Document zDO3amgmnjJ6g1GzLD6qZDzg

Benzene Shanghai Study , ::r: N I :C:rI:l Introduction I Background -ooI 00 ("j,) 0\ January 26, 2001 A. R. Schnatter D LI:8100-VHS-ZVH NCI EXPOSURE ESTIMATING REPORT. , CONCERN NCI MOLECULAR EPI REPORT . 7,6 PPM I BLOOD EFFECTS NCI DOSE-RESPONSE ANALYSIS AML JMDS & NHL EFFECTS O. WONG TRIP . EXPOSURE ASSESSMENT FEASIBLE ~~' BZ STATE OF THE SCIENCE CONFERENCE NO MORE BZex=. ARMSTRONG, IRONS, SCHNATTER TRIP BZ-INDUCED OX PRESENT PROPOSAL REVIEWED BY SAB SOUND PLAN ETHICAL REVIEW PANEL FORMED FURTHER TRIPS LABORATORY SPEC's PROTOCOL DEVELOPMENT Shanghai Benzene Study Structure NHL, AML Study Disease Progression Study Molecular Epidemiology Study ~ I Vl ~ .oo... 00 Uol 00 .H. Cases Controls HOSPITALS WORKSITES Shanghai Benzene Structure NHL, AML CC Study 9D~~~!> Disease Progression I Molecular Marker Study Molecular Epid. Study AA MDS ,,. . \ ,~ ~ ~,- -------------- ------------------ ---- ..---- DIAGNOSIS DATABASE ---------------- ---------------- LABORATORY ~ ~ ~ w 0 R K S I T E S I\ Why Shanghai? Largest Contributor to NCI Study Large Population (....14 million) Organized to Support Research (Fudan, SCDC, etc.) . / / ::r:: t. r;1> N Exposures Relatively High, But Decreasing .. ~~~ I CIl ~ .oo.I... Willing Collaborators T 00 o~ ~ Research know-how ~ Regulatory interest, mandate I~ ~Technology imports ~ IJ\~Influential Contacts ~II~ j .. Study Collaborators and Supporters (Partial List) FuHua - Deputy Dean of Fuda"n University School of Public Health IARC I WHO links - Primary collaborator on all studies - High level links into Chinese provincial & national governments Lu Wei - Deputy Director General, Shanghai CDC ~ - Responsible for enforcement of exposure standards I til ~ oo -00 Lin Guowei - Director of Clinical Epidemiology, Fudan University - Vice President, Shanghai Hematology Society - Past President, Chinese Hematology Society -~ - Primary clinical I diagnostic contact Zhou Shi Zhong - Deputy Director, Institute of Public Health Supervision (CDC) - Responsible for CDC exposure database Responsible for monitoring exposure Liang You-Xin - Chairman, National Committee on Exposure Standards - Chairman, Occupational Preventive Med. Dept. Fudan - Responsible for development of workplace exposu re standards EXTENSIVE COLLABORATIVE TEAM IN PLACE, ANXIOUS TO START Benefits of Extensive Collaboration _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _m'lJl':.,"j.~j.;:, CHINESE PERSPECTIVE Import, Acquires Study Methods Expertise Enhances Professional Advancement - Publications $: N, r/.l Imports.. Leading Technology, Know-How ~ -oo Broadens Training Opportunities 00 .." W Allows Greater Autonomy in Future u.S. PERSPECTIVE Required to Navigate Socio-Political Infrastructure Ensures Adequate Participation Enhances Study Impact, Relevance Improves Business-Regulatory Interface in China Establishes Partner Spokespersons ,.. Summary: Shanghai Findings _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _Ati&_~lC::q\~'~ -. - High exposures - Benzene-induced disease - Good records since 1970s ~ N I C/) ~ 1940's Exposures .oo.I.. 00 A W - Technology sophistication - Willing collaborators - Influential contacts 21st Century Technology Unique, unparalleled research opportunities