Document zdbwG9krEYEMaj9mRGEXdrkB6
MANUFACTURING CHEMISTS ASSOCIATION
1025 CONNECTICUT AVENUE. N.W. WASHINGTON, D. C. 20009 (202)483-6126
CHEMICALS
Research
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July 24, 1974
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To: Subject:
tz=iTechnical Task Group on Vinyl Chloride Research
MCA Submissions for OSHA Hearing Record
Gentlemen:
In response to a number of requests made to industry witnesses at the vinyl chloride hearing, MCA has submitted for the hearing record, the documents itemized in the enclosed letter to OSHA.
Exhibit No. 10, the IBT status report presented by Dr. Torkelson at the New York Academy of Sciences meeting, is enclosed herewith. It will be published in the Annals of NYAS for that meeting.
Sincerely,
KDJ/mb Enclosures
Technical Task Force on Vinyl Chloride Research
vvc 000006114
INTERIM RESUI VS Oil EXPOSURE OF RATS, HAMSTERS AND MICE TO VINYL CHLORIDE
M. L. J. W.
D. E. and J. C.
Koplincjor, Ph.D. f Goode, Ph.D., Gordon, D.V.M., Ph.D.
Calandrc, M.D., Ph.D.
Indus trie 1. Bio-Tost Laboratories , Inc. Northbrook, Illinois
The following data are partial results of a study in progress at the Industrial Rio-Test Laboratories, Inc. The studies art being coordinated for sponsoring companies by the Manufacture Chemists Association. The data arc very incomplete but becau- of their significance were first presented to EPA, NIOSH and OSHA on April II, 1974.
In this study which was designed to complement Maltbni's studies, 100 rats, hamsters and mice of each sex (600 total per exposure group) are being exposed to either 0, 2500, 200 or 50 ppm vinyl chloride vapor 7 hours per day 5 days per week. Mice will be exposed for 9 months and kept for an additional 9 months. Rats and hamsters will be exposed for 12 months and kept for an additional 12 months.
The rats are COBS Charles River; mice are GDI Swiss Charles River; and the hamsters are Golden Syrian from the same source. Food is removed during exposure, water is present and no bedding is used at any time.
Moribund and dead animals (when possible) receive gross autopsies and are photographed. The major organs of all animals are fixed for histological examination.
Only the tissues from a few animals have been examined so far. The table shows the results to date (about 3 months exposure).
000006115 vve
VVC 000006X17
TUMORS IN MICE EXPOSED TO VINYL CHLORIDE FOR EIGHT MONTHS
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