Document zKx56MjaB8XEyEkLrBLK9G3g

-CCrX- Sh s Jeffer son lled ioal College of H xLladelpltia 1025 ITalnut St r e e t Dopt* o f Itrevon tlve IJodioin e D ivision o f In d u str ial lixiicitte ' June 17, 19h9 Dr* Manfred Basd itch D ir ector o f D ealt: and Safe ty Lead In d u st r ie s JUsse o latio n bZO Lexin gton Avenue Hesr Ycris r. ' ' Dear Doctor Bcavditca: I have read with gr eat su rprise in Doctor Fish er *s le t t e r o f Hay 17, 9h9t th at, the authors o f papers en poison in g cine t o the 'in gestion o f ax crayons isave called t h is type of pcdsrasiag HaaiH n oH poison in g. As a m atter of fa c t , not an ilin e hut parsurttran ilin o and henuidino ycHoi? IB far o been d iscu csed a s p ossi b le ton ic agen ts by us as t r o ll as by oth ers. v id lo Doctor Fish er i s ab so lu t e ly r igh t in caaplaoiain c t liat th e prc&Leni Tilth ijiiich t t q a r e ocn frojtiod i s t h at o f a orsaMon n of th e fin ish e d dyes and of ro~ foan in g in t o iae d ia t e c , ho st a t e d errcn eon sly t h a t feedin g c f ilia crayons or p igu sn t s in qu estion t o oain ala "fa i le d t o shew t o x ic s y ^ t c c s . " d l i c i c t a l . could n ot pro duce n etl'jcsa^ lobiaeaia in r a t s , dogs and c a t s, and -so, t oo, iiavc not seen aethemoglo b in e aia in dogs or r ab b it s* llonevei'* dogs and i*abbits do nab r eact o a a ily t o :cotliosoglobinfooi:iing ccapounds, and Doctor I sr a e l B, .Dicex*, -.mo irin dly offer ed t o feed crayons unci piyTorrtu to con dition ed c a t s, ixas ..iron d e fin it e proof o f n eth e-- n oglobin feroafcica ( J. r e d ia t ., 33* 733, l?i;G ). V/o have n ot deserved th e form ation o f I^S in acid stomach flu id , and methc- moglobin b at n ot otilfliaaogloh in v m foun d sp ect r cp h ot oact aLcaljy in th e blood o f th e c a t s mentioned above and in th e c lin ic a l c ase s* Doctor Ieh oe*a statem en t t h at th e form ation of sulfhenx>i5k>biri occu rs a t t a r death i s gen er ally accepted^ Hgs does n ot cczxbino w ith Im oglcb in in v iv o , fh e cyan osis in severe IIpS poison in g i s nob due t o th e fo a a a t io a o f a sp e c ific hemoglobin compound hurt t o a a p l^ d a t ie o by r e s piratory p araly sis. I aa a t a lo ss t o im deratan d hoar ab sor p tion o f lith op aao can p o ssib ly produce th e type o f poison in g observed* 1 a lso wonder whether lith opon c i s p r e se t * in r e d , red-oran ge and oth er crayon s, 4 I am en closin g a carbon copy of t h is l e t t e r in ease you want t o sen d i t t o Doctor F ish e r . X am a lso en closin g a r e p r in t o f se v e r al papers on carbon d isu lp h id e which have ju st been f/ublish ed. * I f I can be c f any fu r t h e r a ssist a n c e t o you, fe e l fr e e , p le ase , t o w r ite t o use* Sin cer ely you rs, i ` / s / II* Dxiegcr . V lr 0 0 1 A 7 r> r J' ' 0 ^ ' If. Br io ger , LI. D. A ssociate P rofessor and D ir ector D ivision o f In d u st r ia l lieclicin o