Document zbdvMREDvOx0qe7pq0vNz9L3B
OFFICE OF THE SECRETARY OF STATE OF THE STATE OF COLORADO
CERTIFICATE
I, Mike Coffman, as the Secretary of State of the State of Colorado, hereby certify that, according to the records of this office,
Cinpathogcn, Inc. is an entity formed or registered under the law of
Dda\varc has complied with all applicable requirements of this office, and is in good standing with this office. This entity has been assigned entity identification number 20071004317 This certificate reflects facts established or disclosed by documents delivered to this office on paper through 03/19/2007 that have been posted, and by documents delivered to this office electronically through 03/22/2007 Cd) 09:59:20 I have affixed hereto the Great Seal of the State of Colorado and duly generated, executed, authenticated, issued, delivered and communicated this official certificate at Denver, Colorado on .03/22/2007 @ 0~:59:20 pursuant to and in accordance with applicable law. This certificate is assigned Confirmation Number 6737575 .
Secretary of State of the State of Colorado
*********************************************EndofCertificate********************************************
Notice: A certifica1e isSU!d electronically from !he Colorado Secretary orSIaJe 's Web site is fully and immedia1ely valid and effective. However, as an oplion, !he isswnce and validily ofa cerlifica1e oblained electronically 7110' be established by visiling !he Certificate Corifirmalion Page of !he Secrelary of SIaJe 's Web site, ht!p:!/ww14csos.sJate.co.us/biz/Cerli{icateSearchCrileriado entering !he certijica1e's corifil'malion number
displayed on !he certijica1e, and following !he instructions displayed C,;'nlirming!he is'f1lance ora rerlil1i:<'Ik' B mel'"A optional and is (/,)1 necessary Jo !he valid and effective issuance ora certificate. For more information, visit our w"l; site, htlp:/{www.sos.slate.co. w/ click Business
Center and select "Frequently Asked Questions. "
CERT_as] Revised 0110212007
SHELL-MCCLURG-067188
01/03/2007 14:11 FAX
~003/005
Uocument processing fee
If document is filed Oll paper
$125.00
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ore subject to change.
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for this form/cover sheet and other
information or print copies of filed
documents, visit W\\'W.sos.Slate.co.us
and select Business Center.
Paper documents must be typewritten or machine prmted.
20071004317 C
$ 125.00
SECRETARY OF STATE
01-03-2007 15=49:16
,IBOVr, SPACr, FOR (JFI'ICF. liSE o'<l.
Statement of Foreign Entity Authority
filed pursuant to 7-90- 30 I, et seq. ann 7-90-R03 of the Colorado Revi~ed Statutes (C.R.S)
ill number (if applicable): 1 True name:
2. Assumed entity nome
(ifditlerelll (rom True name)
Cinpathogen, Inc.
3. Use of Restricted Words (Ifarlyo/rhese
terms ant c..'()lJl"ined in lin l!nlily n,mu,!J JJ'U(iJ
name a/an erllity, trade twme 01' trademark
""<'III"''''!,stut."j ill 11/(.1
",ark 'he "'l'pliclJb/"
bfJx):
o "bank" or "tn1!lt" or any deriv~tjve thereof
o 0"credit union"
"savings and loan"
o "insurance". '\:asunity", "mutual", or "surety"
4. Principal office streel address:
4600 Baseline Road
E-l04 PFB253
Boulder ------,
.
(
C=
-
i
-
t
y
)
.
,
-
-
-
---
-
-
(CSOi;i;J
80303 (Pos/a/lZip cutf~)
(Country -lj ~or U,\J
4. Principal office mailing address:
(if diff<>Nl1l from above)
(StreBi ""me and I'wmb:y ar Post 0.0;,,8 Bo...; irifarmu,;on)
5. Registered agent: (iran individual): OR (ira busines~ organi;t.aLion):
~=(C-ity-l ---------(S-lal-e)-----(-P(-).(t-all~Zip~C~od~e)~--
(I'nn'i"ce - IfIJPpllca{;(~)
(Cammy - If nOI US)
Iroos
Richard
-(""1-0.-0----
(Fb-.,t)
(Middle)
6. The person appointed as registered Ggent in the document has consented to being so appointed.
AUTHORITY
P~~e J of3
Rell. 6/1512005
Received D1-C3-Z00T 03:13pm From-
To-Colorado Secretary 0 Page 003
SHELL-MCCLURG-067189
01/03/2007 14:11 FAX
Ii1~004/005
7. Regi~tered agent street address:
8. Registered agent mailing address:
(it ddferent from nbove)
4600 Baseline Road
E104 PFB25.'3
Boulder
reil}'}
(SII'<fM nome and numb.,.)
..Q... (SlUr,,)
80303 (PosrallZlp Code)
(SII'SI!'! nQ"1e "nd nllm""r ,,,. Pos/ OJ/iN lIlty fn/ormflflnn)
fCil)~
9. Fonn of entity: 10. Jurisdiction offormation:
("mvlnce -llapP/jea"":) Corporation DelawarH
11. Date entity (;oUl.lllenced (or expect.. to commence) transacting business or conducting activities in Colorado:
0110312007 ---(mmltldlyy),)')
12. (Optiollal) Deillyed effective date:
'"
----'---:~-:-:~,..-:--:---
(Slt'lI(>i
(f'""rall?;p C",l~)
(C"untr)' il',wl US;
Notice:
Caming this document to be delivered to the secretary of state for filing shall constitute the affirm~tion or acknowledgment oreaeh indIvidual c!lusing such delivery, under penalties of perjury, that the document is the indivirilJi'l.I'l\ act alld deed, or that the individual in good faith believes the document is the act and deed of the person un whose;! behalf the individual IS e8\lsing the ctoc1Jment to be delivered for tiling, taken In confonnity with the requirements of part 3 of article 90 of title 7, C,R.S. th~ eOHstituent docllment~, and the organic
statutes, and that the individual in good faith believes the facts stated in the dOC,lIIDt:tll an:. InlC aud the document complies with the requirements of thot Part, the constituent documents, and the organic statutes.
Thi.~ perjury nullec appli"'s to each indivirlual who causes this document to be delivered to thc secretory of state, whether or not such individuill i~ named in Ihe document 11:<; one who ha!'! caused it to be delivered,
13, Namc(s) lind flddress{es) of the individual(s) causing the document [0 be delivered for filing:
Seiler
Nathan
------:(l':"".<r-s-')-----
(Fi)'>'t)
fUldd!.)
Cooley Godward Kronish LL....
(S,,.e,,/ """,e "nd'~n-II-",b-.,-,0-'-'P::-O-,<-'I-;;O"'IJfT.r(-a-B~I.' informal/OIl)
380 Interh)!;kRn CI'I'I5cenl. Suite 900
Broomflald
co
-----------,~:~i~-,~-------------~
BOO? 1
(Pos/<r/IZjp Cod,,)
(PI'f->vln,'" - ,fupplicahle)
(C,,'Jn/ry - ifnnr us)
(Ina documfml nf.!f!J nuf sllr!S. the "'l:B nome and addre.l'l' oj mOJ'e rlum tll1P IntJrvidzJtll, H-nw2.ver, lj)'OU wb'h IU ~'Itrl(llh(! nmne (mu udt.l,.f!':;'s
0Ilf""." "ddj!lOtr<ll I"dividllol,' <'c",,,ill/C rhe document 10 be dc/l\cJ'l.'dfor./Wng, m""k rhis h""
IImi j,w/tlde on <rfladrmenl ",,,ling the
n(l1"(' ami l'IJdrC-lJs of$Ur..'/t individl1ul,~.)
Disclaimer:
AUTHORITY
Rev, M1SI20()$
ReceIved 01-03-20D7 03:13pm
Frcm-
To-Colorado Secretary 0 Page 004
SHELL-MCCLURG-067190
01/03/2007 14:12 FaX
@005/005
This form, and any related instnlctions, are not intended to provide legal, business or tax advice, and are offered as a pllblie service witnout representation or warranty. While this tonn is believed to satisfy minimum legal requirements as of its revision date. compliance with applicable law. as the l';ame may be amender! from time to time, relIlliill~ Lhe rel:iplln~ibjliLy of Lhl: uSl:r of Lhi~ fonn. Questions should be addressed to the user's attorney.
AUTHORITY
Received 01-03-2007 D3:13pm From-
To-Colorado Secretary 0 Page 005
SHELL-MCCLURG-067191
DATA FROM DR. IRONS FOR STUDY COMPLETION AND LABORATORY TRANSITION
A BC DE FG H I J K LMN0
1
2
3 able I. UC DHSC PI n A- Stud yComple ion
4
5
<..-ur nIly unae
ec-uo
un-
ec- 10(al
6 P...i.;.f.r..s..(.j.i.i.i.i.e..L..:.:::"'" .
;:7
~~"Q~;,,~ ~,~~~, <I:
(R 1n1\ <I:
l"'~~~ <I: ;~,,';~~
~.
<I:
'~~~
8 9 IProposed Bud~et
$ 1 0,780 $ <~~,~66
60,000 $ 27b,~~6
10
.C~gently. :u;;;( $
..136, '35 $
;j,780 $ ..150,000 .
-$
.4~ 17,515
i' JE11
; '-::-:'" '"12
J"'v~v.~.w 'U"V'
,rr ,on
,'< tv, '';:;
,vv 'r:";;'
'v,
v,v
< 'f) ('"13
14 Proposed Bud~et
$ 500 $
-
- $ 500
15
.Currently . undec $
1 75 $
500 $
-
-$
1,775
16
" "17 roposea tl ua~e "18 b,cc:,
- -- - -
-
Ud~~{- i'3.JJ~ i'9.#~19 IProposedB
$ l' kUi42 $
$ 2~ 9.611'
20
'f21
Currently =u~;;( $
136, 134 $ l' 5 42 $ .
52,849
-$
1~ ~,12:
,,'22 It-'roposea tl uagel
,,'I,f' tL,U"q
,,j"L,btl{ 1,,'I,'lb:::>,fLtI -
,,4,.>" ,:>u" ,,
23
"',,"n.24
. h ,/wo,n r ... ,on/h, """n. ,. ~n"
Ilrn,",,,r
et 1 n1 ?7A
25
26
.. "'27
ft., .."
.
-28
29
10 n ~If'
nQ,,_nR
'"n_n7
n ..,,_n Total
30 31
I~;~%~::~~ J~~~t , < 1<, <li< ~~~,i~6 ,:::::~~~,i~6 i1,i~ b,~~6
< <32 :$.:.:.:.:.:.:.:.:.:.:.:.:..:.:.:.:.:.:.:,.
33 IProposedB LJdIT~t
34 h. ,6
:'0~~'~~~ "k~$< ,066,750.
,,,. ;';;;:";,;,,
$ 3,4: 1,950
.C!'. ,;.;; ,
35
36 PlanA otal (UCD~ SC +JCML !b 5759.864 37
-38 ..
39
40
In n ~Ip
_ne< _n7 n, _n Tntal
: >41 :personiiel:::"""
6,66642 Proposed Bud~et
; < <1< <1< < <43
.....................................................................
$
-
400000 $
40
.$ ...............).
44 45
IP~p,4$ed~ LJ?;~t
46
$
-
tl4U,UUU $
tl~ p,puu
,::::::::c: - ,,
47 Plan B Tota $ 1.24 0.000 48
Irons' new proposal November 9, 2006
SHELL-MCCLURG-067192
DATA FROM DR. IRONS FOR STUDY COMPLETION AND LABORATORY TRANSITION
A 49
rB C D E F G H I J Subtotal UC HSC +Pla A+ Plan $ 6,99~,864
K LMN0
50
51 52
.R.
.. ~ ft
~.
ro'~. ~w . . . . ~ . . R.
,~,-~,wwy
WW.. VR ..
~~~~
.ft \~VVV-~v,
'/
53 .. ..
54 ~
.pv. ,v
,,
55
56
57
58 IT, I ?nn7
59
Jan- ?
Feb-O?
Mar-O?
Apr-O? May-O?
Jun-O?
Jul-O? Auq-O?
ep-O?
o I-O?
Nov-O?
Oec-O Costs
60 Bud el
$ 258,85 $ 255,852 $ 129,852 $ 129,852 $ 129,852
129,852 129,852 $ 29,852 $12 ,852 $129, 52 $129,82 $ 129,852 $ 1,813, 225
61 Fu an $ 126,00 $ 126,000 $ $ $
$ $ $ $ $ $ 252, 000
62
r; ~" 'v, ~ '~<no ~ '~<~~: ~ ,~<~~: ~ ,~~:~~: ~ '~<n~:
,~<~~: ,~~'n~: ~ I~g'~~: ~ ,~ i'~~: ~ '~g' h~~ ~ '~~'n( ~ '~~:no, ~
"~7: ~~~
63
Hislol ogy $ 300 $
$
$
$
$ $ $ $ $ $ 3000
64
Irons' new proposal November 9, 2006
SHELL-MCCLURG-067193
DATA FROM UCHSC AND DR. IRONS - PRESENTED FOR FINISH STUDY OPTION AND FINISH PLUS TRANSITION LABORATORY OPTION
A 1
2 PLAN A - Study Completion
3 4 UCHSC 5 6 7 8 9 10 11 Total Expenditures: 12 Current Grant Funding: 13 Grant budget available 14 15
16 PLAN B - Includes Laboratory Transition
17 18 UCHSC 19 20 21 22 23 24 25 Total Expenditures: 26 Current Grant Funding: 27 Grant budget available
B
Personnel: Operating Expenses: Sub Contracts: Travel: Equipment: Indirect Costs:
Personnel: Operating Expenses: Sub Contracts: Travel: Equipment: Indirect Costs:
CD E F
Project to Date Expenditures on
12/31/05
Projected Expenditures for
2006
Proposed Expenditures in
2007
$ 2,179,252 $ $ 1,557,404 $ $ 6,621,611 $ $ 9,098 $ $ 1,383,491 $ $ 1,002,342 $ $ 12,753,198 $ $ 13,761,880 $ $ 1,008,682 $
472,909 428,608 2,904,807
620 -
233,483 4,040,427 4,000,000
968,256
$ $ $ $ $ $ $ $ $
1,810,560 3,521,450 1,813,224
153,770 7,299,004 570,889 (5,759,859)
Project to Date Expenditures on
12/31/05
Projected Expenditures for
2006
Proposed Expenditures in
2007
$ 2,179,252 $ $ 1,557,404 $ $ 6,621,611 $ $ 9,098 $ $ 1,383,491 $ $ 1,002,342 $ $ 12,753,198 $ $ 13,761,880 $ $ 1,008,682 $
472,909 428,608 2,904,807
620 -
233,483 4,040,427 4,000,000
968,256
$ $ $ $ $ $ $ $ $
2,210,560 4,361,450 1,813,224
153,770 8,539,004 570,889 (6,999,859)
Irons' new proposal November 9, 2006
&[DATE]
SHELL-MCCLURG-067194
DATA FROM UCHSC AND DR. IRONS - PRESENTED FOR FINISH STUDY OPTION AND FINISH PLUS TRANSITION LABORATORY OPTION
G 1
H
2
Proposed
Expenditures in Projected totals
3 2008
12/31/2008
4
5$
600,000 $
5,062,721
6$
- $ 5,507,461
7$
- $ 11,339,642
8$
- $ 9,718
9$
- $ 1,383,491
10 $
- $ 1,389,596
11 $
600,000 $
24,692,628
12 $
- $ 18,332,769
13 $ (6,359,860)
14
15
16
Proposed
Expenditures in Projected totals
17 2008
12/31/2007
18
19 $
600,000 $
5,462,721
20 $
- $ 6,347,461
21 $
- $ 11,339,642
22 $
- $ 9,718
23 $
- $ 1,383,491
24 $
- $ 1,389,596
25 $
600,000 $
25,932,628
26 $ 18,332,769
27 $ (7,599,860)
Irons' new proposal November 9, 2006
&[DATE]
SHELL-MCCLURG-067195
SHANGHAI HEALTH STUDY - BUDGET ESTIMATE TO FINISH STUDY AND SUPPORT PUBLICATIONS AND LABORATORY PERSONNEL
A 1 2 3
4 Cost Centers
BC
Original 2007 EOY projection
D
CURRENT APPROVED
BUDGET Sep-06
E F GH I J K
Proposed
Proposed
Proposed
Increase To
Publication
Laboratory
Finish Study
Support
Support
In 2008
2008 - 2009
2008 - 2009
L
Total
5
6 UCHSC Grant 7 Irons-Field Expense 8 Applied Health Sciences 9 Fudan University 10 Scientific & Ethics Panels 11 Communications 12 Outside LeQal Counsel 13 QAlQC Support 14 API Administrative 15 Exposure Assessment 16 Committed Contingency* 17 Contingency
#REF! #REF! #REF! #REF! #REF! #REF! #REF! #REF! #REF! #REF! #REF!
18,332,769 1,413,428 2,930,841 379,829 473,142 300,000 140,000 50,000 1,445,205 109,000 156,391 642,516
5,759,860 -
798,279 65,000 95,000
200,000 65,000
150,000 165,000
1,000,000
400,000 -
400,000 -
24,892,629 1,413,428 3,729,120 444,829 568,142 500,000 205,000 200,000 1,610,205 109,000 156,391 1,642,516
18
19
Total Expenses #REF!
$ 26,373,121
$ 8,298,139
$ 400,000
$ 400,000
$ 35,471,260
20
21 *Not a cost center
DRAFT
Data from December 14, 2006
SHELL-MCCLURG-067196
3118/07 Proposed Extention of Studies on Benzene Toxicity in Shanghai, China
RESEARCH PROTOCOL AND
CRITERIA DOCUMENT
I. ANALYSIS OF DISEASE PROGRESSION FOR APLASTIC ANEMIA, MYELO-
DYSPLASTIC SYNDROME, ACUTE MYELOGENOUS LEUKEMIA AND BENZENE POISONING IN SHANGHAI, CHINA
II. MOLECULAR EPIDEMIOLOGY OF BENZENE-EXPOSED WORKERS IN
SHANGHAI, CHINA
III. DIAGNOSIS AML AND L YMHOID NEOPLASMS IN SHANGHAI, CHINA
A MULTICENTER INTERNATIONAL STUDY
Richard D. Irons
CINPATHOGEN, INC. BOULDER, COLORADO/SHANGHAI CHINA
INTERNATIONAL CLINICAL AND MOLECULAR RESEARCH CENTER INSTITUTES OF BIOMEDICAL SCIENCES, FUDAN UNIVERSITY SHANGHAI, CHINA
FUDAN UNIVERSITY MEDICAL CENTER, SHANGHAI, CHINA
DEPT. OF PHARMACEUTICAL SCIENCES, SCHOOL OF PHARMACY DEPARTMENT OF PATHOLOGY, SCHOOL OF MEDICINE
UNIVERSITY OF COLORADO DENVER AND HEALTH SCIENCES CENTER, DENVER, CO. SHANGHAI HEMATOLOGY SOCIETY
SHELL-MCCLURG-067197