Document yr27GydJ9byLv9ergxRL3GGpX

V todustrlal Hygiene" Digest - 4l~ August, I9U9 $2,947' Changes In the Blood In Experimental Trinitrotoluene Poisoning. L. Pecora folia ned. 73-^5(1949). Italian.- Rabbits subjected to a chronic poisoning vlth TOT developed a mild anemia vlth a moderate Increase of the leucocytes. While the blood platelets vere reduced markedly, the prothrombin time, coagulation time, and time of retraction of the clot remained unchanged. -- Chem. Absts. i948 Hematology In Experimental Phosphorus Poisoning Treated vlth Llpocalc. L. Pecora. Polla-Med. ^2, 62-72 (1949) Italian Babbits poisoned vlth phosphorus dissolved In oil developed a hypo chromic anemia vlth reduction of platelets. The vhlte cells shoved a fleeting Increase "ad a relative lymphocytosis. Treatment vlth llpocalc J reduced these changes to an Insignificant degree. Theory: the methylating action of llpocalc activates some enzyme systems blocked by the phosphorus. -- Chem. Absts. j 949 Cardiac Stimulation In Carbon Honorlde Asphyxia. H. Schverma, A.C. Ivy and H. Friedman. J. Applied Physiol. 1, 364-368 (Hov. 1948). !i We observed that the Intra-cardiac Injection of epinephrine and atropine In conjunction vlth oxygen administered by a mechanical resuscl- j 4 tator vas effective In resuscitating 4 of 19 dogs asphyxiated vlth carbon . monoxide vhen treatment vas begun one minute after the last gasp and no cardiac. Impulse vas palpable. Under the same conditions the Injection of 0.89 per cent RaCl vas Ineffective In 19 dogs, although It did induce a transitory cardiac activity. In vlev of these observations It Is probable that this treatment Is vorthy of trial as a last resort In human cases of cardiac arrest folloving carbon monoxide asphyxia. -- Authors' Summary 990 The Metabolism of Plutonium In Rats Folloving Intramuscular Injection. fc.O. Scott, Dorothy J. Axelrod, H. Fisher, J.F. Crovley and J.O. Hamilton. J. Biol. Chem. 1J6, 283-293 (Oct. 1948). Plutonium obtained from the Cllntcm Pile vas prepared In the three valence states:+3,+4, and +6. Bach preparation vas diluted vlth Isotonic saline to a concentration of 19 gamma of plutonium per cc. at pH 2.9. TOe X plutonium solutions vere administered to rats orally arid by Intramuscular Injection In the left leg. The animal a vere sacrificed at 4, 16, 64 and 296 days. At autopsy, examination shoved that plutonium In each of Its valence states vas not absorbed except In trace quantities from the gastro J intestinal tract. It Is only partially and elovly absorbed from the In ` jection site and Is deposited mainly In the liver, kidney, spleen, and particularly In the bone. After the longer Intervals, the greatest degree of absorption vas In the +6 valence state end the least In the *4 state. The distribution and excretion vas similar In all the valance rn.tn.ub, which, suggests that plutonium Is converted In the body to only one of the valence states. The chief channel of elimination vas the digestive tract, but the rate of excretion vas very slow. It Is suggested that the highly selective localization cn the bane surface explains the high toxicity of plutonium compared vlth equivalent quantities of radium. --Condensed from Bull. Hyg.