Document zd9wkKwEQj3woG1Z7E5g45yKn
GROUP=A
LEAD BIOAVAILABILITY IN RATS MR 9660
Group A MODEL 6
Non-Linear Least Squares Summary Statistics
Source
DF Sum of Squares
Regression Residual Uncorrected Total
4 18090.836865 65 3627.303435 69 21718.140300
(Corrected Total)
68 15983.665794
Parameter
Estimate
Dependent Variable LEAD
Mean Square
4522.709216 55.804668
QBS
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
A 492.1053534 B 2.7779115 C 0.2500000 D 0.0039122
GROUP
TIME
LEAD
A 0.5 39.80
A 0.5 68.90
A 0.5 21.10
A 0.5 54.60
A 0.5 49,20
A 1.0 18.60
A 1.0 24.60
A 1.0 68.50
A 1.0 22.80
A 1.0 34.10
A 2.0 15.00
A 2.0 15.10
A 2.0 19, 10
A 2.0 16.60
A 2.0 4.10
A 4.0 10.80
A 4.0 7.80
A 4.0 6.80
A 4.0 2.60
A 4.0 20.30
A 8.0 3.20
A 8.0 4.50
A
8.0
6,50
L95M
40.8239 40.8239 40.8239 40.8239 40.8239 24.5633 24.5633 24.5633 24.5633 24.5633 13.5944 13.5944 13.5944 13,5944 13.5944
5.1184 5.1184 5.1184 5.1184 5.1184 0.8258 0.8258 0.8258
FITTED
47.4675 47.4675 47.4675 47,4675 47.4675 30.5933 30.5933 30.5933 30.5933 30.5933 18.1359 18,1359 18.1359 18.1359 18.1359
9.7333 9.7333 9,7333 9.7333 9.7333 4,6411 4.6411 4.6411
U95K
54,1111 54.1111 54.1111 54.1111 54.1111 36.6233 36.6233 36.6233 36.6233 36.6233 22.6774
22,6774 22.6774 22.6774 22.6774 14.3483 14.3483 14.3483 14.3483 14.3483
8.4564 8.4564 8.4564
SE_FIT
3.32656 3,32656 3.32656 3.32656 3.32656 3.01933 3.01933 3.01933 3.01933 3.01933 2.27399 2.27399 2.27399 2.27399 2.27399 2.31078 2.31078 2.31078 2.31078 2.31078 1.91039 1.91039 1.91039
DUP040002217
LEAD BIOAVAILABILITY IN RATS MR 9660
Group A MODEL 6
OBS GROUP
TIME
LEAD
L95M
24 A
8\ 0
3.60
0.8258
25 A
8.0 0.30
0.8258
26 A
12,0
6.10
-0.9577
27 A
12.0
8.50
-0.9577
28 A
12.0
0.80
-0.9577
29 A
12.0
1.97
-0.9577
30 A
24.0
6.40
-2.7044
31 A
24.0
3,30
-2.7044
32 A
24.0
6.60
-2.7044
33 A
24.0
5.20
-2,7044
34 A
24.0
2,70
-2.7044
35 A
48.0
0.30
-2.4237
36 A
48. 0
1.99
-2.4237
37 A
48.0
6.79
-2.4237
38 A
48.0
4.10
-2.4237
39 A
48.0
0.40
-2.4237
40 A
72.0
2.60
-1.7886
41 A
72.0
1.80
-1.7886
42 A
72.0
3.10
-1.7886
43 A
72.0
1.60
-1.7886
44 A
72.0
0.50
-1.7886
45 A
96.0
2.40
-1.3211
46 A
96.0
1.40
-1.3211
47 A
96.0
0.10
-1.3211
48 A
96.0
1.60
-1.3211
49 A
96.0
1.40
-1.3211
50
A
120.0
2.50
-0.9962
51
A
120.0
1.00
-0.9962
52
A
120.0
2.30
-0.9962
53
A
120.0
0.90
-0.9962
54 A 120
0.70
-0.99624
55 A 144
0,80
-0.76754
56 A 144
1.00
-0.76754
57 A 144
1.60
-0.76754
58 A 144
3.00
-0.76754
59 A 144
0.50
-0.76754
60 A 192
0.20
-0.48131
61 A 192
0.60
-0.48131
62 A 192
0.90
-0.48131
63 A 192
0.60
-0.48131
64 A 192
0.20
-0.48131
65 A 240
0,46
-0.31975
66 A 240
0.36
-0,31975
67 A 240
0.40
-0.31975
68 A 240
0.32
-0.31975
69 A 240
0.54
-0.31975
PITTED
U95M
SE_FIT
4,6411 4.6411 2.8240 2.8240 2.8240 2.8240 1.0646 1.0646 1.0646 1.0646 1.0646 0.3335
0.3335 0.3335 0.3335 0,3335 0.1531
0.1531 0.1531 0.1531 0.1531 0.0838 0.0838
0.0838 0.0838 0.0838 0.0510 0.0510
0.0510 0.0510 0.050957
0.033212 0.033212 0.033212 0.033212 0.033212 0.016224 0.016224 0.016224 0.016224 0.016224 0.008972 0.008972 0.008972 0.008972 0,008972
8.4564
8.4564 6.6056
6.6056 6.6056 6.6056 4.8336 4.8336 4.8336 4.8336 4.8336 3.0908 3.0908 3.0908 3.0908 3.0908 2.0949 2.0949 2.0949 2.0949 2.0949 1.4888 1.4888 1.4888 1.4888 1.4888 1.0982 1.0982 1.0982 1.0982 1.09815
0.83396 0.83396 0.83396 0.83396 0.83396 0.51376 0.51376 0.51376 0.51376 0.51376 0.33769
0.33769 0,33769 0.33769 0,33769
1.91039 1.91039 1.89355 1.89355 1.89355 1.89355 1.88720 1.88720 1.88720 1.88720 1.88720 1.38059 1.38059 1.38059 1.38059 1.38059 0.97226
0.97226 0.97226 0.97226 0,97226 0.70350 0.70350 0.70350 0.70350 0.70350 0.52435 0.52435 0.52435 0.52435 0.52435
0.40095 0.40095 0.40095 0.40095 0.40095
0.24912 0,24912 0.24912 0.24912 0.24912 0.16460 0.16460 0.16460 0.16460 0.16460
DUP040002218
GROUP=B
WE
DUP040002219
LEAD BIOAVAILABILITY IN RATS MR 9660
MODEL 6
Non-Linear Least Squares Iterative Phase Dependent Variable LEAD Method: Marquardt
Non-Linear Least Squares Summary Statistics
Dependent Variable LEAD
Source
DF Sum of Squares
Mean Square
Regression Residual Uncorrected Total
4 0.60580910772 66 0.36364089228 70 0.96945000000
0.15145227693 0.00550971049
(Corrected Total)
69 0.61059080000
Parameter
Estimate
A 0.108691433 B 0.869496880 G 0.500000000 D 1.426014371
OBS GROUP
TIME
LEAD
L95M
FITTED
U95M
SE_FIT
1B 2B 3B 4B 5B 6B 7B 8B 9B 10 B 11 B 12 B 13 B 14 B 15 B 16 B 17 B 18 B 19 B 20 B
0.5 0.5 0.5 0.5 0.5
1.0 1.0
1.0 1.0 1.0 2.0
2.0 2.0 2.0 2.0 4.0 4.0 4.0
4.0 4.0
0.029 0.031 0.024 0.021
0.005 0.023 0.029 0.018 0.022
0.020 0.059 0.057 0.047 0.031 0.053 0.155 0.071 0.071 0.197 0.068
-0.01529 -0.01529 -0.01529 -0.01529 -0.01529
0.00424 0.Q0424 0.00424 0.00424 0.00424 0.04605 0.04605 0.04605 0.04605 0.04605 0.09435
0.09435 0.09435 0.09435
0.09435
0.02187 0.02187 0.02187 0.02187 0.02187 0.04556 0.04556 0.04556 0.04556 0.04556 0.08540 0.08540 0.08540 0.08540 0.08540 0.13788 0.13788 0.13788 0.13788 0.13788
0.05903 0.05903 0.05903 0.05903 0.05903 0.08688 0.08688 0.08688 0.08688
0.08688 0.12474 0.12474 0.12474 0.12474 0.12474 0.18141 0.18141 0.18141 0.18141 0.18141
0.018611 0.018611 0.018611 0.018611 0.018611 0.020697 0.020697 0.020697 0.020697 0.020697 0.019708 0.019708
0.019708 0.019708 0.019708 0.021801 0.021801 0.021801 0.021801 0.021801
DUP040002220
LEAD BIOAVAILABILITY IN RATS MR 9660
Group B MODEL 6
OBS GROUP
TIME
LEAD
L95M
FITTED
B95M
SE_FIT
21 B
8.0 0.290
0.13749 0.18028 0,22307 0.021431
22 B
8.0 0.320
0.13749 0.18028 0.22307 0.021431
23 B
8.0 0.530
0,13749 0.18028 0.22307 0.021431
24 B
8.0 0,250
0.13749 0.18028 0.22307 0.021431
25 B
8.0 0.230
0.13749 0,18028 0,22307 0.021431
26 B
12.0 0.136
0.14218 0.18493 0.22769 0.021413
27 B
12.0 0.113
0.14218 0.18493 0.22769 0.021413
28 B
12.0 0.154
0.14218 0.18493 0.22769 0.021413
29 B
12.0 0.208
0.14218 0.18493 0.22769 0.021413
30 B
12.0 0,113
0.14218 0.18493 0.22769 0.021413
31 B
24.0 0.125
0.09183 0.14271 0,19359 0.025484
32 B
24.0 0.055
0.09183 0.14271 0.19359 0.025484
33 B
24.0 0.059
0.09183 0.14271 0.19359 0.025484
34 B
24.0 0.030
0.09183 0.14271 0.19359 0.025484
35 B
24.0 0.043
0.09183 0.14271 0.19359 0.025484
36 B
48.0 0.059
0.02413 0.06568 0.10724 0.020812
37 B
48.0 0.054
0.02413 0.06568 0.10724 0.020812
38 B
48-0 0.039
0.02413 0.06568 0.10724 0.020812
39 B
48.0 0.041
0.02413 0.06568 0.10724 0.020812
40 B
48.0 0,039
0.02413 0.06568 0.10724 0.020812
41 B
72.0 0.036 -0.00708 0.03024 0.06756 0.018694
42 B
72.0 0.034 -0.00708 0.03024 0.06756 0.018694
43 B
72.0 0.030 -0.00708 0.03024 0.06756 0.018694
44 B
72.0 0.035 -0.00708 0.03024 0.06756 0.018694
45 B
72.0 0.015 -0.00708 0.03024 0.06756 0.018694
46 B
96.0 0,050 -0.01541 0.01456 0.04452 0.015007
47 B
96.0 0.082 -0.01541 0.01456 0.04452 0.015007
48 B
96.0 0.336 -0.01541 0.01456 0.04452 0.015007
49 B
96.0 0.064 -0.01541 0.01456 0.04452 0.015007
50 B
96.0 0.074 -0.01541 0.01456 0.04452 0.015007
51 B
120.0 0.022 -0.01461 0.00732 0.02926 0.010987
52 B 120.0 0,032 -0.01461 0.00732 0.02926 0.010987
53 B 120.0 0.016 -0.01461 0.00732 0.02926 0.010987
54 B 120 0.021 -0.014615 .0073205 0.029256 0.010987
55 B 120 0.017 -0.014615 .0073205 0.029256 0.010987
56 B 144 0.032 -0.011475 .0038251 0.019125 0.007663
57 B 144 0.016 -0.011475 .0038251 0.019125 0,007663
58 B 144 0,030 -0.011475 .0038251 0.019125 0.007663
59 B 144 0.017 -0.011475 .0038251 0,019125 0.007663
60 B 144 0,018 -0.011475 .0038251 0.019125 0.007663
61 B 192 0,011 -0.005868 .0011476 0.008164 0.003514
62 B 192 0.027 -0.005868 .0011476 0.008164 0.003514
63 B 192 0.023 -0,005868 .0011476 0.008164 0.003514
64 B 192 0,016 -0.005868 .0011476 0.008164 0.003514
65 B 192 0.012 -0.005868 .0011476 0.008164 0.003514
66 B 240 0,009 -0.002777 .0003805 0.003538 0,001582
67 B 240 0.000 -0.002777 .0003805 0.003538 0.001582
68 B 240 0.000 -0,002777 .0003805 0.003538 0,001582
69 B 240 0.000 -0.002777 .0003805 0.003538 0,001582
70 B 240 0.018 -0.002777 .0003805 0.003538 0.001582
DUP040002221
LEAD BIOAVAILABILITY IN RATS
MR 9660 Group C MODEL 6
Non-Linear Least Squares Summary Statistics
Source
DF Sum of Squares
Regression Residual Uncorrected Total
4 3948.1014775 61 634.6422225 65 4582.7437000
(Corrected Total)
64 2811.0756615
Parameter
Estimate
Dependent Variable LEAD
Mean Square
987.0253694 10.4039709
OBS
1 2 3 4 5 6 7 8
9
10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
A 68.66666398 B 1.51226733 C 0.25208104 D 0.00000000
GROUP
TIME LEAD
C 0,5 15,1
C 0,5 32.5
C 0.5 19,4
C 0.5 11,9
C 0.5 14.2
C 1.0 18.3
c 1.0 17.5
c 1,0 20.7
c 1.0 13.0
c
2.0
7.5
c
2,0
4.3
c 2.0 12.2
c
2.0
9.7
c 2,0 19.1
c 4.0 12.3
c
4.0
6,6
c
4.0
4.4
c
4.0
4.6
c
4-0
7.2
c
8.0
6.3
c
8.0
3.2
c
8.0
0.8
c
8.0
3,9
c
12.0
4.5
L95M
16.4648 16.4648 16.4648 16.4648 16.4648 12.9123 12.9123 12.9123 12,9123
9.3736 9.3736 9.3736 9.3736 9.3736 6.4034 6.4034 6.4034 6.4034 6.4034 3.6262 3.6262 3.6262 3.6262 2.3911
FITTED
19.2871 19.2871 19.2871 19.2871 19.2871 15.1348 15.1348 15.1348 15.1348 11.3392 11.3392 11.3392 11.3392 11,3392
8.0399 8.0399 8.0399 8.0399 8.0399 5.3383 5.3383 5.3383 5.3383 4.0553
U95M
22.1094 22.1094 22.1094 22.1094 22.1094 17.3573 17.3573 17.3573 17.3573 13,3048 13.3048 13.3048 13.3048 13.3048
9.6764 9,6764 9.6764 9.6764 9.6764 7.0505 7.0505 7.0505 7.0505 5.7195
SEJFIT
1,41140 1.41140 1,41140 1.41140 1.41140 1,11146 1.11146 1.11146 1.11146 0.98299 0.98299 0.98299 0.98299 0.98299 0.81839 0.81839 0.81839 0.81839 0.81839 0.85623 0.85623 0.85623 0.85623 0.83225
DUP040002223
GR0UP=C
20 19 18 17 16 15 14 13 12 11 10 9 8 7 6
5
4 3 2 1 0
LEAD BIOAVAILABILITY IN RATS
MR 9660
Group C
MODEL 6
25 G
12.0
5.4
2,3911
26 C
12.0
5.9
2.3911
27 C
12.0
4.3
2.3911
28 C
12.0
6,9
2.3911
29 G
24.0
0.4
0.9564
30 C
24.0
2.1
0.9564
31 C
24.0
1.9
0.9564
32 C
24,0
0.7
0.9564
33 e
48.0 2.2 -0.0173
34 C
48.0 1,2 -0.0173
35 C
48.0 7.9 -0.0173
36 C
48.0 1,7 -0.0173
37 C
48.0 6.9 -0.0173
38 C
72,0 2.8 -0.4261
39 C
72.0 1,4 -0.4261
40 G
72.0
0,7
-0.4261
41 C
72.0 1.3 -0.4261
42 G
72.0 1,0 -0.4261
43 C
96.0 0.7 -0.6167
44 C
96.0 0.4 -0.6167
45 C
96.0 0,1 -0.6167
46 G
96.0 0,9 -0.6167
47 C 120.0 0.6 -0.7031
48 C 120.0 1.6 -0.7031
49 C 120.0 0.5 -0.7031
50 C 120, 0 0.7 -0.7031
51 G 120,0 0.8 -0.7031
52 C 144.0 0.7 -0.7360
53 C 144.0 0.6 -0.7360
54 C 144
1.20 -0.73599
55 C 144
0,50 -0,73599
56 C 192
0.74 -0.72829
57 C 192
0.53 -0.72829
58 C 192
0.43 -0,72829
59 C 192
0.45 -0.72829
60 G 192
0.28 -0.72829
61 G 240
0,41 -0.68278
62 G 240
0.64 -0.68278
63 C 240
0.37 -0.68278
64 C 240
0,58 -0.68278
65 c 240
1.72 -0.68278
4.0553 4.0553 4.0553 4.0553 2.3628 2,3628 2.3628 2.3628 1.2418 1.2418 1.2418 1.2418 1.2418 0.8063 0.8063 0.8063 0.8063 0.8063 0.5772 0.5772 0,5772 0.5772 0.4378 0.4378 0.4378 0.4378
0.4378 0.3451 0.3451 0.34513 0.34513 0.23178 0.23178 0.23178 0.23178 0.23178
0.16675 0.16675 0.16675 0.16675 0.16675
5.7195
5.7195 5,7195 5.7195 3,7693 3.7693 3.7693 3.7693 2.5009 2.5009 2,5009 2.5009 2.5009 2.0387 2.0387 2.0387 2.0387 2.0387 1.7711
1.7711 1.7711 1,7711 1.5786 1.5786 1.5786 1.5786 1.5786 1.4262 1.4262 1.42625 1.42625 1.19186 1.19186 1.19186 1.19186 1.19186 1.01627 1.01627 1.01627 1.01627 1.01627
0.83225 0.83225 0.83225 0.83225 0.70335 0.70335 0.70335 0.70335 0.62968 0.62968 0.62968 0.62968 0.62968 0.61633 0.61633 0.61633 0.61633 0.61633 0.59705 0,59705 0.59705 0,59705 0.57054 0.57054 0.57054 0.57054 0.57054 0.54066 0.54066 0.54066 0.54066 0.48013
0.48013 0.48013 0.48013 0.48013 0.42484 0.42484 0.42484 0.42484 0.42484
GROUPED
t ...rni--p
300
DUP040002225
LEAD BIOAVAILABILITY IN RATS
MR 9660 Group D MODEL 6
Non-Linear Least Squares Summary Statistics
Dependent Variable LEAD
Source
DF Sum of Squares
Mean Square
Regression Residual Uncorrected Total
4 0.33464154863 65 0.08219145137 69 0.41683300000
0.08366038716 0.00126448387
(Corrected Total)
68 0.12113315942
Parameter
Estimate
A 0.0910308867 B 0.2376685463 C 0.5000000000 D 0.3666632213
AREA UNDER THE CURVE - MODEL 6 GROUP D
A B C D F AUC 0.091031 0.23767 0.5 0.36666 2.73333 14.6680
Asymptotic Correlation Matrix
Corr
AB C D
A 1 0 .9831742456 -0.986579985 0. 9268574999
B 0 .9831742456
1 -0.995971899 0. 9739248236
C 0.986579985 0.995971899
1 0.95200606
D 0 .9268574999 0 .9739248236
-0.95200606
1
OBS GROUP
TIME
LEAD
L95M
FITTED
U95M
SE_FIT
1D 2D 3D 4D 5D 6D 7D 8D 9D 10 D
11 D 12 D 13 D 14 D 15 D 16 D 17 D 18 D 19 D 20 D
0.5 0.5 0.5 0.5
0.5 1.0 1.0 1.0 1.0 1.0 2.0 2.0 2.0 2.0 2.0 4.0 4.0 4.0 4.0 4.0
0.110 0.045 0.040 0.069 0.047 0.089
0.048 0.114 0.079 0.037
0.084 0.053 0.036 0.029 0.045 0.120 0.158 0.114 0.109 0.065
0.033598 0.033598 0.033598 0.033598 0.033598 0.053590 0.053590 0.053590 0.053590 0.053590 0.068477 0.068477 0.068477 0.068477 0.068477 0.076314 0.076314 0.076314 0.076314 0.076314
0.059680 0.059680 0.059680 0.059680 0.059680 0.071775 0.071775 0.071775
0.071775 0.071775 0.083867 0.083867 0.083867 0.083867 0.083867 0,094082 0.094082 0.094082 0,094082 0.094082
0.08576 0.08576 0,08576 0.08576
0.08576 0.08996 0.08996 0.08996 0.08996 0.08996 0.09926 0.09926 0.09926 0.09926 0.09926 0.11185 0,11185 0.11185 0.11185 0.11185
0.013059 0.013059 0.013059 0.013059 0.013059 0.009105 0.009105 0.009105 0.009105 0.009105 0.007706 0.007706 0.007706 0.007706
0.007706 0.008897 0.008897 0.008897 0,008897 0.008897
DUP040002226
LEAD BIOAVAILABILITY IN RATS
MR 9660 Group D MODEL 6
OBS GROUP TIME
LEAD
L95M
21 D
8.0 0.124 0.080845
22 D
8.0 0.190 0.080845
23 D
8.0 0.160 0.080845
24 D
8.0 0,121 0,080845
25 D
8,0 0.133 0.080845
26 D
12.0 0.101 0.081418
27 D
12.0 0.032 0.081418
28 D
12.0 0.058 0.081418
29 D
12.0 0.062 0.081418
30 D
12.0 0.072 0.081418
31 D
24.0 0.050 0.074621
32 D
24.0 0.102 0.074621
33 D
24.0 0.123 0.074621
34 D
24,0 0.110 0.074621
35 D
24,0 0,092 0.074621
36 D
48.0 0.096 0.057017
37 D
48.0 0, 088 0.057017
38 D
48.0 0.083 0.057017
39 D
48.0 0.103 0.057017
40 D
48.0 0.041 0.057017
41 D
72,0 0.016 0,043639
42 D
72,0 0.014 0.043639
43 D
72.0 0.074 0.043639
44 D
72.0 0.025 0.043639
45 D
72.0 0.044 0.043639
46 D
96.0 0.082 0.032807
47 D
96.0 0.051 0.032807
48 D
96.0 0,000 0.032807
49 D
96.0 0.000 0.032807
50 D
96.0 0.000 0.032807
51 D 120.0 0.000 0.023690
52 D 120.0 0.000 0.023690
53 D 120.0 0.078 0.023690
54 D 120 0.000 0.023690
55 D 120 0.087 0.023690
56 D 144 0,060 0.016165
57 D 144 0.024 0.016165
58 D 144 0.064 0.016165
59 D 144 0.042 0.016165
60 D 144 0.033 0.016165
61 D 192 0.019 0.005339
62 D 192 0,045 0.005339
63 D 192 0.029 0.005339
64 D 192 0.039 0.005339
65 D 192 0.025 0.005339
66 D 240 0.038 -0,001249
67 D 240
-0,001249
68 D 240 0.065 -0.001249
69 D 240 0.086 -0.001249
70 D 240 0,045 -0.001249
FITTED
0.099626 0.099626 0.099626 0.099626 0.099626 0.099386 0.099386 0.099386 0.099386 0.099386 0.091117 0.091117 0.091117 0.091117 0.091117 0.072531 0.072531 0.072531 0.072531 0.072531 0.058126 0.058126 0.058126 0.058126 0.058126 0.047281 0.047281 0.047281 0.047281 0.047281 0.038981 0.038981 0.038981 0.038981 0.038981 0.032506 0.032506 0.032506 0.032506 0.032506 0.023236 0.023236 0.023236 0.023236 0.023236 0.017095 0.017095 0.017095 0.017095 0.017095
TJ95M
SE__FIT
0.11841 0.11841
0.11841 0.11841 0,11841 0.11735 0.11735 0.11735 0.11735 0.11735 0.10761 0.10761 0.10761 0.10761 0.10761 0.08804 0.08804 0.08804 0.08804
0.08804 0.07261 0.07261 0.07261 0.07261 0.07261 0.06176 0.06176 0.06176 0.06176 0.06176 0.05427 0.05427 0,05427 0.054272 0.054272 0.048847 0.048847 0.048847 0.048847 0.048847 0.041133 0.041133 0,041133
0.041133 0.041133 0.035440 0.035440 0.035440 0.035440
0,035440
0.009404 0.009404 0.009404 0.009404 0.009404 0.008997 0.008997 0.008997 0.008997 0.008997 0.008260 0.008260 0.008260 0.008260 0.008260 0.007768 0.007768 0.007768 0.007768 0,007768 0.007254 0.007254 0.007254 0.007254 0.007254 0.007247
0.007247 0.007247 0.007247 0.007247 0.007656 0.007656 0.007656 0.0076565 0.0076565 0.0081823 0.0081823 0.0081823 0.0081823 0.0081823 0.0089614 0.0089614
0.0089614 0.0089614 0.0089614 0.0091854 0.0091854 0.0091854 0.0091854 0.0091854
DUP040002227
LEAD BIOAVAILABILITY IN RATS
MR 9660 GROUP A LOWER CONFIDENCE BOUND ON AREA
OBS GROUP
TIME
XIM1
XI YLIM1 YLI
1A
0,5 0.0 0,5 423.000 40.8239
2A
1.0
0.5
1.0
40.824
24.5633
3A
2.0
1,0
2.0
24.563
13.5944
4A
4,0 2-0 4,0 13.594 5.1184
5A
8.0
4,0
8,0
5.118
0.8258
6A
12.0
8.0
12.0
0.826
0,0000
7A
24.0
12,0
24,0
0.000
0.0000
8A
48.0
24.0
48.0
0.000 -.... 0.0000
9A
72.0
48.0
72.0
0.000
0.0000
10 A
96.0
72.0
96,0
0,000
0.0000
11
A
120.0
96,0
120.0
0,000
0,0000
12
A
144,0
120.0
144,0
0.000
0.0000
13
A
192.0
144,0
192.0
0.000
0.0000
14
A
240,0
192.0
240.0
0.000
0.0000
ALI
115.956 132.303 151.382 170.094 181.983 183.634 183.634 183.634 183.634 183.634 183.634 183.634 183,634 183.634
GROUP B UPPER CONFIDENCE BOUND ON AREA
OBS GROUP
TIME
XIM1
XI YUIM1
YUI
AUI
1B
0.5
0.0
0.5 0.05903 0.05903
0.0295
2B
1.0
0,5
1.0 0.05903 0.08688
0.0660
3B
2.0
1,0
2.0 0.08688 0.12474
0,1718
4B
4.0
2.0
4.0 0.12474 0.18141
0.4780
5B
8.0
4.0
8.0 0.18141 0.22307
1.2869
6B
12.0
8.0
12.0
0.22307
0,22769
2,1884
7B
24.0
12.0
24.0
0.22769
0.19359
4.7161
8B
48.0
24.0
48.0
0.19359
0.10724
8.3261
9B
72.0
48,0
72.0
0.10724
0.06756
10.4237
10 B
96.0
72.0
96.0
0.06756
0.04452
11.7686
11
B
120.0
96.0
120.0
0.04452
0.02926
12.6540
12
B
144.0
120,0
144.0
0.02926
0.01913
13.2346
13
B
192.0
144.0
192.0
0.01913
0.00816
13.8895
14
B
240.0
192.0
240.0
0.00816
0.00354
14.1704
Conclusion: Since 14.1704 < 183,634, the area under A exceeds that under B,
DUP040002228
LEAD BIOAVAILABILITY IN RATS
MR 9660 GROUP <2 LOWER CONFIDENCE BOUND ON AREA
OBS
GROUP
TIME
XIM1
XI YLIM1
YLI
1C
0,5
0.0
0,5
58.7000
16.4648
2C
1.0
0.5
1.0
16.4648
12.9123
3C
2,0
1.0
2,0
12.9123
9.3736
4C
4.0
2,0
4.0
9,3736
6,4034
5C
8,0
4.0
8.0
6.4034
3,6262
6C
12.0
8.0
12,0
3.6262
2.3911
7c
24.0
12.0
24.0
2.3911
0,9564
8c
48.0
24.0
48.0
0.9564"
0.0000
9c
72,0
48.0
72.0
0.0000
0.0000
10 c
96,0
72.0
96.0
0.0000
0.0000
11
c
120,0
96.0
120,0
0.0000
0.0000
12
c
144.0
120.0
144.0
0.0000
0.0000
13
c
192.0
144.0
192.0
0.0000
0.0000
14
c
240.0
192.0
240.0
0.0000
0.0000
ALI
18.791 26,135 37.278 53.055 73.115 85.149 105.234 116.711 116.711 116.711 116.711 116.711 116.711 116.711
GROUP D UPPER CONFIDENCE BOUND ON AREA
OBS GROUP
TIME
XIM1
XI YUIM1
YUI
AUI
1D
0.5
0.0
0.5
0.08576
0,08576
0.0429
2D
1.0
0.5
1,0
0.08576
0.08996
0.0868
3D
2.0
1.0
2,0 0.08996 0.09926
0.1814
4D
4.0
2.0
4.0
0.09926
0.11185
0,3925
5D
8.0
4.0
8.0 0.11185 0.11841
0.8531
6D
12.0
8.0
12.0
0.11841
0.11735
1.3246
7D
24.0
12.0
24.0
0.11735
0.10761
2.6743
8D
48,0
24,0
48.0
0.10761
0.08804
5.0221
9D
72.0
48.0
72.0
0.08804
0.07261
6.9499
10 D
96.0
72.0
96.0
0.07261
0.06176
8.5624
11
D
120.0
96.0
120.0
0.06176
0,05427
9.9547
12
D
144,0
120.0
144.0
0.05427
0.04885
11.1921
13
D
192,0
144.0
192,0
0.04885
0.04113
13.3517
14
D
240.0
192.0
240.0
0.04113
0.03544
15.1894
Conclusion: Since 15.1894 < 116.711, the area under A exceeds that under B.
DUP040002229