food, Drug, and Cosmetic Act; Notice of public hearing 9-10-79, 9-12-79, 9-14-79; Proposed patient labeling. (44FR40016) MUTAGEN DATA: MMA-SAT CYT-HAM:LNC SLM-DMG-ORL 958 1 200 nmol/PLATE gm/L/27H pL TOXICITY DATA: 1VN-1NFTDLO: 150 ORL-MAN TDLO: 143 ORL-MAN TDLO: 1430 tMS-WMN TDLO: 181 IVN-MAN TDLO: 143 ORL-RAT LD50. 710 1PR-RATLD50: 300 ORL-MUS LDS0: 535 ORL-MUSTDLO: too 1PR-MUS LD50: 220 SCU-MUS LD50: 300" IVN-RBT LD50: 9 pg/kg /kg TFX:SKN TFX:EYE pg/kg TFX:CNS )*/kg TFXrALR TFX:PUL mg/kg mg/kg mg/kg mg/kg/(12D preg) TFX:TER mg/kg mg/kg mg/kg REFERENCES 1.1940 Rtfiilry o/Toik EffacUoJ Chemical Substances, (Update til CIS SOURCESOFINFORMA TtON CIS, El Shst Sptaromtrry Cambridge Xraj Crystal: 439-14-S.OI MOSN/Crs. RTECS: DFU730 CIS, Cl Sfui Sptelromeiry NON-CIS REFERENCES EPA, TSCA Inventory List Mtrrt Index: 2961 NiMH, Ptyebotnpic Drugs; SIS U.S. International Trade Commission NIOSH,NOHS:AI04I ORNL, BMC ORNUETIC IARC, Monograph* (CtninogetikiiyRevlewt) NtMCHEMLINE: TOXUNE tiATARMF.RENCESt TOXICOLOGY REVIEWS AVAILABLE REPORTED W EPA TSCA INVENTOR Y, JUL Y1979 TOXICITY AND HAZARD REVIEW: Valium is a very much used drug by the public. Abuse of this drug may lead to addiction. It seems to work fine as n occasionally prescribed tranquilizer. Human infants on a dose of 150 mg/kg developed severe skin symp toms. In man via oral route damage to eyes and CNS oc curred. IVN application to man causes pulmonary tract damage. As an exper teratogen it should be withheld from women of child bearing age and it must be regarded as a reproductive hazard in the work place. VINYL CHLORIDE CAS #754)1-4 NIOSH #KU 9625000 Syne: cUoroethyiene; chforoethene; monochloroethylene; vinyl chloride monomer; vinyl C monomer; Chlorethene; chlorure de vinyle (French); Winylu chlorek (Polish). GENERAL INFORMATION: Colorless liquid or gas (when inhibited), faintly sweet odor. Slightly soluble in water, bp: --13.4", lei 3.6V*. uel * 33Ve; flash p: --I08F (COC),ft>: --159.7 e,d(liquid): 0.9195 15"/4", vap press: 2600 mm 25, vap d: 2.15, autoign, temp.: 692 "F. RECENT FEDERAL REGISTER CITATIONS: (Diazepam) - -- COMPUTERIZED STRUCTURAL FORMULA: CLAC++C mfiCzHiCI mw: 62.50 CITATION NUMBER - 44.131.135 (44FR40031,7-6-79) COMMONLJSEST) Plastics, j^Frigerantyiw'ganic compounds. PROPOSED RULE: Add 21CFR203, Food & Drug Ad min., Bureau of Drugs, Federal Food, Drug, and Cosmetic Act; Patient labeling requirements: Com ments solicited by 10-4-79. (25FR12592, 26FR8389, 33FRS812, 35FR9001, 42FR37636, 43FR4212, 43FR47178) CITATION NUMBER *44.156.20 (44FR47104,5-10-79) RECENT ACUTE TOXIC DATA:1 MUTAGEN DATA: MMA-SAT SLN-DMG-IHL MRC-SMC MMA-SSP HMA-MUS/SSP MMA-HAM.LNG 20 1 48 16 700 20 pph/4H pph mmol/L/3H mmol/L/30M mg/kg ppb/5H Jin./Feb. 'SI v. - AP000!1833 CYT-HMN:HLA TOXICITY DATA: 10 mmol/L 1HL-MANTCLO: 500 ppm/4Y-l TFXrCAR ORL-RAT LD50: 500 mg/kg ORL-RAT TDLO: 11 gm/kg/3Y-I TFX:CAR IHL-RATTCLO: 50 ppm/52W-l TFXrCAR 1HL-RATTCLO: 6000 ppm/4H/ IHL-MUSTCLO: IHL-OPC LCLO: (I2-I8D pregj - TFX:CAR 50 ppm/30W-l TFX.CAR 20 pph/30M X I 1HL-HAM TCLO: 500 IHL-MUSTC: 2500 ppm/26W-J IHL-RATTC: 250 ppm/52W-I IHL-MUSTC: 50 ppm/47W-l ORL-RAT TD: 34 gm/kg/3Y-l IHL-MUSTC: 2500 ppm/26W-l IHL-MUSTC: 2500 ppm/35W-l IHL-RATTC: 250 ppm/2Y-l IHL-HAM TD: 500 ppm/48W-l IHL-RATTD: 250 ppm/80W-l IHL-RATTD: 50 ppm/37W-i DA TARETEKENCESi TFXrCAR TFX:NEO TFXtCAR TFX:CAR TFX:CAR TFXrNEO TFXrCAR TFXiCAR TFX-.NEO TFXrCAR TFXrCAR A QUA TIC TOXICITY RA TING: TLmt&uver 1000 ppm CA RCINOGENIC DETERMINA TiON.HUMANPOSITI YE IAKC**I9J77.79 THRESHOLD LIMIT VALUE-eir200ppm TOXICOLOGY REVIEW'S A YAICABLE OSHA STA HDA RD--tinTWA I ppm.-CI S ppm/ISM DOT-FLAMMA8LECAS, LABEL.FLAMMABLEGAS OCCUPA TJONAL EXPOSURE TO YIN YL HAUDESrtem Sld-air TH'A I ppm; Cl S ppm/ISM REPORTED/NEPA TSCA INVENTORY, JULY 1979 TOXICITY AND HAZARD REVIEW; Vinyl Chloride Is now known to be a potent human and exper animal care, inhai by man @ 500 ppm caused cancer. Although it was first recognized to cause angiosarcoma of the liver, a rare liver tumor, it is nowjknown to cause brain cancers and lung cancers in humans wOrkiriJ with it. U Has' been termed a multi potent care in that it produces tumors in many different organs and possibly different tumors in the same organs, see table below from C & EN for April 17, 1980 p. 27 Animal 4ata ahow vinyl chlorlda Is a multlpotent carcinogen This tumor typo... is found In... Nephroblastoma Neuroblastoma Rats Rais Mammary carcinoma Rats, mice Pulmonary tumor Mice 8kln tumor* Hamsters Prestomach papilloma Melanoma* Rats, hamsters Hamsters Lymphoma* Hamsters *! cartatn. S*ure: Ciun Mallonl. latilulo OnceJogia, SoWgn*. Italy Vinyl Chloride isjhighly ihai and oral routes and to skin, eyes and mu mem. In high cone, it acts as an anesthetic. Causes skin bums by rapid evaporation and con sequent freezing. Chronic exposure has shown Uver injury in rats and rabbits. Circulatory and bone changes in the fingertips reported in workers handling unpolymerized materials. A recog human care via oral and ihal routes caus ing cancers of the liver; lungs and brain. It is jreproduciive hazard ofthe work place. FIRE HAZARD: Dangerous, when exposed to heat, flame or oxidizers. Large fires of this material are practically inextinguishable. SPONTHEATING: No. EXPLOSION HAZARD: Severe, in the form of vapor, when exposed to heat or flame. Also, on standing, forms peroxides in air and can then explode. DISASTER HAZARD: Very dangereus^xftien heated to decomp, emits highly toxic fumes of/pnosgen$rn react vigorously with oxidizing materials? Before^ storing or handling this material, instructions for its use should be ob tained from the supplier. ENVIRONMENTAL IMPACT INFORMATION IN THE EVENT OF SPILL OR MASSIVE RELEASE; 'PERSISTENCY: Polymerizes in presence of air, oxygen, sunlight or heat. Volatilizes and will leave water quite soon. MAJOR WATER USES THREATENED: Recreational PROBABLE LOCATION AND STATE OF MATE RIAL' Colorless gas. Heavy vapors will cling near ground. Some will dissolve. Polymerizes readily in air or sunlight. WATER CHEMISTR Y: Subject to polymerization. COLOR IN WATER: Colorless f DEGREE OFHAZARD TO PUBLICHEAL 77/^Irriumt. Moderately toxic with Inhalation. Emits highly toxScvapors when heated to decomposition. - ~ AIR POLLUTIONHAZARD: High Uver angiosarcoma Hepatocarcinoma. Exirahepatic angiosarcoma Zymbai gland (sebaceous) carcinoma Rats, mica, hamsters Rats Rats, mice Rats STORAGE AND HANDLING INFORMATION; MODE OF TRANSPOR TATION: Rail 90.03b Barge 2.0*7# Pipe 8,0% CONTAINERS: Pressure cylinders, tank cars, tank barges. u DANGEROUS PROPERTIES OF INDUSTRIAL MATERIALS REPORT AP000II834 GENERAL STORAGE PROCEDURES: Protect against physical damage. Outside or detached storage is preferable. Inside storage should be in a fire resistive storage room, pro- vided with adequate ventilation and free of sources of igni tion and heat. GENERAL HANDLING PROCEDURES: Guard against aU sources of ignition. --------- - TOXIC COMBUSTION PRODUCTS: HQ, rfShosgene^ CO, hazardous, employ self-contained breathing-appaattbS. EXTINGUISHING METHODS Stop flow of gas. Use water to keep containers cool. Do not extinguish unless necessary to effect an immediate shutoff of flow, Dry chemical and carbon dioxide can be used to extinguish vinyl chloride fires. PERSONAL SAFETY PRECAUTIONS: Gas tight gog gles and breathing apparatus is required in fire areas Or where dosed environment or poor ventilation causes high vapor concentrations. Eye goggles and impervious outerwear are recommended for areas where liquid vinyl chloride may be encountered. Evacuate area. Enter from upwind after gas levels have subsided. Notify fire and air authority. Remove ignition sources. COUNTERMEASURES: Use carbon or peat on dissolved portion. AVAILABILITY OF COUNTERMEASURE MATE RIALS: Carbon-water treatment plants, sugar refineries. Peat-nurseries, floral shops. DISPOSAL METHODS: Dilute to 17* solution and \ remove phenol inhibitor as sodium. 1. Pour onto verl micutite, sodium bicarbonate or a sand soda ash mixture (90/10). (Add slaked lime if fluoride is present) mix in paper boxes, place in incinerator, cover with scrap wood and paper, ignite with excelsior train. Stay upwind, or dump in closed incinerator with afterburner 2. Dissolve in flammable solvent and spray in incinerator firebox equipped with after burner and alkali scrubber DISPOSAL NOTIFICATION: Local Air Authority RECENT FEDERAL REGISTER CITATIONS: (Vinyl Chloride) CITATION NUMBER-4S.98.704 (45FR33066ET* 5-19-10) FINAL RULE, PROPOSED RULE: Add 40CFR261, 264, 265, revision of 40CFR260, 262, 263, Environmental Pro tection Agency, Solid Waste Disposal Ad; Hazardous waste constituent; Effective date 11-19-80; Comments solicited by 7-18-80 CITATION NUMBER--45.98.810 (45FR33290ff, 5-19-80) Recovery Act, Safe Drinking Water Act, Clean Water Act, Clean Air Act; National Pollutant Discharge Elimination System, prevention of significant deterioration; Con solidated p^mit regulations; Effective dale 7-J8-80; Effec tive date 11-19-80; Effective date 6-2-80 (45FR26B94, 44FR32854) CITATION NUMBER - 45.98.1396 (45FR33131ff, M9-80) FINAL RULE, PROPOSED RULE: Add 40CFR26], 264, 265, revision of 40CFR260, 262, 263, Environmental Protection Agency, Solid Waste Disposal Act; Constituent for specifically listed hazardous waste REFERENCES i. 1936Registry of TosicEffects ofChrntlcelSubstenets. /Update 9/} C/S SOURCES OF INFORMATION C/S, El Maes Spectrometry CIS, Carbon 13 NMR Spectrometry: 7S-OF4.0I EPA/CfS, OHMfTAOS. 72TI6947 NIOSH/CfS. X7TC1 KU962S0 EPA /C/S, WgterDROP NON-CIS REFERENCES EPA. TSCA Inventory List Merck Index: 9643 EPA. Chemical Spills EPA. AEROS SQTOA T: 3360 CPSC. CHEMRIC EPA, Pesticides -- Registered Inert Ingredients NBS, Gaseous lens NFPA, Hazardous Chemiea/s: 49300 US. Intemntionel Trade Commission EPA, Cipheri Guidelines EPA, Organic Chemical Producers: 3329 1PC, Chemical Product: 3612367376343 IPC. Chemical Plant: 367376443 NSF, Chemicals List: A4.6S EMO/CA. Thermodynamics N/OSH. NOUS: 76*43 ORNL, EMIC ORN'L, ETIC BPA/tERL, Non-Criterlt Pollutant Emissions EPA, Chtmlcel Indicators, Industrial Contamination EPA. Selected Organic Air Pollutants Clean Air Act -- Section 112 EPA, Carcinogen Assessment Group List of Chemicals API/TRC, Thermodynamics end Spectroscopy EPA/NCTR, Industrial Carcinogen and Mutagen Study EPA, Environmental Carcinogen Assessment Program DHEW/NCl, Lehorttnry Chemicals Monographs EPA /NSF, Eton. A Tax. Date -- Selected Comm, Chem. EPA. Potential Carcinogen Study. Selected Chem. IARC, Monographs(Carcinogenicity Reviews/ EPA, Expanded Potential Industrial Car. 4 Mut. Tbx Tips: 9.-9.I:to. 1:13.1:3,1:3.3:3.16:43,1:6 NLM CHEMUNE: TOXUNE NCI, Environmental Determinants of Cancer OSHA. Concentration Limitsfor Gases and Vapors NFPA 449/M. Manual of Hazardous Chemical Reactions: 491M-440 NFPA 433SM, Fire Hazard Properties efFfammahies: 32SM-SI, 323M-I67 EPA, Toxic Substances Control Procedures FINAL RULE: Revision of 40CFR122, 123, 124, 125, En vironmental Protection Agency, Resource Conservation & Jtn./Fefe. *gi *7 AP00011835