Document zdjvz1RY5GqVyxOLeY5LYMO2g

Monsanto *uicer C'HIXCI TO * "s. Medical, A2SC April 9, 1974 Dr. R. E. Kelly A2SA Attached are the abstracts of articles, obtained from a recent TOXLINE search, dealing with the subacute and chronic toxicity of the following chemicals: 1) Acrylonitrile 2 Ethylene I Styrene Vinyl Acetate h Vinyl Chloride Monomer - and FVC Vinylidine Chloride No articles dealing with the toxicity of vinyl bromide were recovered. All available volumes (original to 1969 listings) of the PHS-149 monograph series have also been searched for reference to relevant articles. Information was available on: Styrene (taken from PHS-149, original volume) Kennaway, E.L., 1930, Biochem. J. 24: 497-504 - skin painting of mice resulted in no tumors Styrene (taken from PHS-149, Vol. II) Wolf, M.A., Rowe, V.X,,, McCollister, D.D., Hollingsworth,R.L., and Oyen, I., 1956, Arch. Industr. Health 14: 387-398. a) Rats (M3cP white) - ave. cone, of 9.3 mg/L. vapor inhaled for (105) 7 hr.exposures - 148 d. duration No tumors; conjunctivitis & rhinitis. b) Rats (MW white) - ave. cone, of 6.0-6.3 mg/I*, vapor for (139) 7 hr. exposures - 214 d. duration results - as above, no tumors. e) Rabbits (M&F)[ll ave. cone, of 3.0 mg/L. for (L30) 1 hr. exposures and l2J ave. cone, of 6.0-6.3 mg/L. for (264) 7 hr. exposures No tumors. d) Rhesus Monkeys (M&F)- ave. cone, of 6.0-6.3 mg/L. for (264) 7 hr. exposures - 360 d. duration No tumors. . . . cont. RSV 001X008 R E. Kelly April 9, 1974 Page - 2 - e) Guinea pigs - ave. cone, of 9.3 g/I*. for (9tO^Tlir. exposures, or 6.0-6.3 mg/L. for (139) 7 hr. exposures, or 3.0 mg/L. for (130) 7 hr. exposures No tumors Conjunctivitis & rhinitis in 2 higher levels. Vinyl Chloride Polymer (taken from ^as-149, Vol. l) Oppenheimer, B.S., E. T. Oppenheiser and A.P. Stout. 1952, Proc. Soc. Exper. Biol. & Med. 79: 366-369. -45 Vistar rats - VCP film administered s.c. 44 alive at 189 d. - duration of experiment >22 month -Results 14 sarcomas; 12 fibrosarcomas; 1 liposarcoma; 1 unclassif. malignancy 1st tumor appeared at 1S9 d. /bkp att. Frederick R. Johannsen RSV 001X009 i t Attached are the abstracts of articles* obtained from a recent TOXLINE search* dealing with the subacute and chronic toxicity of the following chemicals: 1} Acrylonitrile 2) Ethylene 3) Styrene 4) Vinyl Acetate cn Vinyl rhlnrlfln Mnnnrpfr - and FVC (6) Vinylldlne ChloridfeJ~> No articles dealing with the toxicity of vinyl bromide were recovered. All available volumes (original to 1969 listings) of the PHS-149 monograph series have also been searched for reference to relevant articles. Information was available on: Styrene (taken from PHS-149, original volume) Kennaway, E.L., 1930, Biochem. J. 24 : 497-504 - skin painting of mice resulted in no tumors Styrene (taken from PHS-149, Vol. II) Wolf, M.A.* Rowe, V.K., McCollister, D. D., Hollingsworth,R.L., and Oyen, I., 1956, Arch. Industr. Health 14: 387-398. *) Rats (M&F white) - ave. cone, of 9.3 mg/L. vapor inhaled for (105) 7 hr.Exposures - 148 d. duration No tumors; conjunctivitis & rhinitis. b) Rats (M&F white) - ave. cone, of 6.0-6,3 mg/L. vapor tor (139) 7 hr. exposures - 214 d. duration results - as above, no tumors. c) Rabbits (M&F)El3 ave. cone, of 3.0 mg/L. for (L30) 7 hr. exposures and 12J ave. cone, of 6.0-6.3 mg/L, for (264) 7 hr. exposures No tumors. d) Rhesus Monkeys (M&F)- ave. cone, of 6.0-6.3 mg/L. for (264) 7 hr. exposures 360 d. duratioi RSV ooiioio No tumors. * cont. (c R. E. Kelly April 9, 1974 Page - 2 - e) Guinea pigs - ave. cone, of 9.3 mg/L. for (90) 7 hr. exposures, or 6.0-6.3 mg/L. for (139) 7 hr. exposures, or 3*0 mg/L. for (130) 7 hr. exposures No tumors Conjunctivitis & rhinitis in 2 higher levels. Vinyl Chloride Polymer (taken from FHS-14y, voi. TJ Oppenheimer, B.S., E. T. Oppenheimer and A.P. Stout. 1952# Proc. Soc. Exper. Biol. & Med. 72* 366-369. -45 Wistar rats - VCP film administered s.c. 44 alive at 189 d. - duration of experiment >22 month -Results 14 sarcomas; 12 fibrosarcomas; 1 liposarcoma; 1 unclassif. malignancy 1st tumor appeared at 189 d. /bkp att. v Prederick R. Johannsen RSV 0011011