Document zQq7m0GB8m32bmb3DNN4JY7Y6

so 000420 MAZ6 - CC: H. V. Bradley D. G. Wika W. A. Bower H. T. Begg Y. L. Power, H.D. J. . Schmid T, L. Schrenk J. F. Thomas B. J. Zipfel 9V& June 14, 1984 PERSONAL & CONFIDENTIAL TO: T. M. KEMP FROM: J. G, ISCHIAVO OPDftTB CM TBB G-8 BIPOD SAMPLING PROGRAM An overall drop continues to be observed in TEFLON Fine Powder/Dispersion and FEP Operators. In Table 1, it can be noted from the most recent blood sample results (right-hand columns) that 10 out of 14 Fine Powder/Dispersion Operators experienced a drop in blood C-8 levels. The 4 remaining Operators experienced increases. However, 3 of those 4 Operators experienced relatively small increases (< 10%) since their last sample was taken. In Table 2, it can be noted from the most recent blood sanple results (right-hand columns) that 8 out of 10 HEP Operators experienced a drop in blood C-8 levels. An additional Operator experienced no change. The one remaining Operator experienced an increase. Data on individuals who left TEFLON* (see Table 3) indicate that the average biological half-life of C-8 in the blood (i.e., the time it takes to reduce blood C-8 level by 50%) is approximately 2,4 years and can vary significantly by individual. Discussion Tables 1 and 2 contain blood C-8 data for TEFLON Fine Powder/Dispersion and FEP Operators. Blood C-8 data were obtained from the FLAIR (Fluoropolymers Laboratory Analysis information Retrieval) program. All blood samples were analyzed by the C-8 specific method. Only data on Operators who have worked in TEFLON HEP or Fine Pcwder/Dispersion at least 730 days as of the first of the 3 listed sample dates are included since new Operators will experience increasing bLood C-8 levels until an equilibrium level is reached. Fine Powder/Dispersion Operators experienced an average 24% drop in blood C-8 levels over the past 2 to 3 years. FEP Operators experienced an average 12% drop in blood C-8 levels over the past 2 to 3 years. 000421 T. M. KEMP - 2- JUNE 14, 1984 Although many of the Fine Pcwder/Dispersion Operators are experiencing blood C-8 decreases, there are 4 Operators whose blood 0-8 levels have increased. However, the increases experienced fcy3 of those 4 Operators were relatively small, that is, less than a 10% increase since their last sample result. The increases experienced by the remaining Operator is believed significant, and follow-up with this Operator will be dene. This particular Operator works a significant amount of overtime which mgy be contributing to the higher-tharrexpected levels. Follow-up with the one EBP Operator experiencing a blood C-8 increase will also be done. Blood C-8 data were obtained on 11 individuals who left TEETCN* due to transfer, resignation or retirement (see Table 3). Data on these individuals indicate that, on the average, it takes about 2.4 years to reduce blood C-8 levels fcy 50%. JGL:mah Attachments 0681m 000422 > TABLE 1 I TEFLON* PINE POWDERAllSPERSICM OPERATORS C-8 BLOOD SAMPLE RESULTS Date of First Sairole 1/14/82 2/18/82 10/8/81 8/7/81 10/1/81 2/11/82 8/12/81 4/2/82 1/7/82 4/6/81 3/11/82 8/19/81 3/26/82 9/15/81 7/16/81 7/16/81 3/3/82 2/9/82 9/8/82 10/9/81 08 in Blood to) 26.0 24.0* 11.0 9.4 8.2 7.0 6.9 5.6 4.4 4.3 3.9 3.5* 2.9* 2.6 2.5 2.5* 1.6 1.5 1.4* 1.3* Days in TEFLON* at SamL^ Date 9,358 2r332 9,260 2,379 5,813 1,989 1,743 8,311 5,765 857 800 871 8,242 9,176 5,652 1,705 5,880 770 829 1,803 X 6.78 ppm Date of 08 in Days in Second Blood . TEFLON* at Sanple to) Sample Date 1/12/83 2/17/83 11/3/82 8/6/82 9/29/82 2/10/83 7/15/82 3/2/83 1/7/83 5/12/82 3/10/83 8/17/82 3/18/83 9/14/82 6/17/82 6/30/82 3/22/83 2/10/82 10/4/83 10/6/82 20.0 25.0* 8.2 7.9 6,5 7.7 5.9 4.2 4.9 5.6 3.6 2.1* 2.8* 2.3 1.8 2.5* 1.5 1.2 1.3* 1.1* 9,721 2,696 9,651 2,743 6,176 2,353 2,080 8,645 6,130 1,258 1,164 1,234 8,599 9,540 5,988 2,054 6,264 1,136 1,220 2,165 X * 5.81 ppm Date of 08 in Days in Third Blood TEFLON* at Sample (mm) Sample Date 1/10/84 18.0 10,084 No Further Data 11/4/83 5.9 10,017 8/5/83 6.0 3,107 9/29/83 5.4 6,541 2/9/84 7.6 2,717 7/12/83 6.0 2,442 2/28/84 4.5 9,008 1/4/84 4.5 6,492 1/18/84 6.5 1,509 3/7/84 3.2 1,526 NO Further Data No Further Data 9/1/83 0.96 9,892 6/15/83 1.6 6,351 No Further Data 6/17/83 0.95 6,351 2/9/84 1.3 1,500 No Further Data No Further Data x * 5.17 ppm * These values ace not included in the column average in order to directly coiqpare the column averages. JGLsmah 6/14/84 0679m 000423 TRBLB 2 TEFLON* FEP QBERMDBS 0-8 SLOOP SAMPLE RESULTS Bate of G-8 in Days in First Blood TEFLON* at Sample (PPM) Sample Date 9/25/81 10/14/81 8/5/81 2/2/82 4/15/82 11/9/81 12/16/81 4/1/81 4/21/81 8/13/81 12/4/81 10/15/81 3/17/82 8/26/81 7.5* 4.5* 4.2 3.1 2.1* .1.8 1.8 1.3 1.25 1.20 0.82* 0.75 0.52 0.51 8,131 7,257 9,456 9,438 8,917 9,139 1,977 5,449 732 8,109 1,145 1,807 5,417 891 X " 1,64 ppm Date of S<econd Sample 9/23/82 8/18/83 7/29/82 2/21/83 4/14/83 12/13/82 1/12/83 3/31/82 10/9/81 7/12/82 12/1/83 10/14/82 3/17/83 7/29/82 C-8 in Blood lEEP) 6.3* 1.3* 4.2 2.8 1.5* 1.6 1.6 0.95 1.2 1.0 0.75* 0.72 0.44 0.48 Days in TEFLON* at Sample Date 8,494 7,930 9,814 9,822 9,281 9,538 2,369 5,813 903 8,442 1,872 2,171 5,782 1,228 X 3 1.50 ppm ate of 0-8 in Third Blood Sample (ppm) Days in TEFLON* at Sample Date No Further Data No Further Data 6/30/83 4.2 10,150 3/6/84 2.6 10,200 No Further Data 11/25/83 1.3 9,881 1/12/84 4/26/83 2.4 0.79 2,734 6,204 12/1/83 1.1 1,686 6/15/83 0.94 8,780 No Further Data 10/12/83 0.46 2,534 3/15/84 0.35 6,145 8/23/83 0.38 1,618 3c 45 ppm * These values are not included in the column average in order to directly conpare the column averages. JGLsmah 6/14/84 0680m t TABLE 3 EMPLOYEES WHO LEFT "TEFLON*" JOBS 0-8 in Blood When Left TEFLON* (ppm) 21.0* 19.0 3.8 2.1 1.3 0.64 0.57 0.22 0.14 0.11 0.11 X = 4.45 Epn 0-8 in Blood at A Later Date (ppm) 8.4 -- 16.0 2.2 1.7 0.49 0.47 0.14 0.15 0.08 0.078 0.053 x = 2.71 ppm Days Elapsed Between Samples 1,044 128 780 785 859 563 730 315 759 780 807 x = 686 days Reason for Leaving TEFLON* Retired from Company Retired from Ccnpany Retired from Conpany Retired from Company Trans. to another WW Div. Resigned from Conpany Trans, to another WW Div. Retired from Ccnpany Trans, to another WW Div. Trans, to another WW Div. Trans, to another WW Div. #.t45^2.71 x 100 = 39,1% average decrease over 686 days (1.9 yr.) 50.0% average decrease would occur over 877 days (2.4 yr.) * Sample was collected 4 months before individual left TEFLON*. All other results in this column represent the blood 0-8 level at the time individual left TEFLON*. JGL:mah 6/14/84 0678m 000425