Document zd2MBdgDqJ6E9zGj9kzYeEx5R

i CMIZ& CHEMICAL MANUFACTURERS ASSOCIATION December 5, 1988 ' ' --' , ^ /} TO: Health and Safety Contacts of CMA Member Companies SUBJECT: ATSDR Draft Toxicological Profiles On April 17, 1987, the Agency for Toxic Substances and Disease Registry (ATSDR) and EPA published a list of the 100 most hazardous substances found at waste sites and guidelines for the development of "toxicological profiles" on those substances (52 Federal Register 12866, 12870). These profiles will be used to estimate "significant human exposure levels", to identify data needs, and to recommend further testing. ATSDR has developed toxicological profiles on the first 25 substances. The profiles will be available in final form in December. The Agency*s next step is to develop draft profiles on the second 25 substances identified on the enclosed priority list. Although ATSDR will conduct its own scientific peer review on each of these chemical-specific toxicological profiles prior to public disclosure, CMA believes that a similar industry review of the profiles is warranted. I solicit your help in volunteering knowledgeable industry scientists, reputable consultants or other industry trade groups to evaluate the second 25 draft toxicological profiles scheduled for release this December. Although this CMA activity is focused on specific chemicals, the reviews prepared by industry panelists will be the basis for an overall CMA evaluation of the general content, format, and process by which these draft toxicological profiles were developed. Our assessment of the profiles on a chemical-specific and general basis will be important to the development of profiles on other listed chemicals during the next few years. As you know, the profiles will likely be used not only for the purposes originally intended by SARA, but as the basis for other federal and state regulatory activities. You can help CMA ensure that the data and conclusions in the profiles are supportable by industry. Please return the attached form by December 30, 1988, indicating each substance of interest to your company and the industry health scientists that will help review and evaluate the toxicological profiles on those substances. Remember to note the names, addresses and the phone numbers of other persons outside of industry known to have expertise on any of the substances. In addition to participating in this activity, you are encouraged to submit comments to ATSDR on behalf of your company. 2501 M Street. NW, Washington. DC 20037 202-887-1100 Telex 89617 |CMA WSH> VVV 000005517 Health and Safety Contacts Second 25 Draft Toxicological December 5, 198S Page 2 Profiles Mote that while it is unlikely that member companies will submit confidential data to CMA in response to this request or as a result of reviewing the toxicological profiles, CMA has set up special safeguards to protect confidential information on specific chemicals from disclosure to competitors or the public. To assure this protection against disclosure, please clearly designate such documents submitted to CMA as "CONFIDENTIAL." Any such submittal should be on plain bond paper and should contain no reference to your company or bear any signature. In January, I will communicate with the persons you've designated as participants in this important activity. Please call Leslie J. King of my staff at 202/887-1323 if you have questions or need more infor mation about the priority list of 200 substances or the development of toxicological profiles. Sincerely yours Enclosure Vice President-Technical Director vw 00000551a SECOND 25 PRIORITY SUBSTANCES FOR ATSDR TOXICOLOGICAL PROFILE DEVELOPMENT (53 Fed, Rea. 41280) CAS NO. Substance Name________________________ 56- 23-5 ........... Carbon tetrachloride 57- 74-9 ............Chlordane 62-75-9 ...............N-nitrosodiraethylamine 72-55-9 ...............4,4-DDE, DDT, DDD 75-00-3 ...............Chloroethane 75-27-4 ...............Bromodichloronethane 75-35-4 ............... 1,1-Dichloroethene 78-59-1 ...............Isophorone 78- 87-5 ............ 1,2-Dichloroethene 79- 00-5 ............ 1,1,2-Trichloroethane 79-43-5 ,............ 1, 1,2,2-Tetrachloroethane 87-86-5 ...............Pentachloropheno 1 91- 94-1 ............ 3,3-Dichlorobenzidine 92- 87-5 ............ Benzidine 107- 06-2 .......... 1,2-Dichloroethane 108- 88-3 .......... Toluene 108-95-2 ............ Phenol 111-44-4 ............ Bis(2-chloroethyl)ether 121-14-2 ............ 2,4-Dinitrotoluene 319-84-6 ............ BHC-alpha, gamma, beta, delta 542-88-1 ............ Bis(chloromethyl)ether 621-64-7 ............ N-nitrosodi-n-propylamine 7439- 97-6 ........Mercury 7440- 66-6 ........Zinc 7782-49-2 ..........Selenium VVV 000005519 ; l. CHEMICAL MANUFACTURERS ASSOCIATION INDUSTRY PEER REVIEW PANELS TO EVALUATE TOXICOLOGICAL PROFILES ON THE SECOND 25 PRIORITY LIST SUBSTANCES UNDER SECTION 110 OF SARA RETURN BY: Decetnber 30, 1986 RETURN TO: Leslie J. King Manager Health, Safety and Chemical Regulations Chemical Manufacturers Association 2501 M Street, NW Washington, D.C. 20037 . (202) 887-1323 *********** Substances (Circle one or more) Carbon tetrachloride Address and Health Scientist(s) Telephone Number Chlordane N-nitrosodimethylaroine 4,4-DDE, DDT, DDD Chloroeth&ne Bromodichloromethane VVV 000005520 1,1-Dichloroethene Isophorone 1.2- Dichloropropane 1.1.2- Trichloroethane 1.1.2.2- Tetrachloroethane_ Pentachlorophenol 3.3- Diehlorobenzidine Benzidine 1,2 -Dichloroethane Toluene Pheno1 Bis(2-chloroethyl)ether 2.4- Dinitrotoluene BHC-alpa, gamma, beta, delta Bis(chloromethyl)ether N-nitrosodi-n-propylamine Mercury i i vVV 000005521 Zinc Selenium ** * * * ***** SUBMITTED BY: NAME: COMPANY:____________________________________ ADORES S: TELEPHONE NUMBER SIGNED VVV 000005522 -3-