Document zQQvzN8aJ345vXXYey0bBGpO0

o rS E A S E S rfif.i A L JH ETALTiH RUTHERFORD T. .JOHNSTONE, M.D. . BR OCKM AN BUILDIN G 520 WEST SEVENTH STREET L os A n g e le s 14, C alif. M ADISON 3 - 2 9 6 5 April 19, 1960 IN D U STR IA L TO XIC O LO G Y PLANT SURVEY Robert Kehoe, M.D. Kettering Laboratory University of Cincinnati Eden! St Cincinnati, Ohio ,- Dear 3-ob: , < In order that you will understand what report I `am referring to in my letter to John Zapp I am enclosing a Thprmofax copy. Are you in agreement with this report? I understand some of our California officials have mis construed your- opinion. Do you feel that the substitution of Tf.iL for TEL is apt to be considerable? . In haste, R. T. Johnston M.D. RTj/rcm Enclosure 2 N 6078 jju t r.he h i p e s t p r a o t i c f t i 'cio ae ; V i o l ' e th yle n e .-'d lb ro o ld ,' h o w e ve r; - t.fmfiixittuurree..' Aobnorrmmaaxl c e na wt rma l -niwe*r-vtwo uus9, `l- ,'-*TEL r a b b i t a-'which- d ie 'dV, The* r e a c ti o n :o f;;r a b b i ta -t to_ TEL^ w a^ qU l e . i?fdlJ f e r e n t fro m ' t h a t . o 'f ;r a t e t o d vth a t- re p o rte d '-`l a ? ^ V / . ') * y ;. ".ai :n?&ii:rWirm*ams '.R_e _p _e a*t e.*d . e ?-* xpos u .r.e.,. '`*o*f ;Tr.ia *te ttoft T '`S-'TL. an.di- THL: vappoorr*--faah~hocow-v~farod-.aa-**. .55*...-*? n e a te r ; cu m u lative , t o x i c i t y o f,.th e l>rnfer% F i v a '^ h W / f J P O - i J J , * . # ourea to 0 .? -m g / lit o le ad * ^ ^ h _ dea ' ...........................i j j -- - Sm * ? i ^ A T ? :* '' "v " ' ' ' ' ` by way of illustration the following examples may .be cited; . In the case of the central nervous system, TML involved the meninges and choroid plexus t o .a greater degree than did Til. Thera v was a consistently greater degree of neuron degeneration in animals ,, exposed to -TML..-than: those exposed to'TEL. This neuron .damage was proportionate- to the dose o f V T M L 'aiid. appeared early after exposure. _ Again cerebral edema >iqb more prominent in,TML? .exposed animals than : in the TEL exposed animals. In the TEL exposed animals, on the con- tr&ry, there was more perivascular reactiori in the ne'rvous tissue than In the TiML animals. . , T. ! In the case of the spleen,'- TML caused progressive decrease 'in^Lynphold and^^gakf-ryiroytef. oomponents- vd i4s>an;i->^er.2 a-'--in -rah?r*b--r* phagesi This ciiaiigt was not ouservad in they ease' of TEu- exposed rats.. By contrast, the liver appeared to be effected somewhat more significantly in TEL animals than,in the TML animals, thus there was more vacuolar degeneration of cells, mere cloudy swelling and more polyploidy in the, animals receiving TJSL. '; tn + h respect to the pancreas, there was significant vacuolar . d e g e n e r a t i o n of the acini in the TEL exposed animals. In some of these animals the process h a d advanced to a cvatii stase. There was al s', appreciuoly mere degeneration of the beta ceils of the pancreatic'. i3leta of TEL exposed animals as compared to "ML animals . -:'? M- 'M In the case of the kidney, tnere was more degeneration of the tuoules in TEL exposed animals than in the TML exposed animals. - On the other hand the glomeruli snowed more ground substance changes^ in t he TM-L than in TEL expf osed ' anim' a. ls.' `.'V, \\ -, J " ir.t; i.ungs we:'" particularly ai footed when those s 'ios tancea-'r/; were inhaled . Inere was more injury to tjjcoc vessels and oar:i liariea \ in the lunge cf animals exposed to TEL than in tnose exposed to TML.1' The bronchioles in tne TLL exposed group el so shcwyjd greater adven-v^. .1"J fu\n i/.I 1. t*b., "MJ `jffYt1#a . *Ph,- n. .o - affected mere si nil leant j.y in TML than in TEL animals. Tne */mph< .4^ tissue underwent alight hypertrophy in Tel- expr l-ri anin rl3, wr.ereaa. t h e r e wa3 a t r o p h y o f lid. .3 9b- ii ba s u o . ; - IJV' DlrCULdTON ` V:; ru.' '' ' ' fh f h e a c u t e l e t h a l d s e o f TML he a d o en s ho w n c b e g r e a t e r . t h a n t h a t o f TEL whon -...a- m a t e r i a 1 g v e r e au mj. n i i eroe* r al 1y, by .Stein 4 a b s o r p t i o n a nd u y i r . n j u . a t i o n { T a b l a ' . ' I l ) . I n &d<u 1 l i e n comparar Te '~ I d o s e 3 o f t h e two c o m p c u r d a **w1 ..h r x o p a c i * c . l e u . i?.c ri Ci wrrr acri:.- . j isterod by inhalation csiij snowed j . to be Uie more . ' lethal of cno two. T  j - 1: f h :;. i # ; / H f . - .** U ' /' , ^ tj vif* r 1 i* : BMM Bi -4r. / \,<t ,L1 '-.M'.'J rii i , - 'ii. i >' ,; [ f``:/ ' : -3,, - -- ------ i-- > ' V J , : >; " .`o 1 - ^ *! p .-* 1 '* .rX -- 1-- * ...*.. . ! - ^.^-_ *Ii #* t* '*" ' 1, '. , .- ' ' * ~-` > 1 ` . ' J \ f.. -..rA---;,:, ' -- -- -- L ,x _ *j. ' .*\< ? "-r,. ii"*. .. '/-'* '-- *-, ..,-J : 0 . n > C * r -- *>>:*v-.V' />" `t-V-f.; * r '% t~.ni .* : -^'j/.,,., ' ;-. ; ' i.' i iV'* ;r.,>>,.-v*sri , -.' `*j ;-j ikWiivVi v -.--te ^ tCr.-.J - V ' :. RTJ/rcm 6^ 7> 'pi y O R D T. JOHNSTONE, M.D. ^ ROCKM AN B U ILD IN G 520 WEST SEVENTH STREET Los A n g eles 14, Calif. MADISON 3 - 2 9 6 5 April 19 I960 IN D U S TR IA L TO XICO LO G Y PLANT SURVEY >*' ' | ` John Zapp, H.D* Haskell Laboratory illlinington 98 , Delaware Dear John* Recently there has cose into ray hands a copy of the "Haskell Report* on results of animal experimentation with tetramethyl lead The sender wrote that it is "confidential*" However I am lead to believe that a great many people know that this gasoline additive is being considered by petroleum industries* The point of this letter is this - ray book is in press but it is probably not too late to squeez in a note regarding ?ML* Is there any reason why DuPont would object? Sincerely yours, R. T* Johnstone, M.D. RTj/rem t '001903