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Mi z j h )t .Date To . T V . f i peseVs t COSMETIC, TOELETRVTti FRAGRANCE ASSOCIATION. INC. 1133 15Ih STREET, N.W., W ASHINGTON, D.C. 20005 PHONE 002) 331-1720 From ,__ Please; C3~J Attend to I j Note and return Note and forward to Files I I See (phone) me re '-- ' attached n I r Prepare reply for my 1-- 1 signature I I Send me information -- required to answer ixfl For your information As requested I I For your comments -- and suggestions r*~I Does attached meet 1-- 1 with your approval? | | As per conversation I I For signature, if you 1-- 1 approve M ake----------------Photo Copies Other Remarks c u~l> & /} C- . XT ZJT , , PLAINTIFFS EXHIBIT WCD-396 Goodhue W CD 000190 Jaxtn&ry 31* 1977 D r . M y ro n A.. M ehlznan* E d ito r Journal ol Toxicology it Eavironm ontal H ealth N ational Institutes o f H ealth P . O.' B o x 1829 R ockville, M aryland 20850 D ear D r. Mehlman: In the N o ve m b e r, 1976. l. s o e o f th e J o u rn a l o f TojH ro lo vv and Environm ental H ealth there m . published an a r tic le _ ^ S t t e d "C onsum er T a ic S n s and P o w d ers: M in era l and C h em ica l C haracterization " by A , N, Rnhl et aL 1 have read the ab ovem entioned a r tic le and in the in te re st o f c o rr e c tin g the re c o rd b y m entioning publications w hich m ay not have been broogld to the S ^ i o n o f th s au th ors, 1 a m en closin g a B e tte r to the E d ito r w h ich J is>ould a p p r e c ia te y o u r p u b lis h in g . Sin cerely y e a rs. G ES:M M S Ene. C a v i a H iI d lc k - S m itb , M . TL C linical A ssistant P ro fesso r D opartm ent d P e d ia tric s C ollege of M edicina and D en tistry of New J e rse y R utgers M edical School Fiscata'w ay* Now J e r s e y 03B54 b e: M r, G eorge Loft M r . M . Q . - T a t l o w ------- SAFETY OF CONSUMER C05METIC TALC PRODUCTS I n a paper e n t i t l e d "M in eral and Chem ical C h a r a c te r i s a tio n o f S e le c te d Consumer T alc P ro d u cts" by Rohl e t a l . p u b lish e d in th e November is s u e af th e J o u rn a l o f Toxicology and E n vironm ental H ealth th e author in d ic a te d th a t the d ise a se p o te n tia l of consumer ta lc p ro d u cts i s unknown and needs in v e s tig a tio n - Eohl e t a l . citci in s ta a c e s of pulm onary d is e a se a s s o c ia te d w ith exposure to t a l c d u s ts b u t f a i l to id e n tif y th e co m position o f th e t a l c d u s ts and th e am ount to which, s u b je c ts w ere ex p o sed . R e c e n tly d i s t i n c t i o n has been made betw een th e co m p o sitio n of i n d u s t r i a l t a l c s and cosm etic g rade ta lc s ,' I n d u s tr ia l grade ta lc s are m ixed m in e ra l d u sts u su ally containing lim ited auounte of ta lc m ineral dust w h ich may be a s s o c ia te d w ith v a ry in g am ounts of a s b e s to s a n d /o r 's i lic a . Cosm etic grade ta lc c o n s is ts ty p i c a l ly of 902 m in e ra l ta lc dust asso cia ted w ith m ineral im p u ritie s as m inor c o n s titu e n ts but fre e of d etecta b le fib ro u s asbestos m inerals (1). T h e p u l m o n a r y f i b r o s i s a s s o c i a t e d w i t h t a l c d u s t a s c i t e d "by R-ohl e t a l . h a s b ee n p r e d o m in a n tly r e p o r t e d to o c c u r among e m p lo y e e s w orking i a in d u s t r i a l enviro n m en ts p r io r to im provem ents i n working, c o n d itio n s . For in s ta n c e , in th e r e f e r e n c e to a r e p o r t by Rubitio (I) th e t a l c m in ers w ere exposed to t a l c d u st known to c o n ta in s ig n if i c a n t am ounts of s i l i c a . ` The example of in c reased pulm onary cancer m entioned by Rohl e t a l . v a a r e p o r t e d m m i n e r s e x p o s e d to i n d u s t r i a l t a l c u s t cor.7 ta in in g a n th o p h y llite and tre m o lite (3 ). K lc in fe ld (4 .5 ) however l a t e r r e p o r t e d t h e t Che in c id e n c e o f ' p u lm onary c a n c e r i n . t h e mine em ployees dropped to th e norm al le v e l fo r th e ir age fo llo w in g im provement in th e w orking e n v iro n o e n t. The b io lo g ic a l a c tiv ity of cosm etic grade ta lc d ust has been evaluated in recent years in co n tro lled anim al dust exposure s tu d ie s and ep id e m io lo g ic a l s tu d ie s conducted i n m ine em ployees ex p o sed to c o s u e t l c g ra d e t a l c d u s t ( 6) . In one study, ham sters were exposed to cosm etic g^adc ta lc d u st a t a weekly exposure le v e l approxim ately 1700 tim es th e amount of t a l c d u s t to w hich an in f a n t w ould he exposed in a w eek ( 6) . The d a ta o b ta in e d ' showed t h a t th e ex p o s e d a n im a ls a t n a t u r a l d e a th shoved no d i f f e r e n c e in in c id e n c e o f any p a th o lo g y noted from th a t observed in .th e c o n tro l anim als s tu d ie d (7) These d a ta and th o se o b ta in ed in o th e r anim al s tu d ie s have -failed to produce any evidence th a t cosm etic ta lc i s a c a rc in o g e n ( 6). Goodhue W CD 000191 -2- P ro sp e ctiv e and re tro s p e c tiv e ep id em io lo g ical s tu d ie s conducted in em ployees m illin g end m ining co sm etic g rade t e l e have shown no d if f e r e n c e In in c id e n c e o f pulm onary f i b r o t i c d is e a se or ca n cer observed In th e mine em ployees when compared v l t h a c o n tr o l unexpoaed c o h o rt even w here e group o f t a l c m ille r s was exposed to ap p ro x im a te ly 7800 tim es th e amount of ta lc d u st in one week than th a t to w hich a consum er would be exposed, in one week (6*3)* . A lthough Rohl e t a l . su g g est th a t cosm etic grade ta le may b e h a z a r d o u s to h e a l t h , th e a v a i l a b l e d a t a i n d i c a t e t h a t th e normal usage of cosm etic grade talc, by th e consumer 1b n o t a hazard to h ealth * G a v i n H i l d i c k - S i a i t h , M, D< C lin ical A ssistan t P ro fesso r, D epartm ent of P e d ia tr ic s C ollege of M edicine and D e n t i s t r y o f New J e r s e y R utgers M edical School . ' P ls c p ta w a y , hew J e r s e y 06954 REFERENCES 1* H a m e r * D . H . , R o l l e , and Sehelz, J.P .? C h a ra c te riz a tio n of T alc and A sso ciate d M in era ls; A merican Indue t r i a l H ygiene A s s o c i a t i o n J o u r n a l , ^ 7 ( 5 ) ! 2 9 6 --30-4, M a y , 1 9 7 6 . 2 . R u b ln o , G. , S c a n s e t t l , G . , P i o l s t t o , G -, and Romano, C .; M o rta lity S tu d ie s of T alc M iners and M ille rs ; J o u rn a l of Oc c u p a t i o n a 1 M e d i c i n e , IB il B 6 - 1 9 3 , M a rc h , 1 9 7 6 . ,3. K le in f e ld , M .J., M e s site , J . , Eooyman, 0 -, and Z ak i, M .H.: M o r t a l i t y Among T a lc M in e r s an d M i l l e r s in. New Y o r k S t a t e ; A r c h i v e s o f E n v i r o n m e n t a l H e a l t h , _14/. 6 6 3 - 5 6 7 , 1 9 6 7 , 4 . K l e i t i f e l d , K . J . : M o r t a l i t y E x p e r i e n c e o f New Y o r k T a l c M iners and H ill e r s . In fo rm atio n C irc u la r 8639, P ro n eed in cs ' o f a S ym posium , o n T a l c , -May 8 , 1 9 7 3 . B u r e a u o f M i n e s , D e p a rtm e n t o f th e I n t e r i o r , W a sh in g to n , D. C, ! | \ 5- X le in f e ld , H ., M e a site , J . \ and Zaki,M -M i, M o r ta lity E x p e r i e n c e s Among T a lc W o r k e r s ; A F o llo w - u p S t u d y ; J o u r n a l o f O c c u p a t i o n a l M e d i c i n e . l_ 6 :3 4 5 -3 4 9 , May 1 9 7 4 . r 6. H ild i c t- S a i th , G avin Y .: The B iology of T a lc ; B r i t l s h l Jo u rn o l } of I n d u s tr ia l M ed icin e. 33, 217-229, November 1976. 7 . W e h n e r , A l f r e d P - , Z v i e k e r , G a r y M . , C a n n o n , W i l l i a m C** mud W a ts o n , C h a r l e s R . t I n h a l a t i o n o f B aby T a l c P o w d e r by H am sters;X V llI I n te r n a tio n a l .Congress on O c c u p a tio n a l H e a lth , i B rig h to n , England, Septem ber, 1975{to be p u b lis h e d ). t 8 . `H i l d i c k - S m i t h , G a v in : T a l c - R e c e n t E p i d e m i o l o g i c a l S t u d i e s ; i P r o c e e d i n g s o f t h e 4 t h I n t e r n a t i o n a l Eympo.siuoi. o a I n h a l e d l P a rtic le B and Vapours-Ediubuirgh 1975, Pergamon P re s s L td ., i O xford. England, 1976 (co be p u b lish e d ). i Goodhue W CD 000192