Document yr3JOvwrnO6n7Lw4LY8BjbDYn
@ HAZLETON oroncs ones ve
cron s onIO
07 KINSMAN BLYD + .0.B0KT643 + MADISON, WISCONSIN $3767 - PH6O082N614E71 + LXT0358RAZTALWES 05
FINAL REPORT
EETEEE\
( sanazies
\w,e 4 as ges"
FRTIOONGXENIRECSOOL6.TOAGYPMESRIEKNIRINVNSIGCE&SMANUFACTURING COMPANY ST. PALL, 55101
SAMPLE NUMBER: 7090576 SAMPLE ENTERED: 0925/8 REPORT PRINTED: 0120/8
SanpLE: T-4102
PURCHASE ORDER NUMBER: 1837389-410 754
ENCLOSED:
PRIMARY EY(EG_ECIDRRIGTUIADTEILOINN/ECSO)RROSION STUDY IN RABBITS oo WHeeyroPsersonne! oo SReefmemraernyces o Rau Data Appendix
s1GNED: SSWTTUEDVYo ENDMIe mR. ECGTLOARZAWo Acute ToxIcoLoGY
6LaTEl 2
00547
@ HrRAZLEeTt.ON05o0neo+mBsASenWcSeCA EO HOCNhEamic6a8! BlaT adicalE SlancS as iisi0on
seni rE: 70905764 sone: Tat0z
acute Tosicolon SStoevren 1. Clara CSSatouilun L.rtenHegoertno.n shoren L. Houery
a oSeebernas.CCorley arnt
ee 2
--
ra TThoopmeas2. FaFineTr, P,h RSobatrt SEalIa auperetor Dboennniise.eHtornton
froneiestenr, sbarators nina) Ustaricarion Ckindgy 3s. Cory, oun
C00548
HAZLETON wmeos sence ET TE
TChemir cal & BioMredircalRScieTnces Division
SLE Mrmr: FI95764 Serpe: Toa102
pose 3
aEeD eve teRITATION ObjaEecEteiinvgeeisnegexTpoosdTaerrteeramnoifgniea 2ttehasetstolsemevpefslotnaonfEceo.oscnutlaeainraoneL.irereyietnatetitooenani"bpiarnmosyducBroeuvdbeifteaosplmlaanutin1ga Ang, Ra RS El TosBPtoSMtatterainaaBlaste orTi-pi at1l0on2: DSaorokneoormbetrei1nigsuidPespansibitity for Starage and Retention: aSTnhoeyeiiitymieitnoemsaaetsmeaerraiene]tlailsra)nuidtes)toeirbemdsinayact:eirotonhnsoa.n'tSeomrpoerrsatnugre Sofoty Precautions: NVooremAehd ShSeranendndideiernrsgd OpBrproeocrreaadttiiirnndggePPrrsaoocrcesesdaeureraed; secarding Tesrrtoeoftmhieunmdad,lis mpoieYncotouannitgnreoadt.dulloitdndarigaeebirbqiuttoesrislsyofpirntohevsiodNceeedswnZsoeeoeetslisaoendntoWc.hoidsteeesrersitnarsat.ienmLpiweseotrtoeunreoodeHnmamtsiaeomnpe1epDer1io5odneoSfvaTotenettreentsoeeaur7AldiSnashyaos iEn'damtihneBe0]t0oTuhYuissebRenrusortiytneheadEComrodeusionnndg,use 3CoonniLieEvDtooSrnhasatdoyerxisatntaeigamsn:etheyHTo"vesroeontadaotsnuimoocensstoseFrraaenndetchseopnetpciaiaseetcse1dasbhevneavehsoovvteesnommampearrneieseaettntt fF aitE eeC Sil. R IER ir rr PTrhFiraneene gatoacneltifenokratemtdohveearntiieanmlta:lsa,dTmhwieeingSihioinenggrliaeof!tnromeSyae2ts0e%coorgteoios2nx1o55nFiisgot,oa rweLerrneiinenicnhodsr3ee4nhours EEraertaraaitrteoins voeocemtyb:otwhsoseaTaoa?untimeantiamatlsaweeve'a tToononsogfoaond f by amT ine) enber ReamsoantforetSTpreeciicsss Sbealteecdtipoenn: itTsh.e lNaevwasZaerablreendamldihimteengalibgimnaonterdabbiittis:is the PreApaAratRion anR d AdmiA nistratI ion of TeAst Hatorisli The semple was dosed as Tra3T0sovtamrtennatth:eontcrvFeaonrcthiaodnrabcTbooinstterorle1?c5aeivFbfheedonT0s.o1paegmel,notfwittthhoe tehleiqieuoaindntrLtaeolsrattompraeatn)er1io5avlehe 1pD0learcceidn TTaEsetEneDr STornoneeseceond froeprneveentnttoectnoaf. ever ial ond' the-n Shiaicd.
COG549
-
@HHa AAZZLLEETTOONN usoemoa snewsmemcmS rancn T cChheammiciacla sBlaMtateesasScloannceessoDviisivaoeon
serie Nimes 70908764
_--
iio
arco eve tmmiTaTION
sities
non ash ne
a ee Ee en Binh ni Sree aSt tohe n72-hnoTur,da2- anCdprles 14bli-edaayycorrernsaetsaidlnigntgsse,etrshoduyiautniyflsuroaryesucaeiinn vuaessewedes
Saiogihntalswewreree yeighed ust priorte tent materielsininistration soy
Siren fetnete: Oteer thenee Totoei rt Tiel Fores: The rou dae an
COG550
HAZLETON worms monn
Chamiat Saat Scinses iio
SarPLE NurBER: 70905764
sorries Tocnz
BESTCOPY AVAILABLE _..
RP srr comers Tost animals aibine robbits - New Zealond ite
Bate Tent Startens 11706787 Date Test Competent 11/70/87
PetraRY Eve RRITATION Scoese
aaserumTION PERIOD
> aRatsniet,sHoan
3 tous:
23
7-2 poiousr:
FTseoenmt
SToErntl ton aa nima Tes tnd nina TMSi nea 3307 558
C0551
HAZLETON womenswencnve Chemie! & ioecicet Scioces iin
corre meer: 70905764
[I
gremzs Toate
ses ave seermeTIn
are Individual EnTavetneta1tion Soares
nitelir an Sh BoJILAg I al Foi S sBalimeeesib 3010338 o0a0%80B 1br 1rsfo3 ::231o2o%zro2 1nonoown
aSgewawmsoobb4s0s 15%.r os3h 1 bor oan m2 GASdheeen.r 11ob 31os %ooa:o}s 1ao 32 1131:1a io%non EaSahweeror os8o%8 855 888 65 aafsobosbneod Foose dGtlwioe.es o11b 023fo01B0 b11s:7 a3301331%2 oouu
2s tegres of spsnity
Es 3: fans,
Tanto 2
TEI recimitionion ER Ss 14 ous
Zciooenseder
Jieo ee
wose :camo mwe:r
nes :
+ animal ound deus at Zoohour ohsmrvatian. COCS52
@ M HALZsLETON eoN ns meme eS i.t as Snsas Gon
coves wren: Fu0ses
see >
veo eve mmr varion
conriuEns
Sn a
ne
mi SHON PSOALOE TORY UR guia. Sem abuse, 3 1 bouts
BO
$+ Grgmseatian tor Segments Somparation spd evglesgenbds Gubghives foraTeting 58 Si
2. ODIrairzCoevam6etie.tes n"[apeDpraaiisral oTofefnitetihtheyanySSaarfaettyyesoaaferiCshCtahimoenimcioacflals1nin FFooness2, Oruse, 2 ot on free ST
00553
Wa wo. TQONE TY Perso`nAnceutle STiogxniactoulroegySheet
Mane
Becky Beckwith
Steve Beloungy Xen Bridges
JobTitle
Sr. Lab. Avtnad Asst.
Lab. Antmal Asst. Sr. Lab. Antal Asst.
Pat Crary
Shane Etth Shawn Frazter Steven N. Glaza
Wolly Hahn Kevin Hamilton Jeet Hicks Calvin Horton Sharen L. Howery
Gregory Johnson Paul Krebs Mayne Medison Scott Mcconnell
_ Shelley McConnell
"Dawn Conant
Don avis
Sr. Lab. Animal Asst.
Lab Animal Asst. Lab Animal Asst. Group Leader
Admin. Clerk Lab. Animal Asst. Sr. Lab. Antmal Asst. Group Leader Administrative Asst.
Lab. Animal Tech. Lab. Antmal Asst. Section Supervisor Lab. Antmal Tech.
Lab. Antmal Tech.
Sr. Lab. Antmal Asst.
Lab. Animal Asst.
Robin Olson
Patricia Padghem Joseph J. Daun Wichael Patzka
30h Pauson
Lab. Animal Asst.
Tem Leader Lab. Antmal Asst. Lab. Animal Asst.
se. Lab: Atma Asst.
Jane Polnow
Lab. Animal Tech.
Dennts 8. Steiner Lab. Animal Tech.
Michael Thestng Lab. Animal Asst.
NPabuelrat6.OlVsaonngen HAadmpionmiesrtrative Asst.
Jin Jirschele LTE
BAEeninnleeHteatnleeH,yR.McTCuornnneerll SMrAa.dnmpiLonaw.berACnlierrakl Asst.
C0C554
Stanature
;
22. rats
Hane 34 Sw Li DST
om
ay Gickes RLOZl 0 UsRJ dein Qe,Zl
hdl Meena
(awsuConedc
Eel,
Le Mn
faicia Todsdur Quiet Of Kal GR
Cp Balan,
Qos Nn
sn 2 Ai
Wyckall Thising
7=;I2.5A4A0
Lo.Ledid,
a FSMoT ly eZ 2imc
Intttals
wm
8 x
Qc
se I se
EN
or PK sang Sa
ane
72d Yo on &
Su
x
WT I
fHrHdere
a ineys sin
el Ee
BODY
e te i i esee nce WEIGHT/uwsE RECORD.
a:KOS Ted
| SBEaErTinCgAith IHangset IMoe; SrI 90 T RsooomrNeo:or vot_1m( a-E rin we _
mansn |0som 1en oi| TRE e rJeS Je] L at[|m oretons temats lls?
o[maoonm | L9Tova] |oame[LoRaEgElPealne E EEi. =
EP EE.
g
= ref 1e | 2 m e E
-
33 OE
woe E {alT--T al-- n a fm a1 h Tr ]o,in the conjunctival sac. =
te poieSdo acom] TTsf to pLaan|PNE iemsans s Sdn m
Reviewed by:
V1La
vate: _/2-$-F7
(00261/ vat)
:
wa: _J09052d
PRIMARY EYE IRRITATION TEST OBSERVATIONS GrTeosutp:nat| eTTrqtIOaAli Test eye: RGAE
_LifWa0sA hs`etehceodntd:esstfeoylelowwaisngwaisnhsetdilwlaittiohnaofmLtoefstlmuakteewrairaml, tap water fornA seconds.
Unwashed
anton) to.
cLoorcnaetailon Toefstans
Tal) eo Hes
omer are
rs
Comun Ree dnesnes:s
onlo | a|d| ob
Qn Period: hour
|"
)) x \) () ()
N
|o |p]
Pel
x
ON
lo I[ T oNT OT
[I [e pe S p T
l 4 le 4 le 3 | | NO A |
psc [2Jac[pc< |[TN] soon torreonen]Na{on |on|||]
Technictan: __x8 ) 777 Date: nlJg7
EYE ICVReaRrlIicTfuAilTeaIdtOeNdByS:bCyO:RE:
va(t0e). Date IT
NA - Not applicable. A - Petite hemorrhaging.
80 -- CBplluearanurclheidnnitgs.cdhiasrcghea.rge. _ Halr loss around the eye. 6F 2- NUsneeavcberlroeeticstwoealrveliaissnu.ga.lize due to W- No reaction to Mgnt.
I - Injected.
J - Corneal epithelial damage, peeling. K - Corneal epithelial damage, piling.
NHL Z-2 CCHooyrrpnnoeepaayllon.ehpeiotvhaeslciuallaridzaamtatgoen,. pitting. PZ pannus.
R
S
-
-
sGUernvaaenbruleleatotipooacnviitssycu.aarlizteissduuee. to
705 - Positive stain retention.
NEG - Negative stain retention.
Reviewed by: JY
(00261/vmt)
Date: 12.887
CO0556
wa:_20905 24 PRIMARY EYE TRRITATION TEST OBSERVATIONS TgTreeossuttpm:oavT etrer a|irTI
washAesethcdeon:Tdosst fovlelowaigng waisnhsetdillAatiihoonQofAfLteosft Tmuakteenrairaal, tap water forn@ seconds.
Unwashed
Lcoocranteiaon Toefstons
PW
I | (HiRbeAKr7?/iJ\hN
m2
(\) ()
|
Se ToS
rn
dness
eefebea Lb LAL
24 Q 4 2A
N
x
eve tmRrTATION score: , ZA.
sate: Technician: -- 11-87 7 lal Calculated By:
DDaatetel
NA - Not applicable.
A55 22-2 CSPFlreuaetrnaiacrtiheeindnthngei:dmctohsracrrhheaa.rggien.g. GEZI2 RUheanciarrbglteTioestsoarvaeriaosnuu:nadliztehedueeye.to 012 NMsohesveercreteaecste.ironintgo,iran.
J - Cornea) epithelial damage, peeling.
XNKUZ72-
ChCCoooyrrrpnnnoeeepaaaylllo
nneeeppoiivttahheesllciiuaatlla
ddaammaaggee,, rtzatton.
ppiiltitnign.g.
7PZ2 spUaennvaneburlsee.otpoacviitsyu:alize dus to
NS3E0S5 GrNapenoausalitatitivvieeonssttsaaeiiannr rrteestvseeunrets.iioonn:.
Reviewed by:
mn
Date: _]2-8-87
-
(00281 vm)
C0055
Ha: PRIMARY EVE IRRITATION TEST OBSERVATIONS GrToeuspt:nateriaIn TIA Test eye:_Right
_L)fAW1asshettahcepeodnwtda:estsetrfoeylfeloorwvMaisnAg wsaeiscnhosnetddisl.wlaittihoyna ofnL toefstlmuakteewrairaml=,
70905 2d
~Unwashed
bse
an
od; R hour:
lLocao tionm o- o]La2gs olro-cxaszu]N TT1]
T-- all c-- oo Head
Cornen - gaat
IE N O 222> NXO O
hi aTONy TT
rs
Lr ir lo TST]
:
aese [2 [3 [1 [IN
sere |[>[3c[je|[TN
Technictan: Sam vate: yl--g7 AN8A-- - BpNleoattnictheaipnphgle.imcoarbrlhea.ging. CPlueraurlendtiscdhiasrcghea.rge. GEF-C- UMHneaacibrrloetliocstsoaraveriaossuu.nadliztehedueeye.to H- sNoeverreeactsiwoenllitnog.light. 12 Injected.
EYE ICRaRlIcTuAlTaItOeNdScBoRyE::_p, Verified By:
ZsDate, Date IT13
JK L
-
-
CCCooorrrnnneeeaaalll
eeepppiiittthhheeellltiiaaalll
dddaaammmaaagggeee,.,
pppiie1teitlniignn.gg..
N4 Z2 CHoyrpnoepaylon.neovascularization.
RP Z- sUPaennvanbeulrsee. otpoacviitsyu.alize due to
PS05- GraPnousliattivieonstsacianr rtiestseunet.ion.
NEG _ Negative stain retention.
Reviewed by: 117
vate: 12-8787
-
(00261/vmt)
00558
wa:_20905 204 PRIMARY EYE IRRITATION TEST OBSERVATIONS GTreosutp:nat_| eIrdnIOaAl: Test eye:RAGE
_Lifiva0Asshe`ttacehpeodnwtda:estsetrfeoyfleloorwwnaisAngwsaeiscnhosnetddisl.wlaittihoynlaofmL toefstlmuakteewrairaml, Unwashed
on op periog: 72 hours
Lcoorcnaetailon loefsions
Corn - gmat
7 on 2
"lola NA T
ns
[oo[TT TNT]
wees Coe Redn ines. [l0 e 3 l[2 a |[ [T IN N\]
wows | [ 2][TN X
sottn orescomesalBaigr
log | V[||]
Technictan: (SNe
eve tCrarlicmualtartoendscBoy:re: _S[0,F5 jn
(Z-nmasn ple>,\ Gate JI-4-)
Date:
987
Verified By:
Date 13-7
NAA - - pNeottiteapphleimcoarbrlhea.ging.
8 -2 BCllaenacrhidnigs.charge.
FED -C- HPNaeucirrruoltelinoctssdariaesracoshu.anrdget.he eye.
G
H
-
-
NUsoneavberlreeeactstiwooenlvliitsnouga.lgihzte .due
to
17 Injected.
3X -- CCoorrnneeaall eeppiitthheelliiaall ddaammaaggee,. ppieleilnign.g. #L -HCyopronpeyaoln.epithelial damage, pitting.
NPR Z--
UCpnoaarnnnbeulasel.
neovasculari
to visualize
zati
due
on.
to
PSOS- GsreavPneoruseliattiovipeoancisttsyac.ianr triestseunet.ion
NEG Negative stain retention.
Reviewed by:
(00261/vmt)
[17
vate: 11-95-87
50055
335
wa:_20905 264 PRIMARY EYE IRRITATION TEST OBSERVATIONS
GrTeosutpm:aterial| TAIN Test eye: RIGRE
_LiiWasAhsetehceodntd:esst feoylelowwaisngwafsnhsetdilwlaititonhaonf)tL eosftmlautkeewrairaml, tap water fora@ seconds.
Unwashed
ob
an period: 9G ho
cLoorcnaetailon Toefstons
Tat) ee Hes
comes comers are
on
|
\)() )
[N
X
|0Ya [an[\NT
Jo[1TR
loTo[[T TXT 7]
Rednesdnss
meee
|L o[T 0[T [|]
NA
IN]
mewse [0|o [||[TX
soon tnormeenealNA [NA |V[| |]
Technician: tate:
17 [156 1-10-87
EYE ICVRaeRlrIciTufAliTaeItdOeNdsyS:CBOy:RE7: _ 7="_ DnSaattSee(5 2(i-:gp2= im3al me
AN8A-- - pBNleoattnictheaipnphgle.imcoarbrlhea.ging.
C - Clear discharge.
0F -- HNPaeulcrrruoltelinoctss daariresaocshu.anrdget.he eye. GZ Usneavbelree stowelvliisnuga.lize due to H - Ho reaction to Mant.
1 - Injected.
JLX Z-~ CCCooorrrnnneeeaaalll eeepppiiittthhheeellliiiaaalll dddaaammmaaagggeee,,, pppiietletiliningng:g..
M - Hypopyon.
N?
~-2
pCUaonnrannbeulasel.
neovascularization.
to visualize due to
S - Gsreavneurlsatoipoancitsyc.ar tissue.
POS - Positive stain retention.
NEG - Negative stain retention.
Reviewed by:
(00261/vmt)
m
vate: /2-2-87
C0560
wa:_10905 2d PRIMARY EYE IRRITATION TEST OBSERVATIONS sTTeerssottwmaiayT et_re._r_|RighEAA
AashAesethcdeon:tdesst fooylelowwiasngwaisnhsetdilwlaitiiNoAn AofMtL eosft Tmuaktoerairanl, tap water foram seconds.
Unwashed
CLoocrarteiaon loefptons
I eee ted
a es
ComunTeednesness
ames wwe
I
(\ ()
[N0]
Xx
II I
AN
lo[o [TTTNT]
|] 0 1] A IN
|0 [o[| [[IN] [0 |o [|[| | |
vate: Technician:
oh
sje)
NAA -rNeottiteappnleimcoarbrlhea.gtng. EB C- BhpCalluiaerranurclhelindontisgss.cdhaiarsrocghuean.rdget.he eye. GFZC NUseenvcaerbraleteicstowealrvleiiasnsug.a,lize due to 1-2 NIonjercetaecdt.ion to. Tight.
EYE IRRITATION score: _\.O (2-an,
n
CVaelrciufliaetdedBy:By: SI DDaattee_ i13 it?
XJ - CCoorrnneeaall eeppiitthheelliiaall ddaammaaggee,, ppeienlign.g. N#L -HCCyooprronnpeeyaaolln:enpeiotvhaeslciuallaridzaamtaigoe,n. pitting. %? pUsanenavnbeulrsee. toopacviitsyu.alize due to 3s05- 2Graonsuiltaitvieonstsaeianr rtiestseunet.ion. NEG Negative stain retention.
Reviewed by: (00261/vmt)
2
ate: 42-88-87
00561
wa: _20905 264 PRIMARY EYE IRRITATION TEST OBSERVATIONS
GTreosutp:maItTeordIiOAal Test eye: _RIGRE
_LifWasheAd: stheecontdesstfoelyleowwiasngwatsnhsetdilwlaittihoynAomftLeosftmlautkeewrairaml, tap water fora@ seconds.
Unwashed
pacts: Dog 14
cLoorcnaetailon Toafstons
Tat) cee Head
mesma
ace n
ComRe ednesners
owes mewse
a
(\ ()
0
X
|0[o[wa NN_[7
[[o [[Io NT]
lolo[[T TNT 7]
l |0o 0 [loo o l [|[TT IN NA ] |0|0 [[1[TX]
Technician: Bh
Date:
fof?
N8AA2- - BpNleoattnictheaipnphgle.imcoarbrlhea.ging. 2 Clear discharge.
0 - Purulent discharge. E - Hair loss around the eye.
6F 2- UNsenecavrbeolrteeicstowealrvleiiasnsug.a.lize due to H1- HIonjercetaecdt.ion to Hght.
EYE [CRaRlIcTuAlTaItOeNdSCBOy:RE: Verified By:
G0ate 1(12--2a0n8i7smal Date [2-2
LJX ~=- CCCooorrrnnneeeaaalll eeepppiiittthhheeellliiiaaa]ll dddaaammmaaagggeee,,. pppiielteitlniignn.gg.. HZ Hypopyon.
N - Corneal neovascularization.
P - Pannus.
R
S
-
-
GsUneravabenlrueslatotiopoancviitssyuc.aarli
ze due
tissue.
to
N7E0G5 -_ NPeogsaittiivvee ssttaaiinn rreetteennttiioonn..
Reviewed wo
100261 /umt)
2 vate: /2-8-27
U6562
BESTCOPY AVAILApBoLeEA
wx 2090 E24
Lem
,
of EAE TT
we en
era
perr rere :
T TRER O ET
VH hesseTspnoG rma).vp s 0 r ree a opr tsernm. mre rs--1-- |0.
gms er ani ee
,
Goto eng ates pare svarston of 11
2
a ETP to m--
miae ttn sto. 7 ren
1 vraize, J. W., "Appraisal ot the Safety of Chemicals in Foods,
005863