Document zZ30YEZQxDnywppKdaMdJeER

". . ..,. Benzene Shanghai Study ~ I til Introduction I Background , I:I-l -ooI 00 Vol 0\ January 26, 2001 A. R. Schnatter D l.IBOO-VHS-ZVH NCI EXPOSURE ESTIMATING REPORT . CONCERN NCI MOLECULAR EPI REPORT 7.6 PPM I BLOOD EFFECTS ~ ~ -~ (9 ~ ~ ~c;e.. NCI DOSE-RESPONSE ANALYSIS AML I MDS & NHL EFFECTS ~. "?~. ~ O. WONG TRIP EXPOSURE ASSESSMENT FEASIBLE BZ STATE OF THE SCIENCE CONFE~ENCE NO MORE BZ~~ .~ ARMSTRONG, IRONS, SCHNATTER TRIP BZ-INDUCED OX PRESENT PROPOSAL REVIEWED BY SAB SOUND PLAN ETHICAL REVIEW PANEL FORMED FURTHER TRIPS LABORATORY SPEC's CONSORTIUM BUILDING PROTOCOL DEVELOPMENT Shanghai Benzene Study Structure NHL, AML Study Disease Progression Study Molecular Epidemiology Study ~ I C/.l ~ .oo... w00 00 ..4~ Cases Controls HOSPITALS Shanghai Benzene Structure NHL, AML CC Study Disease Progression I Molecular Marker Study 9~~~C:C~~ \. ..J AML AA MDS -------- --...~~.-~-- --------- ------~------- ,, ...... ~ \ ....... DIAGNOSIS DATABASE --" --------------------- ---------------~~~- LABORATORY Molecular Epid. Study w o R K S I T E S !\ Why Shanghai? Largest Contributor to NCI Study Large Population (-14 million) Organized to Support Research (Fudan, SCDC, etc.) . / / tExposures Relatively High, But Decreasing l~. - ~~1A Willing Collaborators r' Research know-how Regulatory interest, mandate ~~r Technology imports ~ . I~Q/lI.t~ I ~1~\~~ Influential Contacts (I'~) JP'1~ \ l;;jr'lf" ;tIl .. .. Study Collaborators and Supporters (Partial List) FuHua - Deputy Dean of Fuda-n University School of Public Health - IARC I WHO links - Primary collaborator on all studies High level links into Chinese provincial & national governments Lu Wei Deputy Director General, Shanghai CDC >::t: - Responsible for enforcement of exposure standards N I til ::t: Lin Guowei - Director of Clinical Epidemiology, Fudan University ~ oo -00 - Vice President, Shanghai Hematology Society Past President, Chinese Hematology Society -.j:>. Primary clinical I diagnostic contact Zhou Shi Zhong Deputy Director, Institute of Public Health Supervision (CDC) Responsible for CDC exposure database Responsible for monitoring exposure Liang You-Xin - Chairman, National Committee on Exposure Standards Chairman, Occupational Preventive Med. Dept. Fudan Responsible for development of workplace exposure standards EXTENSIVE COLLABORATIVE TEAM IN PLACE, ANXIOUS TO START '. Benefits of Extensive Collaboration .. CHINESE PERSPECTIVE Import, Acquires Study Methods Expertise Enhances Professional Advancement - Publications Imports.. Leading Technology, Know-How Broadens Training Opportunities Allows Greater Autonomy in Future u.S. PERSPECTIVE Required to Navigate Socio-Political Infrastructure Ensures Adequate Participation Enhances Study Impact, Relevance Improves Business-Regulatory Interface in China Establishes Partner Spokespersons Summary: Shanghai Findings . -.. - High exposures Benzene-induced disease - Good records since 1970s ~ I t:/.I ,~ .oo.I... 1940's Exposures t<X;l - Technology sophistication - Willing collaborators - Influential contacts 21st Century Technology Unique, unparalleled research opportunities