Document yr32zZOVyeq7gpXMRd8NX6X53

i . L Ul'i' i' in V Ilf .1 n:l 'yiv.1, vliilo work in;', ii.ll the ihestosis pat lent s . Ht.- mentions r .> i,.,t i - `vscosis pat l ones vii i;h were thought to bo related to L , origin of t Iv. ii i seusc (purulent bronchitis, bronchopneumonia. tuber- I. c i s , ompbvsv -i - and bronchiectasis) and accompanying di.so.nr. of. which, : ... d on b.- statu : of medical knowledge at that time, were thought to be i:"i'-:l.it>:d t < r the i (feels of the dust. Under the latter, lie makes Llm (ol- i ' hip observation: "There has .also been one case of squamous carcinoma of the pleura. There is no evidence at the moment tiiac cliis was in any way related to flic asbestos is". In 1933, Gloyne was able to provide two additional reports on lung c.'iiuor decocted in asbestosis patients. At that time, he still, was not ail. to make a definite statement as to the possible etiological correla tion of both diseases. Nevertheless, certain histological aspects did appear to indicate this. The first of these two observations concerned a 35-year-old female v.lio had worked for a period of 8 years as an asbestos spinner, and had Chen lived 9 years for 9 years uithout any exposure to the dust. She died, as shown by the autopsy, of moderate asbestosis with a congutum in the right s'ccl ion of the heart, spleen infarct and a meningeal, hemor rhage. On the basis of the right lung upper lobe, a clinically non-identifiable tumor was found, which was approximately the' size of a walnut and which extended into the tip of the enlarged pleura. There were no inctaslascs Co be observed. The cornified pavement epithelium carcinoma orig inated from a small bronchus. The second observation and autopsy also concerned a female who was just turning 71 years of age. Fifteen years prior to her death, she bad once worked for a period of 6 months, and another time for a period of 13 months, in a hazardous duscy mattress and processing department of an u :stur. plmt. In this patient, Gloyne found a moderate case of asbes tosis, with a partly-collapsing tumor in the right lung upper lobe, ascites ;nd thrombosis of the left leg vein. Here too there were no metastases to be observed. Histologically, this was also a cornified carcinoma of the pavement epithelium. In botli cases, the cancer did not appear to be spread to the extent thui it could promote death by itself. The same applied to asbestosis. In the same year (1935) . a .report was .issued by Lynch and Smilh of the Unit<'d Stales i.oni'crning lung cancer in asbestosis patients, in which a .h.tailed history of the disease was given. The 57-year-old patient whose case is described had worked Cor 22 years in a cotton weaving plant, and for 21 years in an asbestos plant, until, his hospitalization; he hail been eoiiip la i ning of shortness of breath for ahout 5 years. Three years prior to his death, he started having occasional pains In the hack and over the lleio last ribs on the right, and again complained of shortness of breath in the last few months of his life. He became weak, coughed, lost his appetite, his temperature rose, he had b.lood in Itis sputum and suffered -2-