Document zQL7mEpoKX78bXe21OL5Gbzja

^P^5T05/5 AND LUNG CANCER Table 2.--Mode of Exposure and Carcinoma available. Sections and eosin and with diagnosis had been xposure, gross apE diffuse interstitial istos fibers and/or 'Mode of . Brposuro VS;;;:..`robrtMton rocesr workers ^i'fjMlnets No. of Coses (S3) 33 9 6 No. With Tumor (10) 3 K&ii'___ -______ _ '^Jfrom. main bronchi, distal air passages, to pleura. The following cases have been H'Npieviously published: case 3, Clinico-Patho- j^i'lpgical Conference, Massachusetts General 7&&Hospital, 1947; case 2, Isselbacher et al, .Is of the ten cases Cwj;1953; and case 8, Jones Williams, 1957. In jxception all were >;ithe present series, particular attention was a maximum num- ^.'focused on the bronchial epithelium. Five tails of exposure ^ ..Cases showed well-marked squamous meta- ft* cinoma cases: six 47 plasia of main bronchi; three of these were workers, and one ^associated with carcinoma but only one was iows the exposure ^ squamous, and the other two were adeno- Kie total series: 33 workers, and six pCcarcinomata. Four of the five showed well%jrharked bronchiectasis. I have previously the distribution of ^discussed and illustrated (1957) changes in . Fabricators in- SSjjKe peripheral alveolar epithelium in this ipinners, and in ^j'eries. workers are those j^.In ten of the 52 cases there was con- g asbestos fibers ayffimitant tuberculosis (19.2%), all without >n of exposure of 'Carcinoma. With two exceptions, both having exception, was 12 jjubapical cavitation, all showed extensive il series the range IJibcrculous bronchopneumonia which was 5 with less and 17 ie cause of death. In the majority, ;xposure. fuberculosis developed a considerable time showed various i, three; anaplastic, .wo; alveolar cell thelioma of pleura, .ible sites of origin, the diagnosis of asbestosis. Histo- fegically, there appeared to be no modification j^fthe tuberculous reaction by the underlying jjjajist fibrosis. rf*iFW0 l^e tcn sl'`cos's to a minor rsfegree. One was an asbestos miner and the e, Sex. Exposure, Ustalogy |her was exposed to silica flour in the manuScture of asbestos pipes. In the total series tlon nijtolosjr here were four others with silicosis, a total |jsixof 52 (11%). Anaplutlc Adooccorcloomi Squtmoui Endothelioma pleure. i Adonocnrclnonm i Bqunmou.i Anaphutlo Alveolar coll I Squamous t AnoplMtle Conclusion |-This report records 52 American cases of jJ?jist0sis among whom there were ten pa- |its with malignant tumors, an incidence ilar to that reported in Britain, any American pathologists permitted access to material and records. (i-Jones Williams, MD, Institute of Pathology. National School of Medicine, Cardiff, Wales. : Williams 45 REFERENCES 1. Andqrson, J., and Campagna, F. A: Asbes tosis and Carcinoma of Lung: Case Report and Review of Literature, Arch Environ Health 1:2732, 1960. 2. Annual Report of Chief Inspector of Fac tories for 1958, London: Her Majesty's Stationery Office, 1959, p 45. 3. Clinieo-Pathological Conference of Massachu setts General Hospital, New Eng J Med 236:407412, 1947. 4. Cordova, J. F.; Tesluk, H.; and Kmidtson, K. P.: Asbestosis and Carcinoma of Lung, Cancer 15:1181-1187, 1962. 5. Doll, R.: Mortality From Lung Cancer in As bestos Workers, Brit J Industr Med 12:81-86, 1955. 6. Egbert, D. S., and Geiger, A. J.: Pulmonary Asbestosis and Carcinoma: Report of Case With Necropsy Findings, Amer Rev Tuberc 34:143-150, 1936. 7. Gloyne, S. R.: Pneumoconiosis: Histological Survey of Necropsy Material in 1205 Cases, Lancet 1:810-814, 1951. 8. Hannon, J. W. 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