Document zdarwMvVq2y6MYonDvmdokQgg

RECEIVED CC: $U SEP 2 01978 Environmental Affairs at* from Bjorn Holmstrom September 11,1978 ft CANCER TEST WORK ON VI NYU DENE CHLORIDE. Vieit to Dr. Lorenzo TOMATIS, Chief, Unit of Caroinogeneeie, International Agenoy for Reeearoh on Canoer (IARC), Lyon, Franoe. It woe with eome difficulty that I made thie appointment and the reaeon for thie ie obvious from what follows. Not only wae there a group to oome on Ootober 25 representing the Amerioan CMA to dieouss the subj ot but Tomatie's group has round no etatistioal proof of oaroinogenio aotion by VDC. Having aooepted my vieit Tomatie wae very oourteoue and fortnright. I am eure you will like to spend eome time with him and hie people next time over here. Thie ie not a Maitoni whom nobody seems to reaoh anymore. In foot Tomatie oomplained about thie attitud f Maltoni'e during an aside in our conversation. t There ie undoubtedly eome embarrassment around the whole eubjeot. Tomatie did in no way try to oonoeal hie perplexity at the IARC results ~ finding no statistical reason to attribute oaroinogenioity to VDC " results that appear in oontrast with Maltoni'e findings. They will oontinue to study the matter. You will find interesting the attached reprint"Tissue-mediated mutagenicity of Vinylidene Chloride ... in Salmonella typhimurium". Thie work done under Tomatie is among the reason for his doubting the final validity of the results so far. I am forwarding separately the following doouments that he was kind to give uet IARC Monograph Vol. 7 whioh deals with VCM on p.291. IARC "Report ... on Epidemioloqioal Studies on VCM exposed people . IARC Report ... on VCM (June 1974) Induotion of gene mutations and gene conversions by VCM metabolites in yeast. (Jan. 1977). Evaluation of oaroinogenioity of Chemicals (April 1978). Mutation induotion in ohinese hamster V79 oells by two VCM metabolites, Chloroethylens Oxide and 2~Ch1oroaoeta1dehyde. 1975. Some aspeots of Metabolio Aotivation of Chemical Caroinogens ... . 1977. w The information Tomatie gave me is not publio. I assume we should handl it as given in oonfidenoe until it is published in the Vol.19 IARC Monograph to be issued end of this year. t CD Graybill CD K raoh CD Twiehau p*-*-- SL 095936