Document zQ5bLadpX8EGd09V3M9KBXgr3

AR226-2822 Company Sanitized. Does not coma-irt 08 bonta&ned components which had hoiliog points in the range > 10C/760 an Sg to 11C/S cffl h|"I Because of the difficulty in aetering a-^^uire^df c ^ a s ^ t .coi^OBlItion, animals were exposed in. two separate teste to two fractions of the mixture one,-an 'udpfer^i^eifoii^'cei^eiit of Iwer^boiii-ng gaehoua cemphuadh the other, a "Bottom Fraction", consisting of tiigherboiling liquid eotejSOiiftdSt, .ggojgediBEfti a).- "goner Fraction"; the teat material was metered as a gao through a glass flowmeter into a measured dil^|hjf:djpiied:ifsf;:Sfcreiia" "Me^diiuKed mixture was then .passed through an filter hell jar containing four young adult rats-, b 'j- wBottomi fafetieagt the teat material was:: naelesied a ,a liquid hy.syrihge drive into a dried air stream which, with its vapor, was then passed into an 8-llter hell jar containing four young adult male CWl-Cfi idta. Results 5 In both tests, survivors were sacrificed 14 days after the exposure. Exposure Nominal Time Concentration (hrs.) Air Flow Cliters/minJ Mortality Ratio Clinic... Signs of Toxicity Gross Pathologic Granges, 40,000 .ppm (ce, 400 mg/X.) 1,92 "Upper greetlea11 4/4 Purina Exposure: rapid, deep,, labored and pumping respire' : tion; prostration; liquid from mouth at death; 3/4 died j in 1After Exposures 1/4 died withj* hour Lethal Concentrations; marked edema and congestloti o lungs with pleural effusion. Sur vivor of 20,000 ppm exposure showed lightly elevated lung weights 14 days poet: exposure 1 Nominal Concentration Exposure Time (hrs.) 20,000 ppm (ca, 200 mg/L) 4 Air Flow (liters/mln,) 1.96 Mortality Ratio 2/4 10,000 ppm (ca, 100 mg/L) 4 1.98 0/4 23,4 rag/L 4 2,00 "Bot 2/4 13,9 mg/L 4 2 .28 0/4 Company Sanitized. Does not contain cr> O >o 09 2 Clinical Signs of Toxicity, During Kxposvre: same as at 40,000 ppm After Exposure: 2/4 died 1 day after exposure; labored respi ration and weight loss for 2 days Gross Pathologic Changes Nonlethal Concentration: none attributable to test material 14 days post exposure During Exposure: labored respi ration; lacrlmation with pig-, mented diacharge around eyes and nose After Exposure: recovery withr in 1 day tom Fraction'* During Exposure; discomfort; labored respiration; gasping After Exposure: labored respiration up to 9 days; weight loss in one survivor until sacrificed; death of 2/4 at 1 and 9 days Lethal Concentration: severe lung damage (no pleural effusion!; lung weights of survivors elevated 14 days post exposure; weights of liver, spleen, kidneys and testes depressed in survivors 14 days post exposure During Exposure: same as at 23.4 mg/L; irritation of nose,j mouth and eyes, pigmented dis4 charge from eyes, in addition; After Exposure: marked weight loss first day followed by Irregular losses and gains; "noisy" respiration for 8 days, Nor.lethal Concentration: eleva tion of lung weights 14 days post exposure; multiple abscesses of iung in l rat <9 3- SKIN IRRITATION AND SENSITIZATION t fc tc Ziocedure: In the test for primarv irriin - - - s?.db:.kdo.fks ln - 1 wLeks later, the ani.als were given challenge coTtsTo S a c t ^ d a ^ d e H i i n l o T "T H ^ R-esuuilttss:. . 8kln t0 See le c h e r they had been sens L2C'd Concentration 100% 10%* ^ H o u r Observation of Irritt-irm Mildt0Severeirrltatlo!^!^ntac^^^J5?? Mild lrritatljn on Intact and abraded skin Sensitltation 0/8 100% 107,* M , . -------- |fH-70n7\ rriCation on intact or abraded akin ^Jj-Tltation on intact or abraded skin 100% 10%,* No irritation on intact or abraded skin No Irritation on intact or abraded skin 100% 10%* No irritation on intact or abraded skin * N lrritation on intact or abraded skin ' ^ A e e t o n e -aiQMne coH:alnln8 m 8ut,,M pij f M (H-2909) ** Nigher-boiling liquid fraction only 0/10 0/10 0/10 saBSssaaiire i* * -* 3* more toxic wt^ h . as a unit, is quoted -- -- Company Sanitized. Does not contain TSCArn 4 prod.,00 a,,T n e" g U doo,," :l0L l tt; u " "de Cel" ': ',lRtU" "as 1 , M ,, of gul,,a piR,. but dld not The other three mixtures were non-i-rr-i foHnn , dennat itis, - ju n,'a P 8 sxin; neither of them produced an allerrcgitc contact HS/mfs Pate: November 1| 1964 Report by: gests-. Henry Sherman Chief, Oral Toxicity Section Approved by: !' 1 / / '.L f; s? j} ; J. ley Cla-^/on asistant '&ivecixfr / igpmpany Sanitized. Does not contain T*r<\ **