Document yrMm0n8og0DGLKJBjMnvDvGNE

\` I r. 7.C. Tolcy -- %'otj York " r. Taul - -.i. Louis "r. 75 ,L. Jenkins -- Anniston i^aaara. ~drur Z. Hardy J.F. reeves (2) A.U. cllcnburg. R.P. Loewan December SO, 1947 Celanese Corporation of Anerlea Central research Laboratory v Suoait. Rev Jersey Gentleman* Dr. L. 3* Bixnbaum As sngrested by nr* R. L. Jenkins In hie letter to you on Deceabar 23, we ere nleaced to write cb'iut /.rocior toxicity considerations. The host published Information ::bout the toxicity of Aroelor vaporo with reference to possible dona re to tie liver Is In a series of three ortlolea written for tho Jo'irr.tl of Industrial Ryrlena and Toxicology. The first article apoecrinir in the September 1937 Issue,--"* - Vol. 19, No. 7 and the second crtiele nubllnh^d in the February 1938 issue, Vol. 20, No. 2 were written by C..P7. Drinker, 15. F. Tsrrcn, and 0. A. Bonnet and cower only Aroclor &4o9. The third article rvltten by Dr. Drinker alone is sore co-ilc.to os It Rives Information about Aroelors 4465, 1254, 1268 and 34G0. 'a particularly wish to refer you to this.artiolo entitled, '"urther Observations on the Possible Oyotenic Toxicity of Certain of the Chlorinated Hydrocarbons with suggestions for Permissible c -- ontr-iions :n the Air of VorJarooms", -.by Cecil X. Drinker, The Jou: .-.1 of I.~ uotrlal Hygiene end Toxlcolopy. Vol. 21, Ho. 5, Key, TSST, In this article Dr. Drinker t jU-lstes the. ccmissible Halts of the compounds In ag. per euble enter of elr in rorkroaas. The following date in an exaerpt pertaining to permissible lioits of various Aroelors: Sfcterlsl Sb. 6 Ho. 9 So. 13 0. 14 Aroelor 4<65 Aroelar 1254 Aroelor 2268 Aroelar 5460 Permissible Linit Vk. per Cu. tf. 0.5 0.5 10.0 0.3 . \ Troa this, it is noted thst there is a carkod variation in the toxlelty of the vapors of different .\r*clo?o. ''o ruote Dr. Drinker, "Aroelors 1268 is alcost noD-taxie*. t:u verors of the other Aroelors studied are toxic end be evoldod. -i ."icrai, the acre highly ehlcriceted biphenyls are less tosAe than tv-o it -r cklorlneted derivatives, probe* SCM 021423 WATER PCB-SD0000026725 bly duo to deereaGed eolubill';'. r -c chlorinated tcr^hcnyls appear to b nor* toxic than ooriu- . aMiviustod biphonyls. "/hero the cold or solvnnt. rtf *.! i,- T*tt the irspregnstion of Aroclara usually only normal rrcsutijr.s or ordinary cleanliness of comcrcial plant practico -.ro Mien the .\roclors ere . eppUod by hot methods, SCO* ' . or higher, the woriaroons should be Tontllotod by Intake and tv." -.i f-..c of mfflelent volume and eloelty to removo the najorlty of the fuses, Where ercr drying ovens are usedk the Vapors rust bo ramrod. 9ugreatlons about this ere given in the ortlels entitled, "Observations on tbs Toxio Sffecta Resulting fToa Exposure to Chlorinated Naphthalene and Chlorinated Phenyls with Suecostlons for '.'roventlsn", by Dr. H. Ton Tedel, Dr. 3a. A. Holla and Dr. Jaaes Donton, published in The Rubber Ace. Yol. 53. No. 5, August 1943. . In General, it is bellevod that the persissible amount of Aroelor vapor in the workroom is evident to the worknea because of an irritating influence on the eye membranes. It tborcfare beoeases a self-revealing slgoal when dan'rrous lovels are reached. If you desire, as vill be glad to lend you an Instrument nbich as have with full instructions for its operation to soasure Arcelor vapors in your workroom atmospheres. This would be tho most certain method to detenains that your aorkinc conditions are safe. * In your latter of Deeeabor 19 to Dr. Jenkins, you ssksd ahether studies have bean nods of tho possible toxicity or dermctltin due to finished mnufsotuzad lteas containing Aroelars es an ingredient. .It aes determined by the skin patch test proesdure given by Dr. Louis Dchnartz and Sr. .`femel 32 I\iek in reprint flb. 2553 fron tho Public Health Reports, Yol. 39, Ho. 17 (April 23, 1944) that cnnvac painted with Aroelor 5460 and an oil ro",triad alkyd resin in such a ranner that each stpiare inch of fhbrio costsined 10.3 mg. of Aroelor 5460, ass neither a skin irritant nor - .tcr.3ltir.er. The following soisacreial applications are some typical large current outlets for Aroelora sad to our knowledge, there is no instance of . difficulty about toxicity even thwih in i number of these sppllcatldta alsratsA tenpenturea are used and consamara coma in rather elosa' contact with the finished earidity containing Aroelor. 737130 U3S 1. Actuating fluid for thrrsostats. 2. Heat transfer sodium. 3. Non-flammable hydro-ills fluid, especially . for die easting nr chines. 4. Adhesives for cany -urpsraai 5. Wood preservative sad sealer treatments. 6. Air compressor lubricant. 7. Plasticiser for nitrocellulose, ethyl Cellulose . and polyvinylchloride costings. (In a number of applications of this type the eonmmar ooass In -- iniBiRii 030608 WATER PCB-SD0000026726 .1 ) Intimate contact with the cm ting compositions* A good example la cootod heels of ladle** she**). 8. Plastlolzr for Purlom. and Pllolit* paints and coatings* 9. Plasticizer for air* Insulating compounds* 10. In tran3foraors and capaoltora* 11 Aa an lapregoant for papor products* 12* Preosura sensitive 3oalers* - 13* In fire ratordant paints and coating*. 14* Inpregpant for textile* 15* Industrial printing, ink*. 16* Stop-off luoquero for electroplating. 17* Ceramic* glaze printleg. 18* Plasticizer for asotrlt conpoeltions* 19* In tb* nannfaetur* of dentures* Based on oor praetlcal experience In the masnfaeture and sals of millions of pounds of Aroclors annually* the point that me mould emphasize is that markers ehor.ld not he exposed to Aroolar vapors and that the sen morkln.'* mith .\roelor3 should observe "good house keeping" rules about keeping tholr clothing and skins fraa of the material and avoid Insertion of it. II Adequate ventilation has proved successful in keeeing the stmosphere free from harmful amounts of .'roclare around machinery and in plants* V^hen you have had opportunity to '-V^e consideration to our above comments* please let ua have ycur thoughts and let u* know If me can ho of further asalstanco to you. . Tours very truly* \ rfc Copied hy re 1/5/48 7. p-nlgBus ScvelopoaBt Department SCH OH1*25 030609 WATER_PCB-SD0000026727