Document zdRQBOe83XjroxQ42vDbV0adg

' JUN--28-1994 09=10 202 887 5427 P.001/002 CHEMICAL MANUFACTURERS ASSOCIATION FAX Cover Sheet To: Company: Telephone #: Fax Number: TrwifhctA tbnj_____________________ From: . f-los SM/? Chemical Manufacturers Association (202)887-1 if!l_ Number of Pages (including cover sheet) 33 9 CP Si -4 co JTJN-28-19S4 09:10 JUN 24 ' 94 09: 44 hK LtUN-tNU-bHrc-i-CH-1 i-i 4i.o 202 887 5427 C33 IU OO^JAJCiWJ r. I Existing Chemicals iXSwrt P.002'002 c.*' ATS OR Chemicals Added to MTL pyx fpa i.sj adding 3.2 chemicals to the Masre Testing Use in response to a reque; t for testing by the Agency for To :ic Substances and Disease ftegist y (ATSDR). The chemicals arei b< nzene, beryllium, chloroethan<, chromium, cyanide, di (2ethylh :xyD phthalate, mercury, methy ene chloride, tetrachloroethyle ie, toluene, trichloroethyl ene, a id vinyl chloride. ATSDI is required to identify the bsuarc dus substances most comm inly found at Superfund sites, i repare toxicological pro files, a id identify priority data needs :or those substances. ATSDI is also required to initiate a roses rch program to meet the prioritf data needs It identifies. In Oct >her 1992, ATSDR requested F.PA tc use its authorities under tsca nd FIFRA to fill some of the data n eds it identified on 37 chemilaills. In its response to ATSDI EPA agreed to develop a test ru ' under section 4 of TSCA to obiu in data on 12 of the chemicals, b l1i noted that a TSCA test rule w raid not be an appropriate mecha tism for obtaining data on the ori r 25 chemicals. Before iniriatii g rulemaking, EPA is invltinj manufacturers of the 12 chemk il,1s listed in the following table i< submit testing plans and enter i; to consent agreements for testing EPA intends to issue a test rule late 1994 for arty of the 12 substailo:es which are not covered by a a nsent order or a voluntary testing tgreernent, Chemical Mercury Vinyl chloride Benzene Tlehloroethylsne Chromium . .... Tetrachloroethylene Cyanide Beryllium Toluene Methylene chloride Chioroethane Testing to bs Proposed Immunotoxicity oral Chronic oral Reproductive oral Acute oral Reproductive inhalation Developmental inhalation Subchronic oral Neurotoxicity oral Subchronic oral Neurotoxicity oral Acute oral Reproductive oral Immunotoxicity oral Reproductive inhalation Neurotoxicity Inhalation Immunotoxicity inhalation Developmental inhalation Acute inhalation Subchronic inhalation Developmental inhalation Fats in soil Acute inhalation Subchronic inhalation with reproductive and pulmonary pathology Developmental Inhalation Immuotoxicity inhalation Bioavailability Fate in air j Comparative Pharmacokinetics Immunotoxicity oral ! Subchronic oral Immunotoxicity oral Developmental oral . Neurotoxicity oral | Comparative Pharmacokinetics 1 Immunotoxicity oral R&S 144779 12 CHEMICALS IM PROGRESS TOTAL P.002 JUN 24 '94 09:44 FR GEON-ENU-SAFE-HEALTH 216 447 6459 TO 33023238105 I Existing Chemicals P.04/25 ATSDR Chemicals Added to MTL EFA is adding ,12 chemicals to the Master Testing List in response to a request tor testing by the Agency for Toxic Substances and Disease Registry (ATSDR), The chemicals are: benzene. l>erylliiim, chloroerhane, chromium, cyanide, di (2etliylhexyl) phthalate, mercury, methylene chloride, tetrachloroethylene, toluene, trichloroethyl ene. and vinyl chloride. ATSDR is required to identify the hazardous substances most commonly found at Superfund sites, prepare toxicological pro files, and identify priority data needs for those substances. ATSDR is also required to initiate a research program to meet the priority data needs it identifies. In October 1992, ATSDR requested EPA to use its authorities under TSCA and FIFRA to fill some of the data needs it identified on 37 chemicals, In its response to ATSDR, EPA agreed to develop a test rule under section 4 of TSCA to obtain data on 12 of the chemi cals, but noted that a TSCA test rule would not be an appropriate mechanism for obtaining data on the other 25 chemicals. Before initiating rulemaking, EPA is inviting manufacturers of the 12 chemicals listed in the following table to submit testing plans and enter into consent agreements for testing. EPA intends to issue a test rule in late 1994 for any of the 12 substances which are not covered by a consent order or a voluntary testing agreement. Chemical Testing to be Proposed Mercury Immunotoxicity oral Chronic oral Reproductive oral Acute oral Vinyl chloride Reproductive inhalation Developmental inhalation Benzene ________ Tiehloroethylene Subchronic oral Neurotoxicity oral Subchronic oral Neurotoxicity oral Chromium j Acute oral | Reproductive oral Immunotoxicity oral Tetrachloroethylene Cyanide Beryllium Toluene Methylene chloride 1 Reproductive inhalation Neurotoxicity inhalation i 1 Immunotoxicity inhalation Developmental inhalation j - Acute inhalation Subchronic inhalation |I Developmental inhalation Fate in soil 1 Acute inhalation Subchronic inhalation with reproductive and pulmonary pathology Developmental inhalation Immuotoxicity inhalation Bioavailability 1 Fate in air | Comparative Pharmacokinetics Immunotoxicity oral i 1 Subchronic oral i Immunotoxicity oral Developmental oral Neurotoxicity oral Chloroethane | Comparative Pharmacokinetics Immunotoxicity oral R&S 144780 12 CHEMICALS IN PROGRESS