Document zbdM023zREL6vzr5RzYG2RYMB

FILE NAME: Colgate (COL) DATE: 1971 Aug 11 DOC#: COL003 DOCUMENT DESCRIPTION: Memo - FDA Meeting - Asbestos in Cosmetic Talcs a*,. Wi ' '-n v . s-.qts.. r.K tV M iS "? , i'ggG arteh t&-i nqi n e e r i n a C e n te r SSpa***1 ' *~ HMO;-FOPf FILE: ' ; ; : , f f i : j , : ^ , ''; : ' ! :; i - it f t f d a im e e t i^ g ; - 4ASBEsa^s>frN|;cos>ffiTic:'%Atcs ' : - ,.-;. ' A0G|St?-3 i ..1*97%,'- D 'fcV - < i j, } The ffcnirpose-arjd, lis]t;*.o"p>artici;pa|ts a n d id is c u s s a n ts .' a r e g iv e n in- t h e '- a t t a c h e d ''t w o h a n d o u t s "fro ri^ t h e ' m e e t i n g - . 4 " .- \ Sdramar y : ; ' i -t. k. liirces'.) -?set- uh,ee lfubaassiis5l;- tixofrr *. t h e - ffle tih g i ald^^r iter^^e'^,hi8'*".maiSsi' t h a t th" f A ::` ' ' - ,, i ,f_ ,, r *. , *i.- <; \ \ e ^ , (.' % ...> >6, i' . . , . , Il;i..- a p e c i t ^ l ^ ' p r b c ^ ^ j e f r ^ o r ^ v r a i y i f t i i ^ f e i a i c ? \* . * - 3 . ; ' V ' f- '-% i i . 2 e v a l u a t e >ctsstaaieidr -t rp 'i- 'iL . >. ` iv '" '-v . ; ' - i 3. d e c id e "on fthe 'a c c e p ta b le - lir a i I'sf o f '- V s b s t o s i and, 4 . b a n -th e i s * l e `o f th o s e i c c s r a c t i c -.ta.C3lwi.ch' th ey, deemed "" u n A c c e p ta b le . y / I ' - ?- - - ;v'!'. ;; Ex.6068-1 CPC-WINKELTRSCPT00001496 *K>*3V ' '> . , .itr Augut 11, 1971 Paga . 1 ' PDA MEETING \ . J. .. ' ASBESTOS INCOSMETfC TALCS 'i Ver.mont ta j ^ a 'li s o u r c f t .o i - ; J s J ) '^ . e a e r a l l y - r e l t ir e l y f r e e o f t 'r - ! j-i' m olX 'te.or kth r.- s b e s i: s v .-in in e r lsT'-. ,; ' . I* &%: i- -Dr. Lewis C r a l l e y i J | tfa -tio n a l. I n s t i o ' v c tc c u p a fc io n a l ? | - - t : t- "" -$. S |tf e b y ,.a n d r H e a 3 ? th ^ 'C in c in n a ti- , O hio-. . i . S e y i 'e i ^ - `` ^ i i 't i b n - . ; o i f ` *'ib e i|" ';e n d r -la te ! t h ' h a z a r d t o . r e p i r a - ' f rM I , t y | M A ^ i ^ t )^ ^ b ^ a ^ ^ i ^ ! ^ e i y cgt'tr<du;cedr a g a iii^ -th e -'. o iic e p t l :o fh e a V V 'mp.'t* 1 v' GwrrtrnXhl*ri<io'ir'>K`R<iVrT:liWrl xh 1 vniihl 4-ah'ari ' Ex.6068-2 CPC-WINKELTRSCPT00001497 August- 11, ; 1971' Page ' 3 ' ` FDAf- MEETING P ..:ASaeST0S:-IHiC.OStlC,.'rECSIii . a U ,5 . ;'^v 7 -J*1- ` ? - *?: v i* - -3j.r> -i - >' ; .i ** v o g y :* * D r;P aul-G ross - In d u s tria ls H ealth Foundation. j * '-7 : Jf i' *-* >' r iv , v r-/,, v D e s"c r ib e d af'nif' fljai>i -E*j x, pi e r iim'j . ein: tsi -' w ith '*t a i c '{pff& vibuijiy u s e d o n p h y - ' sic ia n s* gloves); in je c te d in te n tio n a lly '-ira to b e l l i e s of anim als-. These produced, n o 'granulom as. H ejd escrib ed . in te rtis a c h e a l in - j e c t i p n s of? h a m s t e r s - w i th : t l i r e e t y p e s o f , t a l c ' ( h i g t e n i c k e l , low n i c k e l ;', and- o f f - j t h e - S h e l f 'c o s m e t i c t a l c ) i.:.' -No -fife fd isis' a f t e r i ' two. y e a r s , d e s p i t e , e x c e s s i v e am ounts used-.-; - , H e -'n o te d T an : W e b s te r ' s c o n c ln s io n s ? tK a tr f i b e r s , -m ust: b e t a t . I e a s t s-5 * )n ic ro n s lo n g t o be?. harm ful.' jV .- ' ' - " ~F' .. - ' " y ; P'* jM o rris k a p la h - C onsum ers U nion Ex.6068-3 CPC-WINKELTRSCPT00001498 'sSfeSi-' . A u g u s t 'Xi./ ; i 9 7 l p'dgtf- "4 -` ' *i- FDA (MEETING.. .' ', . ' ASBESTOS t m . COSMETIC; TA&CS/ I s u b j e c t g f 'a s b e s t o s -in;_i n j e c t a b l e d ru g s'; a n d 's t a t e d t h a t 'm o r e ... dxu<gs i n ; a ..s u r v e y at.- the- M t; S in a i ' ' 1- ' gram, in av v i a l . ' P ' asfc^stos-'viii^iun'o'iints 'up* to ' 1 - m ic ro -- ' . : ;. ; r , r i; ' ' S S p e ll - Johns-M anvil.|.e ; Ex.6068-4 CPC-WINKELTRSCPT00001499 'Augua't H , 19.71 Page 5 . t ' - Vf;**- , s-' f. - 1 ;i* -- Tc . - /*, \ * Ex.6068-5 CPC-WINKELTRSCPT00001500 - sfe^'- .iS S S r ' :"^-Tr . A ugust 11, ..1971.;. P'.nae. 6? ' '. ^ ' | }f . . 'p' FDA MEETING 'I ASBESTOS' I COSMETIC TALCS - 2', Ilydr.om.4gh e s i'tle i s f i b r o u s v i 'n fo r m ;' D iam ejter. o f 200 A n g stro m s w ith a- "hole!!; down t h e c a n t e r . ' H ydrom .agnesite i s known t o ' o c c u r i n aom^ t a l c d e p o s i t s . G e ig e r N q u e s tio n s soma o f ' . A rt L an g e'i's l id a n tif ip a tio n o f chrysotide-;. f i b r i l s . .T h isi . was a smoife s'cr& en , b lit a g o o d c o u n t e r . o f f e n s i v e `to - L a n g u r . fin d in g c n r y s d tile ' ev ery w h ere'.. \ i ; . ' . ; j i ?-' f , t ,' ; I Dr.. F.. P i Poo le y . - - U n i v e r s i t y ; o f S o u th ! W ales ' f. " ~ T ! . . | . . r -: : W . ' . . ' E x a m i n e d . t a l c by EM t e c h n i q u e s , i n c l u d i n g h eav y i i q u i d d e n - r s i t y se p a ra tio n in C e n trifu g e . A ll, fib ro u s'1 c o n s titu e n ts were i d e n t i f i e d a s t a l c !b y e l e c t r o n ' d i f f r a c t i o n ! : . | . p . ' g- ^ " ' < , ! D r. R, i F... ftfclle. - Jo h n so fi .& J o h n s o n ''; * ' j, S hoW ed f'b eau ti ku l ! 'e l e c r ( $ |i m i c r b g r a |K s '1 ^ ^ i # i # e d f u p .[ p i a t 'e l e t s .' o f t a l c . S am ples w e re ma'defby' r e p ? l i c a i i '^ k : i i s i n g ..g b l 'd `'p b3i^ddum p la tin g ..|/ . 7 " ,,:f . ; * X - ? '// |. : : - .?, ' ' j Y D f. W. Ft N ich o lso n ' ' f; x f- i 1 ' J:' t ^ ' Sinair Sc.'h6m '$frt4daiJihe - ' i. : " ? 'v .a -.- ' ' '" 'V- i * ?. 5 ic h o d s.o n '' s-' it&f e tt h W v e 'ip rO ilr m ^ n c 'i d e a V ^ ih . d t f t i & n f to initi'ffL%uxVfy'f 7 i, . 7;d'?d\ .7 1W ^-'-zS^r - *. | x - . - , ' :|j. . ]J ' \ : i : s t a t r s t i p a l - sfedy- o f ,the H t.- S i i a 'i^ iu n ^ t'^ u rv e S '- s a m p le s ' o f New 5fjirK|pepp3jfe .'to - i o r r e l t e l iJ& cvandi; t a l `c p b n 'te t- i n t h e i.lu n g s i wi%h t a i c -u sa g e ; .and,7 /' ` h-k-A ' ' 'i 1 Id E .. mb S& 7:. . 7. ' . ^ ; V . , ,7 .*$ *;<i, ^VvYi.'MvOT Ex.6068-6 CPC-WINKELTRSCPT00001501 August .1 1 , J971 Paget 1 ' ., . FliA .'MEETING i. ( [ - ASBESTOS IN COSMETIC'TALCSj; ' .r : 'r ' i .... rh l ? ji . : *, . .. 3i a com pUete _epideraibjlogS.eal s t u d y of- t h e Iworkefrs m in in g ' and - ' producing.cosm etic t a l p s . r < 'i 'j C .. M aqgiore - - M t. {.SihaiA S c h o o l o f M e d ic in e ^ , ~ r I ' . i ? ' R eported on Mt.' S in a i e x p lo r a to r y work' to w a rd s this dev elo p m en t of- in s tr u m e n ta tio n fb r-.ito m p ,lately c h a r a c te r i z i n g rtany and a l l f i b e r s j i n d ' p a r t i c l e s ; ' in} a- sam ple byg-stiape, s i z e , c h e m ic a l ;an & ly siB , e t c . -He i n d i c a t e d t h e .ne$d- f o r a p p r o x im a te ly $300, 000 arid' -2 tb / 3.: y |e a rs . f o r ; d e s i g n , a n d c o n s t r u c t i o n , o f ,'a p r o t o t y p e u n i t . r * .i - S. Sp e il I- s S S /r s . { A tta chmeirt s (2 j :P..| Rad ne s , DH :HSw; / e tdHiC' ', ,'DH Fenner P". .le i'n e w e b e r 'I 4- . HCt.."i", . .fjjj* ( * ; v t - ' &' y : "I Y 1- ||X , , p?" tA#; _ ',1 J - T' f ': f '" ' 1' Ex.6068-7 CPC-WINKELTRSCPT00001502