Document zQ4bwYYd1Keg3NeQ4MDqNw2K6

June 26, 1948 Mr. C . H. VanHartesveldt, Thompson Vita-Meter Corporation, 6402 Cedar Avenue, Cleveland, Ohio. Bear Mr. VanHartesveldt: I send you herewith two copies of a memorandum dealing with the subjects which we have discussed with your people from time to time . In this memo I have outlined very briefly the experimental work which is to be done, and have indicated its probable cost, and have made certain suggestions for a formal agreement in this regard. I have been rather slow in getting this into your hands, but I have been tremendously busy, and I have considered that I was fulfilling my responsibilities to you and your associates by getting the work under way on the basis of our general understanding, with out worrying too much about the formalities. We have taken the necessary steps to get the work started in order to save as much time as possible, and I am glad to report that everything is in order in this regard. I believe the memorandum will clarify any further matters between us. I suggest, therefore, that at your convenience, attention be given to the form of agreement under which this work is to be done. If you are quite content on these matters, after giving them con sideration, I would suggest that you prepare four copies of the agreement and execute them, sending them to me for execution by the Board of Directors of the University in due course. If the simple form, of agreement attached to my memorandum Is satisfactory, you need only fill in the dates and the sum of money involved, making the four copies indicated. If there is anything that Is not clear about our position, please do not hesitate to bring It to my attention. We are not troubled about the details of the agreement, or about the money, so long as we understand each other In a general way.. On the other hand, it is our general practice to have the money paid In In advance, so far as possible. This can be done on a quarterly basis or in a lump sum for the balance of this year. In view of the fact that we have no funds to draw on, I consider it advisable for D r . Kitzmiller to send his expense account for reimbursement at this time. Accordingly I attach it hereto. If you wish, this same procedure can be followed out subsequently, with respect to traveling expense, or it can be taken from the funds provided to us for all experimental purposes. May I suggest that it is Inadvisable that any statements concerning H e 0020647 Mr. C. H. VanHartesveldt - (2) - June 26, 19^8 this work, and more particularly -concerning any apparent results of the work, "be issued to the public press, or technical journals or elsewhere without our being specifically consulted as to the form and content in any such statement. By this means we shall all be saved from embarrassment or from any possibility of a mis-statement or misinterpretation of Information of this type. In making this suggestion I am deliberately calling attention to a news clipping which appeared in the May 19 National Petroleum News on the "Health Question" involved in the use of Vitol. I do not consider that the statement issued in this publication is particularly important or that it creates any embarrassing situation. Nevertheless the statement was issued prematurely, and it goes beyond anything we would be willing to say at this stage of the game. It is not wise toSpromise your own position, nor to compromise your consultants in this'matter, by issuing statements which do not lean over backwards in their critical repre sentation of the facts. Vlth best regards, Cordially yours, BAK ef Enc. Bobert A. Kehoe, M. D. ;...} t, j ., 0020648 MEMO! AED US QH IBVT3 IGAt IQS C ifOIEii'IAL HA2ATPS "Effroi#" os b e h a l ? W I;hQMPgh ^Oeffi, iSS* 'ills investigation a contemplated by ourselves fend agreed upon In principle at a conference in Cleveland# Ohio, on April 2o, 1:943, is to be pursued in two general and complementary phases, namely; (a; determination of the potential hasard of contact of the skin with the "vitol'* mixture containing 3 ml. of tetraethyl lead per gallon# by subjecting experimental animals to such cutaneous contact with the product under conditions and by means comparable to those employed in the investigation of the potential hasarda of cutaneous contact with gasoline containing $ ml. of tetraethyl lead per gallon; lb; determination of the apparent hasards of lead absorption on the part of persons who nave been,and are to be, exposed to such hasarde in the conduct of work which involves the preparation# handling and use of "Vitol'', by carrying out a systematic program of clinical and analytical examinations of available personnel. h e latter work is to be carried out by methods comparable to those used in the investight! of the hasards associated with the manufactur# distribution and us of leaded gasoline, with such improvements in technique as have been found to be useful in recent years.; it would appear from ou1 experience that.the proper exeeution of these investigations m&y be expected to yield a fairly definitive answer to the question of the degree of hasard associated vith such exposure as may occur among garage mechanics, other main tenance personnel, and filling station handlers of the pioduot. ihla does not mean that other questions may not arise, or that new and unanticipated hasards may not be created by subsequent developments and procedures in this business. Nevertheless, this type of investi  gatioa should give a clear indication oi the degree of hazard associated with the handling and use of this product, as com;ared vith that which has been found in association with'the distribution and use of leaded gasoline * Scope and Duration of Investigations it is anticipated that a period' of approximately six months will be required for the completion of the observations on animals. If the results are definitive, it is likely that no. further animal experimentation will be required. If the results are uncertain or ambiguous, the experiments will require sea modification or repeti tion under somewhat different conditions, .bout four months of exposure of the animals will be required, and ease two months will be required for the analytical study of their tissues that is. expected to yield the pertinent information, vlhaae experiment, vei-e Initiated on dune 7, 1^48, after a period of pro-experimental observation oi the animals.) ' ' Periodic clinical examination and laboratory study of exposed personnel will be carried out at quarterly intervals (the first complete study of available personnel ms been made and data will be available shortly > for a sore or lea indefinite period, i.. until it can be established that the lead exposure of the personnel is (lj too small to bo measured, (2) too small to have hygienic significance, or (j?) too great to be within the limits of safety for indefinite periods of occupational exposure. It should be possible to obtain definitive information on this point, insofar aa tit existing condi tions of occupational lead exposure or concerned, in about twelve months. This, according to present plans, will involve four sets of complete physical examinations ii.e. at quarterly intervals; and four K E 002.0630 lor their lead content It Is the intention of the staff of the Kettering Laboratory to undertake and maintain this program of investigation, and at the same time to keep Itself fully informed oi the actual and anticipated developments of this phase of the fuel Industry, in order that any additions or saedifications required to elucidate the real and potential health hazax'ds can be made, To this end, the full cooperation of responsible executives of Thompson Products lac. In providing pertinent information on their plans and progress, is solicited. Probable Cost of Investigations In accordance with the general plan outlined, it is anticipated that the cost of the experimental program vill approximate i5' vithin the calendar year 1$>48. The expense may be broken down, lor purposes of estimation, as follows i (a) ffOKreffl of Animal Experimentation Expenditures for compensation of personnel actually engaged in the animal experiments yX $ *-j Preparation and analysis of tissues 1 # 3--''* ** Cost of animals and food for animals c j-J i normally distributed proportion of expense of general cos t cf operating laboratory (heat, light, power, janitor service, animal care* secretarial service, annuities and pensions* etc.; 1,2 ; Estimated expense *2*7** j . , i'x-Q&vim of Clinical Investigation of Lxrosed rers'dnbael~r~ Conducted la juat-, ;eg teaser 'and ^eceigSeif^ Medical Services %-' >.j -.? Analy tical Service u j * <o uccording and studying data and preparing clinical report 2p (Traveling expense to be reimbursed directly J ' Estimated expense . Total estimated expense 1 2p./. .- Policies of the Laboratory with reference to Conuact of Investingtion It seems advisable In the interest of all concerned that a general undertending concerning the policies of the Laboratory in connection with this work be arrived at and recorded. Per this reason a copy of a short fora of agreement io attached to this sciaorandua. It is apparent that the University of Cincinnati, us represented in this instance by tire Laboratory* wishes to assert and protect its position as a publicly responsible institution. It is equally apparen that it accepts the obligation to protect the sponsor of the work against any unnecessary or inadvertent divulgence cl confidential trade information. The terms of this agreement otherwise deal with the willingness of the sponsor to defray the entire cost of the investigative program within certain agreed upon limitattens with respect to overall sums of money within certakn dates. These t o m s can be rewritten or restated for purposes of detail or clarity by the sponsor, so long as th principles of University responsibility are not violated. It is suggested that the present program be based on the calendar year 1 ^ 8 , and that funds be made available for that purpose. Hovever, the agrment may include a statement or phrase that vill permit of Use extension of the.yprk.beyond December pi, lp48 without fa redrafting of a further formal agreement. neither ve, nor the Board of Directors of the University, are ''sticky `! about details so long as the conditions surrounding the conduct of the work are clear and mutually acceptable- It is also suggested that fund be made available to the end o f the" y e a r w i t h the uncleretending 'ti&t '' any residual sum be returned .to tfa donor or otherwise applied against such further work as may be agreed upon mutually. ri- | abort r ^ e h o e # '^'* b * " "u"" Director, Kettering Laboratory of Applied Physiology, college of Medicine, University of Cincinnati Juno Up, ipf`3 Karl V. Kitzmiller, M.D. Kettering Laboratory College of Medicine Cincinnati 19 Ohio June 25t 1948 Expense of trip to Cleveland for the Thompson Vita-Meter Corporation June l6th to 19th, 1948 Railroad and Pullman Hotel Meals Taxi Tips, Telephone and Telegraph .... * .... $27.52 4.50 12.00 6.10 4.45 T O T A L ............ . $5^.37 0020654