Document zdnv3K7nqygQD7q75GypYOQj6

-I' Monsanto i p-rs.il M4M4M4 Claim 00 M. UMlt|l Mail St. taiHi. Uiiiimi IH|t 1314) 0**4 41000 April 15, 1969 p2>m> Or. Joseph Calandra Industrial Bio-Test Laboratories, Inc. 1810 Frontage Road Northbrook, Illinois 60062 Dear Joe: Concerning my recent telephone conversations with Otis and the exchanges cf correspondence concerning the Aroclor studies at your laboratory, this letter is to authorize you to initiate as soon as possible studies 5 through 9 on the attached. The dollar costs are taken from Dr. Fancher's letter and suggested protocols dated September 9, 1968 and his letter and revised protocol for the chicken and duck studies dated April 10, 1969. In a conversation with Otis yesterday he Indicated that the coat of the chicken and duck studies using three dosage levels for three materials would be $20,000 for chickens and $20,000 for the mallards rather than the $22,500 shown on his letter of April 10. In an attempt to keep our expenditures to approximately $90,000 for the year 1969, I have shewn prorated costs of $96,250 for 1970 and $36,000 for 1971, for those projects which will run through 1970 and Into 1971. I would appreciate it If Dr. Rancher or Mr. Berndt could let me know the date that these various studies are started, perhaps, using your usual forms such as you send Dr. Hunt. $ & Please note that we are deferring the subacute fish toxicity studies until we get a better idea of work which is underway in Europe or other laboratories in the U. S. Best personal regards. Sincerely, /ED APR 17 1369 L B. T. Elmer P. Wheeler Manager, Environmental Health % PW:cJs cc: Otis Fancher, W. R. Richard, R. E. Keller, E. S. Tucker, \ II. Z. Bergen, J. E. Springgate, C. Paton 004229 STLCOPCB4030740 'T'.' *5": TOXICITY STUDIES CM AROCLORE FOR MONSANTO CO. AT INDUSTRIAL BIO-TEST LAsORATORIES 1) Rat tissue studies' (completed) 4 Aroclors, DDT, Toxaphene ft 7**7 2 chlorinated naphthalenes ^ . 1 2) aas* as above in chickens <7W/^ 1069 *500 T 1970 1971 3) Acute Pish toxicity (underway)A%Lh1,600 4 Aroclors - 4 day TI* '> 4) Sub-acute fish toxicity to be deferred 5) 3-generation rat study ^ Pi 2^ 7 10,000 Takes 18 months-total coat $35*000 25,000 6) 2-yr chronic-rats 3 Aroclors as in (5) Total cost $57,500 ez [3 /& / o 12,750 28,750 16,000 7) 2-yr chronic-dogs 3 Aroclors as above d7-z?7 Total cost - $85,000 8) Chicken reproduction, egg shell thickness Q '1`hOC Ca and P content, etc./r 3 Aroclors as above ' 9) Same as 8) but in 9 730} Mallard ducks / 22,500 20,000 20.000 1511354 42,500 20,000 J357533" 357OT 004230 STLCOPCB4030741