Document yrj7Qe7EK3EXXDQ50GO8gqVrr

258 SI CC AU AD TI SO PT CY LA CD AB RN EM 259 SI CC CN AD TI SO PT CY LA CD AB RN EM' CA/102/118996G CA/160006 Haile CL ; Shan YA ; Malone LS ; Northcutt RV Midwest Res. Inst., Kansas City Development of methods for the analysis of purgeable organic priority pollutants in municipal and industrial wastewater treatment sludges Adv. Identif. Anal. Org. Pollut. Water? VOL 2,, 1981,763-91 MONOGRAPH USA ENG 53CYA CBAC COPYRIGHT: CHEM ABS Org pollutant detn wastewater sludge Purge trap org pollutant detn Gas chromatog purge trap analysis Mass spectrometry purge trap analysisjWastewater treatment Anal, of, stirred bottom frit tube in purge-and-trap methods for Sludge 56-23-5? 67-66-3? 71-43-2? 71-55-6? 75-01-4? 75-35-4? 79-01-6? 100-41-4? 107-06-2? 108-90-7? 127-18-4 8505 CA/099/058099Z CA/159002 Enviro Control, Inc. Rockvilie Assessment of engineering control monitoring equipment. Volume I Report? ISS NIOSH-210-79-OOH-VOL-1 ? Order No. PB83-152629,, 1981,157 pp. TECHNICAL REPORT USA ENG D8REP CBAC COPYRIGHT: CHEM ABS Monitoring system air pollution control Phosgene pollution control monitoring evaluation Vinyl chloride pollution control monitoring Cotton dust pollution control monitoring Carbon monoxide pollution control monitoring?Air pollution Control of, monitoring systems for, evaluation of?Cotton Oust of, air pollution by, monitoring syst ems for control of, evaluation of 75-01-4? 75-44-5? 630-08-0 8309 RNW 1746 00009887 VCM PAGE 130 260 SI CC AU AO TI SO PT CY LA CD AB RN EM 261 SI CC AU AD TI SO PT CY LA CD IS AB RN EM 262 SI CC AU TI SO PT CY LA CD IS AB RN CA/098/221040P CA/159002 Himi Y Kanagawa Prefect. Environ. Cent.* Kanagawaken Survey of chemical substances in the atmosphere Kanagawa-ken Taiki Osen Chosa Kenkyu Hokoku; VOL 23,, 1981,163-6 JOURNAL ARTICLE Japan JPN KTOHD CBAC COPYRIGHT: CHEM ABS Chlorohydrocarbon atm Kanagawa JapanjAir pollution By chlorohydrocarbon, in Kanagawa Prefecture, Japan 56-23-55 67-66-3*, 71-55-6; 74-87-3; 75-00-3; 75-01-4; 75-09-2; 79-01-6! 127-18-4 8307 CA/098/094785H CA/159001 De Lorenzo R Serv. Ecol. SIR/CI, Sassari Mechanographic elaboration of data on ambient vinyl chloride monomers obtained using automatic gas chromatography Ann. 1st. Super. Sanita; VOL 17, ISS 3, 1981,515-20 JOURNAL ARTICLE Italy ITA AISSA 0021-2571 CBAC COPYRIGHT: CHEM ABS Vinyl chloride detn air uorkplace;Air analysis Vinyl chloride monomer detn. in, for occupational hazard est. 75-01-4 8304 CA/098/047992P CA/104000 Ungvary G Toxicologic characterization of vinyl chloride. Data for maximum allowable concentration Munkavedelem; VOL 27, ISS 10-12, 1981,34-50 JOURNAL ARTICLE Hung. HUN MUNKA 0027-3619 CBAC COPYRIGHT: CHEM ABS A review with many refs, on the toxicity of vinyl chloride C75-01-4] to humans and lab. animals, including acute, subacute, chronic, and fetal toxicity. Mutagenicity and carcinogenic effects are discussed. The proposed max. allowable concn. in air is 10 mg/m3. 75-01-4 RNW 1747 I 00009889 VCM PAGE 132 CY - Czech. ZP - 100 42/10 LA - ENG CD - 48RKA AB - CBAC COPYRIGHTS CHEM ABS Mutagen monitoring peripheral lymphocyte aberration Plastic worker mutagen monitoringJAir analysis Mutagen monitoring in. by peripheral lymphocyte aberrationLymphocyte Peripheral, aberrations in. mutagen occupational exposure monitoring in relation to RN - 75-01-4; 100-42-55 106-89-8 EM - 8301 266 SI - CA/097/139784E CC - CA/104003 AU - Ilichkin VS ; Butin VN ; Gusev IV ; Podosinnikov SE TI - Toxic effects of combustion products of polymer materials 50 - Bezopasn. Lyudei pri Pozharakh, M.; 1981.53-61 PT - JOURNAL ARTICLE CY - USSR LA - RUS CD - D3RAP AB - CBAC COPYRIGHT: CHEM ABS Title only translated. Polymer combustion product toxicity RN - 75-01-4? 630-08-0 EM - 8211 267 51 - CA/097/121743F CC - CA/104006 AU - Barbin A ; Bartsch H ; Lecomte P ; Radman M AD - Int. Agency Res. Cancer, Lyon TI - On the possible role of the miscoding DNA lesions, 1,N6-ethenoadenine and 3N4-ethenocytosine, in vinyl chloride-induced mutagenesis and careinogenesis SO - NATO Adv. Study Inst. Ser., Ser. A; VOL 40, ISS Chromosome Damage Repair, 1981,461-7 PT - JOURNAL ARTICLE CY - Fr. ZP - F-69372/2 LA - ENG CD - NASSD IS - 0161-0449 AB - CBAC COPYRIGHT: CHEM ABS Chloroacetaldehyde 1107-20-01 And chloroethylene oxide (CEO) [7763-77-11, 2 reactive metabolites of vinyl chloride C75-01-41, were used to introduce increasing amts, of 1N6-ethenoadenine (epsilonA)(I) C13875-63-31 and 3,N4-ethenocytosine (epsilonC)(II) [55662-66-31 residues in poly(dA) [25191-20-21 andpoly(dC) [25609-92-11, resp. The modified polynucleotides were assayed with Escherichia coli DNA polymerase I for their template activity and mis incorporation. The miscoding properties obsd. of epsilonA and epsilonC may explain the mutagenic effects reported for vinyl chloride and its metabolites; these lesions may also represent one of the initial steps in vinyl chloride- or CEO-induced carcinogenesis. RNW 1749 I 00009890 VCM PAGE 133 RN - 75-01-4; 107-20-05 7763-77-1J 13875-63-3; 25191-20-2; 25609-92-1J 55662-66-3 EM - 8211 268 SI CC AU AD TI SO PT CY LA CD AB RN EM CA/097/132757Q CA/159005 Markel HL Jr ; Slovin D Div. Surveill., Hazard Eval. Field Stud., Natl. Inst. Occup. Saf. Health, Cincinnati Health hazard evaluation report no. HHE-79-158-819 Morrilton Plastics Corporation, Morrilton, Arkansas Report; ISS HHE-79-158-819; Order No. PB82-189788,, 1981,18 pp. TECHNICAL REPORT USA ENG D8REP CBAC COPYRIGHT: CHEM ABS Toxic compd exposure plastics manuf{Air pollution By toxic chews., occupational exposure to, health hazrds of, to plastic wanufg. workersjChewicals Air pollution by, occupational exposure to, health hazard of, to plastic wanufg. workers Hazardous;Eye Irritation of, from toxic chew, occupational exposure, in plastic manuf.;Fatigue From toxic chem. occupational exposure, in plastics manuf. Biological;Glues Air pollution by, occupational exposure to, health hazard of, to plastic wanufg. workers;Headache Form toxic chem. occupational exposure, in pulse manuf.jHealth hazard From exposure to plastic fabrication Occupational;Plastics Fabrication of, occupational exposure to, health hazard in relation toJSolvents Air pollution by, occupational exposure to, health hazard of, to plastic manufg. workers 67-64-15 71-55-6} 75-01-4; 75-09-2? 78-93-3J 108-88-3? 108-95-2J 109-99-9 8211 269 SI CC AU AD TI SO PT CY LA CD IS AB RN CA/097/132675M CA/159004 Harris GE ; Tichenor BA Radian Corp., Austin Frequency of fugitive emissions in synthetic organic chemical plants Proc. Annu. Meet. - Air Pollut. Control Assoc.; VOL 74th, ISS Vol. 3, 1981,Paper 61-41.5, 8 pp. JOURNAL ARTICLE USA ENG PRAPA 0099-4081 CBAC COPYRIGHT: CHEM ABS Fugitive emission org chem manufg Waste gas fugitive chem manufg;Organic compounds Fugitive emissions in manuf. of;Waste gases Fugitive emissions, from org. chem. manufg. 50-00-0? 67-64-1? 71-55-6? 74-85-1; 75-01-4? 75-07-0? 78-93-3J 79-01-6? 80-62-6? 98-82-8? 107-06-2? 107-13-1? 108-05-4? RNW 1750 1 00009891 VCM PAGE 134 108-95-2J 124-04-9J 127-18-4 EM - 8211 270 SI - CA/097/114653Y CC - CA/159006 AU - Douglas-Hamilton DH ; Slater RC AD - Avco Everett Res. Lab. Inc. Everett TI - El imination by electron beam irradiation of trace contaminants in gas streams SO - Symp. Proc. - Int. Symp. Plasma Chem., 5th; VOL 2> 1981,726-31 PT - MONOGRAPH CY - USA ZP - 02149 LA - ENG CD - 48JDA AB - CBAC COPYRIGHT: CHEM ABS Electron beam irradn gas contaminant;Electron beam Irradn. by of gases> for trace contaminant removalJGases Purifn. of* by electron beam irradn. RN - 74-93-1; 75-01-4 EM - 8210 271 SI - CA/097/060674K CC - CA/161003 AU - Krasner SW ; Hwang CJ ; Cohen RS ; McGuire MJ AD - Metrop. Water District South. California, La Verne TI - Development of a volatile organic analysis technique for the Orange-Los Angeles County reuse study SO - Chem. Water Reuse; VOL 2,, 1981,17-31 PT - MONOGRAPH CY - USA LA - ENG CD - 46LSA AB - CBAC COPYRIGHT: CHEM ABS Volatite org detn water reuse;Volatile substances Org., detn. of* in recharge water, gas chromatog. and mass spectroscopy in RN - 56-23-5; 67-66-3; 71-43-2; 71-55-65 74-83-95 74-97-55 75-00-3; 75-01-*+; 75-09-2; 75-25-2J 75-27-45 75-34-35 75-35-4; 75-69-45 78-87-55 79-00-5; 79-01-65 79-34-55 95-50-1? 96-12-8J 100-41-4; 106-46-75 107-06-2J 108-88 3! 108-90-75 110-56-55 124-48-15 127-18-4; 156-60-5; 541-73 i; 3017-95-6; 7732-18-5; 10061-01-55 10061-02-6 EM - 8209 272 SI - CA/097/C34349P CC - CA/104003 AU - Chyba A AD - Zakl. Hig. Komunaln., Panstw. Zakl. Hig.* Warsaw TI - Study of the toxicity of a mixture of vinyl chloride and phenol in air SO - Rocs.Panstw. Zakl. Hig.5 VOL 32, ISS 4, 1981,357-61 PT - JOURNALARTICLE CY - Pol. LA - POL RNW 1751 00009892 VCM PAGE 135 CD - RPZHA IS - 0035-7715 AB - CBAC COPYRIGHT: CHEM ABS Mixing 1 mg vinyl chloride E75-01-4] with 1 mg phenol C108-95-2]/m3 antagonized their effects on the nervous system of rats in a 7-mo continuous inhalation test. The mixt. did not effect the learning ability which was impaired by 1 mg/m3 of either component sep. Vinyl chloride alone also extended the blood clotting time. RN - 75-01-4J 108-95-2 EM - 8208 273 SI - CA/097/001601M CC - CA/104000 AU - Kilbey BJ AD - Dep. Genet.* Univ. Edinburg, Edinburgh TI - Comparative mutagenicity of aflatoxin B1 and vinyl chloride SO - Environ. Sci. Res., VOL 24, ISS Comp. Chem. Mutagen., 1981,857-81 PT - JOURNAL ARTICLE CY - UK LA - ENG CD - EVSRB IS - 0090-0427 AB - CBAC COPYRIGHT: CHEM ABS A review with 75 refs, on the comparative mutagenicity of aflatoxin B1 (I) E1162-65-8] and vinyl chloride C75-01-4]. RN - 75-01-45 1162-65-8 EM - 8207 274 SI - CA/096/204558E CC - CA/159000 AU - Pers T ; Pisarzewska E AD - Inst. Ciezkiej Synt. Org. "Blachownia", Kedzierzyn TI - Methods for the removal of vinyl chloride from waste gases during its synthesis and processing SO - Chemik; VOL 34, ISS 11-12, 1981,241-3 PT - JOURNAL ARTICLE CY - Pol. LA - POL CD - CHGLA IS - 0009-2886 AB - CBAC COPYRIGHT: CHEM ABS Review vinyl chloride removal fume Haste gas vinyl chloride reviewJWaste gases Removal of vinyl chloride from RN - 75-01-4 EM - 8207 RNW 1752 00009893 VCM PAGE 136 275 SI CC AU AD TI SO PT CY ZP LA CO IS AB RN EM 276 SI CC AU AD TI SO PT CY ZP LA CD IS AB RN EM CA/096/175416Z CA/104001 Tamburro CH ; Greenberg R Sch. Med., Univ. Louisville* Louisville Effectiveness of federally required medical laboratory screening in the detection of chemical liver injury EHP* Environ. Health Perspect.; VOL 41,, 1981,117-22 JOURNAL ARTICLE USA 40201 ENG EVHPA 0091-6765 CBAC COPYRIGHT: CHEM ABS The gamma-glutamyl transpeptidase [9046-27-93 test provides the highest pos. predicted value as a screening test for identifying individuals with all types of medical diseases followed by the indocyanine green [3599-32-4] clearance* aspartic aminotransferase [9000-97-9], alanine aminotransferase [9000-86-6], radioisotopic liver spleen scans, alk. phosphatase [9001-78-9], and bilirubin [635-65-4]. In the identification of asymptomatic liver disease, the gamma-glutamyl transpeptidase had the least specificity whereas the alk. phosphatase the highest. The indocyanine green clearance provided the best combination of pos. predictive value and sum of specificity and sensitivity. 75-01-45 635-65-45 3599-32-4; 9000-86-6; 9000-97-9; 9001-78-9; 9046-27-9 8206 CA/096/175389T CA/104000 Nauman CH ; Grant WF Biol. Dep., Brookhaven Natl. Lab., Upton Mutagenicity of ethyl methanesulfonate, mitomycin C, and vinyl chloride in the Tradescantia test systems Environ. Sci. Res.; VOL 24, ISS Comp. Chem. Mutagen., 1981,329-38 JOURNAL ARTICLE USA 11973 ENG EVSRB 0090-0427 CBAC COPYRIGHT: CHEM ABS A review with 27 refs, on the mutagenicity of Et methanesulfonate [62-50-0], mitomycin C [50-07-7], and vinyl chloride [75-01-4] in the Tradescantia test systems. 50-07-75 62-50-0? 75-01-4 6206 RNW 1753 00009894 VCM PAGE 137 277 SI CC AU AD TI SO PT CY ZP LA CD IS AB RN EM CA/096/137689H CA/104006 Fabricant JD ; Legator MS Med. Branch, Univ. Texas, Galv'eston Mutagenicity studies of vinyl chloride EHP, Environ. Health Perspect.; VOL 41,, 1981,189-93 JOURNAL ARTICLE USA 77550 ENG EVHPA 0091-6765 CBAC COPYRIGHTS CHEM ABS Mutagenicity studies in man and test organisms clearly demonstrate pos. mutagenic activity of vinyl chloride (VC) C75-01-4). Using a variety of in vitro procedures covering eukaryotes and prokaryotes, pos. effects were found. Cytogenetic in vivo studies in animals and humans indicate not only somatic mutations, but also germinal effects with VC. 75-01-4 8205 278 SI CC AU AD TI SO A PT CY ZP LA CD IS AB RN EM - CA/096/137688G - CA/104006 - John JA ; Smith FA ; Schwetz BA - Toxicol. Res. Lab., Dow Chem. U.S.A., Midland - Vinyl chloride! inhalation teratology study in mice, rats and rabbit s - EHP, Environ. Health Perspect.; VOL 41,, 1981,171-7 - JOURNAL ARTICLE - USA - 48640 - ENG - EVHPA - 0091-6765 - CBAC COPYRIGHT: CHEM ABS The effects of inhaled vinyl chloride (VC) C75-01-4] on mouse, rat, and rabbit embryonal and fetal development were studied. Groups of pregnant mice, rats, and white rabbits were exposed to 500 ppm VC for 7 h daily during the period o* major organogenesis. Subsequently, other groups of mice were similarly exposed to 50 ppm VC, and rats and rabbits were exposed to 2500 ppm. While maternal toxicity was obsd. exposure to VC did not cause significant embryonal or fetal toxicity and was not teratogenic in any of the 3 species. Simultaneous exposure of some of the pregnant animals to VC by inhalation plus 15X EtOH [64-17-51 in the drinking water resulted in toxic effects greater than those assocd. with exposure to VC alone in the 3 species. The fetal effects obsd. were similar To those reported for these 3 species following administration of EtOH without VC exposure. - 64-17-55 75-01-4 - 8205 RNW 1754 00009895 VCM PAGE 138 280 SI - CA/096/137685D CC - CA/104006 AU - Radike HJ 5 Stemmer KL ; Bingham E AD - Mad. Cent.* Univ. Cincinnati, Cincinnati TI - Effect of ethanol on vinyl chloride carcinogenesis SO - EHP* Environ. Health Perspect.; VOL 41,, 1981,59-62 PT - JOURNAL ARTICLE CY - USA ZP - 45267 LA - ENG CO - EVHPA IS - 0091-6765 ,,, AB - CBAC COPYRIGHT: CHEM ABS Four treatment groups (80 male rats/group) were used in a 2 .times. 2 factorial design* inhalation of 600 ppm vinyl chloride (VC) [75-01-4] 4 h/day, 5 days Aik for 1 yr; VC and ingestion of 5X EtOH [64-17-5] in water (vol./vol. ); filtered air and EtOH5 filtered air. Ingestion of EtOH was begun 4 wk prior to inhalation of VC and continued for * I 00009896 VCM PAGE 139 life or termination of the study at 2.5 yr from the 1st VC exposure. In the model system, EtOH potentiated the carcinogenic response to VC in the liver and produced an excess of neoplasms in animals receiving EtOH alone. Inhalation of VC induced angiosarcoma of the liver in 23X of the exposed animals, EtOH in addn. to VC inhalation increased the incidence to 50X. Concomitant administration of VC and EtOH also produced an excess of hepatocellular carcinoma and lymphosarcoma. EtOH with or without VC had a strong tumorigenic effect on the endocrine system. Thus, EtOH is a cocarcinogen in relation to the carcinogen VC. RN - 64-17-55 75-01-4 EM - 8205 281 SI - CA/096/137684C CC - CA/104006 AU - Groth DH ; Coate WB ; Ulland BM > Hornung RW AD - Div. Bicmed. Behav. Sci . , Natl. Inst. Occup. Saf. Health, Bethesda TI - Effects of aging on the induction of angiosarcoma SO - EHP, Environ. Health Perspect.J VOL 41,, 1981,53-7 PT - JOURNAL ARTICLE CY - USA LA - ENG CD - EVHPA IS - 0091-6765 AB - CBAC COPYRIGHT: CHEM ABS Adult albino rats of 4 different ages (6, 18, 32, and 52 wk) were exposed to 940 ppm vinyl chloride C75-01-4] by inhalation for 24 wk, 5 days/wk, for 7 h/day. In each age group, there were 110-128 males and the same no. of females. The similarly housed control group, which was not exposed to vinyl chloride, consisted of the same no. of males and females in each age group. All animals that died spontaneously, or were sacrificed moribund, or were killed at scheduled times (3, 6, and 9 mo after initial exposure) were autopsied. All organs were examd. grossly, and several tissues from each animal were examd. microscopically. The older the rats were when they were exposed, the greater the incidence of angiosarcomas. The . incidences of angiosarcomas in the 4 age groups (from youngest to i oldest) in the exposed males in the nonscheduled sacrifice groups were: 0/37 (OX); 0/44 (OX); 3/45 (6.7Z); and 13/55 (24X). Similarly, for the females, these incidences were: 2/38 (5.3X); 7/47 (15X); 23/49 (47Z); and 11/54 (20X). Most of the angiosarcomas were highly anaplastic, primary tumors in the livers that metastasized to the lungs. Only 1 angiosarcoma was seen in all the control rats; that occurred in s.c. tissue. Thus, older adult animals and females are more susceptible to the angiosarcoma-inducing effects of vinyl chloride than young adult animals and males, resp. RN - 75-01-4 EM - 8205 RNW 1755 00009897 VCM PAGE 140 282 SI CC AU AD TI SO PT CY ZP LA CD IS AB / RN EM 283 SI CC AU A0 TI SO PT CY CA/096/137683B CA/104006 Suzuki Y Mt. Sinai Sch. Med., City Univ. New York, New York Neoplastic and nonneoplastic effects of vinyl chloride in mouse lung EHP, Environ. Health Perspect.; VOL 41,, 1981,31-52 JOURNAL ARTICLE USA 10029 ENG EVHPA 0091-6765 CBAC COPYRIGHT: CHEM ABS Neoplastic effects of vinyl chloride (VC) C75-01-4) were studied in lungs of 27 mice exposed at 2500 and 6000 ppm for 5 and 6 mo (large doses and long-term exposure). The neoplastic cells were transformed from type II alveolar epithelium via its hyperplastic form. Nonneoplastic effects of the chem. were also studied in the 27 mice. Major light microscopic alterations obsd. were proliferation and hypertrophy of the terminal bronchiolar cells, consisting of ciliated and Clara cells, hypersecretion of the epithelial mucin in the goblet cells of both the bronchial and the proximal bronchiolar epithelium, hyperplasia of alveolar epithelium, mobilisation of alveolar macrophages, and occasional presence of peri bronchial or bronchiolar chronic inflammation. Submicrosccpic changes of pulmonary alveoli were represented by focal thickening of the basement membrane, multiple foci of hyperplastic type II cell (the precondition of the alveologenic tumor), active discharge of osmiophilic lamellar bodies from the type II cell and phagocytosis of the bodies by macrophages, appearance of cholesterol crystalloids in the macrophages, degeneration of alveolar septal cells, and occasional appearance of a large nucleus with swelling of the capillary endothelium. The neoplastic effect of vinyl chloride of smaller doses C100, 10, 1 and 0 (control) ppm] and shorter exposure (4 wk) was studied in lungs of 120 mice. A dose-response relation was considered in the incidence of the alveologenic tumor prodn. of VC. Thus, mouse lung is an extremely sensitive indicator of the oncogenicity of VC. 75-01-4 8205 CA/096/137682A CA/104006 Maltoni C ; Lefemine G 5 Ciliberti A i Cotti G 5 Carretti D Inst. Oncol., Bologna Carcinogenic!ty bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis EHP, Environ. Health Perspect.; VOL 41,, 1981,3-29 JOURNAL ARTICLE Italy RNW 1756 00009898 VCM PAGE 141 LA - ENG CD - EVHPA IS - 0091-6765 AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride (VC) (75-01-4), administered by different routes, concns., and schedules of treatment to animals (.apprx.7000) of different species, strains, sex, and age, were studied. The neoplastic effects of the monomer were also detected at low doses. The exptl. and biol. factors greatly affect the neoplastic response to VC. Long-term carcinogenicity bioassays are a unique tool for the identification and quantification of environmental and occupational risks. Precise and highly standardised exptl. procedures are needed to obtain data for risk assessment. RN - 75-01-4 EM - 8205 284 SI CC AU AD TI SO PT CY ZP LA CD IS AB RN EM CA/096/137302B CA/104003 Brenner EA 5 Manchester KL ; Webster I 5 Cantrell AC Natl. Cent. Occup. Health, Johannesburg Attempts to demonstrate short-term metabolic effects of vinyl chloride in normal rat liver Am. J. Ind. Med.5 VOL 2, ISS 2, 1981,153-9 JOURNAL ARTICLE S. Afr. 2000 ENG AJIMD 0271-3586 CBAC COPYRIGHT: CHEM ABS Whether vinyl chloride monomer (VCM) (75-01-4) or 1 of its metabolites, chloracetaldehyde (107-20-0), has a short-term effect on cell metab. was studied. ATP (56-65-5), ATP (58-64-0), And AMP (61-19-8) levels were measured in regenerating rat liver after 4 and 16 h. No changes in the levels of these nucleotides was evident after i.v. injection of VCM immediately after partial hepatectomy. A 2nd technique, that of measuring transmembrane potentials with microelectrodes, was applied both to cells in rat liver slices and pulmonary alveolar macrophages. The addn. of VCM and chloracetaldehyde with the electrodes in position in rat liver slices had no significant effect on transmembrane potentials. The same was true for a series of measurements on macrophages before and after addn. of the test chem. It therefore appears that VCM does not alter general cell metab. but could act on a specific intracellular target. 56-65-5J 58-64-0? 61-19-8? 73-24-5? 75-01-4? 107-20-0 8205 RNW 1757 00009899 VCM PAGE 142 285 SI CC AU AD TI SO PT CY LA CD AB RN EM CA/096/137285Y CA/104003 Sharma RP Utah State Univ., Logan Splenic lymphocyte transformation in culture as a tool for immunotoxicolcgic evaluation of chemicals Immunol. Cons id. Toxicol., VOL 2 1981.133-45 MONOGRAPH USA ENG 47AWA CBAC COPYRIGHT! CHEM ABS In male mice exposed to the phytomitogens phytohemagglutinin Ca lectin derived from Phaseolus vulgaris) and pokeweed mitogen (obtained from Phytolocca americanaj, blast formation of lymphocytes (evaluated by the uptake of 3H-labeled thymidine) in short-term (64-68 h) cultures from spleens decreased with age. The addn. of small amts, of either mouse serum or liver homogenate significantly inhibited the thymidine uptake by cells in culture. Exposure of male mice to different chems. altered the transformation characteristics of their splenic lymphocytes. Addn. of chems. directly to lymphocyte cultures also caused different effects indicating that some of the effects can be caused directly on the cells. Thus, lymphccytv. cultures from spleens can be utilised for toxicity evaluation of chems. on immune functions of the organism. The results con be used to predict immunosuppression or immunostlmulation potential of different chems. 75-01-45 96-09-3! 100-42-5; 123-93-3J 1746-01-6J 15060-26-1 8205 286 SI CA/096/137168N CC CA/104000 AU Chu KC ; Milman HA AD Natl. Cancer Inst. Bethesda TI Review of experimental carcinogenesis by compounds related to vinyl chloride SO EHP, Environ. Health Perspect.5 VOL 41,, 1981,211-20 PT JOURNAL ARTICLE CY USA ZP 20205 LA ENG CD EVHPA IS 0091-6765 AB CBAC COPYRIGHT: CHEM ABS A review with 21 refs, on exptl. carcinogenesis by vinyl chloride analogs. RN 75-01-4 EM - 8205 RNW 1758 I 00009900 VCM PAGE 143 287 SI CC AU AD TI SO PT CY ZP LA CO IS AB RN EH CA/O96/137167H CA/104000 Rice JM bww wui i i iv^ * ism V ^ Prenatal susceptibility to carcinogenesis Dy xenoo substances including vinyl chloride EHP> Environ. Health Perspect.; VOL 41, 1981.179-88 JOURNAL ARTICLE USA 21701 ENG RNW 1759 EVHPA 0091-6765 CBAC COPYRIGHT: CHEM ABS A review with 26 refs, on prenatal susceptibility to carcinogenesis by xenobiotic substances. including vinyl chloride t75-01-4J 75-01-4 8205 00009901 VCM PAGE 144 289 SI - CA/096/117055V CC - CA/104003 AU - Wronska-Nofer T ; Parke M ; Laurman W AD - Inst. Med. Pracy Lods TI - Biochemical changes in vinyl chloride poisoning. I. Effects of exposure to vinyl chloride on lipid metabolism in rats 50 - Med. Pr.J VOL 32, ISS 4, 1981,247-53 PT - JOURNAL ARTICLE CY - Pol. LA - POL CD - MEPAA IS - 0465-5893 AB - CBAC COPYRIGHT: CHEM ABS Chronic exposure of rats to airborne vinyl chloride (I) C75-01-4] at concns. of 50, 500, and 20,000 ppm increased serum levels of total cholesterol (II) (57-88-5), II esters, phospholipids, and triglycerides (III), but the differences with the nonexposed controls were not statistically significant. A distinct fall of II and III levels was found in the rat liver but only at the highest concn. of I. No effects on the levels of lipids in muscles, aortic wall, and connective tissue were obsd. RN - 57-88-5*, 75-01-4 EM - 8205 290 51 - CA/096/099135Q CC - CA/104006 AU - Sal'nikova LS ; Vorontsov RS AD - Inst. Gig. Tr. Profzabol., Moscow TI - Long-term consequences of the effects of vinyl chloride on embryogenesis SO - Gig. Tr. Prof. Zabol.5 ISS 12, 1981,56 PT - JOURNAL ARTICLE CY - USSR LA - RUS CD - GTPZA IS - 0016-9919 AB - CBAC COPYRIGHT: CHEM ABS Mice exposed to 4.8 and 35.3 mg/m3 vinyl chloride (75-01-4) during their antenatal periods showed no blastomogenic effects. No difference between exptl. and control animals were noted in relation to animals with neoplasms, localisation of the tumors, and the degree of neoplastic development. The transplacental uptake route is not adequate for the studv of blastomogenic effects for all chem. compds. RN - 75-01-4 EM - 8205 RNW 1760 00009902 VCM PAGE 145 291 SI CC AU AD TI SO PT CY LA CD IS AB RN EM 292 SI CC AU AD TI SO PT CY LA CD AB RN EM CA/096/098967A CA/104003 Gluszcz M Klin. Chorob Zawodowych, Inst. Med. Pracy, Lodz Difficulties of early diagnosis of liver damage in persons exposed to vinyl chloride Med. Pr.; VOL 32, 1SS 4, 1981,277-82 JOURNAL ARTICLE Pol. POL ME PAA 0465-5893 CBAC COPYRIGHT! CHEM ABS Detns. of alanine aminotransferase [9000-86-63, aspartate aminotransferase C9000-97-9], gamma-glutamyl transpeptidase [9046-27-9], serum cholinesterase [9001-08-5], pseudo-cholinesterase [9001-08-5], alk. phosphatase [9001-78-9], and bilirubin [635-65-4], estns. of the prothrombin Index, as well as proteinograms did not show any significant differences between a group of 228 men and women occupationally exposed to CH2!CHC1 [75-01-4] and a control group of 70 ncnexposed subjects. There was no correlation between the results of bromosulphthalein test, liver scintigraphy, and detn. of the half-life of 1311 elimination from blood, performed in 50 persons with the CH2!CHC1 poisoning suspected. The lack, of a reliable .sthod of early diagnosis of hepatopathy in workers exposec to CH2:CHCl is accented. 75-01-s; 035-65-4; 9000-86-6; 9000-97-9; 9001-08-5; 9001-78-9J 9046-27-9 8205 CA/096/l^:3781H CA/161CC3 Wilson Jl Carborundum Co., Niagara Falls Det ermination of volatile organics in industrial and municipal wastewaters Report; ISS EPA-460/3-81-07; Order No. PB82-119090,, 1981,81 pp. TECHNICAL REPORT USA ENG D8REP CBAC COPYRIGHT! CHEM ABS Volatile org detn wastewater;Volatile substances Org., detn. of, in industrial andmunicipal wastewater 56-23-5; 67-66-3; 71-43-2; 71-55-6; 74-83-9; 74-87-3; 74-95-3; 75-00-3; 75-01-45 75-09-2; 75-25-2; 75-27-45 75-34-35 75-69-4J 75-71-85 78-87-55 78-88-65 79-00-5; 79-01-6; 79-34-5; 100-41-4} 106-46-75 106-93-4} 107-02-85 107-06-2} 107-13-15 108-88-35 108-90-75 110-75-85 124-48-15 127-18-4} 156-60-55 930-66-55 7732-18-55 10061-01-55 10061-02-6 8205 RNW 1761 00009903 VCM PAGE 146 293 SI CC AU TI SO PT CY LA CO AB RN EM CA/096/148253N CA/159005 Fedotova IV > Smulevich VB ; Filatova VS ; Bul'bulyan MA Study of the epidemiology of malignant neoplasms among persons coming in contact with vinyl chloride under industrial conditions Aktual'n. Vopr. Slgieny Truda i Profpatol. v Nekotor. Otraslyakh Khim. Pro-sti i na Avtomob. Transp.5 1981,5-8 JOURNAL ARTICLE USSR RUS D3RAP CBAC COPYRIGHT! CHEM ABS Neoplasm epidemiol vinyl chloride exposure Occupational exposure chloroethene neoplasm epidemiolJNeoplasm Formation of, epidemiol. of, vinyl chloride occupational exposure in relation to 75-01-4 8205 294 SI CC AU TI SO PT CY LA CD AB RN EM CA/096/148240F CA/159005 Bochkareva TV ; Kryzhanovskaya NA Clinical laboratory study of hepato-biliary pathology of workers in the production of vinyl chloride in the light of studies on its carcinogenic hazards Aktual'n. Vopr. Gigieny Truda i Profpatol. v Nekotor. Otraslyakh Khim. Prom-sti i na Avtomob. Transp, 1981,95-8 JOURNAL ARTICLE USSR RUS D3RAP CBAC COPYRIGHT: CHEM ABS Vinyl chloride carcinogen health hazard Biliary tract pathol vinyl chloride Liver pathol vinyl chloride*Bi1iary tract Vinyl chloride occupational exposure in relation to DiseaseJCarcinogens Vinyl chloride, occupational exposure to, biliary tract and liver pathol. in relation tojLiver Vinyl chloride toxicity to 75-01-4 8205 295 SI - CA/096/128863H CC - CA/159005 AU - Weber H ; Reini M 5 Greiser E AD - Staatl. Gewerbearzt, Duesseldorf / TI - German investigations on morbidity and mortality of workers ~h exposed to vinyl chloride SO - EHP, Environ. Health Perspect.; VOL 41,, 1981,95-9 PT - JOURNAL ARTICLE CY - Fed. Rep. Ger. LA - ENG CD - EVHPA IS - 0091-6765 AB - CBAC COPYRIGHT: CHEM ABS Mortality vinyl chloride exposure RNW 1762 00009904 vcn PAGE 147 Germany Morbidity vinyl chloride exposure Germany Occupational vinyl cnicride exposure GermanyjHealth hazard From vinyl chloride exposure.-; in Germany, mortality and morbidity in relation to Occupat:cnal RN - 75-01-4 EM - 8205 296 SI - CA/096/128683Z CC - CA/159001 AU - Il'icheva GV TI - Gas-chromatographic determination of vinyl chloride and 1,2-dichloroethane in waste gases SO - San.-khim. Metody Opredeleniya Vred. Veshchestv, M.; 1981,75-8 PT - JOURNAL ARTICLE CY - USSR LA - RUS CD - D3RAP AB - CBAC COPYRIGHT: CHEM ABS Vinyl chloride detn waste gas Dichloroethane detn waste gas Gas chromatog waste gas analysisjWaste gases Dichloroethane and vinyl chloride detn. in, by gas chromatog. RN - 75-01-45 107-06-2 EM - 8205 297 SI - CA/096/128642K CC - CA/159000 AU - Dimmick WF AD - Emiss. Stand. Eng. Div. EPA, Research Triangle Park TI - EPA programs of vinyl chloride monitoring in ambient air SO - EHP, Environ. Health Perspect.; VOL 41,, 1981,203-6 PT - JOURNAL ARTICLE CY - USA ZP - 27711 LA - ENG CD - EVHPA IS - 0091-6765 AB - CBAC COPYRIGHT: CHEM ABS Review vinyl chloride ambient airjAir pollution By vinyl chloride, in ambient air, monitoring of, Environmental Protection Agency Programs of RN - 75-01-4; 9002-86-2 EM - 8205 _ ... RNW 1763 00009905 VCM PAGE 148 cc - CA/ AU - Err- AD - Ber . Chem. Ind. Nuernberg TI - V in identification and solution of a problem SO - J. rel.; VOL 3, ISS 4, 1981,258-60 PT - JOLr ,,lE CY - Fed. `, ZP - D-85 LA - ENG CD - JVTtu IS - 0193- AB - CBAC 'vHT: CHEM ABS Vinyl chloride occupational health hazar =ease occupational vinyl chloride;Air pollution By vinyl ide, occupational exposure to, health hazards of, and prevent.c, r thereof RN - 75-01-4 EM -- 8205 * * * * E N D OF OFFLINE PRINT * * * * # RNW 1764