Document zdKwprw0018evymwqgXdqZaL6

AR226-2757 E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 1005-80 Material Tested tiaskell No. lj$.?83-- Study Initiated/Completed 10/-/80 - 10/9/80 ^Material Submitted Washington Works Parkersburg, WV EYE IRRITATION TEST IN RABBITS Procedure; One tenth milliliter of undiluted test material was placed into the right conjunctiva! sac of each of 2 male New Zealand White rabbits. After 2U seconds, 1 treated eye was washed with cap water for 1 minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris and conjunctiva were raade with an ophthalmoscope at 1 and 4 hours, and at 1, 2 and 3 days; Fluor-i-etrip stain and a slit-lamp biomicroscape were used at examinations after the day of treatment. Resultg' Dose 0.1 ml 0.1 mi Treatment Not Washed Washed Cornea General area of slig it clouding at 1 hr; decreas ing to a small area at 4 hr. Sna1..'1 area of alight clouding at 1 hr. decreas ing to a local area 4 hr-1 day. Ocular Effects Iris Conjunctiva No involve ment. Redness: None. Swelling;glight 1-4 hr. Disehayge;Kild at 4 hr. No involve ment. Redness; None. Swelling:Slignt i-4 Discharge:None. Compaq Sannrzed. Doe not contain TSCA CBt r^^\ Summary; |j^^Dcaused slight cornea! clouding and mild conjunctivitis in a washed ic caused alight rabbit eye. In an eye Created and promptly Both -ished and unwashed syea created corneal clouding and slight conjunctivitis. were normal 2 days after treatment. This compound may produce slight to mild eye irritation. In the event of eye contact, flush with copious amounts of water. ^tftye Report by; j^y^A .V ^) 'Ji^\ SLynn S. Silber Technicibn Approved by; -SfeLG-ie^ri.ajelJd :Lf.. IKce^nwne^i^,,______ Chief, Acute Investigations Section LSS:jrg Study Director: 0. L. Dashiell JDate la'-jodi peasmber 9, 1980