Document zb9eXDbn3o5xNrOeqMj8g97G0

FILE NAME Corning OC DATE 1967 Feb 16 DOC OC029 DOCUMENT DESCRIPTION Memo RE Carcinogenicity of Asbestos as Contained in Kaylo . BERGH an BERGH BERGH BERGH BERGH cata ke tS BERGH BERGH BERGH BERGH BERGH BERGH BERGH BERGH BERGH BERGH BERGH BERGH , eas INING COMPANY CORESPONDENCE CORRESPONDENCE To Subject M. Hardwick - Berlin 3. C. Taylor CARCINOGENICITY OF ASBESTOS AS CONTAINED IN KAVLO POCF175 POCF175 Dato = February 16 1967 eh F. H. Edwards R. E. Grimmie + Berlin R. F. Shannon - Granville Since there appears to be a state of to the likelihood that near panic on the part of some relative cancer will result from prolonged exposure to the tahsibsestos fraction of Kaylo dust I am putting down the opinions I have in regard as a result of having read the available articies and on the subject to daco abstract First , J. S. Harrington of the Royal Cancer Hospital in London suspects that carcinogenesis is due to the strongly presence of carcinogenic poly- cyclic hydrocarbene or other organic materials in the natural or oils of asbestos Such oils have been found by extraction to rangceontfarommina003ti00n3g to 13 for crocidolite and amosite asbestos the former greater amount There may be considerable variation froumsually containing = asbestos to the other and within any one sample one type of o- There are two major azosite asbestos mining areas in South North miles West Cape apart G. the other in the Northern K. Suis - Cremer of Transvaal Africa These areas one are in the 300 of Mines the Miner's Medical Bureau Department Johannesburg South Africa reports a most remarkable phenomeDCT The high occur in prevalence of pleural mesothelioma in the North the Northern Transvaal Medical facilities West Cape does not in the lilo andag are of equai standard The prevalence of asbestos fibers in the sputum was remarkably similar for all groups in both arees The author of this paper states that none of the factors examined explains sTahetisfactorily the absence of mesotheliomas of the pleure in the Trad question in my mind is deas the amosite from one area contain a carcinogenic oil whereas the one little This question does not from the other does in the not or contains contains appear particular pepna J. C. Nammer of the M.R.C. Phoumoconiosis Research Unit in mports that in South Africa nore than 100 cases of pulmonarGylammaolriggannancWyales. have been confirmed histologically Nearly all of these cases have been confined to one asbestos mining mining area Chemical that oil investigations have abod particular ctoynpteaionfingasbceasrtcosinogenic hydrocarbons are present naturally in this . At prament 7. E. Smith and Monas Hiller are conducting snsive studies Feigh Dickinson University at Madison New Jersey on carcinogenic PLAINTIFF'S EXHIBIT OCF 323 2 oils that may be associated with wide acceptance rather than the that the mineral asbestos Apparently the theory is causative of cancer is the gaining organic contaminant itself The point of this part of the discussion any of the organic carcinogenic oils is of course does any or could Kayle after having been subjected remain in the asbestos fraction of Would there be chemical to the severe conditions of the autoclavs alteration in the thermal decomposition Would they be drivepnresoefnfcbeyosftelaimmedisWtoiullldattihoenre be In view of the nature of the studies University I should think being carried out at Fairleigh Dickinson that the investigators there would welcome the opportunity to study the effects of asbestos that itself . had been taken from Kayla The second point of this discussion deals Dr. Selikoff's paper that with the turmoil caused by reporting the high appeared incidence of in the April 6 1964 issue of the J.A and Newark New Jersey engaged icnanicnesrulaamtoinogn mw emobrekrs of unions in New York Dr. Selikoff limited his or longer to insulation dsutsutdy t Seolemcetnedwiw te hrea 5h3i2story of exposure of 20 years men on the union rolls = porfioJarnuary 1. 1943. Of these 632 men 339 had been as to 1924. The remaining 293 men reached the exposed to asbestos just exposure point at some time after 20 first- January 1 1943 and before the end of 1952 It is these dates insulations could cases of 20 years and it would have on the market that are significant in that they show that not have been involved to calcium silicate and longer exposure any appreciable extent in these been late in the Kaylo was the first of this type 1940's before any significant amount was Among the group of the 632 workers under and pleure during the 1958-1962 period study 18 died of cancer of the lung Even within this latest time bracket reported none could have worked for the specified period of 20 exclusively with or more years calcium silicate insulation Thus Kaylo insulation is indicted by direct evidence only by inference and The only common denominator is that aassbseosctioastiiosn aand act component of thermal insulation in general The carcinogenic property or contaminant of possibility that the calcium silicate processing should asbestos may be eliminated during not be ignored or dismissed from consideration WCT.ngm WCT.ngm wer 7. C. Taylor 01 009 0324