Document zQRB736axqppd5JGOYRQvK0JR

Minutes of Meeting Ethyl Medical Department February i960 Vernon Manor Hotel Cincinnati, Ohio '-sent at Meeting: -)r. Kehoe Dr. Kitzmiller Dr. Princi Mr. ./heeler Mr. Cholak Dr. Sanders Dr. Schradin D r . Bock Dr. Sprunk Dr. Brus t Dr. Horton Dr. Davis Dr . Kit zmlller opened the meeting at 9:/+5 AM. A 3 the first order of bus iness, Dr. Kitzmille r requested clan ificat;ion of the role of D r . Kehoe as consultant to Ethyl Co i'por ation anci to the Medical Depart m e n t . Dr c Kehoe replied as foil ows. He des cribed the early his tory cf ni s; relationship to Ethyl Corporation . He st res sea the ciolic ate fea1.ance of relationships between his universi ty responsib iiit ies ana his responsibil ities to the Ethyl Corpora tion. Since 195 -- > h 0V/ever , his role has bee n that of consultant tc the Core ora tion with particular reference to the experimental work performed at the Kettering Laboratory for the Corporation. He has been par ticularly concerned where the problems under consideration relate to the matters of the public health. He has continued to main tain relationships with the United States Public Health Service ana the Canadian Government in these matters. In addition, he has been concerned with the tetramethyl lead program and the organic manganese and nickel programs. He stated that his pre sent medical activities for the Corporation were entirely outside cf the day-by-day activities of the Medical Department. Unless consulted by the Medical Department, he planned not to be con cerned with the affairs and operation of the Medical Department. Dr. princi asked the question of who is to decide the priority of reports where individuals have dual responsIbi1it y , both to the Kettering Laboratory and to the Ethyl Corporation, Dr, Kshoe answered that the individual with dual responsibilit\r would have to make his own decision as best he could. Dr. princi raised a specific point in illustration of his question. It; had to ao with a memorandum from Dr. Horton to Dr. Brust concerning information about the toxicity of AN compounds for an Ethyl brocnure. Neither Dr. Kitzmiller nor Dr. Sanders had been informed of this request. )jj$ I 0 2 2 4 9 -c L - ;hoe suggested that this was a problem of intra-labor 'cation. That properly, Dr, Kitzmilie r ano Dr. Dane ers : have been informed by means cf cai'bcn copies of the cori1e :nce. Dr. Kitzmiller added that genera lly he would 1ike to :e copies of all memoranda concerning tne activities of th s 1 department. However, in this ins tan ce he thougnt that trie :--e of toxicological information coula b handled w thout .rect knowledge. Dr. Kehoe suggested t t -renerai xv tnes e ms could be resolved without difficult y out that tr re be instances in which it 'would be diff icult tc deci o ' r', o p o kions to the university endeu and ooli gations to tne Cor .on started. He suggested that it woul u be important to ; responsibilities as carefully as poss iole to avoia futa re :ulties such as might arise in the area s of confidentiali 'cmat ion. .1czmiller raised the question of the handling of confidential - "ration by secretaries. Dr. Kehoe replica that in certain ..aces it is essential that secretaries be hired specifically ve affairs of the Corporation and be permitted to navale cori ntia 1 information apart from the general university activities. ..Ltzmiller raised the question which referred to an earlier m e of Dr. Kehoe 3. Dr. Kehoe had stated that if the organi.r.a1 pattern interfered with the accomplishment cf the work of oxrtrnent that the organizational pattern would have to oe .sea. Dr. Kitzmiller suggested that If such were necessary ,ve organizational pattern might be altered to avoid inter vith the accomplishment of the work of the department. vse brought up the point that it is necessary for the Tcxi'v Division to inform the Director of the Laboratory of its '.'ties even before the Director of the iledical Department cf lor deration may be informed about the results cf certain, of n-perimental projects that relate to the Ethyl Corporation > .' '".oe suggested that copies of correspondence sent to the i becica Director are not sufficient to inform the Director m- Laboratory and that personal and telephone conversa tic:;.-: 'liish the job more effectively. banders suggested that the problems of communi ca tion concernexperimental work were primarily a matter of Kettering Lacora- erganization and it was not primarily u matter of concern of -Odical Department of the Corporation. He did request claris?> t-or. cf his source of information concerning toxicologic inferxc if he were to remain the liaison between the Kettering Labo- ana the Ethyl Research Laboratories at Detroit. winders suggested that he be informed as to how much informa vere available about new materials ana wanted to know whether -t was to ge't his information directly from the Director V lettering Laboratory or from the Director of the Division fcs. i 02250 / / f /u / 3- of -poxi col ogy of th e Ke 11 nning Laboratory. Dr. Ko tc0 sug f i sted cha t thi s probl era could r.et be resolved at -J 'ea cifi:r slxch Ciij x!fi sent on e . H e ad ded th~i erre Ethyl Core ora ti on ha s u3 3a1ly v-i f i -- C6 iV ec tha c inf orma tu or. wr1*'ch is ava ila ole as rom ot1J a 3 Vas pra r>tical to pr ovid e it. D r . Ki tzmi H e r adde a eha t un organizsiiona 1 pa ctern -Ls c s n sfi t up i.f1or che Lieciical Depart m.ent that will el ini na te thO r.if piCu1 tles .vhiCh have ari sQn in the pa sc. He asked Dr Ke hoe t0 ola r-Lf*-- C .h e are a of ac tivi ties of cne kaltering Labors tor v cha c clpP 0z a e con cern of the Medi cal De pa rtment of che Cor por a ti on Dr. Kencs sugge sted tha t i t would not oe too a i ffi c ui Co se oa _ rat 0 the fur.ctions of the IIedic.al De parine nt of th Q n0r>po ratior; fro i the a ct ivi ties of th Q Kettering Labrate - w i ' J as r Iat ea to fio mea ica 1 pro b lem s of tne Corporation. Dr. L eho a ticld ea hna U toxico logic inf ormati on of interest to th e Det ro it La b0ra bOP es of the Corco ration could be handled G j_re ct 1J b j the Di r fi c - tor of t he Kett erin g Labo ra tory or by the per scns in ch a la boi*a - cory concerned with che toxicology activities. Dr. Kehoe added that there would be a time when the toxicologic information developed by the laboratory becomes of greac impor tance tc the Medical Department. He cited the example of tetram.ethyl lead in its early evaluation in the laboratory. he also suggested that the transfer of this information from tne labora tory tc the Medical Department of the Corooration could be accom odi shed easily. Dr. Kitzniller asked about the priorities of research on new prod ucts ana as tc whether or not this priority was directed by the needs of the Detroit Laboratory or by pressure from tne Sales d e partment of the Corporation. Dr. Kehoe replied thj t in terms of : '.e screening procedures the Kettering Laboratory knows only chat -or- Etnyl Laboratories at Detroit or at Bator; ucuge nave become in- treated in the compounds submitted for toxicity screening. L r , Kehoe added that the laboratory is not concerned 'with tne interest of other activities of tire Corporation relating to new compounds screened by the Kettering Laboratory for tne uetrcic aasoratory. ' vehoe suggested that at the Detroit and catn Lou La cora '3 , Drs. Sorunk and Bock 'were the members of the ba ical cent oi t-h\e Corooration concerned wi n trie problem. Dr. um.r. >.r added that there is now a consul ting team within che al Deoartment to orovide information ,o the medical aepart a n + i 'du Detroit and Eaton riouge concc>rning the toxicit;.j of new materials. Dr. Kitzniller suggested that periodic prrcogress re torts from. Dr. Brust to the Director of the Medicai department `-f the Corooration 'would belo the Medical Department in advising / the physicians at Baton xiouge and at Detroit of the amount of in formation known on new compounds. Dr. Brust requested information concerning his past failures to provide information to the Corporation. He adcxed the following to illustrate his difficulties. He has receivQa materials from, the Ethyl Laboratory at Detroit for screening without any know ledge as to the potential use of the material to be screened. Expensive procedures nay be carried out which centri bute no use ful information to the Detroit Laboratories before the Toxicology Division is aware of the potential use of the material. Dr. Hehce suggested that further information be requested from the Detroit Laboratories before any screening procedures have been carried out, Dr, Bock mentioned the fact that until a few years ago no repre sented the Medical Department at Baton Hougs and screened all m a terials for the benefit of the Kettering Laboratory before they were shipped from Baton nouge to the Kettering Laboratory. In recent years, however, this system has broken ccvvn because of in ternal difficulties at Eaton Rouge. Dr, Bock mentioned that prior to lbi+5 the bay-by-day medical activities at the Baton Rouge plant were managed by the DuPont Medical Staff located at that plant and chat: the Liecical Depart sent of the Ethyl Corporation had only an informal aavisory re lationship to that department ne added that the local medical activities at Baton Rouge hav usually boeri a matter of concern only to the medical people at Baton Rouge. Cholak raised a question of his relationsnip to the weuic aepa rtmsnt of the Corporation. He wanted to know vnether or not repo rts of analytical determinations go to the people in the Cor- tion who request the services. The alternative wouia be the Lssicn of reports to the Director of the Kettering Labors tor; Kehoe reolied that all work done by the Kettering Laborst V> T ' v' J . Ethyl Corporation should be reviewed one uir 0f lering Laboratori 0 : ime oerson u: ateo c j tc 0.v the reports. He added than chax*ges uro made to she Co r- jc ra tion by the Kettering Laboratory for work done as a servi and therefore are primarily a function of the laboratory* He aug ea that advice and consultation, given by members of the Ko Ing Laboratory Staff to the Corporation at the time of visits the places of manufacture or laboratory development are no t rr. I"1 r.orcern to the Kettering Laboratory directly. Dr. Kitzmiller re-enforced the statement of Dr. Eehoe by reading a memo from Dr. Kehoe to the Kettering Laboratory Staff concernir: the furnishing of information directly to the outlying es tsolish tents of the Ethyl Corporation. The memo requested chat all ana lytical information performed for che Corporation by the Ketteri La coratory be submitted to the Director for review prior to the sending of this informati or: directly concerned. 01 t h e Co r co r Dr, Kehoe presented a discuss Lor. . concerning the change In the limit to gasoline, recently the [ -tea Sta greed that the industry r.av .nc re a - => to the extent of ml per alien,, j:*. v the recent Kettering La bora tor nirlirotlo logical Effects of the Increase Lr. ta.c Le--. also mentioned the fact that knit.-,. otat-y, has published a report on tho exporter h u ts traethyl lead in gasoline. t e r a .ns',^a 0?> o f ~ *an O C l l c v Tit n y l l e a n :11c He a l t h 30 r*v I c 0 - a c c-n t ? n t Of . ga s o l i : : - 0p -s Ir t he i. wu t Ex o e co p ie s r*t e d 3i 0 - of li"'"ppi 0f 1c ~h\ s o l i. n o , "7Q Ho a l t ; ; S e n v i c ^ s e i: Lhe Uso o f The United btates Public Healta S-rvlr- an of neither permitting or prohibit 1r. * tr.e 1 gasoline but merely permitting th inuustr he aoaec that the reversal In atticuue r-,on the prohibition of incr-s^mh Ir.u. unite Li,a 0 0 1e Ci a n a 11 i t uo e i ea s e I n 1e a d i n g o f 00 p r o ce eu rs i\.o t t 0 v->i n g 0n La its cora own . , tory o f ga S Ul i n -'-s i n measure'influenced by the reports of oho marketing o-ool- --nd y , Detroit Laboratories that lean consumption woulu noV'co o"mar'"3 edl,^ loxi t.ie irantxn of p e r n ss ui; to _ric t'ease the l-^-'c; it * :rcm 3 to 4 ml per gallon. This privilege will only" be usea m areas where otner notaoas of pruuuc In.g or'-h' octane gasoline are not available to the refiner's,, The meeting was interrupted at noon for lunch, ihelir.g was resumed at 1:00 Pi: wi thout Dr. Kehoe, u` * Ki oir.ilxsr called lor cu^stionr. roncernin:* the ooc' in'*s o*' the morning. Dr. Sprunk requester clarification of''th - ' - m o r a r ^ u - concerning t.ne reporting of Kettorin; Laboratory a n a i - t ^ O ,, ,, O Y O Dr. nitzmiiler clarified this and ' c i t g - h m the ues l r e ^ 7 e 3 0 " ^ ihnoe to review all Kettering analytical laboratory oat- n o r` *t- tr.eir ceing sent to the various departments o, "Coreo ra 11or:, D r , oitzmiller also uddea sh u t the x n u u o t r : -.1 '-im a - Dthyi Co roo ration- Medical D-pertm-nt at hr- n- 11-r -'a C o t --3 .V,,s preparea to go cut to ail outlylr. ; Diri ' of -- - - po rat ion to advise concerning the r o l e that the Kett =r l ~ V a b o r - - ' tory should play In the control of hazarcs at the j* '' ` ~ " c r i e s a n a a t m a n u f a c t u r i n g f a c i l i t i e s o f t h e t h y l " C c r o o r a t i c r ^ '*" - * l*j- " i l l e r r e a d u .ie a n n o u n c e r u e n t -ano d e s c r i p t i o n o f ' t - e i n - a us t r i a l H e a l t h Team o f t h e m e d i c a l D e o u r t m e n t ~ o f fh ls w i l l be a v a ila b le fo r la b or in s p e ct io n . he Cor"oo" ra` t*i~on L'p elaborated on the concept of the Industrial Health T^am as follows. All medical advice to -the comoati^ should com f-0~3 tne ileal cal Director. All medical control at"the olant `or r - a r m la ocratory level should be nancleu through the chief o n y s i c i L V a t ^ -6 laboratory concerned, Dr. Princi da: ci?; :f an hypothetical problem starting with proc trial. The procedures described were a ime a :f new information as raoialy as oossible an, - yuu" this information il. .hi n Torma - ,1 a also be available for describution to other activities :rpcration and to public Health officials who may be con- tn the public health hazards associated with the use of rial. Dr. Princi also described the Industrial Hygiene .ich is in the process of being prepared by hr, wheeler. . . g r i n d emphasized the need for an annual report which should - suomltte to the i.ieaical Director. Dr. Princi requested that '.munications from members of the Corporation Lleuical Department the laboratory not go to Dr. Kehoe routinely. If It is neces: - dor Dr. Kehoe to be notified concerning these requests that - so notified by separate communication. . iluzm.iller clarified the role of Dr. Brust in the preparation / Zthyl Medical Department manuals. Dr. Brust will furnish in .mmation available in the reports of the Toxicology Division of 'lettering Laboratory and material developed out of new experir:t -1 crk done by the Division of Toxicology. ust raised the question of responsibility on the part a 1 : n a ;rave lin g thro ugh the Detroit Labo ru tory wh o mwap ce re- meo ! me; .cal ooinions on the scene Dr. princi rei ;-:d M :e policy that all members of the Cincinnati Medical Le- :ment v/ho visit other facilities of the Corporation will r e . 0 w , ins physician on the local scene and that all opinions reco: .endations be delivered eithe: to tae j:i j 'un c t. with the ohysiclans recommendations or. X - - > i, ?o ' Dr Brust raised the question of unofficial reports or. tox- j O u* ; dies and the hazards of reporting such information to - n p n rch personnel before the final answer mas oeen obtained. Pr ir. 1 reoliea that r:o information should be giver, unless e is -rr.oupn reas on to be certain chat the answer 3anu reiterated joint D r . Bock commented on the pros a c t i v e changes ir; the Lleuical aecartment structure and in general expressed approval of the iuea. Be aid raise several questions, however. i'he first question me raised was that of titles of persons. he suggested that each olar.t nave its own plant Medical Director and that the heaa of tae Central Medical Department of the Corporation be called Chief Medical Director of the Corporation. Dr. Bock also rais-'a the question as to whether or not the plant physician should be re sponsible for the environmental survey and control of the plant. He was of the opinion that the physician should be concerned only with the detection of illness of individuals who work within the plant. There was considerable difference of opinion among other 0225 7- - persons present as to whether the physician should be con cornea with industrial hygiene problems. Dr. Kitzniller reiterated tne fact that the Industrial Health Team was designed to provide service to the physician on the local scene. The repones of this team will be made to the local plant pnysician. The local plant physician will then be responsible for che transmission of this informacin to slant oersonnel. Dr. Bock agreed that the Medical Director at the slant coula be the responsible person if his position in the management scale .vas commensurate with his responsibilities for the maintenance of the health of the plant. Dr. Kitzmiller surges tea chat Dr. Bock could command any of the resources of the Ideal cal Depart ment for the evaluation of problem situations by communicating directly with Dr. Princi. Dr. Bock raised the question cf the authority of the Medical D e partment tc effect any changes in the o per at lor. of the plant. His experience at Baton rtouge had led him to the oelief thuc management would have to be changed considerably before they would accept the concept that the Medical Department of the Corporation has authority to effect changes for the purposes of control of health hazards. Dr. Kitzmillor suggested that the Medical Depart ment could use its influence if plant management were net receptive to suggestions made by the local medical department. Mr. Chclak raised the question cf whether or net the Industrial Hygienist, Mr. '.Vheeler, should inspect planes without prior an nouncement fie contended that the unannounced a poearar.ee of c; ncustrial Hygienist would not be calculated to engender c um of co-operation on the part cf the plant manager. Dr. Princi greed and stated that the description of th activities c nous trial iygienist should be re-written so that L v i s i t ;iarv ana research laboratories be orimarilv on a scn; Hr. ./heeler explained that as of the present time he h s cover: on_y the manufacturing plants. He has been to tne Det ox t ij d scries once on an informal visit. He has been invitee to t he as Sarnia, but-he has not as yet visited that plans. Is was agreed that the Industrial Hygienist ana the Industrial Health Team would submit its report to both Dr. Princi ana to tne local plant Medical Director. The local Medical Director will then have the responsibility to bring the recommenaacions to the Industrial Health Team to the attention of the plant manager. Dr. Bock mentioned that Mr. Turner has recently maae specific re c ommendations in writing to the people who are in the research ana development group concerning the communications pattern which should be followed for the purpose of handling the health control problems. Dr. Bock suggested that the Medical Department look into the specific f) / 9 V K -3- recommendations made by I.Ir. Turner in this m s one t to cstermir.e whether or not they are in harmony with the recor.:msncations made by Dr. Princi at this meeting. hr. wheeler brought up the question of the differences of medical practice among the various plants. He cite- the differences in practice in regard to audiometry ana to restrictions that exist between the Houston plant and the Eaton .\ouge plant. Dr. Princi suggested that such differences in practice be brought up at annual meetings of the Medical department an- oe aiscussea to determine whether or not there are good reasons for d 1ff erences in oractice. Dr. aock agreed with the desirability of working out cetails of policy procedures for the medical departments of all slants at subsequent meetings. Dr. Kehoe returned to the meeting at this point. He distributed conies of the resort of the United States public Health Service concerning the addition of 4. cc of TEL to marketable gasoline. He stressed the points that (1) United States public Health Service does not have the power to encourage the use of it, (k) that this report is neither a regulation nor should it be interpreted as an agreement between -the United States Public Health Service ana the industry to permit the industry to do this. Dr. ivehoe stated that to the best of his knowledge there are no state laws which restrict the use of t etraebhyl lead in gasoline. He aid mention the pro posed law in the state of California which will set a maximum a l lows* ole concentration for lead in the atmosphere. Just what this limit will be and how it will be cnfcrc"a were not discussed. ur nenoe aesc: bed _prosp_ective use o. le ao in ga scline - a iscussed the name of company involved a no the geo '-tt>>v*"i^gjphi cal area hich this material is to be introduced. Dr. .ehoO Q esc o experimental study In which the effects of te ram eth 1otn 1n X 1 L, motive fuel were studied in a group of taxi-c: D Cl.T`C VSI'S .-a .Iscussea the relative toxicities of tetraethyl leva ana tetru- ' a ; yl lead. He stressed" the fact that the character ..f lead in the exhaust is not changed substantially when tecramethyl leau is sues tituted for tetraethyl lead in gasoline. Tetramethyl lead is cons iderably more volatile than tetraethyl lead. The rate of skin uoso ration of tetramethyl lead is much less than that of tetru- e thy 1 lead. Dr. Kehoe has discussed the possibility of substituting tetramethyl lead for tetraethyl lead with persons in the United States Public Health Service. These discussions have been held at an informal level. At this point persons in the United States Public Health Service are deciding whether or not a statement should be issued to the public relative to the substitution of tetrametnyl leua for tetraethyl lead. Under any circumstances, it will oe the obliga cion of the Ethyl Corporation to continue to obtain data on the likely effects of tetrametnyl lead on the public health until it is certain that tnese are not significantly greater than those of tetraethyl lean. Inasmuch as TML produces approximately one ana one-half times the octane boost of TEL of the same inorganic leua content, Dr. he hoe will suggest that for the present tine the industry limit the a c aition of Ti.1L to the extent of 2 cc. Because TI1L is more volatile than TEL, Dr. Kehoe suggested that the handling problems associate with Ti.IL will be greater than those created by TEL. h r . .heeler added that the use of methyl chloride In the manufacture of TI.1L may require more control than was required by the use of etnyl chloride in the production of TEL. Dr. Bock described the prospective plans for following the men at Baton itouge who will be making TML. Only three men will be con cerned directly with its manufacture. The maintenance personnel will be used interchangeably in the TI.1L ana TEL units so that it will not be possible to follow their lead excretion rates as a con trol measure. No data were obtained from the personnel who worked with TML in the development stage. Mr. ./heeler also raised the question of the inaavisabllity of aerating to scrub TML out of the sludge of the manufacture of TML. High volatility of TML makes it inadvisable to do this. How this problem will be handled has not yet been aeciaeu. Dr. Brust described the experimental program contemolatec for the evaluation of toxicity of TML. Dr. Horton described prospective studies of the absorption ar.c excretion of TML as determined by use of raaio Isotopes, .-it pres ent, the laboratory is using tritiatea conpcunas. In the near future they hope to incorporate the use of raaiun-D in tetramethyl lead for the purpose of following the metabolism of tetrametnyl lead in animals. . Dr. Kitzmiller closed the meeting at 5:55 BM. '